metronidazole has been researched along with Gastrointestinal Hemorrhage in 37 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients presenting because of major upper gastrointestinal hemorrhage from peptic ulcer and whose ulcers healed in a study in which they were randomized to receive ranitidine alone or triple therapy plus ranitidine were followed up regularly with endoscopy." | 5.07 | Treatment of Helicobacter pylori reduces the rate of rebleeding in peptic ulcer disease. ( Graham, DY; Hepps, KS; Lew, GM; Ramirez, FC; Saeed, ZA, 1993) |
| "Here, we report a case of amoebic colitis in which peripheral neuropathy occurred approximately 24 hours after administering metronidazole." | 1.56 | [Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report]. ( Hotta, Y; Ikeda, K; Isozaki, Y; Nagao, Y; Oaku, T; Oyamada, H; Sekoguchi, S; Takemura, K; Yamada, N; Yamane, S, 2020) |
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| "Abdominal pain is common feature of Henoch-Schonlein purpura, which may mimic appendicitis, leading to unnecessary laparotomy." | 1.35 | Gangrenous appendicitis in a child with Henoch-Schonlein purpura. ( Amouzeshi, A; Jalali, AN; Jangjoo, A, 2008) |
| "The development of toxic megacolon as a complication of infectious colitis is rare." | 1.33 | Toxic megacolon complicating Escherichia coli O157 infection. ( Koerner, RJ; McElroy, J; Nayar, DM; Pai, P; Vetrivel, S, 2006) |
| "Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80." | 1.28 | Substitution of factor XIII: a therapeutic approach to ulcerative colitis. ( Classen, M; Gain, T; Heinmüller, M; Lorenz, R; Tornieporth, N, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.81) | 18.7374 |
| 1990's | 9 (24.32) | 18.2507 |
| 2000's | 8 (21.62) | 29.6817 |
| 2010's | 11 (29.73) | 24.3611 |
| 2020's | 5 (13.51) | 2.80 |
| Authors | Studies |
|---|---|
| McDonald, NM | 1 |
| Piovezani Ramos, G | 1 |
| Sweetser, S | 1 |
| Oaku, T | 1 |
| Yamada, N | 1 |
| Ikeda, K | 1 |
| Yamane, S | 1 |
| Takemura, K | 1 |
| Hotta, Y | 1 |
| Sekoguchi, S | 1 |
| Isozaki, Y | 1 |
| Nagao, Y | 1 |
| Oyamada, H | 1 |
| Sosa Solís, AM | 1 |
| Fernández Antuña, L | 1 |
| Royo Cuadra, Y | 1 |
| Castellarnau Figueras, E | 1 |
| AnilKumar, M | 1 |
| Savage, E | 1 |
| Thota, PN | 1 |
| Pui, WC | 1 |
| Chieng, TH | 1 |
| Siow, SL | 1 |
| Nik Abdullah, NA | 1 |
| Sagap, I | 1 |
| Sethi, S | 1 |
| Puri, A | 1 |
| Sachdeva, S | 1 |
| Dalal, A | 1 |
| Tanaka, K | 1 |
| Fujiya, M | 1 |
| Sakatani, A | 1 |
| Fujibayashi, S | 1 |
| Nomura, Y | 1 |
| Ueno, N | 1 |
| Kashima, S | 1 |
| Goto, T | 1 |
| Sasajima, J | 1 |
| Moriichi, K | 1 |
| Okumura, T | 1 |
| Gravito-Soares, M | 1 |
| Gravito-Soares, E | 1 |
| Tomé, L | 1 |
| Ortiz, V | 1 |
| Klein, L | 1 |
| Channell, S | 1 |
| Simpson, B | 1 |
| Wright, B | 1 |
| Edwards, C | 1 |
| Gilbert, R | 1 |
| Day, R | 1 |
| Caddy, SL | 1 |
| Vipani, A | 1 |
| Yang, MX | 1 |
| Torrijo Gómez, I | 1 |
| Uribe Quintana, N | 1 |
| Catalá Llosa, J | 1 |
| Raga Vázquez, J | 1 |
| Sellés Dechent, R | 1 |
| Martín Dieguez, MC | 1 |
| Báguena Requena, G | 1 |
| Asencio Arana, F | 1 |
| Weiner, JP | 1 |
| Wong, AT | 1 |
| Schwartz, D | 1 |
| Martinez, M | 1 |
| Aytaman, A | 1 |
| Schreiber, D | 1 |
| Jangjoo, A | 1 |
| Amouzeshi, A | 1 |
| Jalali, AN | 1 |
| Dinleyici, EC | 1 |
| Eren, M | 1 |
| Yargic, ZA | 1 |
| Dogan, N | 1 |
| Vandenplas, Y | 1 |
| Nakanishi, Y | 1 |
| Seno, H | 1 |
| Chiba, T | 1 |
| Yamashita, Y | 1 |
| Sahakitrungruang, C | 2 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 2 |
| Atittharnsakul, P | 2 |
| Rojanasakul, A | 1 |
| Gupta, R | 1 |
| Wellman, G | 1 |
| Hussain, SZ | 1 |
| Kanjanasilp, P | 1 |
| Malakorn, S | 1 |
| Chattopadhyay, A | 1 |
| Martinez, MW | 1 |
| Petre, S | 1 |
| Wisinger, D | 1 |
| Temesgen, Z | 1 |
| Nayar, DM | 1 |
| Vetrivel, S | 1 |
| McElroy, J | 1 |
| Pai, P | 1 |
| Koerner, RJ | 1 |
| Douglas, JG | 1 |
| Crucioli, V | 1 |
| Omrani, G | 1 |
| Rastegar-Lari, A | 1 |
| Khamseh, M | 1 |
| al-Tawil, YS | 1 |
| Gilger, MA | 1 |
| Gopalakrishna, GS | 1 |
| Langston, C | 1 |
| Bommer, KE | 1 |
| Graham, DY | 1 |
| Hepps, KS | 1 |
| Ramirez, FC | 1 |
| Lew, GM | 1 |
| Saeed, ZA | 1 |
| Kmiot, WA | 1 |
| Hesslewood, SR | 1 |
| Smith, N | 1 |
| Thompson, H | 1 |
| Harding, LK | 1 |
| Keighley, MR | 1 |
| Fock, KM | 1 |
| Lee, CL | 1 |
| Tu, TC | 1 |
| Wu, CH | 1 |
| Chen, TK | 1 |
| Chan, CC | 1 |
| Huang, SH | 1 |
| Lee, SC | 1 |
| Wuorela, M | 1 |
| Räihä, I | 1 |
| Romero Gómez, M | 1 |
| Martínez Delgado, C | 1 |
| Grande, L | 1 |
| Otero Fernández, MA | 1 |
| Vargas, J | 1 |
| Castro Fernández, M | 1 |
| Chan, FK | 1 |
| Chung, SC | 1 |
| Suen, BY | 1 |
| Lee, YT | 1 |
| Leung, WK | 1 |
| Leung, VK | 1 |
| Wu, JC | 1 |
| Lau, JY | 1 |
| Hui, Y | 1 |
| Lai, MS | 1 |
| Chan, HL | 1 |
| Sung, JJ | 1 |
| Bjarnason, I | 1 |
| Hayllar, J | 1 |
| Smethurst, P | 1 |
| Price, A | 1 |
| Gumpel, MJ | 1 |
| Lorenz, R | 1 |
| Heinmüller, M | 1 |
| Classen, M | 1 |
| Tornieporth, N | 1 |
| Gain, T | 1 |
| de Leeuw, P | 1 |
| de Mot, H | 1 |
| Dugernier, T | 1 |
| Wautelet, J | 1 |
| Bohy, E | 1 |
| Delmée, M | 1 |
| Kingston, RD | 1 |
| Duthie, J | 1 |
| Gorski, AM | 1 |
| Goulet, O | 1 |
| Jehannin, B | 1 |
| Nihoul-Fékété, C | 1 |
| Ricour, C | 1 |
| Archampong, EQ | 1 |
| Clark, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase IV Study Comparing Helicobacter Pylori Empiric Eradication With Test-Guided Treatment in Patients With Peptic Ulcer Bleeding[NCT00687336] | Phase 4 | 178 participants (Anticipated) | Interventional | 2008-03-31 | Recruiting | ||
| "A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metronidazole and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
60-Year-Old Man With Syncope, Abdominal Pain, and Hematochezia.
Topics: Abdominal Pain; Colon; Colonoscopy; Diagnosis, Differential; Emergency Service, Hospital; Follow-Up | 2019 |
Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding.
Topics: Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Hyperbaric Oxygenation; Metronidaz | 2016 |
Peptic ulcer disease in the 1990s: an Asian perspective.
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asia; Bismu | 1997 |
Surgical problems in amoebiasis.
Topics: Abscess; Amebiasis; Amebicides; Anti-Bacterial Agents; Appendicitis; Colonic Diseases; Dysentery, Am | 1973 |
8 trials available for metronidazole and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
A Randomized Controlled Trial of Novel Treatment for Hemorrhagic Radiation Proctitis.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Disinfectants; Electrocoagulation; Female; | 2020 |
Evaluating the effect of metronidazole plus amoxicillin-clavulanate versus amoxicillin-clavulanate alone in canine haemorrhagic diarrhoea: a randomised controlled trial in primary care practice.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Diarrhea; Dog Disease | 2018 |
Clinical efficacy of Saccharomyces boulardii and metronidazole compared to metronidazole alone in children with acute bloody diarrhea caused by amebiasis: a prospective, randomized, open label study.
Topics: Adolescent; Child; Diarrhea; Dysentery, Amebic; Female; Gastrointestinal Hemorrhage; Humans; Male; M | 2009 |
A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis.
Topics: Administration, Oral; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; | 2012 |
Treatment of Helicobacter pylori reduces the rate of rebleeding in peptic ulcer disease.
Topics: Adult; Aged; Bismuth; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Hemorrhage; Hel | 1993 |
Intravenous eradication therapy for bleeding gastroduodenal ulcer associated with Helicobacter pylori infection.
Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Administration Schedule; Fem | 2000 |
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug The | 2001 |
Serious postoperative bleeding associated with a single intravenous dose of cefuroxime and metronidazole.
Topics: Aged; Cefuroxime; Cephalosporins; Colonic Neoplasms; Drug Combinations; Female; Gastrointestinal Hem | 1986 |
25 other studies available for metronidazole and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
[Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report].
Topics: Aged; Antiprotozoal Agents; Dysentery, Amebic; Gastrointestinal Hemorrhage; Humans; Male; Metronidaz | 2020 |
Perianal disease as the first manifestation in paediatric Crohn's disease.
Topics: Abscess; Adalimumab; Anemia, Hypochromic; Azathioprine; Child; Crohn Disease; Fissure in Ano; Gastro | 2020 |
A Curious Case of Bloody Diarrhea.
Topics: Adult; Antiprotozoal Agents; Diarrhea; Entamoeba histolytica; Entamoebiasis; Gastrointestinal Hemorr | 2020 |
Erythrophagocytosis in colonic mucosa: real-time amazing display.
Topics: Adult; Amebiasis; Antiprotozoal Agents; Colorectal Neoplasms; Gastrointestinal Hemorrhage; Humans; I | 2020 |
Second-line therapy for Helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis.
Topics: Abdominal Pain; Aged; Amoxicillin; Biopsy; Colitis; Colon; Colonoscopy; Female; Gastrointestinal Hem | 2017 |
What Hides Behind Bloody Diarrhea?
Topics: Aged; Amebicides; Antigens, Protozoan; Diarrhea; Entamoeba histolytica; Entamoebiasis; Gastrointesti | 2018 |
Intestinal Spirochetosis Masquerading as Inflammatory Bowel Disease.
Topics: Adult; Anemia; Anti-Bacterial Agents; Brachyspira; Delayed Diagnosis; Diagnosis, Differential; Gastr | 2019 |
[Fulminant Clostridium difficile colitis].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficile; Colectomy; Enterocol | 2016 |
Gangrenous appendicitis in a child with Henoch-Schonlein purpura.
Topics: Abdominal Pain; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Arthralgia; Ceftriaxo | 2008 |
Education and imaging. Hepatobiliary and pancreatic: multiple sexually transmitted infections.
Topics: Acute Disease; Anti-Infective Agents; Antiprotozoal Agents; Antiviral Agents; Colonoscopy; Entamoebi | 2010 |
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
A 14-year-old with rectal bleeding and abdominal pain.
Topics: Abdominal Pain; Adolescent; Brachyspira; Colonoscopy; Erythromycin; Female; Gastrointestinal Hemorrh | 2011 |
Necrotizing amebic colitis: the plea for an early diagnosis.
Topics: Amebicides; Colon; Dysentery, Amebic; Gastrointestinal Hemorrhage; Humans; Infant; Metronidazole; Ne | 2003 |
Intestinal spirochetosis and diarrhea, commensal or causal.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Biopsy; Colitis, Microscopic; D | 2004 |
Toxic megacolon complicating Escherichia coli O157 infection.
Topics: Adult; Anti-Infective Agents; Antibodies, Bacterial; Ciprofloxacin; Colitis; Colon; Escherichia coli | 2006 |
Spirochaetosis: a remediable cause of diarrhoea and rectal bleeding?
Topics: Diarrhea; Gastrointestinal Hemorrhage; Humans; Male; Metronidazole; Middle Aged; Rectal Diseases; Sp | 1981 |
Effect of single dose of secnidazole in treatment of intestinal amoebiasis.
Topics: Abdominal Pain; Adult; Amebicides; Animals; Carrier State; Case-Control Studies; Defecation; Dysente | 1995 |
Invasive Blastocystis hominis infection in a child.
Topics: Animals; Biopsy; Blastocystis hominis; Blastocystis Infections; Child, Preschool; Colonoscopy; Feces | 1994 |
Evaluation of the inflammatory infiltrate in pouchitis with 111In-labeled granulocytes.
Topics: Acute Disease; Biopsy; Chronic Disease; Gastrointestinal Hemorrhage; Granulocytes; Humans; Indium Ra | 1993 |
One-week low-dose triple therapy is effective in treating Helicobacter pylori-infected patients with bleeding peptic ulcers.
Topics: Adult; Aged; Clarithromycin; Drug Therapy, Combination; Female; Follow-Up Studies; Gastrointestinal | 1998 |
Acute haemorrhagic colitis possibly caused by Clostridium perfringens.
Topics: Aged; Anti-Bacterial Agents; Clostridium Infections; Clostridium perfringens; Colitis; Female; Gastr | 2000 |
Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastrointestinal Hemorrhage; Humans; Inflamma | 1992 |
Substitution of factor XIII: a therapeutic approach to ulcerative colitis.
Topics: Adrenal Cortex Hormones; Adult; Blood Coagulation Disorders; Colitis, Ulcerative; Factor XIII; Facto | 1991 |
Primary infection of ascitic fluid with Clostridium difficile.
Topics: Ascites; Clostridium; Clostridium Infections; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; H | 1990 |
[Digestive hemorrhage and bacterial overgrowth in children].
Topics: Bacterial Infections; Child; Colistin; Female; Gastrointestinal Hemorrhage; Humans; Metronidazole | 1988 |