metronidazole has been researched along with Endocarditis, Bacterial in 17 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole has dramatically improved the prognosis of patients with endocarditis due to anaerobic gram-negative bacilli." | 2.41 | Gram-Negative anaerobic endocarditis: two case reports and review of the literature. ( Bisharat, N; Elias, M; Goldstein, L; Raz, R, 2001) |
| "Metronidazole was introduced (500mg X 3 by day)." | 1.72 | ( Boukobza, M; Duval, X; Laissy, JP; Raffoul, R, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Boukobza, M | 1 |
| Raffoul, R | 1 |
| Duval, X | 1 |
| Laissy, JP | 1 |
| Finn, T | 1 |
| Schattner, A | 1 |
| Dubin, I | 1 |
| Cohen, R | 1 |
| Nielsen, SY | 1 |
| Nørskov-Lauritsen, N | 1 |
| Pérez-Jacoiste Asín, MA | 1 |
| Fernández-Ruiz, M | 1 |
| Serrano-Navarro, I | 1 |
| Prieto-Rodriguez, S | 1 |
| Aguado, JM | 1 |
| Noman, F | 1 |
| Khan, SG | 1 |
| Khursheed, M | 1 |
| Noor, SA | 1 |
| Abubaker, J | 1 |
| Wang'ondu, RW | 1 |
| Murray, TS | 1 |
| Viaznikov, VA | 1 |
| Derbenev, OA | 1 |
| Bartlett, JG | 1 |
| Geraci, JE | 1 |
| Wilson, WR | 1 |
| Mani, V | 1 |
| Cartwright, K | 1 |
| Dooley, J | 1 |
| Swarbrick, E | 1 |
| Fairclough, P | 1 |
| Oakley, C | 1 |
| Bisharat, N | 1 |
| Goldstein, L | 1 |
| Raz, R | 1 |
| Elias, M | 1 |
| Seggie, J | 1 |
| Galgiani, JN | 1 |
| Busch, DF | 1 |
| Brass, C | 1 |
| Rumans, LW | 1 |
| Mangels, JI | 1 |
| Stevens, DA | 1 |
| Goldman, PL | 1 |
| Durack, DT | 1 |
| Petersdorf, RG | 1 |
| Kolander, SA | 1 |
| Cosgrove, EM | 1 |
| Molavi, A | 1 |
| Buu-Hoi, AY | 1 |
| Joundy, S | 1 |
| Acar, JF | 1 |
| Finegold, SM | 1 |
| Rosenblatt, JE | 1 |
4 reviews available for metronidazole and Endocarditis, Bacterial
| Article | Year |
|---|---|
Polymicrobial endocarditis involving Veillonella parvula in an intravenous drug user: case report and literature review of Veillonella endocarditis.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Endocarditis, Bacterial; Gram-Negative Bacterial Infectio | 2013 |
Metronidazole.
Topics: Anaerobiosis; Bacteria; Bacterial Infections; Endocarditis, Bacterial; Humans; Kinetics; Metronidazo | 1981 |
Gram-Negative anaerobic endocarditis: two case reports and review of the literature.
Topics: Aged; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Echocardiography, Transes | 2001 |
Clostridial endocarditis. Report of a case caused by Clostridium bifermentans and review of the literature.
Topics: Adult; Clostridium Infections; Cocaine; Endocarditis, Bacterial; Humans; Male; Metronidazole; Substa | 1989 |
13 other studies available for metronidazole and Endocarditis, Bacterial
| Article | Year |
|---|---|
Topics: Abscess; Adult; Anti-Bacterial Agents; Aortic Valve; Cefotaxime; Endocarditis; Endocarditis, Bacteri | 2022 |
Topics: Aged; Anti-Infective Agents; Diagnostic Errors; Echocardiography, Transesophageal; Endocarditis, Bac | 2018 |
Multispacer sequence typing of Coxiella burnetii DNA from removed prosthetic heart valve material discloses first human case of infective endocarditis caused by MST_18.
Topics: Abscess; Aged; Aortic Valve; Coxiella burnetii; Denmark; DNA, Bacterial; Doxycycline; Echinocandins; | 2019 |
"Moraxella lacunata" endocarditis treated with penicillin.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Endocarditis, Bacterial; Gentamici | 2008 |
Relapse of polymicrobial endocarditis in an intravenous drug user.
Topics: Adult; Ceftriaxone; Coinfection; Eikenella corrodens; Endocarditis, Bacterial; Gram-Negative Bacteri | 2011 |
[Surgical strategy in active infective endocarditis].
Topics: Adult; Anti-Infective Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Endocarditis, | 2004 |
Symposium on infective endocarditis. III. Endocarditis due to gram-negative bacteria. Report of 56 cases.
Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valve Prosthesis; H | 1982 |
Antibiotic prophylaxis in gastrointestinal endoscopy: a report by a Working Party for the British Society of Gastroenterology Endoscopy Committee.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophyla | 1997 |
Fusobacterium endocarditis treated with metronidazole.
Topics: Adult; Ampicillin; Drug Therapy, Combination; Endocarditis, Bacterial; Fusobacterium Infections; Hum | 1978 |
Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole.
Topics: Abscess; Administration, Oral; Adult; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infec | 1978 |
Effect of antibiotics on the prevention of experimental Bacteroides fragilis endocarditis.
Topics: Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Endocarditis, Bacteria | 1978 |
Endocarditis caused by Capnocytophaga ochracea.
Topics: Adult; Capnocytophaga; Cytophagaceae; Endocarditis, Bacterial; Humans; Male; Metronidazole | 1988 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |