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metronidazole and Anemia, Fanconi

metronidazole has been researched along with Anemia, Fanconi in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Voter, AF1
Manthei, KA1
Keck, JL1
Tinsa, F1
Necib, N1
Guesmi, M1
Bousnina, O1
Douira, W1
Bousetta, K1
Bousnina, S1

Other Studies

2 other studies available for metronidazole and Anemia, Fanconi

ArticleYear
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
    Journal of biomolecular screening, 2016, Volume: 21, Issue:6

    Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc

2016
Fanconi anemia complicated by neutropenic enterocolitis.
    La Tunisie medicale, 2008, Volume: 86, Issue:11

    Topics: Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Blood Transfusion; Ceftazidime; Drug Thera

2008