metronidazole has been researched along with Pouchitis in 46 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pouchitis: Acute INFLAMMATION in the INTESTINAL MUCOSA of the continent ileal reservoir (or pouch) in patients who have undergone ILEOSTOMY and restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The fecal flora obtained from 13 patients with ulcerative colitis was examined at the beginning of a pouchitis episode before treatment, during treatment with metronidazole or ciprofloxacin, and during pouchitis-free periods." | 9.11 | Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis. ( Gosselink, MP; Hop, WC; Laman, JD; Ruseler-van Embden, JG; Schouten, WR; van Lieshout, LM, 2004) |
| "Four-week treatment with a combination of metronidazole and ciprofloxacin is highly effective in patients with active recurrent or refractory pouchitis, objectively improving the inflammation and quality of life." | 9.10 | Four-week open-label trial of metronidazole and ciprofloxacin for the treatment of recurrent or refractory pouchitis. ( Campieri, M; Gionchetti, P; Helwig, U; Kamm, MA; Mimura, T; Nicholls, RJ; Poggioli, G; Rizzello, F; Schreiber, S; Talbot, IC, 2002) |
| "Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics." | 9.09 | A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001) |
| "In this retrospective cohort study, we demonstrated no significant difference in the real-world effectiveness of ciprofloxacin, metronidazole, or combination therapy for the initial episode of pouchitis." | 8.31 | The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study. ( Barnes, EL; Desai, A; Kochhar, GS, 2023) |
| " Patients with ulcerative colitis were divided into five groups: a) no history of pouchitis (pouch for at least 2 years; n = 8); b) past episode(s) of pouchitis but no active disease for the previous year (n = 9); c) pouchitis in the past year but presently inactive (n = 9); d) ongoing antibiotic treatment (metronidazole or ciprofloxacin) for pouchitis (n = 11); e) currently suffering from pouchitis (n = 8)." | 7.73 | Association between fecal hydrogen sulfide production and pouchitis. ( Furne, JK; Levitt, MD; Madoff, RD; Ohge, H; Rothenberger, DA; Springfield, J, 2005) |
| " Acute pouchitis: One study compared ciprofloxacin with metronidazole." | 5.41 | Systematic review and meta-analysis of randomised controlled trials: Medical therapies for the treatment and prevention of pouchitis. ( Alphonsus, L; Beaton, M; Bessissow, T; De Silva, TA; Hanzel, J; Jairath, V; Kayal, M; Ma, C; MacDonald, JK; Sedano, R; Singh, S, 2023) |
| " When compared to placebo, rifaximin was found to be the best antibiotic for acute pouchitis whereas ciprofloxacin ranked highest against metronidazole." | 5.22 | Network meta-analysis: efficacy of treatment for acute, chronic, and prevention of pouchitis in ulcerative colitis. ( Poo, S; Segal, JP; Sriranganathan, D, 2022) |
| "The fecal flora obtained from 13 patients with ulcerative colitis was examined at the beginning of a pouchitis episode before treatment, during treatment with metronidazole or ciprofloxacin, and during pouchitis-free periods." | 5.11 | Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis. ( Gosselink, MP; Hop, WC; Laman, JD; Ruseler-van Embden, JG; Schouten, WR; van Lieshout, LM, 2004) |
| "Patients with pouchitis at least twice in the previous year or requiring continuous antibiotics, associated with a pouchitis disease activity index (PDAI) > or =7 (0 = perfect; 18 = worst), in whom remission was induced by four weeks of combined metronidazole and ciprofloxacin, were randomised to receive VSL#3 6 g or placebo once daily for one year or until relapse." | 5.11 | Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. ( Campieri, M; Gionchetti, P; Helwig, U; Kamm, MA; Mimura, T; Nicholls, RJ; Poggioli, G; Rizzello, F; Schreiber, S; Talbot, IC, 2004) |
| "Budesonide enemas are an alternative treatment for active pouchitis, with similar efficacy but better tolerability than oral metronidazole." | 5.10 | Budesonide enema in pouchitis--a double-blind, double-dummy, controlled trial. ( Bai, JC; Boerr, L; Cabanne, A; Camartino, G; Doldán, I; Gil, A; Gonzalez, O; Graziano, A; Huernos, S; Kogan, Z; Lumi, M; Negreira, S; Peredo, H; Sambuelli, A; Sugai, E, 2002) |
| "Four-week treatment with a combination of metronidazole and ciprofloxacin is highly effective in patients with active recurrent or refractory pouchitis, objectively improving the inflammation and quality of life." | 5.10 | Four-week open-label trial of metronidazole and ciprofloxacin for the treatment of recurrent or refractory pouchitis. ( Campieri, M; Gionchetti, P; Helwig, U; Kamm, MA; Mimura, T; Nicholls, RJ; Poggioli, G; Rizzello, F; Schreiber, S; Talbot, IC, 2002) |
| "Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics." | 5.09 | A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001) |
| "For acute pouchitis, very low quality evidence suggests that ciprofloxacin may be more effective than metronidazole." | 4.91 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Pardi, DS; Sandborn, WJ; Singh, S; Stroud, AM, 2015) |
| "For acute pouchitis, ciprofloxacin was more effective than metronidazole, while budesonide enemas and metronidazole were similarly effective." | 4.86 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Cima, RR; Holubar, SD; Pardi, DS; Sandborn, WJ, 2010) |
| "The odds ratios of inducing a response using oral metronidazole or bismuth carbomer foam enemas compared with placebo in active chronic pouchitis were 26." | 4.80 | Pharmacotherapy for inducing and maintaining remission in pouchitis. ( Jewell, D; McLeod, R; Sandborn, W, 2000) |
| "In this retrospective cohort study, we demonstrated no significant difference in the real-world effectiveness of ciprofloxacin, metronidazole, or combination therapy for the initial episode of pouchitis." | 4.31 | The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study. ( Barnes, EL; Desai, A; Kochhar, GS, 2023) |
| "5%) used antibiotics for pouchitis, predominantly ciprofloxacin." | 4.12 | Long-term Antibiotic Treatment in Pouchitis-Patterns of Use and Safety. ( Avraham, Y; Banon, L; Bar, N; Cohen, NA; Dotan, I; Dubinsky, V; Gophna, U; Maharshak, N; Tulchinsky, H; Weiss, GA, 2022) |
| "The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat this condition." | 3.80 | Role of probiotics in the management of pouchitis. ( Guslandi, M, 2014) |
| "Fourteen consecutive patients with symptomatic pre-pouch ileitis were treated with ciprofloxacin 500 mg b." | 3.75 | An open study of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis. ( Bell, AJ; Ciclitira, PJ; Clark, SK; McLaughlin, SD; Nicholls, RJ; Tekkis, PP, 2009) |
| "The antibiotics, metronidazole and ciprofloxacin, are the first-line treatment for pouchitis." | 3.73 | Successful treatment of severe pouchitis with rebamipide refractory to antibiotics and corticosteroids: a case report. ( Kakumu, S; Konagaya, T; Miyata, M; Mori, T, 2006) |
| " Patients with ulcerative colitis were divided into five groups: a) no history of pouchitis (pouch for at least 2 years; n = 8); b) past episode(s) of pouchitis but no active disease for the previous year (n = 9); c) pouchitis in the past year but presently inactive (n = 9); d) ongoing antibiotic treatment (metronidazole or ciprofloxacin) for pouchitis (n = 11); e) currently suffering from pouchitis (n = 8)." | 3.73 | Association between fecal hydrogen sulfide production and pouchitis. ( Furne, JK; Levitt, MD; Madoff, RD; Ohge, H; Rothenberger, DA; Springfield, J, 2005) |
| "The observing of pouchitis at a patient with ulcerative colitis with onset 4 months after the closing of the ileostoma, protecting the reservoir and with good response to metronidazole, was the reason for performing a literature review of the modern problems of this complication." | 3.72 | [Pouchitis, on the basis of a single observation]. ( Aleksandrova, A; Nedin, D, 2004) |
| "Four studies assessed treatment of acute pouchitis." | 2.61 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019) |
| "Patients with pouchitis have a wide range of symptoms, endoscopic and histologic features, disease course, and prognosis." | 2.61 | Prevention and Medical Treatment of Pouchitis In Ulcerative Colitis. ( Benlice, C; Shen, B; Steele, SR, 2019) |
| "Pouchitis is a common and long-term complication of ileal pouch-anal anastomosis in patients with underlying ulcerative colitis." | 2.43 | [Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis]. ( Fujii, T; Kawamata, S; Matsushita, M; Okazaki, K; Shimatani, M, 2005) |
| "Pouchitis is an idiopathic inflammatory bowel disease, which occurs in up to 50% of patients operated on for ulcerative colitis with ileal pouch-anal anastomosis (IPAA)." | 2.43 | [Probiotics--should we change the treatment strategy for pouchitis?]. ( Kjeldsen, J; Klinge, LG, 2006) |
| "Treatment of pouchitis is largely empirical and few controlled studies have been carried-out." | 2.41 | Review article: treatment of mild to moderate ulcerative colitis and pouchitis. ( Amadini, C; Campieri, M; Gionchetti, P; Rizzello, F; Venturi, A, 2002) |
| "Some ulcerative colitis patients develop complications after IPAA and are subsequently diagnosed with Crohn's disease." | 2.41 | Complications after ileal pouch-anal anastomosis. ( Lichtenstein, GR; Stein, RB, 2000) |
| "The elective treatment for acute pouchitis is antibiotics." | 1.56 | Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment. ( Barreiro-de Acosta, M; Beltrán, B; Chaparro, M; Espín, E; Ferrer Bradley, I; Gisbert, JP; Guarner, F; Gutiérrez, A; Marín-Jimenez, I; Nos, P; Rodríguez-Lago, I, 2020) |
| "Some patients have recurrence of flares, or become antibiotic-dependent, and require repeated courses or prolonged periods of antibiotic therapy." | 1.56 | Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy. ( Bar, N; Dotan, I; Dubinsky, V; Godny, L; Golan, N; Gophna, U; Keizer, D; Rabinowitz, K; Reshef, L; Tulchinsky, H; Yadgar, K; Zonensain, K, 2020) |
| "Four studies assessed treatment of acute pouchitis." | 1.51 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019) |
| "Pouchitis was classified as acute or chronic pouchitis." | 1.39 | Clinical features and management of pouchitis in Japanese ulcerative colitis patients. ( Bando, T; Ikeuchi, H; Matsuoka, H; Takesue, Y; Tomita, N; Uchino, M, 2013) |
| "Pouchitis is the most common long-term complication after restorative total proctocolectomy and IPAA for ulcerative colitis." | 1.38 | The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis. ( Funayama, Y; Haneda, S; Ogawa, H; Sasaki, I; Shibata, C; Suzuki, H; Takahashi, K; Watanabe, K, 2012) |
| "The incidence of PPI in patients with ulcerative colitis/indeterminate colitis is 5." | 1.35 | Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( Bell, AJ; Ciclitira, PJ; Clark, SK; McLaughlin, SD; Nicholls, RJ; Tekkis, PP, 2009) |
| "Pouchitis is often diagnosed based on symptoms and empirically treated with antibiotics (treat-first strategy)." | 1.32 | A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Remzi, FH; Shen, B; Shermock, KM, 2003) |
| "The medical treatment of acute pouchitis was usually oral metronidazole (250 mg twice daily) for 2 weeks or oral ciprofloxacin (200 mg thrice daily) in patients who could not tolerate metronidazole." | 1.32 | Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients. ( Ikeuchi, H; Nakamura, M; Nakano, H; Noda, M; Uchino, M; Yamamura, T; Yanagi, H, 2004) |
| "A further 2 patients (4%) had treatment resistant pouchitis and required pouch excision." | 1.31 | Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome. ( Bartolo, DC; Madiba, TE, 2001) |
| "Episodic pouchitis is easily treated and causes minimum functional consequences, whereas chronic pouchitis increases defecation frequency and needs prolonged medication." | 1.30 | Functional results after restorative proctocolectomy complicated by pouchitis. ( Järvinen, H; Keränen, U; Luukkonen, P, 1997) |
| "Metronidazole treatment reduced histology score (6." | 1.30 | A rat model of ileal pouch-rectal anastomosis. ( Hummel, B; Lacey, S; Lichtman, SN; Sartor, RB; Wang, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.52) | 18.2507 |
| 2000's | 25 (54.35) | 29.6817 |
| 2010's | 11 (23.91) | 24.3611 |
| 2020's | 7 (15.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bar, N | 2 |
| Avraham, Y | 1 |
| Dubinsky, V | 2 |
| Cohen, NA | 1 |
| Weiss, GA | 1 |
| Banon, L | 1 |
| Tulchinsky, H | 2 |
| Maharshak, N | 1 |
| Gophna, U | 2 |
| Dotan, I | 2 |
| Poo, S | 1 |
| Sriranganathan, D | 1 |
| Segal, JP | 1 |
| Alphonsus, L | 1 |
| De Silva, TA | 1 |
| Ma, C | 1 |
| MacDonald, JK | 1 |
| Hanzel, J | 1 |
| Beaton, M | 1 |
| Bessissow, T | 1 |
| Kayal, M | 1 |
| Sedano, R | 1 |
| Singh, S | 4 |
| Jairath, V | 1 |
| Barnes, EL | 1 |
| Desai, A | 1 |
| Kochhar, GS | 1 |
| Emile, SH | 1 |
| Horesh, N | 1 |
| Freund, MR | 1 |
| Garoufalia, Z | 1 |
| Gefen, R | 1 |
| Khan, SM | 1 |
| Silva-Alvarenga, E | 1 |
| Wexner, SD | 1 |
| Reshef, L | 1 |
| Keizer, D | 1 |
| Golan, N | 1 |
| Rabinowitz, K | 1 |
| Godny, L | 1 |
| Yadgar, K | 1 |
| Zonensain, K | 1 |
| Nguyen, N | 2 |
| Zhang, B | 2 |
| Holubar, SD | 4 |
| Pardi, DS | 5 |
| Barreiro-de Acosta, M | 1 |
| Marín-Jimenez, I | 1 |
| Rodríguez-Lago, I | 1 |
| Guarner, F | 1 |
| Espín, E | 1 |
| Ferrer Bradley, I | 1 |
| Gutiérrez, A | 1 |
| Beltrán, B | 1 |
| Chaparro, M | 1 |
| Gisbert, JP | 1 |
| Nos, P | 1 |
| Argollo, M | 1 |
| Kotze, PG | 1 |
| Lamonaca, L | 1 |
| Gilardi, D | 1 |
| Furfaro, F | 1 |
| Yamamoto, T | 1 |
| Danese, S | 1 |
| Benlice, C | 1 |
| Shen, B | 5 |
| Steele, SR | 1 |
| Guslandi, M | 1 |
| Stroud, AM | 1 |
| Sandborn, WJ | 3 |
| McLaughlin, SD | 2 |
| Clark, SK | 2 |
| Bell, AJ | 3 |
| Tekkis, PP | 2 |
| Ciclitira, PJ | 3 |
| Nicholls, RJ | 5 |
| He, X | 1 |
| Bennett, AE | 2 |
| Lian, L | 1 |
| Turroni, S | 1 |
| Vitali, B | 1 |
| Candela, M | 1 |
| Gionchetti, P | 4 |
| Rizzello, F | 4 |
| Campieri, M | 4 |
| Brigidi, P | 1 |
| Cima, RR | 1 |
| Suzuki, H | 1 |
| Ogawa, H | 1 |
| Shibata, C | 1 |
| Haneda, S | 1 |
| Watanabe, K | 1 |
| Takahashi, K | 1 |
| Funayama, Y | 1 |
| Sasaki, I | 1 |
| Uchino, M | 2 |
| Ikeuchi, H | 2 |
| Matsuoka, H | 1 |
| Bando, T | 1 |
| Takesue, Y | 1 |
| Tomita, N | 1 |
| Shermock, KM | 1 |
| Fazio, VW | 3 |
| Achkar, JP | 3 |
| Brzezinski, A | 3 |
| Bevins, CL | 2 |
| Bambrick, ML | 2 |
| Remzi, FH | 3 |
| Lashner, BA | 4 |
| Mimura, T | 2 |
| Helwig, U | 2 |
| Poggioli, G | 2 |
| Schreiber, S | 2 |
| Talbot, IC | 2 |
| Kamm, MA | 2 |
| Nakano, H | 1 |
| Nakamura, M | 1 |
| Yanagi, H | 1 |
| Noda, M | 1 |
| Yamamura, T | 1 |
| Gosselink, MP | 1 |
| Schouten, WR | 1 |
| van Lieshout, LM | 1 |
| Hop, WC | 1 |
| Laman, JD | 1 |
| Ruseler-van Embden, JG | 1 |
| Herrlinger, K | 1 |
| Stange, EF | 1 |
| Forbes, A | 1 |
| Ellis, HJ | 1 |
| Aleksandrova, A | 1 |
| Nedin, D | 1 |
| Ohge, H | 1 |
| Furne, JK | 1 |
| Springfield, J | 1 |
| Rothenberger, DA | 1 |
| Madoff, RD | 1 |
| Levitt, MD | 1 |
| Okazaki, K | 1 |
| Matsushita, M | 1 |
| Kawamata, S | 1 |
| Shimatani, M | 1 |
| Fujii, T | 1 |
| Sherman, K | 1 |
| Miyata, M | 1 |
| Konagaya, T | 1 |
| Kakumu, S | 1 |
| Mori, T | 1 |
| Klinge, LG | 1 |
| Kjeldsen, J | 1 |
| Parsi, MA | 1 |
| Ellis, JJ | 1 |
| Keighley, MR | 1 |
| Keränen, U | 1 |
| Luukkonen, P | 1 |
| Järvinen, H | 1 |
| Lichtman, SN | 1 |
| Wang, J | 1 |
| Hummel, B | 1 |
| Lacey, S | 1 |
| Sartor, RB | 1 |
| Stein, RB | 1 |
| Lichtenstein, GR | 1 |
| Sandborn, W | 1 |
| McLeod, R | 1 |
| Jewell, D | 1 |
| Balbir-Gurman, A | 1 |
| Schapira, D | 1 |
| Nahir, M | 1 |
| Zeitz, M | 1 |
| Ormsby, AH | 1 |
| Seidner, DL | 1 |
| Madiba, TE | 1 |
| Bartolo, DC | 1 |
| Sambuelli, A | 1 |
| Boerr, L | 1 |
| Negreira, S | 1 |
| Gil, A | 1 |
| Camartino, G | 1 |
| Huernos, S | 1 |
| Kogan, Z | 1 |
| Cabanne, A | 1 |
| Graziano, A | 1 |
| Peredo, H | 1 |
| Doldán, I | 1 |
| Gonzalez, O | 1 |
| Sugai, E | 1 |
| Lumi, M | 1 |
| Bai, JC | 1 |
| Amadini, C | 1 |
| Venturi, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531] | Phase 2 | 2 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Lack of enrollment) | ||
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis[NCT00583076] | Phase 2 | 19 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Fecal Microbiota Transplantation for the Treatment of Chronic Pouchitis[NCT03538366] | 10 participants (Actual) | Interventional | 2018-05-15 | Completed | |||
| Exploring the Mechanism of a Probiotic Combination VSL#3 in Irritable Bowel Syndrome: a Randomized Double Blind Placebo Controlled Study[NCT00786123] | 40 participants (Anticipated) | Interventional | 2006-05-31 | Completed | |||
| Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease[NCT00114465] | Phase 4 | 38 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for metronidazole and Pouchitis
| Article | Year |
|---|---|
Network meta-analysis: efficacy of treatment for acute, chronic, and prevention of pouchitis in ulcerative colitis.
Topics: Anti-Bacterial Agents; Colitis, Ulcerative; Humans; Metronidazole; Network Meta-Analysis; Pouchitis; | 2022 |
Systematic review and meta-analysis of randomised controlled trials: Medical therapies for the treatment and prevention of pouchitis.
Topics: Adult; Budesonide; Ciprofloxacin; Humans; Metronidazole; Pouchitis; Randomized Controlled Trials as | 2023 |
A Systematic Review and Meta-analysis of Randomized Clinical Trials on the Prevention and Treatment of Pouchitis after Ileoanal Pouch Anastomosis.
Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Pouchitis; Proctoc | 2023 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; | 2019 |
Prevention of Postoperative Recurrence in CD: Tailoring Treatment to Patient Profile.
Topics: Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Patient-Centered Care; Pouchitis; Practic | 2019 |
Prevention and Medical Treatment of Pouchitis In Ulcerative Colitis.
Topics: Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Humans; Male; Metronidazole; | 2019 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Adult; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metro | 2015 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Adult; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metronidazole; Po | 2010 |
[Chronic inflammatory bowel diseases].
Topics: Adrenal Cortex Hormones; Adult; Aminosalicylic Acids; Anti-Bacterial Agents; Anti-Infective Agents; | 2004 |
[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis].
Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Immunologic Factor | 2005 |
[Probiotics--should we change the treatment strategy for pouchitis?].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Evidence-Based Medicine; Humans; Metron | 2006 |
Review article: the management of pouchitis.
Topics: Diagnosis, Differential; Humans; Metronidazole; Pouchitis | 1996 |
Complications after ileal pouch-anal anastomosis.
Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Crohn Disease; Humans; Male; Metronidazol | 2000 |
Pharmacotherapy for inducing and maintaining remission in pouchitis.
Topics: Adult; Bismuth; Butyrates; Enema; Humans; Metronidazole; Postoperative Complications; Pouchitis; Rem | 2000 |
[Guidelines of the DGVS. Pouchitis. German Society of Digestive and Metabolic Diseases].
Topics: Aftercare; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2001 |
Review article: treatment of mild to moderate ulcerative colitis and pouchitis.
Topics: Administration, Oral; Administration, Rectal; Anti-Infective Agents; Anti-Inflammatory Agents; Anti- | 2002 |
7 trials available for metronidazole and Pouchitis
| Article | Year |
|---|---|
Antibiotics and probiotics in chronic pouchitis: a comparative proteomic approach.
Topics: Anti-Bacterial Agents; Bibliometrics; Biopsy; Chronic Disease; Ciprofloxacin; Drug Therapy, Combinat | 2010 |
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis.
Topics: Adult; Ciprofloxacin; Drug Therapy, Combination; Feces; Female; Humans; Male; Metronidazole; Middle | 2004 |
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis.
Topics: Adult; Ciprofloxacin; Drug Therapy, Combination; Feces; Female; Humans; Male; Metronidazole; Middle | 2004 |
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis.
Topics: Adult; Ciprofloxacin; Drug Therapy, Combination; Feces; Female; Humans; Male; Metronidazole; Middle | 2004 |
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis.
Topics: Adult; Ciprofloxacin; Drug Therapy, Combination; Feces; Female; Humans; Male; Metronidazole; Middle | 2004 |
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti | 2004 |
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti | 2004 |
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti | 2004 |
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti | 2004 |
Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Follow-Up Studies; H | 2005 |
Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Follow-Up Studies; H | 2005 |
Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Follow-Up Studies; H | 2005 |
Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Follow-Up Studies; H | 2005 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal | 2001 |
Budesonide enema in pouchitis--a double-blind, double-dummy, controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Budesonide | 2002 |
Four-week open-label trial of metronidazole and ciprofloxacin for the treatment of recurrent or refractory pouchitis.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Female; Humans; Male; Metron | 2002 |
23 other studies available for metronidazole and Pouchitis
| Article | Year |
|---|---|
Long-term Antibiotic Treatment in Pouchitis-Patterns of Use and Safety.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Pouchitis; Proctoc | 2022 |
The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Male; Metronidazole; Pouchitis; P | 2023 |
Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Cytokines; Drug Resistance, Bacterial; Feces; | 2020 |
Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment.
Topics: Acute Disease; Advisory Committees; Algorithms; Anti-Bacterial Agents; Biological Products; Budesoni | 2020 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; | 2019 |
Role of probiotics in the management of pouchitis.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Intestines; Metronidazol | 2014 |
An open study of antibiotics for the treatment of pre-pouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis.
Topics: Adult; Anal Canal; Anastomosis, Surgical; Anti-Bacterial Agents; Ciprofloxacin; Female; Humans; Ileu | 2009 |
Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Budesonide; Ciprofloxacin; Colitis, Ul | 2009 |
Recurrent cytomegalovirus infection in ileal pouch-anal anastomosis for ulcerative colitis.
Topics: Ciprofloxacin; Colitis, Ulcerative; Colonic Pouches; Cytomegalovirus Infections; Dietary Supplements | 2010 |
The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Colonic Pou | 2012 |
Clinical features and management of pouchitis in Japanese ulcerative colitis patients.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Age of Onset; Aged; Anti-Bacterial Agents; Asian Peop | 2013 |
A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis.
Topics: Aged; Anal Canal; Anastomosis, Surgical; Ciprofloxacin; Clinical Trials as Topic; Cohort Studies; Co | 2003 |
Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female | 2004 |
Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteria; Cell Division; Cells, Cultured; Colonic Po | 2004 |
Clinical management of pouchitis.
Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H | 2004 |
Clinical management of pouchitis.
Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H | 2004 |
Clinical management of pouchitis.
Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H | 2004 |
Clinical management of pouchitis.
Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H | 2004 |
[Pouchitis, on the basis of a single observation].
Topics: Adolescent; Anti-Infective Agents; Bulgaria; Colitis, Ulcerative; Follow-Up Studies; Humans; Male; M | 2004 |
Association between fecal hydrogen sulfide production and pouchitis.
Topics: Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Feces; Female; Humans; Hydrogen Sulfide; | 2005 |
Successful treatment of severe pouchitis with rebamipide refractory to antibiotics and corticosteroids: a case report.
Topics: Adrenal Cortex Hormones; Adult; Alanine; Anti-Bacterial Agents; Humans; Male; Metronidazole; Pouchit | 2006 |
Cost-effectiveness of quantitative fecal lactoferrin assay for diagnosis of symptomatic patients with ileal pouch-anal anastomosis.
Topics: Anal Canal; Anastomosis, Surgical; Anti-Infective Agents; Biopsy; Colonic Pouches; Cost-Benefit Anal | 2008 |
Functional results after restorative proctocolectomy complicated by pouchitis.
Topics: Adolescent; Adult; Aged; Anal Canal; Anastomosis, Surgical; Case-Control Studies; Chronic Disease; C | 1997 |
A rat model of ileal pouch-rectal anastomosis.
Topics: Allopurinol; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Free Radical Sca | 1998 |
Arthritis related to ileal pouchitis following total proctocolectomy for ulcerative colitis.
Topics: Adult; Anti-Bacterial Agents; Arthritis, Reactive; Colitis, Ulcerative; Female; Humans; Male; Metron | 2001 |
Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Colitis, Ulcerative; Female; Humans; Incidenc | 2001 |