metronidazole has been researched along with Cranial Nerve II Diseases in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole is a nitroimidazole antibiotic used in treating anaerobic bacteria and protozoal infections." | 1.56 | Reversible optic neuropathy secondary to metronidazole. ( Anwyll, N; Gerry, P; Gormley, J, 2020) |
| "Metronidazole is a little known cause of drug-induced optic neuropathy." | 1.34 | Reversible optic neuropathy due to metronidazole. ( Kent-Smith, B; McGrath, NM; Sharp, DM, 2007) |
| "Whipple's disease can affect the periorbital tissues and the optic nerve, causing massive exophthalmos and serious transient visual loss." | 1.34 | Orbital manifestation of whipple's disease: an atypical case. ( Arnold, M; Clemetson, IA; Iizuka, T; Lieger, O; Otto, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nuro, E | 1 |
| Bursztyn, LL | 1 |
| Mendonça, DA | 1 |
| Pelz, DM | 1 |
| Budhram, A | 1 |
| Anwyll, N | 1 |
| Gerry, P | 1 |
| Gormley, J | 1 |
| McGrath, NM | 1 |
| Kent-Smith, B | 1 |
| Sharp, DM | 1 |
| Lieger, O | 1 |
| Otto, S | 1 |
| Clemetson, IA | 1 |
| Arnold, M | 1 |
| Iizuka, T | 1 |
4 other studies available for metronidazole and Cranial Nerve II Diseases
| Article | Year |
|---|---|
Neuroimaging Evidence of Optic Tract Involvement in Metronidazole-Induced Optic Neuropathy.
Topics: Humans; Metronidazole; Neuroimaging; Optic Nerve; Optic Nerve Diseases; Optic Tract | 2023 |
Reversible optic neuropathy secondary to metronidazole.
Topics: Adult; Crohn Disease; Electroretinography; Evoked Potentials, Visual; Humans; Male; Metronidazole; O | 2020 |
Reversible optic neuropathy due to metronidazole.
Topics: Aged; Anti-Infective Agents; Electrophysiology; Female; Humans; Metronidazole; Optic Nerve Diseases; | 2007 |
Orbital manifestation of whipple's disease: an atypical case.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Decompression, Surgical; Exophthalmos; Hu | 2007 |