metronidazole has been researched along with Bile Duct Diseases in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Bile Duct Diseases: Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Bao, L | 1 |
| Yu, X | 1 |
| Zhu, C | 1 |
| Xu, J | 1 |
| Wang, Y | 1 |
| Yin, M | 1 |
| Li, Y | 1 |
| Li, W | 1 |
| Larchet, M | 1 |
| Duhamel, G | 1 |
| Pariente, D | 1 |
| Dumont, M | 1 |
| Degott, C | 1 |
| Godeau, E | 1 |
| Erlinger, S | 1 |
| Goulet, O | 1 |
| Ricour, C | 1 |
1 review available for metronidazole and Bile Duct Diseases
| Article | Year |
|---|---|
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
1 trial available for metronidazole and Bile Duct Diseases
| Article | Year |
|---|---|
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
1 other study available for metronidazole and Bile Duct Diseases
| Article | Year |
|---|---|
Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report.
Topics: Adult; Anti-Bacterial Agents; Bile Duct Diseases; Bile Ducts, Intrahepatic; Cephalosporins; Clotrima | 2017 |