metronidazole has been researched along with Rupture, Spontaneous in 34 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rupture, Spontaneous: Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-four consecutive children with performed appendicitis were treated with intravenous and rectal metronidazole combined with another antimicrobial agent." | 7.66 | Perforated appendicitis in children: use of metronidazole for the reduction of septic complications. ( Guiney, EJ; O'Donnell, B; Puri, P; Rangecroft, L; Zervos, G, 1981) |
| "In a previous prospective randomized trial, we found a once-a-day regimen of ceftriaxone and metronidazole to be an efficient, cost-effective treatment for children with perforated appendicitis." | 5.14 | A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial. ( Aguayo, P; Andrews, WS; Fraser, JD; Holcomb, GW; Keckler, SJ; Leys, CM; Murphy, JP; Newland, JG; Ostlie, DJ; Sharp, RJ; Sharp, SW; Snyder, CL; St Peter, SD, 2010) |
| "Fifty-four consecutive children with performed appendicitis were treated with intravenous and rectal metronidazole combined with another antimicrobial agent." | 3.66 | Perforated appendicitis in children: use of metronidazole for the reduction of septic complications. ( Guiney, EJ; O'Donnell, B; Puri, P; Rangecroft, L; Zervos, G, 1981) |
| "Intravenous metronidazole was administered to a patient with peritonitis caused by a ruptured amebic liver abscess." | 3.66 | Intravenous metronidazole in the treatment of ruptured amebic liver abscess. ( Edmisten, C; Gall, SA; Vernon, RP, 1980) |
| "None of these patients had a fever or leukocytosis at discharge." | 2.70 | Oral antibiotics in the management of perforated appendicitis in children. ( Abarbanell, A; Gollin, G; Moores, D, 2002) |
| "Surgical wound infections were significantly reduced by the collagen-gentamicin implant." | 2.69 | Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. ( Delgado, FJ; Guerrero, TS; Guzmán Valdivia Gomez, G; Lluck, MC, 1999) |
| "Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa." | 2.67 | Analysis of cefepime tissue penetration into human appendix. ( Appleman, MD; Berne, TV; Chin, A; Gill, MA; Heseltine, PN; Knupp, CA; Okamoto, MP; Sclar, DA; Yellin, AE, 1991) |
| "Metronidazole was administered and the patient was discharged 31 days after surgery." | 1.33 | Cardiac tamponade due to intrapericardial rupture of an amebic liver abscess. ( Miyauchi, T; Murakami, E; Sawamura, T; Takiya, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 10 (29.41) | 18.2507 |
| 2000's | 9 (26.47) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Whelan-Johnson, S | 1 |
| Isaacs, J | 1 |
| Pullan, RD | 1 |
| Kiyak, G | 1 |
| Ergul, E | 1 |
| Celik, A | 1 |
| Fraser, JD | 1 |
| Aguayo, P | 1 |
| Leys, CM | 1 |
| Keckler, SJ | 1 |
| Newland, JG | 1 |
| Sharp, SW | 1 |
| Murphy, JP | 1 |
| Snyder, CL | 1 |
| Sharp, RJ | 1 |
| Andrews, WS | 1 |
| Holcomb, GW | 1 |
| Ostlie, DJ | 1 |
| St Peter, SD | 1 |
| Kumar, R | 1 |
| Sundar, S | 1 |
| Sharma, P | 1 |
| Sarin, SK | 1 |
| Chang, HR | 1 |
| Lee, JJ | 1 |
| Lin, CB | 1 |
| Gollin, G | 2 |
| Abarbanell, A | 1 |
| Moores, D | 1 |
| Velez, MC | 1 |
| Athale, UH | 1 |
| Loe, W | 1 |
| Warrier, RP | 1 |
| Bukhari, AJ | 1 |
| Miyauchi, T | 1 |
| Takiya, H | 1 |
| Sawamura, T | 1 |
| Murakami, E | 1 |
| Ugajin, T | 1 |
| Miyatani, H | 1 |
| Watanabe, Y | 1 |
| Nishida, J | 1 |
| Yoshida, Y | 1 |
| Saksø, P | 1 |
| Gottrup, F | 1 |
| Ibarra-Pérez, C | 1 |
| Puri, P | 1 |
| Rangecroft, L | 1 |
| Zervos, G | 1 |
| Guiney, EJ | 1 |
| O'Donnell, B | 1 |
| Gall, SA | 1 |
| Edmisten, C | 1 |
| Vernon, RP | 1 |
| Meng, XY | 1 |
| Wu, JX | 1 |
| Schmitt, M | 1 |
| Bondonny, JM | 1 |
| Delmas, P | 1 |
| Galifer, RB | 1 |
| Revillon, Y | 1 |
| Robert, M | 1 |
| von Birgelen, C | 1 |
| von Schönfeld, J | 1 |
| Görge, G | 1 |
| Fabry, W | 1 |
| Layer, P | 1 |
| Gomersall, LN | 1 |
| Currie, J | 1 |
| Jeffrey, R | 1 |
| Guzmán Valdivia Gomez, G | 1 |
| Guerrero, TS | 1 |
| Lluck, MC | 1 |
| Delgado, FJ | 1 |
| Ohlin, B | 1 |
| Cederberg, A | 1 |
| Forssell, H | 1 |
| Solhaug, JH | 1 |
| Tveit, E | 1 |
| Angel, C | 1 |
| Chand, N | 1 |
| Sankar, A | 1 |
| Rowen, J | 1 |
| Murillo, C | 1 |
| Püspök, A | 1 |
| Kiener, HP | 1 |
| Susani, M | 1 |
| Müller, C | 1 |
| Rice, HE | 1 |
| Brown, RL | 1 |
| Caty, MG | 1 |
| Gilbert, J | 1 |
| Skinner, MA | 1 |
| Glick, PL | 1 |
| Azizkhan, RG | 1 |
| Fazlullah, S | 1 |
| Singh, KP | 1 |
| Sreemannarayana, J | 1 |
| Mehdiratta, KS | 1 |
| Okamoto, MP | 1 |
| Chin, A | 1 |
| Gill, MA | 1 |
| Yellin, AE | 1 |
| Berne, TV | 1 |
| Heseltine, PN | 1 |
| Appleman, MD | 1 |
| Knupp, CA | 1 |
| Sclar, DA | 1 |
| Salim, AS | 1 |
| Birkigt, HG | 1 |
| Beyer, H | 1 |
| Elechi, EN | 1 |
| Etawo, SU | 1 |
| Brousil, L | 1 |
| Ralls, PW | 1 |
| Barnes, PF | 1 |
| Johnson, MB | 1 |
| De Cock, KM | 1 |
| Radin, DR | 1 |
| Halls, J | 1 |
| Höllwarth, M | 1 |
| Graf, D | 1 |
| Kurz, R | 1 |
| Sauer, H | 1 |
| Ulbak, S | 1 |
| Adamsen, S | 1 |
| Christensen, PB | 1 |
| Kronborg, O | 1 |
| Andersen, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis (Randomized, Controlled Clinical Trial)[NCT01115153] | 150 participants (Actual) | Interventional | 2007-12-31 | Completed | |||
| Collagen-Gentamicin Implant in the Treatment of Contaminated Surgical Abdominal Wounds - A Randomized Controlled Trial[NCT00977405] | Phase 2 | 70 participants (Anticipated) | Interventional | 2009-09-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 trials available for metronidazole and Rupture, Spontaneous
| Article | Year |
|---|---|
A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; C | 2010 |
Oral antibiotics in the management of perforated appendicitis in children.
Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Append | 2002 |
A Danish multicenter study: cefoxitin versus ampicillin + metronidazole in perforated appendicitis.
Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Cefoxitin; Child; | 1984 |
[Antibiotic therapy of perforated appendicitis in children: comparison between the amoxicillin-clavulanic acid and the benzylpenicillin-netilmicin-metronidazole combinations].
Topics: Adolescent; Amoxicillin; Appendicitis; Child; Child, Preschool; Clavulanic Acids; Drug Therapy, Comb | 1993 |
Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; | 1999 |
Piperacillin/tazobactam compared with cefuroxime/ metronidazole in the treatment of intra-abdominal infections.
Topics: Abdominal Abscess; Appendicitis; Bacterial Infections; beta-Lactamase Inhibitors; Cefuroxime; Drug T | 1999 |
Results of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis.
Topics: Administration, Oral; Adolescent; Ampicillin; Appendicitis; Child; Child, Preschool; Clavulanic Acid | 2001 |
Analysis of cefepime tissue penetration into human appendix.
Topics: Adolescent; Adult; Appendectomy; Appendicitis; Appendix; Ascitic Fluid; Cefepime; Cephalosporins; Cl | 1991 |
[General or individually calculated preventive antibiotic administration. Summary of the Magdeburg appendicitis study].
Topics: Acute Disease; Adult; Ampicillin; Appendectomy; Appendicitis; Female; Humans; Infusions, Intravenous | 1991 |
[Antibiotic treatment of perforated appendicitis in childhood--a prospective study].
Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Clinical Trials as Topic; Drug Combination | 1986 |
[Rectal versus intravenous metronidazole treatment following perforated appendicitis. A randomized study].
Topics: Adolescent; Aged; Appendectomy; Appendicitis; Child; Child, Preschool; Humans; Injections, Intraveno | 1985 |
23 other studies available for metronidazole and Rupture, Spontaneous
| Article | Year |
|---|---|
Sacro-iliac osteomyelitis in a 13 year old boy following perforated appendicitis.
Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe | 2013 |
Spontaneous rupture of the rectum with evisceration of small intestine through the anus.
Topics: Aged; Anal Canal; Anti-Bacterial Agents; Anti-Infective Agents; Anus Diseases; Ceftriaxone; Female; | 2008 |
Conservative management of liver abscess complicated by hepatogastric fistula.
Topics: Adult; Anti-Bacterial Agents; Antiprotozoal Agents; Digestive System Fistula; Drainage; Gastric Fist | 2011 |
Pleural empyema secondary to rupture of amoebic liver abscess.
Topics: Adult; Amebicides; Drainage; Empyema, Pleural; Follow-Up Studies; Humans; Iodoquinol; Liver Abscess, | 2012 |
Acute perforative appendicitis during preoperative chemotherapy for Wilms tumor.
Topics: Abdominal Pain; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Ceftazi | 2003 |
Ruptured amebic liver abscess.
Topics: Adult; Cefuroxime; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Follow-Up Studies | 2003 |
Cardiac tamponade due to intrapericardial rupture of an amebic liver abscess.
Topics: Adult; Cardiac Tamponade; Cardiovascular Surgical Procedures; Diagnosis, Differential; Fever; Humans | 2005 |
Pictures in clinical medicine. Perforated amebic huge liver abscess successfully treated with metronidazole.
Topics: Adult; Animals; Antiprotozoal Agents; Humans; Liver Abscess, Amebic; Male; Metronidazole; Rupture, S | 2008 |
[Metronidazole in perforated appendicitis. A retrospective study on the effect of metronidazole administered peroperatively].
Topics: Adolescent; Adult; Aged; Appendectomy; Appendicitis; Bacterial Infections; Child; Child, Preschool; | 1982 |
Thoracic complications of amebic abscess of the liver: report of 501 cases.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drainage; Emetine; Humans; Liver Abscess, Amebic; | 1981 |
Perforated appendicitis in children: use of metronidazole for the reduction of septic complications.
Topics: Adolescent; Appendectomy; Appendicitis; Bacterial Infections; Child; Child, Preschool; Humans; Infan | 1981 |
Intravenous metronidazole in the treatment of ruptured amebic liver abscess.
Topics: Adult; Humans; Injections, Intravenous; Liver Abscess, Amebic; Male; Metronidazole; Peritonitis; Rup | 1980 |
Perforated amebic liver abscess: clinical analysis of 110 cases.
Topics: Adolescent; Adult; Aged; Drainage; Female; Humans; Liver Abscess, Amebic; Male; Metronidazole; Middl | 1994 |
[Amebic liver abscess with hepatobronchial fistula].
Topics: Bronchial Fistula; Female; Fistula; Humans; Liver Abscess, Amebic; Liver Diseases; Metronidazole; Mi | 1994 |
Amoebiasis: a rare cause of cardiac tamponade.
Topics: Adult; Cardiac Tamponade; Drainage; Humans; Imipenem; Liver Abscess, Amebic; Male; Metronidazole; Ru | 1994 |
Gastric wall erosion by an amebic liver abscess in a 3-year-old girl.
Topics: Amebicides; Anti-Infective Agents; Biopsy; Cefotaxime; Cephalosporins; Chemotherapy, Adjuvant; Child | 2000 |
Gastric perforation of a left lobe amoebic liver abscess.
Topics: Adult; Animals; Anti-Infective Agents; Antifungal Agents; Biopsy, Needle; Follow-Up Studies; Gastros | 2000 |
Pleuro-pulmonary lesions in amebic liver abscess.
Topics: Adult; Drug Therapy, Combination; Emetine; Empyema; Female; Humans; Liver Abscess, Amebic; Metronida | 1978 |
Intraperitoneal rupture of amebic liver abscess.
Topics: Adult; Child, Preschool; Drainage; Emetine; Humans; Laparotomy; Liver Abscess, Amebic; Male; Metroni | 1977 |
Jejunostomy feeding for the conservative management of spontaneous rupture of the oesophagus.
Topics: Adult; Cefotaxime; Drug Therapy, Combination; Enteral Nutrition; Esophageal Diseases; Humans; Jejuno | 1991 |
Management of intraperitoneal rupture of amoebic liver abscess: a 6-year experience with 11 cases in Port Harcourt, Nigeria.
Topics: Abdomen, Acute; Humans; Liver Abscess, Amebic; Metronidazole; Peritoneal Cavity; Rupture, Spontaneou | 1991 |
[Long-term experience with rectal administration of metronidazole in the treatment of perforated appendicitis].
Topics: Abdomen; Abscess; Adolescent; Adult; Appendicitis; Child; Female; Humans; Intestinal Perforation; Ma | 1988 |
Medical treatment of hepatic amebic abscess: rare need for percutaneous drainage.
Topics: Chloroquine; Drug Evaluation; Drug Therapy, Combination; Follow-Up Studies; Humans; Liver; Liver Abs | 1987 |