metronidazole has been researched along with Splenic Diseases in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Splenic Diseases: Diseases involving the SPLEEN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 7.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess." | 3.69 | Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report. ( Lawford, R; Sorrell, TC, 1994) |
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 3.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ueno, T | 1 |
| Ito, M | 1 |
| Arai, A | 1 |
| Suzuki, C | 1 |
| Tomiyama, M | 1 |
| Goret, NE | 1 |
| Goret, CC | 1 |
| Duggal, S | 1 |
| Mahajan, RK | 1 |
| Biswas, NK | 1 |
| Chandel, DS | 1 |
| Duggal, N | 1 |
| Hans, C | 1 |
| Daneshmend, TK | 1 |
| Homeida, M | 1 |
| Kaye, CM | 1 |
| Elamin, AA | 1 |
| Roberts, CJ | 1 |
| Galifer, RB | 1 |
| Rodière, M | 1 |
| Peskine, F | 1 |
| Ferran, JL | 1 |
| Lawford, R | 1 |
| Sorrell, TC | 1 |
| Wagner, VP | 1 |
| Smale, LE | 1 |
| Lischke, JH | 1 |
1 review available for metronidazole and Splenic Diseases
| Article | Year |
|---|---|
Splenic abscess is extremely rare after amoebic dysentery. A case report and review of the literature.
Topics: Abscess; Adult; Amebicides; Anti-Bacterial Agents; Bacteremia; Combined Modality Therapy; Cross Infe | 2019 |
6 other studies available for metronidazole and Splenic Diseases
| Article | Year |
|---|---|
Convulsive seizures caused by metronidazole-induced encephalopathy.
Topics: Abdominal Abscess; Anti-Infective Agents; Brain Diseases; Cerebellar Nuclei; Humans; Magnetic Resona | 2019 |
Splenic abscess due to Salmonella enterica Serotype typhi in a young adult.
Topics: Abdominal Abscess; Anti-Bacterial Agents; Ceftriaxone; Humans; Male; Metronidazole; Ofloxacin; Salmo | 2008 |
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Kinetics; Liver Cirrhosis; Liver Diseases, Parasi | 1982 |
[Splenic abscess caused by Ristella fragilis : a case report of a 2 years-old boy (author's transl)].
Topics: Abscess; Bacteroides fragilis; Bacteroides Infections; Child, Preschool; Clindamycin; Humans; Male; | 1981 |
Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.
Topics: Adult; Amebiasis; Ataxia; Central Nervous System Diseases; Humans; Liver Abscess, Amebic; Male; Metr | 1994 |
Amebic abscess of the liver and spleen in pregnancy and the puerperium.
Topics: Adolescent; Adult; Amebiasis; Chloroquine; Emetine; Female; Humans; Infant, Newborn; Liver Abscess, | 1975 |