metronidazole and isoniazid

metronidazole has been researched along with isoniazid in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (10.81)	18.7374
1990's	1 (2.70)	18.2507
2000's	12 (32.43)	29.6817
2010's	19 (51.35)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Anderson, SW; Arain, TM; Baker, WR; Barry, CE; Kreiswirth, BN; Langhorne, MH; McMurray, DN; Sherman, DR; Stover, CK; Towell, JA; VanDevanter, DR; Warrener, P; Yuan, Y	1
Topliss, JG; Yoshida, F	1
Franzblau, S; Hevener, K; Jones, VC; Lee, RE; Lenaerts, AJ; McNeil, MR; Tangallapally, RP; Wang, Y; Yendapally, R	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S	1
Bitting, C; Gruppo, V; Johnson, CM; Lenaerts, AJ; Marietta, KS; Orme, IM; Woolhiser, L	1
Lombardo, F; Obach, RS; Waters, NJ	1
Basaraba, RJ; Brooks, EJ; Caraway, ML; Driver, ER; Hoff, DR; Lenaerts, AJ; Orme, IM; Peloquin, CA; Ryan, GJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Desiraju, GR; Gupta, RK; Thakur, TS; Tyagi, JS	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barad, HA; Gupta, VK; Kant, R; Pansuriya, BR; Parmar, NJ	1
Chopra, S; Doppalapudi, RS; Franzblau, SG; Green, CE; Iyer, LV; Koolpe, GA; Madrid, PB; Matsuyama, KN; Riccio, ES; Ryan, KJ; Tambo-Ong, AA; Tran, TB; Wan, B	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cai, G; Cho, S; Franzblau, SG; Jaki, BU; Lee, IA; McAlpine, JB; Napolitano, JG; Pauli, GF; Suh, JW; Wang, Y; Yang, SH	1
Chaturvedi, V; Dasgupta, A; Gupta, AD; Jaiswal, S; Kashyap, VK; Khan, SR; Krishnan, MY; Lal, J; Roy, KK; Saxena, AK; Sharma, A; Sharma, SK; Singh, S; Sinha, S; Srivastava, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Bonnet, M; Cooper, CB; Denny, WA; Franzblau, SG; Lee, HH; Thompson, AM; Wan, B; Wong, GS	1
Anjum, MN; Arfan, M; Ayaz, M; Batool Kazmi, ST; Farooq, S; Haq, IU; Iftikhar, F; Rashid, U; Ullah, A	1
Ang, CW; Avery, VM; Blaskovich, MAT; Butler, MS; Cooper, MA; Debnath, A; Hahn, HJ; Jarrad, AM; Jones, AJ; Karoli, T; Pelingon, R; Sykes, ML; Tan, L; West, NP; Woods, K	1
Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K	1
Chuttani, HK; Kakar, PN; Malhotra, KK; Pathak, LR; Pillay, P	1
Sinha, PK; Thakur, CP	1
Alterthum, K; Bauer, P; Stünkel, S; Windorfer, A	1
Berman, JD; Lee, LS	1
Herbert, D; Kubendiran, G; Paramasivan, CN	1
Kibadi, K	1
Barry, CE; Dartois, V; Flynn, JL; Goodwin, MB; Janssen, C; Johnston, PJ; Klein, E; Lin, PL; Via, L	1
Jhobta, A; Kanga, A; Mokta, J; Negi, RS; Singh, DV; Verma, G; Verma, S	1
Caminero Luna, JA; Cerezo Lajas, A; de Miguel Díez, J; Rodríguez Guzmán, MDC	1

Reviews

1 review(s) available for metronidazole and isoniazid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for metronidazole and isoniazid

Article	Year
Inefficacy of ethambutol, ethambutol plus isoniazid, INH plus rifampicin, co-trimoxazole and metronidazole in the treatment of kala-azar. The Journal of tropical medicine and hygiene, 1989, Volume: 92, Issue:6 Topics: Antiprotozoal Agents; Drug Therapy, Combination; Ethambutol; Female; Follow-Up Studies; Humans; Isoniazid; Leishmaniasis, Visceral; Male; Metronidazole; Random Allocation; Rifampin; Trimethoprim, Sulfamethoxazole Drug Combination	1989

Article

Year

Inefficacy of ethambutol, ethambutol plus isoniazid, INH plus rifampicin, co-trimoxazole and metronidazole in the treatment of kala-azar.

The Journal of tropical medicine and hygiene, 1989, Volume: 92, Issue:6

Topics: Antiprotozoal Agents; Drug Therapy, Combination; Ethambutol; Female; Follow-Up Studies; Humans; Isoniazid; Leishmaniasis, Visceral; Male; Metronidazole; Random Allocation; Rifampin; Trimethoprim, Sulfamethoxazole Drug Combination

1989

Other Studies

35 other study(ies) available for metronidazole and isoniazid

Article	Year
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature, 2000, Jun-22, Volume: 405, Issue:6789 Topics: Animals; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Microbial; Drug Resistance, Multiple; Guinea Pigs; Lipids; Metronidazole; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Tuberculosis	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. Journal of medicinal chemistry, 2004, Oct-07, Volume: 47, Issue:21 Topics: Amides; Animals; Antitubercular Agents; Databases, Factual; Furans; Intramolecular Transferases; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Tuberculosis, Pulmonary	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen	2007
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Animals; Antitubercular Agents; Biological Availability; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyridones; Quinolones; Treatment Outcome; Tuberculosis, Pulmonary	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11 Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Female; Guinea Pigs; Isoniazid; Lung; Metronidazole; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Spleen; Tuberculosis, Pulmonary	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Aerobiosis; Antitubercular Agents; Bacterial Proteins; Binding Sites; Computational Biology; DNA, Bacterial; Drug Design; Gene Expression Regulation, Bacterial; Hypoxia; Models, Molecular; Mycobacterium tuberculosis; Protamine Kinase; Protein Conformation; Sequence Homology; Transcription, Genetic	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines. Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12 Topics: Antifungal Agents; Antitubercular Agents; Aspergillus fumigatus; Azo Compounds; Benzopyrans; Candida albicans; Crystallography, X-Ray; Gram-Negative Bacteria; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microwaves; Molecular Structure; Mycobacterium tuberculosis; Pyrrolidines; Stereoisomerism; Thiosemicarbazones	2012
Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Drug Discovery; Female; Isomerism; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitrofurans; Nitroimidazoles; Oxides; Quinoxalines; Rats; Tirapazamine; Triazines; Tuberculosis; Vero Cells	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. Journal of natural products, 2013, Nov-22, Volume: 76, Issue:11 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Streptomyces; Vero Cells	2013
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4 Topics: Adenosine Triphosphate; Animals; Antitubercular Agents; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Mycobacterium Infections, Nontuberculous; Mycobacterium smegmatis; Mycobacterium tuberculosis; Proton-Translocating ATPases; Quinolines; Rats, Sprague-Dawley; Sulfonamides; Tuberculosis	2015
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Amines; Antitubercular Agents; Dose-Response Relationship, Drug; Imidazoles; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Parasitic Sensitivity Tests; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2017
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. ACS medicinal chemistry letters, 2017, Dec-14, Volume: 8, Issue:12 Topics:	2017
Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Topics: Amino Acids; Anti-Bacterial Agents; Bacillus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Hydrophobic and Hydrophilic Interactions; Isoniazid; Metronidazole; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Salmonella typhi; Staphylococcus aureus; Structure-Activity Relationship; Trimethoprim; Urease	2018
Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. Journal of medicinal chemistry, 2018, 12-27, Volume: 61, Issue:24 Topics: Animals; Antiparasitic Agents; Antitubercular Agents; Caco-2 Cells; Drug Design; Drug Evaluation, Preclinical; Drug Stability; Entamoeba histolytica; Giardia lamblia; Humans; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Nitroimidazoles; Structure-Activity Relationship	2018
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4 Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry	2020
Unusual presentation of primary amoebic meningoencephalitis--a serious diagnostic and therapeutic problem. The Journal of tropical medicine and hygiene, 1978, Volume: 81, Issue:6 Topics: Adult; Amebiasis; Chloramphenicol; Drug Therapy, Combination; Female; Humans; Isoniazid; Meningoencephalitis; Metronidazole; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Streptomycin; Sulfadiazine	1978
[Effects of drug interaction in infancy (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1980, Volume: 128, Issue:10 Topics: Carbamazepine; Child; Chloramphenicol; Clonazepam; Dexamethasone; Drug Interactions; Humans; Isoniazid; Metronidazole; Phenobarbital; Phenytoin; Sulfonamides; Valproic Acid	1980
Activity of oral drugs against Leishmania tropica in human macrophages in vitro. The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:5 Topics: Antiprotozoal Agents; Cells, Cultured; Drug Interactions; Humans; Isoniazid; Ketoconazole; Leishmania; Macrophages; Metronidazole; Nitrofurans; Phenothiazines; Quinacrine; Rifampin; Sulfamethoxazole; Trimethoprim	1983
Action of metronidazole in combination with isoniazid & rifampicin on persisting organisms in experimental murine tuberculosis. The Indian journal of medical research, 1998, Volume: 108 Topics: Animals; Antitubercular Agents; Drug Therapy, Combination; Female; Isoniazid; Metronidazole; Mice; Mice, Inbred BALB C; Rifampin; Tuberculosis	1998
[Mycobacterium ulcerans infection treated by Rifater, pyrazynamide, Myambutol, and surgery: a case report with a 6-year follow-up]. Medecine et maladies infectieuses, 2008, Volume: 38, Issue:3 Topics: Anti-Bacterial Agents; Buruli Ulcer; Child; Chloramines; Combined Modality Therapy; Drug Combinations; Drug Therapy, Combination; Ethambutol; Female; Follow-Up Studies; Humans; Isoniazid; Mastectomy; Metronidazole; Mycobacterium ulcerans; Nitrofurantoin; Pleurisy; Prednisolone; Pyrazinamide; Recurrence; Rifampin; Skin Transplantation	2008
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-28, Volume: 109, Issue:35 Topics: Animals; Antiprotozoal Agents; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Interferon-gamma; Isoniazid; Latent Tuberculosis; Macaca fascicularis; Metronidazole; Mycobacterium tuberculosis; Secondary Prevention; Tuberculoma; Tuberculosis, Pulmonary	2012
Dual infection with pulmonary tuberculosis and Lophomonas blattarum in India. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015, Volume: 19, Issue:3 Topics: Antiprotozoal Agents; Antitubercular Agents; Bronchoalveolar Lavage; Ceftriaxone; Dose-Response Relationship, Drug; Humans; India; Isoniazid; Lung Diseases, Parasitic; Male; Metronidazole; Middle Aged; Mycobacterium tuberculosis; Parabasalidea; Rifampin; Trophozoites; Tuberculosis, Pulmonary	2015
Antituberculosis Treatment in a Patient with Celiac Disease. Archivos de bronconeumologia, 2018, Volume: 54, Issue:6 Topics: Aged; Antitubercular Agents; Celiac Disease; Diarrhea; Diet, Gluten-Free; Drug Compounding; Drug Substitution; Drug Therapy, Combination; Ethambutol; Glutens; Hemoptysis; Humans; Isoniazid; Male; Metronidazole; Moxifloxacin; Pyrazinamide; Rifampin; Smoking; Tomography, X-Ray Computed; Tuberculosis, Pulmonary	2018