Hidradenitis Suppurativa

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

Synonym
Hidradenitis Suppurativa

Excerpt	Reference
"Hidradenitis suppurativa is a disabling disease."	( Finley, EM; Ratz, JL, 1996)
"Verneuil's disease (hidradenitis suppurativa) is a chronic inflammatory, suppurating and fistulizing disease of apocrine sweat gland-bearing skin."	( Destrumelle, N; Dupond, AS; Humbert, P; Lamfichekh, N; Mantion, G; Runser, C, 2001)
"Hidradenitis suppurativa is a scarring disease of the skin that causes deep cysts and abscesses on the axillae and anogenital areas."	( Scheman, AJ, 2002)
"Although hidradenitis suppurativa is a common and serious skin condition, its treatment is not well established."	( García, FJ; Jiménez-Gallo, D; Martorell, A; Pascual, JC; Pereyra-Rodríguez, J; Salgado, L; Villarrasa, E, 2015)
"Hidradenitis suppurativa is a common debilitating skin disease that has been neglected by science."	( Gulliver, WP; van der Zee, HH, 2016)
"Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%."	( Agut-Busquet, E; García-Malinis, A; Gilaberte, Y; Luelmo, J; Ribera-Pibernat, M; Romaní, J, 2016)
"Hidradenitis suppurativa is a chronic inflammatory cutaneous disorder that involves the infundibular terminal follicles in areas rich in apocrine glands and associated with the formation of abscesses and fistulating sinus."	( Shirah, BH; Shirah, HA, 2017)
"Hidradenitis suppurativa is a debilitating inflammatory skin disease with a chronic course and often disappointing response to treatment."	( Okoye, GA; Perng, P; Zampella, JG, 2017)
"Hidradenitis suppurativa is a chronic, recurrent, and debilitating skin condition."	( Alhusayen, R; Lansang, P; Lee, EY; Shear, N; Yeung, J, 2017)
"The management of hidradenitis suppurativa is multidisciplinary, involving general measures, medical treatment and surgery."	( Bodin, F; Chaput, B; Gall, Y; Grolleau, JL; Konstantinou, MP; Laloze, J; Paul, C; Robert, E, 2017)
"Hidradenitis suppurativa is an inflammatory disease associated with subcutaneous nodules/abscesses that occur commonly in the axillary, inguinal, and perineal regions."	( Asamoah, P; Gross, M; Viglianti, BL; Wale, DJ; Wong, KK, 2018)
"Hidradenitis suppurativa is a chronic, recurring, and disabling inflammatory condition of the skin."	( Mordon, S, 2018)
"Hidradenitis suppurativa is a recurrent inflammatory skin condition characterized by abscesses and boils, predominantly in the groin, armpit, and buttocks areas."	( Clark, AK; Quinonez, RL; Saric, S; Sivamani, RK, 2017)
"Hidradenitis suppurativa is often associated with pain and decreased quality of life."	( Crouse, L; Dong, L; Fajgenbaum, K; Sayed, C; Zeng, D, 2020)
"Hidradenitis suppurativa is a chronic folliculitis affecting intertriginous areas."	( Bragg, DA; Litzner, B; Wipperman, J, 2019)
"Hidradenitis suppurativa is a complex, chronic, difficult to treat condition belonging to the spectrum of cutaneous immune-mediated inflammatory diseases."	( De Simone, C; Garcovich, S; Giovanardi, G; Malvaso, D; Peris, K, 2020)
"Hidradenitis suppurativa is a complex disorder, the pathogenesis of which is still unsolved."	( Aboud, C; Cannistrà, C; Zamaria, N, 2020)
"Hidradenitis suppurativa is a chronic and debilitating inflammatory condition related to a permanent obstruction of the pilosebaceous units."	( Alonso, A; Anjos, JLV; Cunha-Filho, M; Gelfuso, GM; Gratieri, T; Pereira, MN; Pires, FQ; Tolentino, S, 2021)
"Hidradenitis suppurativa is a chronic, inflammatory, burdensome skin disease where current first-line treatments are limited to topical and/or systemic antibiotics which cannot be applied for long-term disease management."	( Grabbe, S; Kirschner, U; Matusiak, Ł; Nikolakis, G; Ruckes, C; Schultheis, M; Staubach, P; Szepietowski, JC; von Stebut, E, 2022)

Excerpt	Reference
"Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available."	( Bastuji-Garin, S; Canoui-Poitrine, F; Faye, O; Gabison, G; Gener, G; Poli, F; Pouget, F; Revuz, JE; Viallette, C; Wolkenstein, P, 2009)
"Hormonal therapy is a potential treatment for hidradenitis suppurativa (HS)."	( Golbari, NM; Kimball, AB; Porter, ML, 2019)
"Effective anti-inflammatory treatments for hidradenitis suppurativa (HS) are limited."	( Prens, EP; van der Zee, HH; van Doorn, MBA; Vossen, ARJV, 2019)
"The successful treatment of hidradenitis suppurativa (HS) with intralesional photodynamic therapy (IL-PDT) has been previously reported in some case series published a few years ago."	( Corral-Magaña, O; Del Pozo, LJ; Garcias-Ladaria, J; Martín-Santiago, A, 2021)
"Hormonal treatments in hidradenitis suppurativa: a systematic review."	( Hsiao, JL; Jeong, C; Masson, R; Shi, VY; Shih, T, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (0.72)	23.3326
1990's	23 (5.50)	12.5806
2000's	45 (10.77)	18.1394
2010's	198 (47.37)	28.8240
2020's	149 (35.65)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
aminolevulinic acid	medium	20	1
acetic acid	low	1	0
salicylic acid	low	2	0
histamine	low	1	0
iodine	low	2	0
kynurenine	low	1	0
pyruvaldehyde	low	1	0
inositol	low	1	0
nickel	low	1	0
niacinamide	medium	2	1
pyrazinamide	low	1	0
trimethyloxamine	low	1	0
acetaminophen	low	3	0
azathioprine	low	4	0
verapamil	low	1	0
celecoxib	low	1	0
ciprofloxacin	low	1	0
dapsone	low	15	0
flutamide	low	2	0
gabapentin	low	2	0
gentamicin	medium	2	1
lidocaine	low	1	0
isoniazid	low	3	0
khellin	low	4	0
metronidazole	low	6	0
ofloxacin	low	1	0
oxybutynin	low	2	0
resorcinol	medium	7	1
sulfamethoxazole	low	1	0
sulfasalazine	low	1	0
thalidomide	medium	12	3
triclosan	low	1	0
trimethoprim	low	1	0
prednisolone	low	5	0
spironolactone	low	10	0
prednisone	low	5	0
triiodothyronine	low	1	0
alanine	low	2	0
lysine	low	1	0
methylene blue	medium	7	1
colchicine	medium	2	1
ficusin	low	1	0
valine	low	1	0
dichlorodiphenyldichloroethane	low	2	0
tryptophan	low	1	0
arginine	low	1	0
triamcinolone acetonide	medium	1	1
ethyl citrate	low	1	0
methylprednisolone	low	2	0
benzoyl peroxide	medium	2	1
cyclohexanol	low	1	0
pyrroles	low	1	0
thiophenes	low	1	0
indazoles	low	2	0
cyproterone acetate	low	2	0
alpha-aminopyridine	low	1	0
gluconic acid	low	6	0
copper gluconate	low	6	0
erythromycin	low	2	0
ethylnitrosourea	low	1	0
ethambutol	low	1	0
dicloxacillin	low	1	0
neodymium	low	1	0
silver	low	1	0
yttrium	low	1	0
ethinyl estradiol-norgestrel combination	low	1	0
trolamine salicylate	low	22	0
triamcinolone	medium	11	1
tridemorph	low	1	0
timolol	low	1	0
permethrin	low	1	0
finasteride	medium	12	1
adapalene	low	1	0
duloxetine hydrochloride	low	1	0
venlafaxine hydrochloride	low	1	0
trazodone hydrochloride	medium	2	1
5-methylcytosine	low	1	0
fluorodeoxyglucose f18	low	2	0
5-hydroxymethylcytosine	low	1	0
oxazolidin-2-one	low	1	0
nicotine	low	1	0
homocysteine	low	3	0
glucuronic acid	low	1	0
imipenem, anhydrous	low	1	0
methotrexate	low	9	0
beta-lactams	low	2	0
ertapenem	low	8	0
moxifloxacin	low	4	0
methyl 5-aminolevulinate	low	2	0
sorafenib	low	2	0
elastin	low	2	0
inositol 3-phosphate	low	1	0
cortodoxone	low	1	0
meropenem	low	1	0
linezolid	low	2	0
tretinoin	low	4	0
tacrolimus	low	4	0
clindamycin	medium	60	6
zithromax	low	2	0
alitretinoin	low	2	0
roflumilast	low	1	0
bromochloroacetic acid	low	11	0
fusidic acid	low	2	0
lincomycin	low	2	0
lithium	low	2	0
osteoprotegerin	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
leukotriene b4	low	2	0
humulene	low	1	0
ethyl linoleate	low	1	0
isotretinoin	medium	28	1
sphingosine 1-phosphate	low	1	0
acitretin	low	14	0
sirolimus	low	3	0
su 11248	low	1	0
aluminum	low	2	0
ramipril	low	1	0
fumarates	low	2	0
silicon	low	1	0
pregabalin	low	1	0
dutasteride	low	1	0
amoxicillin-potassium clavulanate combination	low	1	0
mocetinostat	low	2	0
tofacitinib	low	1	0
pazopanib	low	2	0
liraglutide	low	2	0
glucagon-like peptide 1	low	2	0
gdc-0973	low	1	0
calpain	low	1	0
ro13-9904	low	2	0
gdc 0449	low	1	0
plx4032	low	3	0
glycolipids	low	1	0
baricitinib	low	1	0
piperidines	low	2	0
interleukin-8	low	3	0
pf 3084014	low	1	0
tetracycline	medium	4	1
chlortetracycline	low	1	0
minocycline	low	6	0
warfarin	low	1	0
phenprocoumon	low	1	0
lymecycline	low	2	0
transforming growth factor beta	low	2	0
vitamin b 12	low	4	0
norgestrel	low	1	0
cyclosporine	low	11	0
technetium tc 99m medronate	low	1	0
muramidase	low	2	0
exudates	low	1	0
folic acid	low	2	0
rifampin	medium	44	2
leptin	low	3	0

Protein Targets (1,812)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	34	0	0	34
ATAD5 protein, partial	16	0	0	16
GLS protein	13	0	0	13
Microtubule-associated protein tau	20	0	0	20
Smad3	13	0	0	13
aldehyde dehydrogenase 1 family, member A1	31	0	0	31
thyroid stimulating hormone receptor	21	0	0	21
nuclear receptor subfamily 1, group I, member 3	30	0	0	30
progesterone receptor	29	0	0	29
EWS/FLI fusion protein	30	0	0	30
retinoic acid nuclear receptor alpha variant 1	38	0	0	38
retinoid X nuclear receptor alpha	40	0	0	40
estrogen-related nuclear receptor alpha	44	0	0	44
estrogen nuclear receptor alpha	63	0	0	63
peroxisome proliferator activated receptor gamma	32	0	0	32
aryl hydrocarbon receptor	24	0	0	24
chromobox protein homolog 1	20	0	0	20
thyroid hormone receptor beta isoform 2	37	0	0	37
peripheral myelin protein 22	19	0	0	19
cytochrome P450 3A4 isoform 1	20	0	0	20
Gamma-aminobutyric acid receptor subunit pi	20	4	2	26
ATP-binding cassette sub-family C member 3	0	49	0	49
Multidrug resistance-associated protein 4	0	49	0	51
Solute carrier family 22 member 6	0	2	0	3
Carbonic anhydrase 12	0	4	0	6
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	14	0	14
Voltage-dependent calcium channel gamma-2 subunit	22	0	0	22
Bile salt export pump	0	61	0	61
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	9	0	12
Carbonic anhydrase 2	0	9	1	14
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	2	1	4
Cytochrome P450 1A2	0	10	1	13
Prostaglandin G/H synthase 1	0	3	1	4
Carbonic anhydrase 3	0	4	0	6
Cytochrome P450 3A4	0	22	1	26
Cytochrome P450 2D6	0	12	1	14
Cytochrome P450 2C9	0	18	1	21
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	20	4	2	26
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	20	4	2	26
Gamma-aminobutyric acid receptor subunit gamma-2	20	4	3	27
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	22	0	0	22
Gamma-aminobutyric acid receptor subunit alpha-5	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-3	20	4	2	26
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	3
Carbonic anhydrase 4	0	4	0	6
Prostaglandin G/H synthase 1	0	4	0	5
Carbonic anhydrase 6	0	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-2	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-4	20	4	2	26
Gamma-aminobutyric acid receptor subunit gamma-3	20	4	2	26
Gamma-aminobutyric acid receptor subunit alpha-6	20	4	2	26
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Prostaglandin G/H synthase 2	0	4	6	12
Carbonic anhydrase 7	0	5	0	7
Nuclear receptor ROR-gamma	15	1	2	18
Cytochrome P450 2J2	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	20	5	3	28
Gamma-aminobutyric acid receptor subunit beta-3	20	4	2	26
Gamma-aminobutyric acid receptor subunit beta-2	20	4	3	27
Carbonic anhydrase 9	0	7	0	9
GABA theta subunit	20	4	2	26
Canalicular multispecific organic anion transporter 1	0	46	0	46
Carbonic anhydrase 15	0	4	0	6
Carbonic anhydrase 13	0	3	0	5
Gamma-aminobutyric acid receptor subunit epsilon	20	4	2	26
Carbonic anhydrase 14	0	4	0	6
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
toxin B	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	3	11	14
Tyrosine-protein kinase Fyn	0	0	11	11
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Luciferase	13	0	0	13
USP1 protein, partial	26	0	0	26
TDP1 protein	44	0	0	44
AR protein	46	0	0	46
glucocorticoid receptor [Homo sapiens]	39	0	0	39
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	29	0	0	29
vitamin D3 receptor isoform VDRA	13	0	0	13
flap endonuclease 1	10	0	0	10
serine/threonine-protein kinase PLK1	4	0	0	4
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	5	0	0	5
geminin	51	0	0	51
survival motor neuron protein isoform d	10	0	0	10
histone acetyltransferase KAT2A isoform 1	10	0	0	10
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	33	0	0	33
Rap guanine nucleotide exchange factor 4	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
farnesoid X nuclear receptor	25	0	0	25
peroxisome proliferator-activated receptor delta	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	26	0	0	26
activating transcription factor 6	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
Histone H2A.x	13	0	0	13
Bloom syndrome protein isoform 1	14	0	0	14
heat shock protein beta-1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 1	36	0	0	36
nuclear receptor ROR-gamma isoform 1	15	0	0	15
lamin isoform A-delta10	38	0	0	38
60 kDa chaperonin	0	3	0	3
Retinoic acid receptor alpha	0	5	5	14
60 kDa heat shock protein, mitochondrial	0	4	0	4
Retinoic acid receptor beta	0	5	5	14
Retinoic acid receptor gamma	0	5	5	14
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Spike glycoprotein	23	0	1	24
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
ATP-dependent phosphofructokinase	13	0	0	13
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	2	0	4
Chain A, Ferritin light chain	16	0	0	16
Chain A, Cruzipain	10	0	0	10
acetylcholinesterase	11	0	0	11
SMAD family member 2	12	0	0	12
SMAD family member 3	12	0	0	12
GLI family zinc finger 3	45	0	0	45
estrogen receptor 2 (ER beta)	20	0	0	20
pregnane X nuclear receptor	36	0	0	36
thyroid stimulating hormone receptor	19	0	0	19
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Renin	0	1	1	2
Retinoic acid receptor alpha	0	3	3	6
Retinoic acid receptor gamma	0	2	3	5
Retinoic acid receptor RXR-alpha	0	4	4	10
Retinoic acid receptor beta	0	2	3	5
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	3	3
Retinoic acid receptor RXR-alpha	0	3	4	7
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	2	4	6
Retinoic acid receptor RXR-gamma	0	2	4	6
Type-1 angiotensin II receptor	0	0	1	1
Cellular retinoic acid-binding protein 1	0	3	0	4
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	0	1	1
Oxysterols receptor LXR-beta	0	1	1	2
Cellular retinoic acid-binding protein 1	0	0	3	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Oxysterols receptor LXR-alpha	0	0	1	1
Heat shock protein HSP 90-alpha	0	0	2	2
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Kappa-type opioid receptor	0	2	1	4
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	5	1	6
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	5	6
Chain A, Beta-lactamase	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	11	0	0	11
Gamma-aminobutyric acid receptor subunit rho-1	0	1	2	3
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Cytochrome P450 2C19	0	12	1	14
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Carboxylic ester hydrolase	0	1	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	20	0	0	20
phosphopantetheinyl transferase	14	0	0	14
NFKB1 protein, partial	4	0	0	4
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	7	0	0	7
DNA polymerase iota isoform a (long)	13	0	0	13
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	8	0	0	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Cationic amino acid transporter 3	0	2	0	2
interleukin 8	13	0	0	13
Fumarate hydratase	9	0	0	9
thioredoxin glutathione reductase	9	0	0	9
G	22	0	0	22
polyprotein	9	0	0	9
P53	1	0	0	1
arylsulfatase A	11	0	0	11
IDH1	16	0	0	16
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	10	0	0	10
Interferon beta	33	0	0	33
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Inositol hexakisphosphate kinase 1	22	0	0	22
ATPase family AAA domain-containing protein 5	19	0	0	19
Ataxin-2	20	0	0	20
Protein-arginine deiminase type-4	0	11	0	11
cytochrome P450 2C9, partial	22	0	0	22
PPM1D protein	15	0	0	15
Bone morphogenetic protein receptor type-1B	0	0	10	10
Membrane-associated progesterone receptor component 1	0	0	8	8
Serine/threonine-protein kinase PLK4	0	2	10	12
ATP-dependent RNA helicase DDX3X	0	0	10	10
Pyridoxal kinase	0	0	10	10
Citron Rho-interacting kinase	0	0	10	10
Serine/threonine-protein kinase Chk1	0	2	10	12
Aurora kinase A	0	2	10	12
Cyclin-G-associated kinase	0	2	10	12
Ephrin type-B receptor 6	0	0	10	10
Peroxisomal acyl-coenzyme A oxidase 3	0	0	10	10
Receptor-interacting serine/threonine-protein kinase 2	0	1	10	11
Dynamin-like 120 kDa protein, mitochondrial	0	0	10	10
Tyrosine-protein kinase JAK2	0	6	10	19
Eukaryotic translation initiation factor 5B	0	0	5	5
Rho-associated protein kinase 2	0	1	10	11
Serine/threonine-protein kinase ULK1	0	0	10	10
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	10	10
Ribosomal protein S6 kinase alpha-5	0	1	10	11
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	10	10
Ribosomal protein S6 kinase alpha-4	0	0	10	10
Serine/threonine-protein kinase 16	0	0	10	10
Serine/threonine-protein kinase 10	0	0	10	10
Serine/threonine-protein kinase D3	0	0	10	10
Structural maintenance of chromosomes protein 2	0	0	9	9
Mitogen-activated protein kinase kinase kinase 6	0	0	10	10
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	10	10
Serine/threonine-protein kinase LATS1	0	0	10	10
Serine/threonine-protein kinase PAK 4	0	2	10	12
Tyrosine-protein kinase ABL1	0	4	12	16
Epidermal growth factor receptor	0	4	10	14
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	6	6
ADP/ATP translocase 2	0	0	10	10
Protein kinase C beta type	0	1	10	11
Insulin receptor	0	3	10	13
Cyclin-dependent kinase 1	0	1	10	11
Glycogen phosphorylase, liver form	0	0	10	10
Tyrosine-protein kinase Fes/Fps	0	0	10	10
Adenine phosphoribosyltransferase	0	0	6	6
Tyrosine-protein kinase Yes	0	0	10	10
Tyrosine-protein kinase Lyn	0	0	10	10
Proto-oncogene tyrosine-protein kinase receptor Ret	0	3	10	13
Insulin-like growth factor 1 receptor	0	0	10	10
Signal recognition particle receptor subunit alpha	0	0	7	7
Cytochrome c1, heme protein, mitochondrial	0	0	10	10
Hepatocyte growth factor receptor	0	2	10	12
Tyrosine-protein kinase HCK	0	2	10	12
Platelet-derived growth factor receptor beta	0	5	10	15
Serine/threonine-protein kinase A-Raf	0	2	10	12
Glycogen phosphorylase, brain form	0	0	10	10
Breakpoint cluster region protein	0	1	11	12
Serine/threonine-protein kinase pim-1	0	1	10	11
Fibroblast growth factor receptor 1	0	3	10	13
DNA topoisomerase 2-alpha	0	1	8	13
Cyclin-dependent kinase 4	0	1	10	11
ADP/ATP translocase 3	0	0	10	10
Inosine-5'-monophosphate dehydrogenase 2	0	0	9	9
Proto-oncogene tyrosine-protein kinase Src	0	2	10	12
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	9	9
Serine/threonine-protein kinase B-raf	0	5	12	18
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	10	10
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	10	10
Tyrosine-protein kinase Fer	0	0	10	10
Protein kinase C alpha type	0	1	10	11
cAMP-dependent protein kinase catalytic subunit alpha	0	0	10	10
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	10	10
Casein kinase II subunit alpha'	0	0	10	10
Ras-related protein Rab-6A	0	0	8	8
Ephrin type-A receptor 1	0	0	10	10
Multifunctional protein ADE2	0	0	10	10
cAMP-dependent protein kinase catalytic subunit gamma	0	0	8	8
cAMP-dependent protein kinase catalytic subunit beta	0	0	10	10
Ferrochelatase, mitochondrial	0	0	11	11
Ribosomal protein S6 kinase beta-1	0	1	9	10
Tyrosine-protein kinase JAK1	0	6	12	21
Cyclin-dependent kinase 2	0	4	11	15
Beta-adrenergic receptor kinase 1	0	0	10	10
Probable ATP-dependent RNA helicase DDX6	0	0	10	10
Mitogen-activated protein kinase 3	0	1	10	11
MAP/microtubule affinity-regulating kinase 3	0	0	10	10
Deoxycytidine kinase	0	0	10	10
Mitogen-activated protein kinase 1	0	4	10	14
Ephrin type-A receptor 2	0	0	10	10
Ephrin type-B receptor 2	0	0	10	10
Non-receptor tyrosine-protein kinase TYK2	0	6	12	21
UMP-CMP kinase	0	0	5	5
Phosphatidylethanolamine-binding protein 1	0	0	8	8
Wee1-like protein kinase	0	0	10	10
Heme oxygenase 2	0	0	10	10
S-adenosylmethionine synthase isoform type-2	0	0	10	10
DnaJ homolog subfamily A member 1	0	0	10	10
RAC-alpha serine/threonine-protein kinase	0	3	10	13
RAC-beta serine/threonine-protein kinase	0	0	10	10
DNA replication licensing factor MCM4	0	0	9	9
Myosin-10	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 2	0	2	10	12
Receptor-type tyrosine-protein kinase FLT3	0	3	10	14
Bone morphogenetic protein receptor type-1A	0	0	10	10
Activin receptor type-1B	0	0	10	10
TGF-beta receptor type-1	0	0	10	10
Serine/threonine-protein kinase receptor R3	0	0	7	7
TGF-beta receptor type-2	0	0	10	10
Electron transfer flavoprotein subunit beta	0	0	8	8
Tyrosine-protein kinase CSK	0	1	10	11
Glycine--tRNA ligase	0	0	10	10
Protein kinase C iota type	0	0	10	10
Exosome RNA helicase MTR4	0	0	10	10
Tyrosine-protein kinase Tec	0	1	10	11
Tyrosine-protein kinase ABL2	0	0	10	10
Tyrosine-protein kinase FRK	0	0	10	10
G protein-coupled receptor kinase 6	0	0	6	6
Tyrosine-protein kinase SYK	0	1	10	11
26S proteasome regulatory subunit 6B	0	0	10	10
Mitogen-activated protein kinase 8	0	1	10	11
Mitogen-activated protein kinase 9	0	0	10	10
Dual specificity mitogen-activated protein kinase kinase 3	0	0	10	10
Casein kinase I isoform alpha	0	2	10	12
Casein kinase I isoform delta	0	0	10	10
MAP kinase-activated protein kinase 2	0	1	10	11
Elongation factor Tu, mitochondrial	0	0	10	10
Cysteine--tRNA ligase, cytoplasmic	0	0	10	10
Casein kinase I isoform epsilon	0	0	10	10
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	10	10
Dual specificity protein kinase CLK1	0	0	10	10
Dual specificity protein kinase CLK2	0	0	9	9
Dual specificity protein kinase CLK3	0	0	8	8
Glycogen synthase kinase-3 alpha	0	0	10	10
Glycogen synthase kinase-3 beta	0	2	10	12
Cyclin-dependent kinase 7	0	0	10	10
Cyclin-dependent kinase 9	0	0	10	10
Ras-related protein Rab-27A	0	0	9	9
Interleukin-1 receptor-associated kinase 1	0	0	10	10
Ribosomal protein S6 kinase alpha-3	0	2	10	12
Serine/threonine-protein kinase Nek2	0	1	10	11
Serine/threonine-protein kinase Nek3	0	0	10	10
Tyrosine-protein kinase JAK3	0	6	6	16
Dual specificity mitogen-activated protein kinase kinase 6	0	0	10	10
LIM domain kinase 1	0	0	10	10
LIM domain kinase 2	0	0	10	10
Mitogen-activated protein kinase 10	0	0	10	10
Tyrosine--tRNA ligase, cytoplasmic	0	0	10	10
5'-AMP-activated protein kinase subunit gamma-1	0	0	10	11
Ephrin type-B receptor 3	0	0	10	10
Ephrin type-A receptor 5	0	0	10	10
Ephrin type-B receptor 4	0	2	10	12
Ephrin type-A receptor 4	0	0	10	10
Adenylate kinase 2, mitochondrial	0	0	10	10
Adenosine kinase	0	0	9	9
Ras-related protein Rab-10	0	0	10	10
Actin-related protein 3	0	1	10	11
Actin-related protein 2	0	0	8	8
GTP-binding nuclear protein Ran	0	0	10	10
Casein kinase I isoform gamma-2	0	0	10	10
Cyclin-dependent kinase 3	0	0	8	8
Cyclin-dependent kinase 6	0	1	10	11
Cyclin-dependent-like kinase 5	0	1	10	11
Cyclin-dependent kinase 16	0	0	10	10
Cyclin-dependent kinase 17	0	0	10	10
ATP-dependent 6-phosphofructokinase, platelet type	0	0	10	10
Dual specificity mitogen-activated protein kinase kinase 1	0	3	10	13
DNA topoisomerase 2-beta	0	0	10	10
Protein kinase C theta type	0	0	10	10
Activin receptor type-1	0	0	10	10
Macrophage-stimulating protein receptor	0	0	10	10
Focal adhesion kinase 1	0	1	10	11
Protein kinase C delta type	0	0	10	10
Tyrosine-protein kinase BTK	0	1	10	11
Activated CDC42 kinase 1	0	0	10	10
Epithelial discoidin domain-containing receptor 1	0	0	10	10
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	10	10
Serine/threonine-protein kinase 4	0	0	10	10
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	10	12
Dual specificity mitogen-activated protein kinase kinase 5	0	0	10	10
Mitogen-activated protein kinase 7	0	0	10	10
Serine/threonine-protein kinase PAK 2	0	0	10	10
Serine/threonine-protein kinase 3	0	0	10	10
Mitogen-activated protein kinase kinase kinase 1	0	0	10	10
Integrin-linked protein kinase	0	0	10	10
Rho-associated protein kinase 1	0	0	10	10
Non-receptor tyrosine-protein kinase TNK1	0	0	10	10
Serine/threonine-protein kinase ATR	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	10	10
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	10	10
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	10	10
Activin receptor type-2B	0	0	10	10
Bone morphogenetic protein receptor type-2	0	0	10	10
Protein-tyrosine kinase 6	0	0	10	10
cGMP-dependent protein kinase 1	0	0	10	10
Cyclin-dependent kinase 13	0	0	10	10
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	10	10
Protein-tyrosine kinase 2-beta	0	0	10	10
Maternal embryonic leucine zipper kinase	0	0	10	10
Structural maintenance of chromosomes protein 1A	0	0	9	9
Chromodomain-helicase-DNA-binding protein 4	0	0	10	10
Peroxisomal acyl-coenzyme A oxidase 1	0	0	9	9
Ephrin type-A receptor 7	0	0	8	8
Delta(24)-sterol reductase	0	0	9	9
Ribosomal protein S6 kinase alpha-1	0	1	10	11
Dual specificity testis-specific protein kinase 1	0	0	9	9
Myosin light chain kinase, smooth muscle	0	0	10	10
Mitogen-activated protein kinase 11	0	1	10	11
Serine/threonine-protein kinase STK11	0	0	10	10
Serine/threonine-protein kinase N1	0	0	10	10
Serine/threonine-protein kinase N2	0	0	10	10
Mitogen-activated protein kinase 14	0	4	10	14
Calcium/calmodulin-dependent protein kinase type IV	0	0	10	10
Mitogen-activated protein kinase kinase kinase 11	0	0	10	10
MAP kinase-activated protein kinase 3	0	0	3	3
Discoidin domain-containing receptor 2	0	2	10	12
AP2-associated protein kinase 1	0	3	10	13
Myosin light chain kinase 3	0	0	10	10
Uncharacterized aarF domain-containing protein kinase 5	0	0	6	6
Putative heat shock protein HSP 90-beta 2	0	0	10	10
Rab-like protein 3	0	0	8	8
Serine/threonine-protein kinase MRCK alpha	0	0	10	10
Serine/threonine-protein kinase MRCK gamma	0	0	9	9
Acyl-CoA dehydrogenase family member 10	0	0	9	9
Serine/threonine-protein kinase ULK3	0	0	10	10
Uncharacterized protein FLJ45252	0	0	10	10
Acyl-CoA dehydrogenase family member 11	0	0	9	9
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	9	9
Serine/threonine-protein kinase MARK2	0	0	10	10
ATP-dependent RNA helicase DHX30	0	0	8	8
Serine/threonine-protein kinase TAO1	0	0	10	10
STE20-related kinase adapter protein alpha	0	0	10	10
Myosin-14	0	0	10	10
AarF domain-containing protein kinase 1	0	0	10	10
ATP-dependent RNA helicase DDX42	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	10	10
MAP kinase-activated protein kinase 5	0	1	10	11
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	3	3
Misshapen-like kinase 1	0	0	8	8
Atypical kinase COQ8A, mitochondrial	0	0	10	10
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	10	10
Mitogen-activated protein kinase 15	0	0	10	10
Serine/threonine-protein kinase Nek9	0	0	10	10
ATP-dependent RNA helicase DDX1	0	0	10	10
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	10	10
Aurora kinase B	0	1	10	11
Calcium/calmodulin-dependent protein kinase type 1G	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	10	10
PAS domain-containing serine/threonine-protein kinase	0	0	7	7
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	10	10
EKC/KEOPS complex subunit TP53RK	0	0	10	10
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	10	10
Mitogen-activated protein kinase kinase kinase 5	0	0	10	10
Mitogen-activated protein kinase kinase kinase 3	0	0	10	10
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	10	10
Nucleolar GTP-binding protein 1	0	0	10	10
Serine/threonine-protein kinase D2	0	0	10	10
NUAK family SNF1-like kinase 2	0	0	8	8
RNA cytidine acetyltransferase	0	0	10	10
Serine/threonine-protein kinase SIK2	0	0	10	10
STE20-like serine/threonine-protein kinase	0	0	10	10
Serine/threonine-protein kinase TAO3	0	0	10	10
dCTP pyrophosphatase 1	0	0	10	10
Dual specificity protein kinase CLK4	0	0	9	9
Casein kinase I isoform gamma-1	0	0	10	10
Serine/threonine-protein kinase PAK 6	0	1	7	8
Phenylalanine--tRNA ligase beta subunit	0	0	10	10
Isoleucine--tRNA ligase, mitochondrial	0	0	7	7
BMP-2-inducible protein kinase	0	0	10	10
Obg-like ATPase 1	0	0	7	7
Midasin	0	0	10	10
Interleukin-1 receptor-associated kinase 4	0	0	10	10
Mitogen-activated protein kinase kinase kinase 20	0	1	10	11
Cyclin-dependent kinase 12	0	0	10	10
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	9	9
Serine/threonine-protein kinase 26	0	0	10	10
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	10	10
Serine/threonine-protein kinase NLK	0	0	10	10
5'-AMP-activated protein kinase subunit gamma-2	0	0	10	11
Serine/threonine-protein kinase TBK1	0	2	10	12
Septin-9	0	0	10	10
Ribosomal protein S6 kinase alpha-6	0	0	10	10
TRAF2 and NCK-interacting protein kinase	0	0	10	10
Serine/threonine-protein kinase TAO2	0	0	10	10
Long-chain-fatty-acid--CoA ligase 5	0	0	8	8
Serine/threonine-protein kinase ICK	0	0	10	10
RAC-gamma serine/threonine-protein kinase	0	0	10	10
Serine/threonine-protein kinase 38-like	0	0	9	9
Serine/threonine-protein kinase SIK3	0	0	10	10
Mitogen-activated protein kinase kinase kinase 2	0	0	10	10
Thyroid hormone receptor-associated protein 3	0	0	8	8
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	10	10
Receptor-interacting serine/threonine-protein kinase 3	0	1	10	11
Serine/threonine-protein kinase MRCK beta	0	0	10	10
Interleukin-1 receptor-associated kinase 3	0	0	10	10
Serine/threonine-protein kinase 24	0	0	9	9
Casein kinase I isoform gamma-3	0	0	10	10
Mitogen-activated protein kinase kinase kinase 4	0	0	10	10
thyroid hormone receptor beta isoform a	19	0	0	19
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
DNA polymerase kappa isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	2	0	0	2
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	6	0	10
Solute carrier organic anion transporter family member 1B1	0	10	0	13
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	12	0	0	12
pregnane X receptor	12	0	0	12
caspase 7, apoptosis-related cysteine protease	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	27	0	0	27
cytochrome P450 2D6	14	0	0	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
67.9K protein	15	0	0	15
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	9	0	0	9
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-7	7	0	0	7
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	17	0	0	17
potassium voltage-gated channel subfamily H member 2 isoform d	14	0	0	14
caspase-3	7	0	0	7
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	4	0	4
3-phosphoinositide-dependent protein kinase 1	0	1	5	6
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	6	0	6
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	3	2	7
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	8	0	8
Neuronal acetylcholine receptor subunit beta-2	1	3	2	7
Beta-3 adrenergic receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	10	0	10
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	7	1	9
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	9	1	10
Adenosine receptor A1	0	3	0	4
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	8	1	9
Sodium-dependent serotonin transporter	0	4	1	5
Delta-type opioid receptor	0	3	1	4
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	5	0	5
Bifunctional epoxide hydrolase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	1	0	3
Alpha-1A adrenergic receptor	0	10	0	10
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	4
Histone deacetylase 4	0	3	0	3
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	7	0	7
Prostaglandin G/H synthase 2	0	1	0	1
Histone deacetylase 1	0	4	0	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
P2Y purinoceptor 12	0	1	0	1
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	6	0	0	6
PAX8	0	0	0	2
15-lipoxygenase, partial	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
PINK1	2	0	0	2
glucocerebrosidase	6	0	0	6
Parkin	4	0	0	4
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	6	0	0	6
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	7	0	0	7
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	5	0	0	5
importin subunit beta-1 isoform 1	5	0	0	5
mitogen-activated protein kinase 1	10	0	0	10
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	2
snurportin-1	5	0	0	5
melanocortin receptor 4	0	2	1	3
CAAX prenyl protease	0	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
bcl-2-related protein A1	0	2	0	2
urokinase plasminogen activator surface receptor precursor	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	6	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	3	0	4
Glutathione reductase, mitochondrial	0	4	0	6
Integrin beta-3	2	0	0	2
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	2	0	0	2
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	8	3	0	11
Histamine H2 receptor	8	0	1	9
TAR DNA-binding protein 43	11	0	0	11
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	6	0	6
Spermine oxidase	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	6	0	10
DNA gyrase subunit B	0	6	0	10
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA gyrase subunit A	0	2	0	3
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	5	0	7
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	4	0	8
Potassium voltage-gated channel subfamily H member 2	0	14	0	16
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
endonuclease IV	5	0	0	5
Thrombopoietin	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
nuclear receptor subfamily 0 group B member 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
neuropeptide S receptor isoform A	4	0	0	4
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	3
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	7	2	17
Tubulin alpha-3C chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
D(1A) dopamine receptor	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
Glucocorticoid receptor	0	16	3	24
Progesterone receptor	0	5	1	7
Glycine receptor subunit alpha-1	0	16	0	16
Androgen receptor	0	9	1	10
Androgen receptor	0	15	0	16
Glycine receptor subunit beta	0	16	0	16
Glycine receptor subunit alpha-2	0	16	0	16
Glycine receptor subunit alpha-3	0	16	0	16
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A2a	0	1	0	2
Mu-type opioid receptor	0	4	0	4
ORF73	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Myeloperoxidase	0	3	0	3
Dihydrofolate reductase	0	6	0	7
5-hydroxytryptamine receptor 6	0	4	0	4
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	2	0	2
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-b-lactamase	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	4
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	7	7
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
Albumin	0	1	11	12
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
Cytochrome P450 1B1	0	2	0	2
Lanosterol 14-alpha demethylase	0	3	0	3
50S ribosomal protein L36 2	0	4	1	5
Pantothenate synthetase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Vpr	5	0	0	5
Estrogen receptor	0	6	2	8
Cytochrome P450 2B6	0	1	1	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
Adenosine receptor A2a	0	3	0	3
Kappa-type opioid receptor	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	4	2	6
Acetylcholinesterase	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Cytochrome P450 2A6	0	5	1	6
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
Beta-secretase 1	0	1	0	1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
nonstructural protein 1	3	0	0	3
Cocaine esterase	0	1	0	2
Arylacetamide deacetylase	0	1	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
DNA polymerase beta	5	0	0	5
Thymidylate synthase	0	5	0	5
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	4	3	7
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Cell division cycle 7-related protein kinase	0	0	5	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	9	9
Cyclin-dependent kinase-like 5	0	0	8	8
High affinity nerve growth factor receptor	0	0	9	9
Dual specificity protein kinase TTK	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 4	0	0	8	8
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	8	8
Choline-phosphate cytidylyltransferase A	0	0	4	4
Serine/threonine-protein kinase PLK1	0	3	9	12
Protein kinase C zeta type	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	8	8
MAP/microtubule affinity-regulating kinase 4	0	0	9	9
Dual specificity testis-specific protein kinase 2	0	0	6	6
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	10	1	12
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	8	8
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
Estrogen receptor	0	0	3	3
Guanine nucleotide-binding protein G	2	0	0	2
Estrogen receptor beta	0	0	3	3
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	1	0	1
regulator of G-protein signaling 4	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Albumin	0	0	2	2
Sodium-dependent dopamine transporter	0	1	0	1
Smoothened homolog	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	4
Sonic hedgehog protein	0	1	0	2
Sonic hedgehog protein	0	1	0	1
Smoothened homolog	0	2	2	4
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Serine/threonine-protein kinase N3	0	0	7	7
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	3	3	6
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	2	0	0	2
apical membrane antigen 1, AMA1	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	3	0	3
Histamine H2 receptor	0	3	2	5
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Histamine H1 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Solute carrier family 22 member 1	0	2	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	3
Solute carrier family 22 member 2	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Histamine H3 receptor	0	1	2	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	1	1
Muscarinic acetylcholine receptor M2	0	5	1	7
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	3	1	4
Replicase polyprotein 1ab	0	3	1	4
Muscarinic acetylcholine receptor M1	0	3	0	4
Alpha-2C adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	1	3
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	0	0	2
B2 metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	1	3
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
Leukotriene C4 synthase	0	0	5	5
tyrosine-protein kinase Yes	7	0	0	7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	5	7
Serine/threonine-protein kinase 25	0	0	5	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	5	5
Serine/threonine-protein kinase RIO3	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 7	0	1	5	6
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	5	6
Peripheral plasma membrane protein CASK	0	0	5	5
Serine/threonine-protein kinase DCLK1	0	0	5	5
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	5	5
Muscle, skeletal receptor tyrosine-protein kinase	0	0	5	5
Mitogen-activated protein kinase 13	0	1	5	6
Mitogen-activated protein kinase kinase kinase 13	0	0	5	5
Death-associated protein kinase 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 7	0	0	5	5
NUAK family SNF1-like kinase 1	0	1	5	6
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	5	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	5	5
Serine/threonine-protein kinase PAK 3	0	0	5	5
Serine/threonine-protein kinase 17B	0	0	5	5
Cyclin-dependent kinase 14	0	0	5	5
Serine/threonine-protein kinase OSR1	0	0	5	5
Serine/threonine-protein kinase Chk2	0	1	5	6
RAF proto-oncogene serine/threonine-protein kinase	0	4	6	11
Receptor tyrosine-protein kinase erbB-2	0	2	5	7
Macrophage colony-stimulating factor 1 receptor	0	3	5	8
Proto-oncogene tyrosine-protein kinase ROS	0	0	5	5
Tyrosine-protein kinase Fgr	0	0	7	7
Wee1-like protein kinase 2	0	0	5	5
Uncharacterized serine/threonine-protein kinase SBK3	0	0	5	5
Mast/stem cell growth factor receptor Kit	0	5	5	10
Insulin receptor-related protein	0	0	5	5
Platelet-derived growth factor receptor alpha	0	4	5	9
Vascular endothelial growth factor receptor 1	0	4	5	9
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	5	5
Serine/threonine-protein kinase MAK	0	0	5	5
Cyclin-dependent kinase 11B	0	0	5	5
Fibroblast growth factor receptor 2	0	1	5	6
Receptor tyrosine-protein kinase erbB-3	0	0	5	5
Fibroblast growth factor receptor 4	0	0	5	5
Fibroblast growth factor receptor 3	0	0	5	5
Protein kinase C eta type	0	0	5	5
Activin receptor type-2A	0	0	5	5
Ephrin type-A receptor 3	0	0	5	5
Ephrin type-A receptor 8	0	0	5	5
Leukocyte tyrosine kinase receptor	0	0	5	5
Tyrosine-protein kinase receptor UFO	0	1	5	6
Mitogen-activated protein kinase 4	0	0	5	5
G protein-coupled receptor kinase 4	0	0	5	5
Tyrosine-protein kinase receptor Tie-1	0	0	5	5
Vascular endothelial growth factor receptor 3	0	4	5	9
Vascular endothelial growth factor receptor 2	0	7	6	14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	5	8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	5	7
Serine/threonine-protein kinase mTOR	0	4	6	10
Megakaryocyte-associated tyrosine-protein kinase	0	0	5	5
Tyrosine-protein kinase TXK	0	1	5	6
Tyrosine-protein kinase ZAP-70	0	0	5	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	5	7
Cyclin-dependent kinase 8	0	1	5	6
Tyrosine-protein kinase Blk	0	1	5	6
Cytoplasmic tyrosine-protein kinase BMX	0	1	5	6
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	5	5
Serine/threonine-protein kinase Nek4	0	0	5	5
Death-associated protein kinase 1	0	0	5	5
Mitogen-activated protein kinase 12	0	1	5	6
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	5	7
Ephrin type-B receptor 1	0	0	5	5
Hormonally up-regulated neu tumor-associated kinase	0	0	5	5
Serine/threonine-protein kinase SIK1	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 4	0	0	5	5
Cell division control protein 2 homolog	0	0	5	5
Calcium-dependent protein kinase 1	0	0	5	5
Casein kinase II subunit alpha	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	5	5
SRSF protein kinase 2	0	0	5	5
Mitogen-activated protein kinase kinase kinase 9	0	0	5	5
Serine/threonine-protein kinase PknB	0	0	5	5
Cyclin-dependent kinase-like 1	0	0	5	5
Protein kinase C epsilon type	0	1	5	6
Angiopoietin-1 receptor	0	2	5	7
Mitogen-activated protein kinase kinase kinase 10	0	0	5	5
Tyrosine-protein kinase receptor TYRO3	0	0	5	5
Cyclin-dependent kinase 18	0	0	6	6
Tyrosine-protein kinase ITK/TSK	0	1	5	6
Myotonin-protein kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 12	0	0	5	5
Tyrosine-protein kinase Mer	0	1	7	8
Serine/threonine-protein kinase PAK 1	0	0	5	5
cGMP-dependent protein kinase 2	0	0	5	5
Serine/threonine-protein kinase PRP4 homolog	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 1	0	2	5	7
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	5	5
Calcium/calmodulin-dependent protein kinase type 1	0	0	5	5
Serine/threonine-protein kinase D1	0	0	5	5
Serine/threonine-protein kinase 38	0	0	5	5
Receptor tyrosine-protein kinase erbB-4	0	1	5	6
Ribosomal protein S6 kinase alpha-2	0	0	5	5
Rhodopsin kinase GRK1	0	0	5	5
NT-3 growth factor receptor	0	0	5	5
BDNF/NT-3 growth factors receptor	0	0	5	5
Mitogen-activated protein kinase 6	0	0	5	5
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	5	5
Serine/threonine-protein kinase SBK1	0	0	5	5
Mitogen-activated protein kinase kinase kinase 19	0	0	5	5
Serine/threonine-protein kinase TNNI3K	0	1	5	6
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	5	6
Tyrosine-protein kinase JAK2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	5	5
Dual serine/threonine and tyrosine protein kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 15	0	0	5	5
Serine/threonine-protein kinase tousled-like 2	0	0	5	5
Serine/threonine-protein kinase 32C	0	0	5	5
Serine/threonine-protein kinase pim-3	0	0	5	5
Serine/threonine-protein kinase VRK2	0	0	5	5
Myosin light chain kinase family member 4	0	0	5	5
Homeodomain-interacting protein kinase 1	0	1	5	6
Calcium/calmodulin-dependent protein kinase type 1D	0	0	5	5
Cyclin-dependent kinase-like 3	0	0	5	5
Serine/threonine-protein kinase BRSK2	0	0	5	5
Serine/threonine-protein kinase NIM1	0	0	5	5
Serine/threonine-protein kinase ULK2	0	0	5	5
Serine/threonine-protein kinase DCLK2	0	0	5	5
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	5	5
Casein kinase I isoform alpha-like	0	0	5	5
Homeodomain-interacting protein kinase 4	0	1	5	6
Myosin-IIIa	0	0	5	5
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	5	5
Serine/threonine-protein kinase Nek11	0	0	5	5
Serine/threonine-protein kinase BRSK1	0	0	5	5
Serine/threonine-protein kinase 35	0	0	5	5
Rhodopsin kinase GRK7	0	0	5	5
Serine/threonine-protein kinase 32A	0	0	5	5
Myosin-IIIb	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	5	5
Cyclin-dependent kinase-like 2	0	0	5	5
Serine/threonine-protein kinase Sgk3	0	0	5	5
Atypical kinase COQ8B, mitochondrial	0	0	5	5
Cyclin-dependent kinase 15	0	0	5	5
SRSF protein kinase 1	0	0	5	5
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	5	5
Serine/threonine-protein kinase RIO1	0	0	5	5
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	5	5
Serine/threonine-protein kinase RIO2	0	0	5	5
Cyclin-dependent kinase 19	0	1	5	6
Transient receptor potential cation channel subfamily M member 6	0	0	5	5
Testis-specific serine/threonine-protein kinase 1	0	0	5	5
Serine/threonine-protein kinase 33	0	0	5	5
Serine/threonine-protein kinase DCLK3	0	0	5	5
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	5	5
Homeodomain-interacting protein kinase 2	0	1	5	6
Tyrosine-protein kinase Srms	0	0	5	5
Homeodomain-interacting protein kinase 3	0	1	5	6
Serine/threonine-protein kinase PLK3	0	2	5	7
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	5	6
Serine/threonine-protein kinase Nek6	0	0	5	5
SNF-related serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase LATS2	0	0	5	5
Serine/threonine-protein kinase 36	0	0	5	5
Serine/threonine-protein kinase 32B	0	0	5	5
Serine/threonine-protein kinase PLK2	0	2	5	7
Serine/threonine-protein kinase MARK1	0	0	5	5
Serine/threonine-protein kinase pim-2	0	0	6	6
Serine/threonine-protein kinase PAK 5	0	1	5	6
eIF-2-alpha kinase GCN2	0	0	5	5
Serine/threonine-protein kinase 17A	0	0	5	5
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	5	5
Ephrin type-A receptor 6	0	0	5	5
Death-associated protein kinase 2	0	0	5	5
Serine/threonine-protein kinase tousled-like 1	0	0	5	5
ALK tyrosine kinase receptor	0	1	5	6
SRSF protein kinase 3	0	0	5	5
Cyclin-dependent kinase 11A	0	0	5	5
Aurora kinase C	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	5	5
Microtubule-associated serine/threonine-protein kinase 1	0	0	5	5
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	1	3
Cyclin-A2	0	1	0	1
Cyclin-A1	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Amyloid-beta precursor protein	0	4	0	4
Sodium/myo-inositol cotransporter 2	0	1	0	1
histone deacetylase 9 isoform 3	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	2	0	2
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	3	0	6
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	2
5-hydroxytryptamine receptor 2B	0	9	0	9
Olfactory receptor 51E2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Reverse transcriptase/RNaseH	0	3	4	14
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Renin	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Dihydrofolate reductase	0	7	0	8
Dipeptidyl peptidase 4	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	2	1	5
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 8	0	1	0	4
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	3
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1D adrenergic receptor	0	3	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Stromelysin-1	0	3	1	4
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Imidazoleglycerol-phosphate dehydratase	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Ryanodine receptor 1	0	1	0	1
Acetylcholinesterase	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Exoribonuclease H	0	1	0	1
Protease	0	6	2	8
Cardiac ryanodine receptor 2	0	1	0	1
Fructose-1,6-bisphosphatase 1	0	0	0	1
Reverse transcriptase	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	2	0	2
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Translocator protein	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
STE24	0	0	0	1
Trypsin	0	0	0	1
D(3) dopamine receptor	0	4	0	4
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	4	4
Tubulin alpha-1A chain	0	0	4	4
Receptor protein-tyrosine kinase	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Presenilin-1	0	1	0	1
Presenilin-2	0	1	0	1
Gamma-secretase subunit APH-1B	0	1	0	1
Nicastrin	0	1	0	1
Gamma-secretase subunit APH-1A	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Pirin	0	1	0	1
GTPase KRas	0	1	0	1
Serine/threonine-protein kinase B-raf	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Heat shock factor protein 1	0	1	0	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Cyclin-dependent kinase 10	0	0	2	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	4	1	6
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Tyrosinase	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier organic anion transporter family member 2B1	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Caspase-1	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A1	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	2
Phosphodiesterase	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Aromatase	0	2	0	2
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Protein delta homolog 1	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	4	0	4
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	2
Transthyretin	0	1	1	3
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Delta	0	1	0	1
Cycloeucalenol cycloisomerase	0	1	0	1
Sterol-8,7-isomerase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor alpha	0	2	2	4
Thyroid hormone receptor beta	0	2	2	4
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Arginase 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (418)

Protein Targets (1,812)

Hidradenitis Suppurativa

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (418)

Drugs Studied (188)

Protein Targets (1,812)