metronidazole has been researched along with Barrett Epithelium in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Incidence rates of Barrett's esophagus and adenocarcinoma in each group were evaluated by histological analysis." | 1.43 | Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma. ( Arakawa, T; Fujiwara, Y; Gi, M; Nagami, Y; Sawada, A; Shiba, M; Tanaka, F; Tanigawa, T; Tominaga, K; Wanibuchi, H; Watanabe, T; Yamagami, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zagari, RM | 1 |
| Romano, M | 1 |
| Ojetti, V | 1 |
| Stockbrugger, R | 1 |
| Gullini, S | 1 |
| Annibale, B | 1 |
| Farinati, F | 1 |
| Ierardi, E | 1 |
| Maconi, G | 1 |
| Rugge, M | 1 |
| Calabrese, C | 1 |
| Di Mario, F | 1 |
| Luzza, F | 1 |
| Pretolani, S | 1 |
| Savio, A | 1 |
| Gasbarrini, G | 1 |
| Caselli, M | 1 |
| Sawada, A | 1 |
| Fujiwara, Y | 1 |
| Nagami, Y | 1 |
| Tanaka, F | 1 |
| Yamagami, H | 1 |
| Tanigawa, T | 1 |
| Shiba, M | 1 |
| Tominaga, K | 1 |
| Watanabe, T | 1 |
| Gi, M | 1 |
| Wanibuchi, H | 1 |
| Arakawa, T | 1 |
2 other studies available for metronidazole and Barrett Epithelium
| Article | Year |
|---|---|
Guidelines for the management of Helicobacter pylori infection in Italy: The III Working Group Consensus Report 2015.
Topics: Amoxicillin; Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bac | 2015 |
Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma.
Topics: Adenocarcinoma; Ampicillin; Anastomosis, Surgical; Animals; Anti-Bacterial Agents; Barrett Esophagus | 2016 |