metronidazole has been researched along with Lock Jaw in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The occurrence of postoperative pain, swelling, trismus, SSI and AO were compared between the groups." | 2.76 | Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study. ( Akadiri, AO; Arotiba, JT; Fasola, OA; Olusanya, AA, 2011) |
| "Metronidazole, used for prevention and treatment of infections in oral and maxillofacial surgery is frequently prescribed three times daily, but research into its pharmacokinetics has shown that a twelve hourly dosage regimen achieves and maintains therapeutic serum concentrations." | 2.67 | Metronidazole: two or three times daily--a comparative controlled clinical trial of the efficacy of two different dosing schedules of metronidazole for chemoprophylaxis following third molar surgery. ( Earl, PD; Lloyd, CJ, 1994) |
| "Tetanus is a life-threatening infectious neurological condition that has become uncommon due to large-scale immunization campaigns." | 1.91 | Case Report: A Challenging Case of Tetanus Presenting with Headache. ( Azlan, EAM; Ismail, M; Pathi, NM; Rahim, AIA; Rahman, MR; Sulaiman, WAW, 2023) |
| "He was successfully treated with tetanus antitoxin without any adverse events." | 1.62 | Cephalic tetanus manifesting as isolated facial nerve palsy- a case report from rural Armenia. ( Acharya, D; Arakelyan, A; Gautam, J; Kishmiryan, A; Ohanyan, A; Shoura, S; Singh, BM; Vahanyan, A, 2021) |
| "Tetanus is a rare diagnosis in the developed world but sporadic cases do occur." | 1.40 | Cephalic tetanus complicating geriatric fall. ( La Varis, T; Mason, D; McCabe, J, 2014) |
| "On examination he was noted to have trismus, generalised muscle spasms, diaphoresis and emotional lability and he was diagnosed with generalised tetanus." | 1.36 | Generalised tetanus in an unvaccinated adult. ( Cavanagh, S; Fleming, C; Muldoon, EG, 2010) |
| "The patient was successfully treated for Tetanus with complete recovery." | 1.32 | Case report of tetanus in an immunized, healthy adult and no point of entry. ( Erogul, M; Hahn, BJ; Sinert, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Kishmiryan, A | 1 |
| Gautam, J | 1 |
| Acharya, D | 1 |
| Singh, BM | 1 |
| Ohanyan, A | 1 |
| Arakelyan, A | 1 |
| Vahanyan, A | 1 |
| Shoura, S | 1 |
| Rahim, AIA | 1 |
| Azlan, EAM | 1 |
| Rahman, MR | 1 |
| Pathi, NM | 1 |
| Ismail, M | 1 |
| Sulaiman, WAW | 1 |
| Nascimento, FA | 1 |
| Hammoud, N | 1 |
| Augusto, FD | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| McCabe, J | 1 |
| La Varis, T | 1 |
| Mason, D | 1 |
| Muldoon, EG | 1 |
| Cavanagh, S | 1 |
| Fleming, C | 1 |
| Olusanya, AA | 1 |
| Arotiba, JT | 1 |
| Fasola, OA | 1 |
| Akadiri, AO | 1 |
| Van Damme, PA | 1 |
| Hahn, BJ | 1 |
| Erogul, M | 1 |
| Sinert, R | 1 |
| Herrman, H | 1 |
| Braekhus, A | 1 |
| Aaserud, O | 1 |
| Aukrust, P | 1 |
| Stubhaug, A | 1 |
| Hassel, B | 1 |
| Lloyd, CJ | 1 |
| Earl, PD | 1 |
| Rüttimann, S | 1 |
3 trials available for metronidazole and Lock Jaw
| Article | Year |
|---|---|
Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study.
Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibi | 2011 |
Metronidazole: two or three times daily--a comparative controlled clinical trial of the efficacy of two different dosing schedules of metronidazole for chemoprophylaxis following third molar surgery.
Topics: Adolescent; Adult; Chi-Square Distribution; Drug Administration Schedule; Female; Humans; Male; Mand | 1994 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
10 other studies available for metronidazole and Lock Jaw
| Article | Year |
|---|---|
Cephalic tetanus manifesting as isolated facial nerve palsy- a case report from rural Armenia.
Topics: Aged; Anti-Bacterial Agents; Armenia; Bell Palsy; Diagnosis, Differential; Facial Paralysis; Humans; | 2021 |
Case Report: A Challenging Case of Tetanus Presenting with Headache.
Topics: Adult; Female; Headache; Humans; Metronidazole; Tetanus; Tetanus Toxoid; Trismus | 2023 |
Teaching Video NeuroImages: Cephalic tetanus: Not every facial weakness is Bell palsy.
Topics: Anti-Bacterial Agents; Bell Palsy; Debridement; Diagnosis, Differential; Facial Injuries; Facial Mus | 2019 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Cephalic tetanus complicating geriatric fall.
Topics: Accidental Falls; Aged, 80 and over; Anti-Infective Agents; Debridement; Facial Muscles; Female; For | 2014 |
Generalised tetanus in an unvaccinated adult.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Clostridium tetani; Diazepam; Humans; Magnesium | 2010 |
Noma.
Topics: Africa; Anti-Bacterial Agents; Child; Diagnosis, Differential; Humans; Metronidazole; Noma; Postoper | 2004 |
Case report of tetanus in an immunized, healthy adult and no point of entry.
Topics: Anti-Infective Agents; Anticonvulsants; Emergency Medical Services; Humans; Immunization; Infusions, | 2004 |
Early treatment of tetanus-induced trismus with botulinum toxin A.
Topics: Aged, 80 and over; Anti-Infective Agents; Antidotes; Botulinum Toxins, Type A; Drug Administration S | 2008 |
[Lockjaw].
Topics: Aged; Anti-Bacterial Agents; Clostridium tetani; Female; Humans; Metronidazole; Tetanus; Trismus | 1999 |