metronidazole has been researched along with Complication, Postoperative in 295 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation." | 9.15 | Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011) |
| "To estimate the efficacy of preoperative administration of intravaginal metronidazole for the prevention of postcesarean endometritis." | 9.09 | Adjunctive intravaginal metronidazole for the prevention of postcesarean endometritis: a randomized controlled trial. ( Kaunitz, AM; Pitt, C; Sanchez-Ramos, L, 2001) |
| "A controlled, randomized trial with blind assessment of end points is described comparing ceftriaxone (1 g) given at induction of anesthesia with gentamicin (2 mg/kg) and metronidazole (500 mg) (GM), three times, every eight hours starting at induction, in preventing wound, chest, and urinary tract infections following bowel operations." | 9.07 | Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial. ( Morris, WT, 1993) |
| "In the multivariate analysis of the 520 cases, we confirmed that the use of metronidazole vaginal tablets could reduce the vaginal bacteria-related postoperative complications rate by more than half (odds ratio, 0." | 8.31 | Preventive effect of metronidazole vaginal tablets on vaginal bacteria-related postoperative complications with total laparoscopic hysterectomy. ( Fujimoto, A; Honda, M; Isono, W; Matsuyama, R; Nishii, O; Okamura, A; Saito, A; Tsuchiya, A; Tsuchiya, H, 2023) |
| "Recent studies are discordant regarding postoperative use of piperacillin/tazobactam (PT) versus ceftriaxone/metronidazole (CM) for pediatric complicated appendicitis." | 8.31 | Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole. ( Abdullah, F; Alayleh, A; Carter, M; De Boer, C; Goldstein, SD; Hu, A; Linton, S; Pitt, JB; Raval, M; Zeineddin, S, 2023) |
| "Rates of organ space infection and resource utilization were similar in children with complicated appendicitis treated with ceftriaxone plus metronidazole and piperacillin/tazobactam." | 8.12 | Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis. ( Anandalwar, SP; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2022) |
| "After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem." | 7.96 | Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020) |
| "The aim of this study was to evaluate the efficacy of combined therapy with metronidazole and broad-spectrum antibiotics for patients with perforated appendicitis who underwent surgical intervention." | 7.85 | The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis. ( Geng, Q; Guo, C; Shang, Q; Zhang, X, 2017) |
| "In a prospective study, 182 consecutive patients were included for the treatment of intraabdominal sepsis with adjuvant metronidazole lavage that was carried out at the end of the operative procedures." | 7.69 | Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study. ( Saha, SK, 1996) |
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 7.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| "To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation." | 5.15 | Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011) |
| " There is scarce information regarding the prophylactic effects of oral metronidazole on postoperative complications of anal fissure." | 5.13 | A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy. ( Bolandparvaz, S; Hosseini, SV; Nouri Amirkolaee, M; Sabet, B, 2008) |
| "In a randomized controlled trial of 269 patients aged 15-70 years with non-perforated appendicitis undergoing open appendicectomy; 92 received single dose preoperative (group A), 94 received three-dose (group B) and 83 received 5-day perioperative (group C) regimens of cefuroxime and metronidazole." | 5.11 | Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ( Chung, SS; Fok, KL; Fung, TM; Lam, YH; Mui, LM; Ng, CS; Ng, EK; Wong, SK, 2005) |
| "To estimate the efficacy of preoperative administration of intravaginal metronidazole for the prevention of postcesarean endometritis." | 5.09 | Adjunctive intravaginal metronidazole for the prevention of postcesarean endometritis: a randomized controlled trial. ( Kaunitz, AM; Pitt, C; Sanchez-Ramos, L, 2001) |
| "A controlled, randomized trial with blind assessment of end points is described comparing ceftriaxone (1 g) given at induction of anesthesia with gentamicin (2 mg/kg) and metronidazole (500 mg) (GM), three times, every eight hours starting at induction, in preventing wound, chest, and urinary tract infections following bowel operations." | 5.07 | Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial. ( Morris, WT, 1993) |
| "In a double-blind, cross-over trial with metronidazole (Flagyl) 400 mg twice daily and placebo given to suitably adjusted ileostomy operated patients during two week periods, no significant reduction could be demonstrated in gaseous discomfort as measured by the number of bag emptyings per day, as well as gaseous symptoms in the form of the passage of flatulence from the stoma and borborygmi." | 5.06 | Metronidazole versus placebo in the treatment of gaseous discomfort in patients having an ileostomy. A double-blind cross-over investigation. ( Funder, V; Kjaergaard, J; Ottsen, B, 1988) |
| "In a double-blind controlled trial the effect of prophylactic metronidazole on postabortal infection in women with a history of pelvic inflammatory disease (PID) was assessed." | 5.06 | Prophylactic antibiotics in women with a history of pelvic inflammatory disease undergoing first-trimester abortion. ( Heisterberg, L, 1987) |
| "A multi-centre double-blind, placebo-controlled clinical trial was performed to determine the minimum number of doses of metronidazole required for effective prophylaxis of vaginal cuff abscess following hysterectomy." | 5.06 | A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy. ( Haverkorn, MJ, 1987) |
| "The aim of this study was to compare the prophylactic effects of netilmicin plus metronidazole administered for one day and of doxycycline administered for five days on the incidence of postoperative sepsis in patients undergoing elective colorectal surgery." | 5.06 | A comparison between netilmicin with metronidazole and doxycycline as prophylaxis in elective colorectal surgery. ( Brolin, J; Lahnborg, G; Ljung, A; Rietz, KA, 1986) |
| "One hundred and eight adult patients undergoing appendicectomy (37 advanced appendicitis and 71 early appendicitis or normal appendices) were randomised into a trial comparing the effects of ampicillin (anti-aerobic) and metronidazole (anti-anaerobic) based regimes." | 5.05 | Metronidazole v ampicillin: differing effects on the postoperative recovery. ( Chant, AD; Machin, D; Turner, DT, 1984) |
| "For acute pouchitis, very low quality evidence suggests that ciprofloxacin may be more effective than metronidazole." | 4.91 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Pardi, DS; Sandborn, WJ; Singh, S; Stroud, AM, 2015) |
| " For the treatment of acute pouchitis (4 RCTS, 5 agents), ciprofloxacin was more effective at inducing remission than metronidazole." | 4.86 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Cima, RR; Holubar, SD; Pardi, DS; Sandborn, WJ, 2010) |
| "To determine the effectiveness of medical therapy (including metronidazole, bismuth carbomer enemas, oral probiotic bacteria, butyrate suppositories, and glutamine suppositories) for inducing a response or maintaining remission in pouchitis." | 4.80 | Pharmacotherapy for inducing and maintaining remission in pouchitis. ( Jewell, D; McLeod, R; Sandborn, W, 2000) |
| "In the multivariate analysis of the 520 cases, we confirmed that the use of metronidazole vaginal tablets could reduce the vaginal bacteria-related postoperative complications rate by more than half (odds ratio, 0." | 4.31 | Preventive effect of metronidazole vaginal tablets on vaginal bacteria-related postoperative complications with total laparoscopic hysterectomy. ( Fujimoto, A; Honda, M; Isono, W; Matsuyama, R; Nishii, O; Okamura, A; Saito, A; Tsuchiya, A; Tsuchiya, H, 2023) |
| "Recent studies are discordant regarding postoperative use of piperacillin/tazobactam (PT) versus ceftriaxone/metronidazole (CM) for pediatric complicated appendicitis." | 4.31 | Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole. ( Abdullah, F; Alayleh, A; Carter, M; De Boer, C; Goldstein, SD; Hu, A; Linton, S; Pitt, JB; Raval, M; Zeineddin, S, 2023) |
| "Rates of organ space infection and resource utilization were similar in children with complicated appendicitis treated with ceftriaxone plus metronidazole and piperacillin/tazobactam." | 4.12 | Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis. ( Anandalwar, SP; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2022) |
| "After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem." | 3.96 | Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020) |
| "Rectal swab cultures identify patients with ciprofloxacin-resistant rectal flora who have an eight-fold risk of sepsis." | 3.96 | Effect of Augmented Antimicrobial Prophylaxis and Rectal Swab Culture-guided Targeted Prophylaxis on the Risk of Sepsis Following Transrectal Prostate Biopsy. ( Dall'Antonia, M; Eragat, M; Hadjipavlou, M; Hammadeh, MY; Kenny, C; Mulhem, W; Pantelidou, M; Wood, C, 2020) |
| "The aim of this study was to evaluate the efficacy of combined therapy with metronidazole and broad-spectrum antibiotics for patients with perforated appendicitis who underwent surgical intervention." | 3.85 | The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis. ( Geng, Q; Guo, C; Shang, Q; Zhang, X, 2017) |
| "In complicated appendicitis, empirical perioperative addition of gentamycin to ceftriaxone and metronidazole did not reduce the risk of developing intra-abdominal abscess, compared to changing antibiotics on clinical grounds." | 3.74 | Antibiotics and postoperative abscesses in complicated appendicitis: is there any association? ( Chan, TK; Chui, CH; Jacobsen, AS; Ong, CP, 2008) |
| "Of 1,184 patients who completed the follow-up protocol, 88 patients (male: female = 31:57) who had received metronidazole could be matched by gender, age, NSAIDs used, number of hemorrhoids resected and operation in the same period with 88 patients (male:female = 31:57) who had not." | 3.74 | Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study. ( Pattana-arun, J; Wesarachawit, W, 2007) |
| "In a prospective study, 182 consecutive patients were included for the treatment of intraabdominal sepsis with adjuvant metronidazole lavage that was carried out at the end of the operative procedures." | 3.69 | Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study. ( Saha, SK, 1996) |
| "Serum levels of tobramycin were determined with an enzyme immunoassay technique in 20 puerperal women with postcesarean endometritis who were being treated with metronidazole-tobramycin." | 3.67 | Tobramycin dosing in the puerperal patient. ( Pastorek, JG; Phelan, M; Ragan, FA, 1987) |
| " Metronidazole was as efficient as ampicillin in achieving a significant reduction in major morbidity, pelvic sepsis, and the "quantity" of postoperative fever." | 3.66 | Simplified antibiotic prophylaxis for vaginal hysterectomy. ( Jackson, P; Ridley, WJ, 1979) |
| "A double-blind trial of perioperative intravenous metronidazole treatment to prevent infections at the operative site and unexplained fever after abdominal hysterectomy was conducted in 106 patients." | 3.66 | Double-blind trial of perioperative intravenous metronidazole prophylaxis for abdominal hysterectomy. ( Aoki, FY; Finkelstein, F; Ogilvie, RI; Richards, GK; Seymour, RJ; Vincelette, J, 1982) |
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 3.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| " A blinded observer determined adverse event (AE) causality, and clinical outcomes up to the late follow-up visit." | 2.90 | Safety and Efficacy of Ceftazidime-Avibactam Plus Metronidazole in the Treatment of Children ≥3 Months to <18 Years With Complicated Intra-Abdominal Infection: Results From a Phase 2, Randomized, Controlled Trial. ( Bradley, JS; Broadhurst, H; Cheng, K; Gardner, A; Mendez, M; Newell, P; Prchlik, M; Stone, GG; Talley, AK; Tawadrous, M; Wajsbrot, D; Yates, K; Zuzova, A, 2019) |
| "The primary outcome was pelvic infection within 14 days after surgery." | 2.90 | A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery. ( Acam, J; Ahmed, I; Arulkumaran, S; Bar-Zeev, S; Bhutta, ZA; Bishop, JRB; Chibwana, J; Chirwa, A; Chiudzu, G; Coomarasamy, A; Daniels, J; Desmond, N; Ditai, J; Ekunait, J; Goranitis, I; Gulmezoglu, AM; Hewitt, CA; Ismail, H; Iyaku, M; Lissauer, D; Makiika, JJ; Mataya, R; Mbaruku, G; Mboma, A; Merriel, A; Mhango, C; Middleton, L; Mphasa, C; Mwalwanda, C; Ngalawesa, T; Oladapo, OT; Otim Tom, C; Qureshi, R; Roberts, T; Simon, B; Tambala, T; Taulo, F; Unzia, H; Watts, G; Weeks, A; Wilson, A; Zamora, J, 2019) |
| "To determine the late recurrence rate of appendicitis after antibiotic therapy for the treatment of uncomplicated acute appendicitis." | 2.87 | Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. ( Aarnio, M; Grönroos, JM; Hurme, S; Jartti, A; Mecklin, JP; Nordström, P; Paajanen, H; Rantanen, T; Rautio, T; Salminen, P; Sand, J; Tuominen, R; Virtanen, J, 2018) |
| "Dry socket was the most common complication in the antibiotics group (six subjects), while acutely inflamed sockets was the most common in the placebo group (five subjects)." | 2.82 | Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? ( Adetoye, JO; Dipo-Fagbemi, IM; Ebigwei, S; Gbotolorun, OM; Olojede, AO, 2016) |
| "The occurrence of postoperative pain, swelling, trismus, SSI and AO were compared between the groups." | 2.76 | Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study. ( Akadiri, AO; Arotiba, JT; Fasola, OA; Olusanya, AA, 2011) |
| "More than 80% of Crohn's disease (CD) patients undergoing resection suffer recurrence of their disease." | 2.73 | Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. ( Aerden, I; D'Haens, GR; Noman, M; Rutgeerts, P; Van Assche, G; Van Olmen, G; Vermeire, S, 2008) |
| "Patients with colorectal cancer treated from May 6, 2004, to April 25, 2005." | 2.73 | Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. ( Fujita, S; Ikeda, E; Kondo, K; Moriya, Y; Ohue, M; Saito, N; Takii, Y; Yamada, T, 2007) |
| "Between 1982 and 1988, MRRC RAMS carried out a prospective clinical trial of preoperative radiotherapy (20 Gy/5 days) in combination with metronidazole (given orally, 3 times, 5 gms per metre(2))." | 2.71 | Preoperative radiotherapy in combination with metronidazole for resectable gastric cancer: long-term results of a phase 2 study. ( Berdov, BA; Skoropad, VY; Zagrebin, VM, 2003) |
| "Metronidazole was added to the ciprofloxacin-amoxicillin regimen where anaerobic infection was suspected." | 2.71 | Piperacillin-tazobactam versus ciprofloxacin plus amoxicillin in the treatment of infective episodes after liver transplantation. ( Burroughs, A; Fisher, N; Hastings, M; Kibbler, C; Mutimer, D; O'Grady, J; Patch, D; Philpott-Howard, J; Rolando, N; Wade, J; Wendon, J, 2003) |
| "There was no recurrence of the volvulus at 1 to 6 years follow up but 8 patients (9." | 2.68 | Extraperitonealization for sigmoid volvulus: a reappraisal. ( Khanna, AK; Kumar, K; Misra, MK, 1995) |
| "Metronidazole was well tolerated by the mother and with this type of administration regimen, the fetus is not exposed to the drug." | 2.67 | Prevention of postcesarean infectious morbidity with a single dose of intravenous metronidazole. ( Garcia-Rojas, JM; Lozada-Leon, JD; Ruiz-Moreno, JA, 1991) |
| "Metronidazole has been used to treat pouchitis, but there are no controlled data that show it is effective." | 2.67 | Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis. ( Madden, MV; McIntyre, AS; Nicholls, RJ, 1994) |
| "Development of surgical wound infection (as evidenced by the presence of pus), death, or discharge from hospital." | 2.67 | Single dose cefotaxime plus metronidazole versus three dose cefuroxime plus metronidazole as prophylaxis against wound infection in colorectal surgery: multicentre prospective randomised study. ( Cole, DS; Kingston, RD; Peel, AL; Rowe-Jones, DC; Shaw, JF; Teasdale, C, 1990) |
| "The incidence of wound infections and the duration of hospitalization were significantly reduced in patients undergoing vaginal hysterectomy with or without vaginal repair." | 2.67 | Single-dose prophylaxis in hysterectomies. An interim analysis. ( Boodt, PJ; Janknegt, R; Snijders, WP, 1990) |
| "Cefuroxime was successful, metronidazole failed in the prevention of minor morbidity." | 2.67 | Vaginal hysterectomy: cefuroxime, metronidazole or both? ( Kauer, FM; Manson, WL; Wijma, J, 1990) |
| "The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]." | 2.67 | Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis. ( Eckenhausen, FW; Jonker, PL, 1990) |
| "Patients were assessed for infections at six weeks after discharge from the hospital." | 2.66 | A new bowel preparation for elective colon and rectal surgery. A prospective, randomized clinical trial. ( Beart, RW; Dozois, RR; Farnell, MB; Heppell, J; Pemberton, JH; Ready, RL; Washington, JA; Wolff, BG; Zinsmeister, AR, 1988) |
| "A dosing regimen for administration of metronidazole to patients undergoing emergency surgery was designed using pharmacokinetic data." | 2.66 | Design and trial of a metronidazole loading dose regimen for patients undergoing emergency surgery. ( Farmer, C; Ioannides-Demos, LL; McLean, AJ; Spicer, WJ, 1989) |
| "Piperacillin was well-tolerated." | 2.66 | Piperacillin for prophylaxis in gynecological surgery. ( Heintz, AP; Mattie, H; Smit, I; Trimbos, JB; van Lindert, AC, 1989) |
| "The overall rate of infection was 41 percent in the oral neomycin and erythromycin group (n = 29) compared with 9." | 2.66 | Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. ( Burdon, DW; Keighley, MR; Weaver, M; Youngs, DJ, 1986) |
| " On the basis of pharmacokinetic investigations, administration of the antibiotic 30 min preoperatively fulfills this requirement." | 2.66 | [Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery]. ( Anagnostou, M; Bleier, R; Borneff, M; Geyer, G; Hartmetz, G; Roser, F, 1987) |
| " The serum bioavailability of the rectal form was 80% with a peak serum concentration of 10 mg/l four hours after dosing." | 2.65 | [Prevention of postoperative anaerobic infections. Economic significance of metronidazole suppositories]. ( Dauphin, A; Desmonts, JM; Farinotti, R; Fichelle, A; Sainte-Marie, D, 1984) |
| "Metronidazole prophylaxis was associated with a dramatic reduction from 18 percent to 1 percent of major postoperative wound and pelvic infections." | 2.65 | Single dose metronidazole prophylaxis in gynaecological surgery. ( Jackson, P; Pattison, NS; Ridley, WJ, 1979) |
| "Many patients with Crohn's disease present with the complications of infection." | 2.65 | Infection and the use of antibiotics in Crohn's disease. ( Keighley, MR, 1984) |
| "Metronidazole was more effective in pain control than Arnica (p less than 0." | 2.65 | Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial. ( Kaziro, GS, 1984) |
| "Four studies assessed treatment of acute pouchitis." | 2.61 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019) |
| "Whether bacterial vaginosis (BV) is acquired from an endogenous or an exogenous source is subject to controversy." | 2.43 | Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. ( Bergström, M; Forsum, U; Jacobsson, B; Larsson, PG; Strand, A; Wölner-Hanssen, P, 2005) |
| "Pouchitis is a common and long-term complication of ileal pouch-anal anastomosis in patients with underlying ulcerative colitis." | 2.43 | [Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis]. ( Fujii, T; Kawamata, S; Matsushita, M; Okazaki, K; Shimatani, M, 2005) |
| "Some ulcerative colitis patients develop complications after IPAA and are subsequently diagnosed with Crohn's disease." | 2.41 | Complications after ileal pouch-anal anastomosis. ( Lichtenstein, GR; Stein, RB, 2000) |
| "Crohn's recurrence is the appearance of objective signs defined radiologically, endoscopically or pathologically of Crohn's disease in the bowel of a patient who has previously had a resection of all macroscopically diseased tissue." | 2.40 | [Drug prevention of Crohn disease recurrence in the neo-terminal ileum after ileocolic resection]. ( Rutgeerts, P; Vermeire, S, 1998) |
| "The latter category includes pelvic inflammatory disease, pelvic thrombophlebitis, septic abortion, and premature rupture of the membranes." | 2.36 | Infections in the female genital tract. ( Gall, SA, 1983) |
| "Acute appendicitis is the most frequent surgical emergency in the paediatric population." | 1.72 | Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients. ( Andrey, V; Crisinel, PA; Gerber, F; Joseph, JM, 2022) |
| "Infections from penetrating brain injuries (PBI) lead to higher morbidity and mortality rates." | 1.56 | Evaluation of prophylactic antibiotics in penetrating brain injuries at an academic level 1 trauma center. ( Adamski, J; Marut, D; McKenzie, C; Shammassian, B; Traeger, J, 2020) |
| "We hereby, report a case of brain abscess in a 50-year-old man, who suffered a head trauma followed by decompression surgery 10 months ago." | 1.56 | Intracranial abscess due to Prevotella bivia: First case report from India. ( Biswas, R; Samantaray, S; Sasidharan, GM, 2020) |
| "The elective treatment for acute pouchitis is antibiotics." | 1.56 | Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment. ( Barreiro-de Acosta, M; Beltrán, B; Chaparro, M; Espín, E; Ferrer Bradley, I; Gisbert, JP; Guarner, F; Gutiérrez, A; Marín-Jimenez, I; Nos, P; Rodríguez-Lago, I, 2020) |
| "Four studies assessed treatment of acute pouchitis." | 1.51 | Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019) |
| "Among these, a minimal anastomotic leakage may lead to gas spreading into surrounding soft tissues." | 1.43 | Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible? ( Frassani, S; Gabrielli, F; Guttadauro, A; Macchini, D; Maternini, M, 2016) |
| "Clostridium difficile infection is considered a major cause of nosocomial diarrhoea in developed countries and is increasingly becoming more important as an etiologic agent of community diarrhoea, also in patients without risk factors." | 1.40 | [Epidemiology of Clostridium difficile-associated disease (CDAD) in Salamanca]. ( Calvo-García, N; de Frutos-Serna, M; García-Sánchez, JE; Hernández-Egido, S; María-Blázquez, A; Siller-Ruiz, M, 2014) |
| "This study evaluated the incidence and treatment of pouchitis in Japanese ulcerative colitis patients." | 1.39 | Clinical features and management of pouchitis in Japanese ulcerative colitis patients. ( Bando, T; Ikeuchi, H; Matsuoka, H; Takesue, Y; Tomita, N; Uchino, M, 2013) |
| "Acquired long QT syndrome is a rare condition whose diagnosis is of vital importance given the risk of torsade de pointes and sudden death." | 1.36 | [Perioperative acquired long QT syndrome: a case report]. ( Arizaga, A; Goitia, L; Pérez, P; Sebastián, P; Taibo, JM, 2010) |
| "Total excision of dermal sinus tract, dermoid cyst, and the intramedullary abscess by means of a L2-S3 laminectomy, followed by antibiotic therapy resulted in good functional recovery." | 1.35 | Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion. ( Cekinmez, M; Erdogan, B; Sener, L; Tufan, K, 2008) |
| "Anterior necrotizing scleritis is a rare but potentially devastating complication of ocular surgery that most often occurs after cataract surgery in elderly patients who may have an underlying systemic autoimmune condition(1) or, less likely, an infectious cause." | 1.34 | Anterior necrotizing scleritis after strabismus surgery in a child. ( Blaikie, AJ; Gole, GA; Kearney, FM, 2007) |
| "Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients." | 1.33 | A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient. ( Alişir, S; Cağatay, A; Görçin, S; Güven, D; Oztürk, S; Tufan, F; Türkmen, A, 2006) |
| "This case emphasizes the importance of adequately dosed antibiotic therapy, also for unusual bacteria such as species of Aeromonas." | 1.33 | [Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria]. ( Bomke, AK; Feyerherd, P; Podbielski, A, 2006) |
| "Amoxicillin was the most frequently prescribed antibiotic." | 1.32 | Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait. ( Adib, SM; Al-Mutawa, S; Rotimi, VO; Salako, NO, 2004) |
| "1 year after drug therapy the recurrence of CDU is revealed in 16." | 1.31 | [Current principles of the use of laparoscopic surgery in gastroduodenal ulcer]. ( Fedorov, AV; Sazhin, VP, 2001) |
| "The conservative treatment of ano-rectal fistulae in Crohn's disease is selected according to the clinical activity and chronicity of the underlying disease." | 1.30 | [Conservative therapy of fistulas of the anorectal area in Crohn disease]. ( Brucks, U; Malfertheiner, P; Peitz, U, 1999) |
| "The postoperative complications were suppuration of the wall (n = 4), intestinal fistula (n = 3), evisceration, and residual abscess." | 1.29 | [Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases]. ( Ibile, A; Malonga, E; Masso-Misse, P; Yao, JG, 1994) |
| "Four cases are reported of pseudomembranous colitis (PMC) that developed 1 to 18 months (mean, 8 months) after definitive surgery for Hirschsprung's disease (Soave endorectal pull-though, 2; Duhamel procedure, 2)." | 1.28 | Pseudomembranous colitis following resection for Hirschsprung's disease. ( Bagwell, CE; Langham, MR; Mahaffey, SM; Shandling, B; Talbert, JL, 1992) |
| "The incidence of postoperative infections ranged from 40 to 46% in the first 3 groups, in contrast to only 6% in the fourth group (p less than 0." | 1.27 | Clinical studies of 4 methods of bowel preparation in colorectal surgery. ( Debo Adeyemi, S; Tai da Rocha-Afodu, J, 1986) |
| "OH-tinidazole was not detected in patient specimens (assay standards ensured that it could be assayed)." | 1.27 | Comparative pharmacokinetics of metronidazole and tinidazole and their tissue penetration. ( Bergan, T; Leinebø, O; Solhaug, JH; Søreide, O, 1985) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| "None of the patients developed postoperative wound infections or adverse reactions." | 1.26 | Cefuroxime and metronidazole in gynaecological surgery. ( Kingston, J; Leabeater, B, 1981) |
| "Metronidazole was included in over 95% of all the prophylactic regimens and was often combined with other drugs when the appendix was gangrenous and perforated." | 1.26 | Prophylaxis of infection after appendicectomy: a survey of current surgical practice. ( Campbell, WB, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 130 (44.07) | 18.7374 |
| 1990's | 56 (18.98) | 18.2507 |
| 2000's | 50 (16.95) | 29.6817 |
| 2010's | 45 (15.25) | 24.3611 |
| 2020's | 14 (4.75) | 2.80 |
| Authors | Studies |
|---|---|
| Naples, R | 1 |
| Perlmutter, BC | 1 |
| Thomas, JD | 1 |
| McMichael, J | 1 |
| Bottino, R | 1 |
| Solomina, J | 1 |
| Trucco, M | 1 |
| Augustin, T | 1 |
| Simon, R | 1 |
| Walsh, RM | 1 |
| Kashtan, MA | 1 |
| Graham, DA | 1 |
| Melvin, P | 1 |
| Hills-Dunlap, JL | 1 |
| Anandalwar, SP | 1 |
| Rangel, SJ | 1 |
| Gazal, G | 1 |
| Al-Samadani, KH | 1 |
| Alsaidalani, HM | 1 |
| Karbouji, GA | 1 |
| Alharbi, AM | 1 |
| Anzinger, FX | 1 |
| Rothe, K | 1 |
| Reischl, S | 1 |
| Stöss, C | 1 |
| Novotny, A | 1 |
| Wilhelm, D | 1 |
| Friess, H | 1 |
| Neumann, PA | 1 |
| Gerber, F | 1 |
| Joseph, JM | 1 |
| Crisinel, PA | 1 |
| Andrey, V | 1 |
| Duarte Thibault, M | 1 |
| Milen, A | 1 |
| Burns, L | 1 |
| Tilea, A | 1 |
| Piehl, K | 1 |
| Morgan, D | 1 |
| Okamura, A | 1 |
| Isono, W | 1 |
| Tsuchiya, A | 1 |
| Honda, M | 1 |
| Saito, A | 1 |
| Tsuchiya, H | 1 |
| Matsuyama, R | 1 |
| Fujimoto, A | 1 |
| Nishii, O | 1 |
| Zeineddin, S | 1 |
| Pitt, JB | 1 |
| Linton, S | 1 |
| De Boer, C | 1 |
| Hu, A | 1 |
| Carter, M | 1 |
| Alayleh, A | 1 |
| Abdullah, F | 1 |
| Raval, M | 1 |
| Goldstein, SD | 1 |
| Nguyen, N | 2 |
| Zhang, B | 2 |
| Holubar, SD | 4 |
| Pardi, DS | 4 |
| Singh, S | 3 |
| Hadjipavlou, M | 1 |
| Eragat, M | 1 |
| Kenny, C | 1 |
| Pantelidou, M | 1 |
| Mulhem, W | 1 |
| Wood, C | 1 |
| Dall'Antonia, M | 1 |
| Hammadeh, MY | 1 |
| Marut, D | 1 |
| Shammassian, B | 1 |
| McKenzie, C | 1 |
| Adamski, J | 1 |
| Traeger, J | 1 |
| Bunces-Orellana, O | 1 |
| Arevalo-Vidal, E | 1 |
| Bustos-Galarza, K | 1 |
| Ferrín-Viteri, M | 1 |
| Oleas, R | 1 |
| Baquerizo-Burgos, J | 1 |
| Puga-Tejada, M | 1 |
| Barreiro-de Acosta, M | 1 |
| Marín-Jimenez, I | 1 |
| Rodríguez-Lago, I | 1 |
| Guarner, F | 1 |
| Espín, E | 1 |
| Ferrer Bradley, I | 1 |
| Gutiérrez, A | 1 |
| Beltrán, B | 1 |
| Chaparro, M | 1 |
| Gisbert, JP | 1 |
| Nos, P | 1 |
| Samantaray, S | 1 |
| Biswas, R | 1 |
| Sasidharan, GM | 1 |
| Ghidini, G | 1 |
| Manfredi, M | 1 |
| Giovannacci, I | 1 |
| Mergoni, G | 1 |
| Sarraj, A | 1 |
| Mureddu, M | 1 |
| Giunta, G | 1 |
| Bonanini, M | 1 |
| Meleti, M | 1 |
| Vescovi, P | 1 |
| Avila, M | 1 |
| Funston, JR | 1 |
| Axtell, AA | 1 |
| Lentz, SE | 1 |
| Shang, Q | 1 |
| Geng, Q | 1 |
| Zhang, X | 1 |
| Guo, C | 1 |
| Taleb, M | 1 |
| Nardi, N | 1 |
| Arnaud, A | 1 |
| Costet, N | 1 |
| Donnio, PY | 1 |
| Engrand, C | 1 |
| Habonimana, E | 1 |
| Wodey, E | 1 |
| Tattevin, P | 1 |
| Desai, A | 1 |
| Krishnan, A | 1 |
| Zaghloul, A | 1 |
| McClure, M | 1 |
| Calaway, AC | 1 |
| Jacob, JM | 1 |
| Tong, Y | 1 |
| Shumaker, L | 1 |
| Kitley, W | 1 |
| Boris, RS | 1 |
| Cary, C | 1 |
| Kaimakliotis, H | 1 |
| Masterson, TA | 1 |
| Bihrle, R | 1 |
| Koch, MO | 1 |
| Salminen, P | 2 |
| Tuominen, R | 2 |
| Paajanen, H | 2 |
| Rautio, T | 2 |
| Nordström, P | 2 |
| Aarnio, M | 2 |
| Rantanen, T | 2 |
| Hurme, S | 2 |
| Mecklin, JP | 2 |
| Sand, J | 2 |
| Virtanen, J | 2 |
| Jartti, A | 2 |
| Grönroos, JM | 2 |
| Rhyne, RR | 1 |
| Hale, AL | 1 |
| Watson, DS | 1 |
| Smith, DE | 1 |
| Lissauer, D | 1 |
| Wilson, A | 1 |
| Hewitt, CA | 1 |
| Middleton, L | 1 |
| Bishop, JRB | 1 |
| Daniels, J | 1 |
| Merriel, A | 1 |
| Weeks, A | 1 |
| Mhango, C | 1 |
| Mataya, R | 1 |
| Taulo, F | 1 |
| Ngalawesa, T | 1 |
| Chirwa, A | 1 |
| Mphasa, C | 1 |
| Tambala, T | 1 |
| Chiudzu, G | 1 |
| Mwalwanda, C | 1 |
| Mboma, A | 1 |
| Qureshi, R | 1 |
| Ahmed, I | 1 |
| Ismail, H | 1 |
| Oladapo, OT | 1 |
| Mbaruku, G | 1 |
| Chibwana, J | 1 |
| Watts, G | 1 |
| Simon, B | 1 |
| Ditai, J | 1 |
| Otim Tom, C | 1 |
| Acam, J | 1 |
| Ekunait, J | 1 |
| Unzia, H | 1 |
| Iyaku, M | 1 |
| Makiika, JJ | 1 |
| Zamora, J | 1 |
| Roberts, T | 1 |
| Goranitis, I | 1 |
| Bar-Zeev, S | 1 |
| Desmond, N | 1 |
| Arulkumaran, S | 1 |
| Bhutta, ZA | 1 |
| Gulmezoglu, AM | 1 |
| Coomarasamy, A | 1 |
| Kolwijck, E | 1 |
| Seegers, AEM | 1 |
| Tops, SCM | 1 |
| van der Heijden, AG | 1 |
| Sedelaar, JPM | 1 |
| Ten Oever, J | 1 |
| Iio, K | 1 |
| Ariyama, Y | 1 |
| Tomita, H | 1 |
| Sakakibara, H | 1 |
| Hataya, H | 1 |
| Duclaux-Loras, R | 1 |
| Berthiller, J | 1 |
| Ferroni, A | 1 |
| Chardot, C | 1 |
| Goulet, O | 1 |
| Lacaille, F | 1 |
| Norsa, L | 1 |
| Bradley, JS | 1 |
| Broadhurst, H | 1 |
| Cheng, K | 1 |
| Mendez, M | 1 |
| Newell, P | 1 |
| Prchlik, M | 2 |
| Stone, GG | 1 |
| Talley, AK | 1 |
| Tawadrous, M | 1 |
| Wajsbrot, D | 1 |
| Yates, K | 1 |
| Zuzova, A | 1 |
| Gardner, A | 1 |
| Mañosa, M | 1 |
| Cabré, E | 1 |
| Bernal, I | 1 |
| Esteve, M | 1 |
| Garcia-Planella, E | 1 |
| Ricart, E | 1 |
| Peñalva, M | 1 |
| Cortes, X | 1 |
| Boix, J | 1 |
| Piñol, M | 1 |
| Gassull, MA | 1 |
| Domènech, E | 1 |
| Knott, EM | 1 |
| Thomas, P | 1 |
| Sharp, NE | 1 |
| Gasior, AC | 1 |
| St Peter, SD | 1 |
| Siller-Ruiz, M | 1 |
| Calvo-García, N | 1 |
| Hernández-Egido, S | 1 |
| María-Blázquez, A | 1 |
| de Frutos-Serna, M | 1 |
| García-Sánchez, JE | 1 |
| Villegas-Betanzo, P | 1 |
| Martínez-Jiménez, MA | 1 |
| Guevara-Torres, L | 1 |
| Quintero-Meza, K | 1 |
| Sánchez-Aguilar, M | 1 |
| Arriaga-Caballero, JE | 1 |
| Mukku, KK | 1 |
| Raju, S | 1 |
| Yelanati, R | 1 |
| Rinta-Kiikka, I | 1 |
| Reibetanz, J | 1 |
| Germer, CT | 1 |
| Stroud, AM | 1 |
| Sandborn, WJ | 2 |
| Vahdad, MR | 1 |
| Nissen, M | 1 |
| Semaan, A | 1 |
| Klein, T | 1 |
| Palade, E | 1 |
| Boemers, T | 1 |
| Foroutan, HR | 1 |
| Troebs, RB | 1 |
| Cernaianu, G | 1 |
| Torrijo Gómez, I | 1 |
| Uribe Quintana, N | 1 |
| Catalá Llosa, J | 1 |
| Raga Vázquez, J | 1 |
| Sellés Dechent, R | 1 |
| Martín Dieguez, MC | 1 |
| Báguena Requena, G | 1 |
| Asencio Arana, F | 1 |
| Ikeda, A | 1 |
| Konishi, T | 1 |
| Ueno, M | 1 |
| Fukunaga, Y | 1 |
| Nagayama, S | 1 |
| Fujimoto, Y | 1 |
| Akiyoshi, T | 1 |
| Yamaguchi, T | 1 |
| Gbotolorun, OM | 1 |
| Dipo-Fagbemi, IM | 1 |
| Olojede, AO | 1 |
| Ebigwei, S | 1 |
| Adetoye, JO | 1 |
| Macchini, D | 1 |
| Guttadauro, A | 1 |
| Frassani, S | 1 |
| Maternini, M | 1 |
| Gabrielli, F | 1 |
| Loozen, CS | 1 |
| Kortram, K | 1 |
| Kornmann, VN | 1 |
| van Ramshorst, B | 1 |
| Vlaminckx, B | 1 |
| Knibbe, CA | 1 |
| Kelder, JC | 1 |
| Donkervoort, SC | 1 |
| Nieuwenhuijzen, GA | 1 |
| Ponten, JE | 1 |
| van Geloven, AA | 1 |
| van Duijvendijk, P | 1 |
| Bos, WJ | 1 |
| Besselink, MG | 1 |
| Gouma, DJ | 1 |
| van Santvoort, HC | 1 |
| Boerma, D | 1 |
| Tufan, K | 1 |
| Cekinmez, M | 1 |
| Sener, L | 1 |
| Erdogan, B | 1 |
| D'Haens, GR | 1 |
| Vermeire, S | 2 |
| Van Assche, G | 1 |
| Noman, M | 1 |
| Aerden, I | 1 |
| Van Olmen, G | 1 |
| Rutgeerts, P | 2 |
| Ong, CP | 1 |
| Chan, TK | 1 |
| Chui, CH | 1 |
| Jacobsen, AS | 1 |
| Hosseini, SV | 1 |
| Sabet, B | 1 |
| Nouri Amirkolaee, M | 1 |
| Bolandparvaz, S | 1 |
| Abbas, M | 1 |
| Nafeh, AE | 1 |
| Elsebae, M | 1 |
| Farouk, Y | 1 |
| Iesalnieks, I | 1 |
| Glass, H | 1 |
| Kilger, A | 1 |
| Ott, C | 1 |
| Klebl, F | 1 |
| Agha, A | 1 |
| Schlitt, HJ | 1 |
| Strauch, U | 1 |
| Wang, Y | 1 |
| Shen, B | 2 |
| Williams, RN | 1 |
| Hemingway, D | 1 |
| Miller, AS | 1 |
| He, X | 1 |
| Bennett, AE | 1 |
| Lian, L | 1 |
| Goitia, L | 1 |
| Pérez, P | 1 |
| Sebastián, P | 1 |
| Taibo, JM | 1 |
| Arizaga, A | 1 |
| Stanley, JD | 1 |
| Burns, RP | 1 |
| Davaus Gasparetto, T | 1 |
| Marchiori, E | 1 |
| Menezes, P | 1 |
| Zanetti, G | 1 |
| Mary, N | 1 |
| Mahmood, TA | 1 |
| Cima, RR | 1 |
| Sheikh, Z | 1 |
| Khan, AS | 1 |
| Khan, S | 1 |
| Olusanya, AA | 1 |
| Arotiba, JT | 1 |
| Fasola, OA | 1 |
| Akadiri, AO | 1 |
| Romero-Pizarro, Y | 1 |
| Muñoz-Algarra, M | 1 |
| Fernández-Mateos, C | 1 |
| Sánchez-Romero, I | 1 |
| Treszezamsky, AD | 1 |
| Feldman, D | 1 |
| Sarabanchong, VO | 1 |
| Stathas, T | 1 |
| Mallis, A | 1 |
| Mastronikolis, NS | 1 |
| Naxakis, SS | 1 |
| Dimaka, K | 1 |
| Panogeorgou, T | 1 |
| Stavrou, S | 1 |
| Margaritis, V | 1 |
| Kourousis, C | 1 |
| Papadas, TA | 1 |
| Leeuwenburgh, MM | 1 |
| Monpellier, V | 1 |
| Vlaminckx, BJ | 1 |
| Go, PM | 1 |
| Knežević, M | 1 |
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| Takesue, Y | 2 |
| Tomita, N | 1 |
| Hussain, MI | 1 |
| Alam, MK | 1 |
| Al-Qahatani, HH | 1 |
| Al-Akeely, MH | 1 |
| Jussila, A | 1 |
| Färkkilä, M | 1 |
| Järvinen, HJ | 1 |
| Emil, S | 1 |
| Laberge, JM | 1 |
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| Shaw, K | 1 |
| Skoropad, VY | 1 |
| Berdov, BA | 1 |
| Zagrebin, VM | 1 |
| Gascón, AR | 1 |
| Gutiérrez-Aragón, G | 1 |
| Hernández, RM | 1 |
| Errasti, J | 1 |
| Pedraz, JL | 1 |
| Philpott-Howard, J | 1 |
| Burroughs, A | 1 |
| Fisher, N | 1 |
| Hastings, M | 1 |
| Kibbler, C | 1 |
| Mutimer, D | 1 |
| Patch, D | 1 |
| Rolando, N | 1 |
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| Wendon, J | 1 |
| O'Grady, J | 1 |
| Lodha, A | 1 |
| Wales, PW | 1 |
| James, A | 1 |
| Smith, CR | 1 |
| Langer, JC | 1 |
| Rao, K | 1 |
| Sekar, U | 1 |
| Iraivan, KT | 1 |
| Abraham, G | 1 |
| Soundararajan, P | 1 |
| Kamar, M | 1 |
| Raziel, A | 1 |
| Susmallian, S | 1 |
| Kyzer, S | 1 |
| Charuzi, I | 1 |
| La Torre, F | 1 |
| Nicolai, AP | 1 |
| Swain, BT | 1 |
| Ellis, CN | 1 |
| Spies, CD | 1 |
| von Dossow, V | 1 |
| Eggers, V | 1 |
| Jetschmann, G | 1 |
| El-Hilali, R | 1 |
| Egert, J | 1 |
| Fischer, M | 1 |
| Schröder, T | 1 |
| Höflich, C | 1 |
| Sinha, P | 1 |
| Paschen, C | 1 |
| Mirsalim, P | 1 |
| Brunsch, R | 1 |
| Hopf, J | 1 |
| Marks, C | 1 |
| Wernecke, KD | 1 |
| Pragst, F | 1 |
| Ehrenreich, H | 1 |
| Müller, C | 1 |
| Tonnesen, H | 1 |
| Oelkers, W | 1 |
| Rohde, W | 1 |
| Stein, C | 1 |
| Kox, WJ | 1 |
| Salako, NO | 1 |
| Rotimi, VO | 1 |
| Adib, SM | 1 |
| Al-Mutawa, S | 1 |
| Englert, C | 1 |
| Aebert, H | 1 |
| Lenhart, M | 1 |
| Solleder, A | 1 |
| Nerlich, M | 1 |
| Neumann, C | 1 |
| Kalaycý, M | 1 |
| Cadavi, F | 1 |
| Altunkaya, H | 1 |
| Gül, S | 1 |
| Ackgöz, B | 1 |
| Larsson, PG | 1 |
| Bergström, M | 1 |
| Forsum, U | 1 |
| Jacobsson, B | 1 |
| Strand, A | 1 |
| Wölner-Hanssen, P | 1 |
| Okazaki, K | 1 |
| Matsushita, M | 1 |
| Kawamata, S | 1 |
| Shimatani, M | 1 |
| Fujii, T | 1 |
| Mui, LM | 1 |
| Ng, CS | 1 |
| Wong, SK | 1 |
| Lam, YH | 1 |
| Fung, TM | 1 |
| Fok, KL | 1 |
| Chung, SS | 1 |
| Ng, EK | 1 |
| Dignass, AU | 1 |
| Bomke, AK | 1 |
| Feyerherd, P | 1 |
| Podbielski, A | 1 |
| Oztürk, S | 1 |
| Tufan, F | 1 |
| Alişir, S | 1 |
| Görçin, S | 1 |
| Güven, D | 1 |
| Cağatay, A | 1 |
| Türkmen, A | 1 |
| Kearney, FM | 1 |
| Blaikie, AJ | 1 |
| Gole, GA | 1 |
| Kim, KA | 1 |
| Wry, P | 1 |
| Hughes, E | 1 |
| Butcher, J | 1 |
| Barbot, D | 1 |
| Forgues, D | 1 |
| Habbig, S | 1 |
| Diallo, AF | 1 |
| Kalfa, N | 1 |
| Lopez, M | 1 |
| Allal, H | 1 |
| Guibal, MP | 1 |
| Sabatier-Laval, E | 1 |
| Galifer, RB | 1 |
| Fujita, S | 1 |
| Saito, N | 1 |
| Yamada, T | 1 |
| Takii, Y | 1 |
| Kondo, K | 1 |
| Ohue, M | 1 |
| Ikeda, E | 1 |
| Moriya, Y | 1 |
| Khan, MN | 1 |
| Vidya, R | 1 |
| Lee, RE | 1 |
| Ea, HK | 1 |
| Zeller, V | 1 |
| Chicheportiche, V | 1 |
| Desplaces, N | 1 |
| Ziza, JM | 1 |
| Wesarachawit, W | 1 |
| Pattana-arun, J | 1 |
| Okada, T | 1 |
| Sasaki, F | 1 |
| Honda, S | 1 |
| Naito, S | 1 |
| Todo, S | 1 |
| Pekova, L | 1 |
| Shomov, G | 1 |
| Mladenova, I | 1 |
| Pellicano, R | 1 |
| Romero Ganuza, FJ | 1 |
| Robinson, AS | 1 |
| Levinson, M | 1 |
| Houang, ET | 1 |
| Watson, C | 1 |
| Howell, R | 1 |
| Chapman, M | 1 |
| Amarin, ZO | 1 |
| Grant, KA | 1 |
| Gini, PC | 1 |
| Chukudebelu, WO | 1 |
| Kraft-Kinz, J | 1 |
| Kronberger, L | 1 |
| Farinotti, R | 2 |
| Sainte-Marie, D | 1 |
| Fichelle, A | 1 |
| Dauphin, A | 2 |
| Desmonts, JM | 2 |
| Flannigan, GM | 1 |
| Clifford, RP | 1 |
| Carver, RA | 1 |
| Yule, AG | 1 |
| Madden, NP | 1 |
| Ivchenko, VN | 1 |
| Mel'nik, VM | 1 |
| Kaziro, GS | 1 |
| Wacha, H | 1 |
| Probst, M | 1 |
| Kocherovets, VI | 1 |
| Stolbovoĭ, AV | 1 |
| Dzhalashev, IaKh | 1 |
| Keighley, MR | 9 |
| Opŭlchenova, G | 1 |
| Kvist Poulsen, H | 1 |
| Borel, J | 1 |
| Gall, SA | 1 |
| Molkhou, JM | 1 |
| Billebaud, T | 1 |
| Houry, S | 1 |
| Huguier, M | 1 |
| Drenick, EJ | 4 |
| Bassett, LW | 1 |
| Stanley, TM | 1 |
| Závadová, M | 1 |
| Adamicka, V | 1 |
| Adensámová, J | 1 |
| Brezinová, L | 2 |
| Tynková, S | 1 |
| Bergan, T | 3 |
| Kosmidis, J | 1 |
| Amon, I | 1 |
| Amon, K | 1 |
| Zschiesche, M | 1 |
| Chant, AD | 1 |
| Turner, DT | 1 |
| Machin, D | 1 |
| Bye, K | 1 |
| Reiertsen, O | 1 |
| Rosseland, AR | 1 |
| Helsingen, N | 1 |
| Manthorpe, T | 1 |
| Justesen, T | 2 |
| Walker, EM | 1 |
| Gordon, AJ | 1 |
| Warren, RE | 1 |
| Hare, MJ | 1 |
| Barone, C | 1 |
| Hell, K | 1 |
| Fisler, J | 1 |
| Johnson, D | 1 |
| Bell, GA | 1 |
| Fothergill, J | 1 |
| Murphy, J | 1 |
| Smith, JA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial[NCT05943223] | Phase 2 | 16 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| "A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| Study of Surgical Treatment (Open Appendicectomy) Versus Antibiotic Treatment (Ertapenem) in the Treatment of Acute Uncomplicated Appendicitis[NCT01022567] | 530 participants (Actual) | Interventional | 2009-11-30 | Active, not recruiting | |||
| Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases[NCT04462588] | 64 participants (Actual) | Observational [Patient Registry] | 2019-06-01 | Completed | |||
| A Single Blind, Randomised, Multi-centre, Active Controlled, Trial To Evaluate Safety, Tolerability, Pharmacokinetics And Efficacy Of Ceftazidime And Avibactam When Given In Combination With Metronidazole, Compared With Meropenem, In Children From 3 Month[NCT02475733] | Phase 2 | 83 participants (Actual) | Interventional | 2015-08-01 | Completed | ||
| Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis[NCT02789865] | Phase 2 | 240 participants (Anticipated) | Interventional | 2016-05-31 | Not yet recruiting | ||
| Mutil-institutions Comparing Antibiotic Therapy With Laparscopic Appendectomy in Pediatric Chronic Appendicitis[NCT03754387] | 200 participants (Anticipated) | Interventional | 2019-01-01 | Enrolling by invitation | |||
| A Prospective Non-randomized Controlled, Multicenter, Multidisciplinary Trial Comparing Appendectomy and Conservative Treatment for Patients With Uncomplicated Acute Appendicitis (the ACTUAA STUDY).[NCT03080103] | 300 participants (Actual) | Observational | 2017-06-01 | Completed | |||
| Randomised, Double-blind, Placebo-controlled, Parallel-group, Multicentre, Interventional Clinical Trial to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus in the Symptomatic Treatment of Haemorrhoids[NCT05750563] | 80 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | |||
| Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis (Randomized, Controlled Clinical Trial)[NCT01115153] | 150 participants (Actual) | Interventional | 2007-12-31 | Completed | |||
| Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin[NCT00292708] | Phase 3 | 500 participants | Interventional | 2004-05-31 | Completed | ||
| ERAS Lazio Network Clinical Registry[NCT03353311] | 1,000 participants (Actual) | Observational [Patient Registry] | 2014-09-01 | Completed | |||
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531] | Phase 2 | 2 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Lack of enrollment) | ||
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis[NCT00583076] | Phase 2 | 19 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Trimethoprim-sulfamethoxazole Versus Placebo in the Treatment of Cutaneous Abscesses in the Emergency Department[NCT00867789] | 140 participants (Actual) | Interventional | 2009-03-31 | Terminated (stopped due to Slow enrollment due to subjects not meeting inclusion/exclusion criteria) | |||
| A Randomized Trial of Intranasal Fentanyl Versus Placebo as an Adjunct to Lidocaine Infiltration in Adults Undergoing Abscess Incision and Drainage in the Emergency[NCT03872700] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A successful treatment is determined by resolution of the appendicitis by means of the assigned treatment. (NCT01022567)
Timeframe: Up to 10 years
| Intervention | percentage of successful treatment (Number) |
|---|---|
| Appendectomy | 99.6 |
| Antibiotic Therapy | 72.7 |
A participant was said to have clinical relapse if met either 1 of the following criteria: reappearance or worsening of signs and symptoms of cIAI that required further antimicrobial therapy and/or surgery, or death after TOC in which cIAI was contributory. LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 |
| Meropenem | 0 |
A participant was said to have clinical relapse if me either 1 of the following criteria: reappearance or worsening of signs and symptoms of cIAI that required further antimicrobial therapy and/or surgery, or death after TOC in which cIAI was contributory. LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 |
| Meropenem | 0 |
Emergent Infections was an intra-abdominal culture identified pathogen other than a baseline pathogen during the course of active treatment with study therapy along with worsening signs and symptoms of infection requiring alternative antimicrobial therapy, new infection was an intra-abdominal culture identified pathogen other than a baseline pathogen at any time after study treatment has finished along with worsening signs and symptoms of infection requiring alternative antimicrobial therapy. TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). Participants with any (super infections or new infections) of the infections were reported. (NCT02475733)
Timeframe: TOC visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 |
| Meropenem | 0 |
Emergent infections were categorized as super infections and new infections. Superinfection: An intra-abdominal culture identified pathogen other than a baseline pathogen during the course of active treatment with study therapy along with worsening signs and symptoms of infection requiring alternative antimicrobial therapy. New infection: An intra-abdominal culture identified pathogen other than a baseline pathogen at any time after study treatment had finished along with worsening signs and symptoms of infection requiring alternative antimicrobial therapy. Participants with any (super infections or new infections) of the infections were reported. (NCT02475733)
Timeframe: Baseline up to 50 days
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 |
| Meropenem | 0 |
Favorable CR was defined as resolution of all acute signs and symptoms of complicated intra- abdominal infection (cIAIs), or improvement to such an extent that no further antimicrobial therapy was required, or improvement but not enough to switch to oral therapy and still on IV study drug at end of 72 hours and had met following criterion: absence of new signs and symptoms, improvement in at least 1 symptom/sign (fever, pain, tenderness, elevated White Blood Cells [WBCs], elevated c-reactive protein) from baseline and no worsening symptom/sign. (NCT02475733)
Timeframe: End of 72 hours study drug treatment on Day 1
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 93.4 |
| Meropenem | 90.9 |
Favorable CR was resolution of all acute signs and symptoms of cIAI or improvement to such an extent that no further antimicrobial therapy was required, or improvement in participants who had switch to oral therapy and met the following criterion: afebrile (temperature <=38.0°C) for at least 24 hours, absence of new and improvement in at least 1 symptom or sign (fever, pain, tenderness, elevated WBCs, elevated c-reative-protein) from baseline and worsening of none. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: EOIV visit (anytime from Day 4 up to 16)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 96.7 |
| Meropenem | 100 |
Favorable CR was resolution of all acute signs and symptoms of cIAI, or improvement to such an extent that no further antimicrobial therapy was required. EOT visit occurred within 48 hours after completion of the last dose of oral switch therapy or at time of premature discontinuation/early withdrawal from study (if on oral switch therapy). (NCT02475733)
Timeframe: EOT visit (up to Day 17)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 91.8 |
| Meropenem | 100 |
Favorable CR was resolution of all acute signs and symptoms of cIAI, or improvement to such an extent that no further antimicrobial therapy was required. TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). (NCT02475733)
Timeframe: TOC visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) |
|---|---|
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 91.8 |
| Meropenem | 95.5 |
EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline, EOIV visit (anytime from Day 4 up to 16)
| Intervention | degree Celsius (Mean) | |
|---|---|---|
| Baseline | Change at EOIV | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 37.35 | -0.78 |
| Meropenem | 37.16 | -0.60 |
EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline, EOIV visit (anytime from Day 4 up to 16)
| Intervention | kilograms (Mean) | |
|---|---|---|
| Baseline | Change at EOIV | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 40.58 | -0.38 |
| Meropenem | 38.35 | -1.06 |
EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline, EOIV visit (anytime from Day 4 up to 16)
| Intervention | beats per minute (Mean) | |
|---|---|---|
| Baseline | Change at EOIV | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 102.1 | -15.2 |
| Meropenem | 103.0 | -15.4 |
EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline, EOIV visit (anytime from Day 4 up to 16)
| Intervention | breaths per minute (Mean) | |
|---|---|---|
| Baseline | Change at EOIV | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 22.4 | -1.3 |
| Meropenem | 22.9 | -1.3 |
EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline, EOIV visit (anytime from Day 4 up to 16)
| Intervention | millimeter of mercury (mmHg) (Mean) | |||
|---|---|---|---|---|
| SBP: Baseline | SBP: Change at EOIV | DBP: Baseline | DBP: Change at EOIV | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 109.7 | -4.0 | 63.5 | 1.3 |
| Meropenem | 111.6 | -6.0 | 63.1 | -2.8 |
Physical examination included an assessment of the following: general appearance, skin, head and neck (including ears, eyes, nose and throat), lymph nodes, thyroid, respiratory system, cardiovascular system, abdomen, musculoskeletal system (including spine and extremities), and neurological system. Participants with new or aggravated abnormal physical examination findings with regard to baseline findings were reported. Abnormality in physical examinations were based on blinded observer's discretion. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: EOIV visit (anytime from Day 4 up to 16)
| Intervention | percentage of participants (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Abdomen | Cardiovascular System | General Appearance | Head and Neck | Lymph Nodes | Musculoskeletal System | Neurological System | Respiratory System | Skin | Thyroid | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 6.6 | 0 | 1.6 | 0 | 0 | 0 | 0 | 3.3 | 1.6 | 0 |
| Meropenem | 18.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Percentage of participants with Cephalosporin class effects (defined as adverse event of special interest (AEoSI) within the safety topics (ST) of hypersensitivity/anaphylaxis) and additional AEs (which included AEs of seizures, diarrhea, renal disorder, and liver disorder relevant to the cephalosporin class within the ST and AEs with preferred term in the system organ class of nervous system disorder system organ class based on MedDRA 20.0) were reported in this outcome measure. (NCT02475733)
Timeframe: Baseline until the LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| AE in the ST of Diarrhea | AEoSI in the ST of Hypersensitivity/Anaphylaxis | AE in the ST of Liver Disorder | AE in the ST of Renal Disorder | AEs with PTs in the Nervous System Disorder SOC | AE of seizure | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 1.6 | 4.9 | 0 | 0 | 1.6 | 0 |
| Meropenem | 0 | 13.6 | 0 | 0 | 4.5 | 0 |
CrCl is a measure of glomerular filtration rate (GMFR), an index of kidney function. It is the volume of blood plasma that is cleared of creatinine by the kidneys per unit time. Percentage of participants with CrCl in the following categories were reported: <30 mL/min/1.73 m^2, >=30 to <50 mL/min/1.73 m^2, >=50 mL/min/1.73 m^2 to <80 mL/min/1.73 m^2, and >=80 mL/min/1.73 m^2. (NCT02475733)
Timeframe: Day 7
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| CrCl: <30mL/min/1.73 m^2 | CrCl: >=30 to <50mL/min/1.73 m^2 | CrCl: >=50 to <80mL/min/1.73 m^2 | CrCl: >=80mL/min/1.73 m^2 | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 | 0 | 0 | 50.8 |
| Meropenem | 0 | 0 | 0 | 59.1 |
CrCl is a measure of GMFR, an index of kidney function. It is the volume of blood plasma that is cleared of creatinine by the kidneys per unit time. Percentage of participants with CrCl in the following categories were reported: <30 mL/min/1.73 m^2, >=30 to <50 mL/min/1.73 m^2, >=50 mL/min/1.73 m^2 to <80 mL/min/1.73 m^2, and >=80 mL/min/1.73 m^2. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: EOIV visit (anytime from Day 4 up to 16)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| CrCl: <30mL/min/1.73 m^2 | CrCl: >=30 to <50mL/min/1.73 m^2 | CrCl: >=50 to <80mL/min/1.73 m^2 | CrCl: >=80mL/min/1.73 m^2 | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 | 0 | 0 | 82.0 |
| Meropenem | 0 | 0 | 0 | 81.8 |
CrCl is a measure of GMFR, an index of kidney function. It is the volume of blood plasma that is cleared of creatinine by the kidneys per unit time. Percentage of participants with CrCl in the following categories were reported: <30 mL/min/1.73 m^2, >=30 to <50 mL/min/1.73 m^2, >=50 mL/min/1.73 m^2 to <80 mL/min/1.73 m^2, and >=80 mL/min/1.73 m^2. LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| CrCl: <30mL/min/1.73 m^2 | CrCl: >=30 to <50mL/min/1.73 m^2 | CrCl: >=50 to <80mL/min/1.73 m^2 | CrCl: >=80mL/min/1.73 m^2 | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 | 0 | 1.6 | 6.6 |
| Meropenem | 0 | 0 | 0 | 9.1 |
CrCl is a measure of GMFR, an index of kidney function. It is the volume of blood plasma that is cleared of creatinine by the kidneys per unit time. Percentage of participants with CrCl in the following categories were reported: <30 mL/min/1.73 m^2, >=30 to <50 mL/min/1.73 m^2, >=50 mL/min/1.73 m^2 to <80 mL/min/1.73 m^2, and >=80 mL/min/1.73 m^2. TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). (NCT02475733)
Timeframe: TOC visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| CrCl: <30mL/min/1.73 m^2 | CrCl: >=30 to <50mL/min/1.73 m^2 | CrCl: >=50 to <80mL/min/1.73 m^2 | CrCl: >=80mL/min/1.73 m^2 | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 0 | 0 | 3.3 | 42.6 |
| Meropenem | 0 | 0 | 0 | 59.1 |
ECG parameters included maximum QT intervals using Fridericia's correction (QTcF). Maximum QTcF >450 millisecond (ms); maximum QTcF >480 ms; and maximum QTcF >500 ms. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. (NCT02475733)
Timeframe: Baseline until the EOIV visit (anytime from Day 4 to 16)
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| Maximum QTcF Interval : >450 ms | Maximum QTcF Interval : >480 ms | Maximum QTcF Interval : >500 ms | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 1.6 | 1.6 | 0 |
| Meropenem | 4.5 | 4.5 | 4.5 |
Favorable CR was resolution of all acute signs and symptoms of cIAI, or improvement to such an extent that no further antimicrobial therapy was required, or improvement in participants who had switch to oral therapy and met the following criterion: afebrile (temperature <=38.0°C) for at least 24 hours, absence of new and improvement in at least 1 symptom or sign (fever, pain, tenderness, elevated WBCs, elevated c-reative-protein) from baseline and worsening of none. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. EOT visit occurred within 48 hours after completion of last dose of oral switch therapy or at time of premature discontinuation/early withdrawal from study (if on oral switch therapy). TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). (NCT02475733)
Timeframe: End of 72 hours study drug treatment on Day 1, EOIV (anytime from Day 4 up to 16), EOT visit (up to Day 17) and TOC visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| End 72 hours study medication | EOIV | EOT | TOC | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 98.0 | 98.1 | 94.2 | 92.9 |
| Meropenem | 95.0 | 100 | 100 | 95.0 |
Favorable microbiological response was achieved when all baseline pathogens were eradicated or presumed eradicated based on investigator's discretion. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. EOT visit occurred within 48 hours after completion of last dose of oral switch therapy or at time of premature discontinuation/early withdrawal from study if on oral switch therapy (which occurred within the maximum study treatment duration of 15 days). EOIV visit occurred within 24 hours after completion of last infusion of the study drug. TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: EOIV visit (Day 4 up to 16), EOT visit (up to Day 17), TOC visit (up to a maximum study duration of 50 days) and LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| EOIV | EOT | TOC | LFU | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 96.0 | 90.0 | 90.0 | 90.0 |
| Meropenem | 100 | 100 | 94.7 | 94.7 |
Favorable microbiological response was achieved when all baseline pathogens were eradicated or presumed eradicated based on investigator's discretion. EOIV visit occurred within 24 hours after completion of last infusion of the study drug. EOT visit occurred within 48 hours after completion of last dose of oral switch therapy or at time of premature discontinuation/early withdrawal from study if on oral switch therapy (which occurred within the maximum study treatment duration of 15 days). TOC visit occurred within 8 to 15 days after last dose of any study drug (IV or oral). LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: EOIV visit (Day 4 up to 16), EOT visit (up to Day 17), TOC visit (up to a maximum study duration of 50 days) and LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| EOIV | EOT | TOC | LFU | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 97.5 | 91.7 | 90.0 | 89.2 |
| Meropenem | 100 | 100 | 93.3 | 92.9 |
Criteria for potentially clinically significant laboratory abnormalities: Chemistry (calcium: <0.7*lower limit of normal range [LLN] and >30 percent decrease from baseline [DFB]; alanine aminotransferase [ALT]: >3*upper limit of normal range [ULN] and >300 percent IFB; alanine aminotransferase [AST]: >3*ULN and >300 percent IFB) and hematology (platelets: >2*ULN and >100 percent IFB). LFU visit occurred within 20 to 35 days after last dose of study treatment (IV or oral). (NCT02475733)
Timeframe: Baseline until the LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Chemistry: Calcium | Chemistry: ALT | Chemistry: AST | Hematology: Platelets | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 1.9 | 1.7 | 1.8 | 3.3 |
| Meropenem | 0 | 0 | 0 | 0 |
An AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. An SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged in-patient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent AEs were events between first dose of study drug and up to late follow-up (LFU) visit (20 to 35 days after last dose of study treatment [IV or oral]) that were absent before treatment or that worsened relative to pretreatment state. AEs included both SAE and non-SAE. (NCT02475733)
Timeframe: Baseline until the LFU visit (up to a maximum study duration of 50 days)
| Intervention | percentage of participants (Number) | |
|---|---|---|
| AEs | SAEs | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 52.5 | 8.2 |
| Meropenem | 59.1 | 4.5 |
(NCT02475733)
Timeframe: 15, 30-90, 300-360 minutes post-dose on Day 3
| Intervention | nanogram per milliliter (Geometric Mean) | |||||
|---|---|---|---|---|---|---|
| Ceftazidime: 15 minute post-dose on Day 3 | Ceftazidime: 30-90 minute post-dose on Day 3 | Ceftazidime:300-360minute post-dose on Day 3 | Avibactam: 15 minute post-dose on Day 3 | Avibactam: 30-90 minute post-dose on Day 3 | Avibactam: 300-360 minute post-dose on Day 3 | |
| Ceftazidime- Avibactam (CAZ-AVI) Plus Metronidazole | 63565.5 | 38048.0 | 4603.0 | 12186.2 | 6548.6 | 821.5 |
(NCT00867789)
Timeframe: two years
| Intervention | Percentage of outcomes assessed (Number) |
|---|---|
| Trimethoprim-sulfamethaxazole | 0 |
| Sugar Pill | 0 |
Patient reported NRS pain scores after Blunt Dissection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.1 |
| Placebo | 4.4 |
Patient reported NRS pain scores after Irrigation. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.4 |
| Placebo | 2.6 |
Patient reported NRS pain scores after Lidocaine injection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Following Lidocaine injection measured once anytime up to 12 minutes after intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.4 |
| Placebo | 8.0 |
Patient reported pain after Packing of abscess. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once at the time of completion of application of the bandage, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.5 |
| Placebo | 3.9 |
Patient reported NRS pain scores following Incision. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.9 |
| Placebo | 3.9 |
Patient reported pain scores at baseline. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.3 |
| Placebo | 8.1 |
Patient reported pain scores for overall Procedure assessed immediately after placement of dressing at the end of procedure. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once following placement of dressing at completion of procedure, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 6.2 |
| Placebo | 7.0 |
27 reviews available for metronidazole and Complication, Postoperative
| Article | Year |
|---|---|
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; | 2019 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Adult; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metro | 2015 |
Clostridium difficile and the surgeon.
Topics: Anti-Infective Agents; Clostridioides difficile; Colectomy; Enterocolitis, Pseudomembranous; Feces; | 2010 |
Preventing infective complications relating to induced abortion.
Topics: Abortion, Induced; Adolescent; Adult; Antibiotic Prophylaxis; Azithromycin; Cost-Benefit Analysis; D | 2010 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Adult; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metronidazole; Po | 2010 |
[Postoperative recurrence of subdural empyema].
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Combined Modality Therap | 2011 |
Acute post-surgical bilateral orbital gas-producing infection - a case report and literature review.
Topics: Acute Disease; Anti-Bacterial Agents; Drug Therapy, Combination; Emphysema; Eye Infections, Bacteria | 2012 |
[Can the postoperative relapse of Crohn disease be influenced?].
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Clinical Trials as Top | 2001 |
Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Clindamycin; Disease Transmission, Infectious; Female; | 2005 |
[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis].
Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Immunologic Factor | 2005 |
[Pancreatitis associated with metronidazole].
Topics: Abdominal Injuries; Acute Disease; Adult; Anti-Bacterial Agents; Cervical Vertebrae; Clostridium Inf | 2008 |
[Use of metronidazole and its analogs in surgery].
Topics: Bacteria; Bacterial Infections; DNA, Bacterial; Female; Gram-Negative Anaerobic Bacteria; Humans; In | 1983 |
[Non-clostridial anaerobic infection in diseases of the liver and biliary tract (review of the Soviet and foreign literature)].
Topics: Age Factors; Aged; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Biliary Tract D | 1984 |
[Anaerobic infections and their importance in surgery].
Topics: Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Cephalosporins; | 1984 |
Infections in the female genital tract.
Topics: Abortion, Septic; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; En | 1983 |
[Should preventive antibiotics be prescribed in surgery of the appendix, biliary tract, stomach and duodenum?].
Topics: Anti-Bacterial Agents; Appendectomy; Biliary Tract Surgical Procedures; Cefazolin; Cephalosporins; C | 1983 |
The action of metronidazole on anaerobic bacilli and similar organisms.
Topics: Administration, Oral; Anaerobiosis; Animals; Bacteria; Bacterial Infections; Bacteroides Infections; | 1981 |
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
[Drug prevention of Crohn disease recurrence in the neo-terminal ileum after ileocolic resection].
Topics: Anti-Inflammatory Agents; Budesonide; Colon; Crohn Disease; Follow-Up Studies; Humans; Ileum; Mesala | 1998 |
Microsporidia infection in transplant patients.
Topics: Animals; Anti-Infective Agents; Cyclosporine; Diarrhea; Feces; Graft Rejection; Heart Transplantatio | 1999 |
[Prophylactic administration of antibiotics in surgery].
Topics: Antibiotic Prophylaxis; Cephalosporins; Humans; Metronidazole; Postoperative Complications; Prognosi | 1996 |
Complications after ileal pouch-anal anastomosis.
Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Crohn Disease; Humans; Male; Metronidazol | 2000 |
Pharmacotherapy for inducing and maintaining remission in pouchitis.
Topics: Adult; Bismuth; Butyrates; Enema; Humans; Metronidazole; Postoperative Complications; Pouchitis; Rem | 2000 |
Bacteroides fragilis endophthalmitis: a case report.
Topics: Aged; Aged, 80 and over; Bacteroides fragilis; Bacteroides Infections; Cataract Extraction; Endophth | 1990 |
Antibiotics in colorectal surgery.
Topics: Colon; Humans; Metronidazole; Postoperative Complications; Premedication; Rectum | 1990 |
Pouchitis (pouch ileitis).
Topics: Anastomosis, Surgical; Humans; Ileitis; Ileostomy; Inflammatory Bowel Diseases; Metronidazole; Posto | 1989 |
Pre-operative antimicrobial prophylaxis of infection.
Topics: Anti-Infective Agents; Bacterial Infections; Humans; Metronidazole; Postoperative Complications; Pre | 1985 |
109 trials available for metronidazole and Complication, Postoperative
| Article | Year |
|---|---|
A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dry Socket | 2022 |
A Prospective Program to Reduce the Clinical Incidence of Clostridium difficile Colitis Infection after Cystectomy.
Topics: Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Asymptomatic Diseases; Clostridioides difficile | 2019 |
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D | 2018 |
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D | 2018 |
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D | 2018 |
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D | 2018 |
A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery.
Topics: Abortion, Spontaneous; Administration, Oral; Adolescent; Adult; Africa South of the Sahara; Antibiot | 2019 |
Safety and Efficacy of Ceftazidime-Avibactam Plus Metronidazole in the Treatment of Children ≥3 Months to <18 Years With Complicated Intra-Abdominal Infection: Results From a Phase 2, Randomized, Controlled Trial.
Topics: Adolescent; Age Factors; Anti-Bacterial Agents; Azabicyclo Compounds; Ceftazidime; Child; Child, Pre | 2019 |
Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn's disease: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Anti-Infective Agents; Azathioprine; Crohn Disease; Double-Blind Method; Drug The | 2013 |
Reduced use of computed tomography in patients treated with interval appendectomy after implementing a protocol from a prospective, randomized trial.
Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Drainage; Female; Follow-Up S | 2013 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; | 2015 |
[Optimal management of Crohn's disease after intestinal resection].
Topics: Adalimumab; Colonoscopy; Combined Modality Therapy; Crohn Disease; Humans; Metronidazole; Postoperat | 2015 |
Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Antib | 2016 |
Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction?
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Double-Blind Method; Dry Socket; Female; Humans; Male; Me | 2016 |
Randomized clinical trial of extended versus single-dose perioperative antibiotic prophylaxis for acute calculous cholecystitis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Antibiotic Prophylaxis; Cefazolin; Cefuroxime | 2017 |
Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial.
Topics: Adult; Aged; Anti-Infective Agents; Azathioprine; Combined Modality Therapy; Crohn Disease; Drug The | 2008 |
A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy.
Topics: Administration, Oral; Adult; Anal Canal; Anti-Infective Agents; Female; Fissure in Ano; Humans; Male | 2008 |
Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study.
Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibi | 2011 |
Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help?
Topics: Aged; Anti-Infective Agents; Combined Modality Therapy; Cutaneous Fistula; Female; Humans; Incidence | 2011 |
Role of postoperative antibiotics after appendectomy in non-perforated appendicitis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendi | 2012 |
Preoperative radiotherapy in combination with metronidazole for resectable gastric cancer: long-term results of a phase 2 study.
Topics: Adenocarcinoma; Adult; Aged; Female; Gastrectomy; Humans; Male; Metronidazole; Middle Aged; Neoadjuv | 2003 |
Piperacillin-tazobactam versus ciprofloxacin plus amoxicillin in the treatment of infective episodes after liver transplantation.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Do | 2003 |
Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinati | 2004 |
Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Appen | 2005 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Ampicillin combined with sulbactam or metronidazole for single-dose chemoprophylaxis in major gynaecological surgery.
Topics: Adult; Ampicillin; beta-Lactamase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female | 1984 |
[Prevention of postoperative anaerobic infections. Economic significance of metronidazole suppositories].
Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Biological Availability; Humans; Injections, Intra | 1984 |
Antibiotic prophylaxis in acute appendicitis.
Topics: Acute Disease; Administration, Oral; Adolescent; Appendectomy; Appendicitis; Clinical Trials as Topi | 1983 |
Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial.
Topics: Clinical Trials as Topic; Humans; Metronidazole; Molar, Third; Pain, Postoperative; Placebos; Plants | 1984 |
[Healing of the sacral wound cavity after abdomino-perineal extirpation of the rectum. A prospective randomized study using metronidazole].
Topics: Abdomen; Clinical Trials as Topic; Humans; Metronidazole; Perineum; Postoperative Complications; Pro | 1984 |
Infection and the use of antibiotics in Crohn's disease.
Topics: Abscess; Anus Diseases; Bacterial Infections; Clinical Trials as Topic; Crohn Disease; Drug Combinat | 1984 |
T-tube suction drainage and/or prophylactic two-dose metronidazole in abdominal hysterectomy.
Topics: Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Dose-Response Relationship, Drug; Femal | 1984 |
[Should preventive antibiotics be prescribed in surgery of the appendix, biliary tract, stomach and duodenum?].
Topics: Anti-Bacterial Agents; Appendectomy; Biliary Tract Surgical Procedures; Cefazolin; Cephalosporins; C | 1983 |
Metronidazole v ampicillin: differing effects on the postoperative recovery.
Topics: Adolescent; Ampicillin; Appendectomy; Appendicitis; Female; Fever; Humans; Male; Metronidazole; Post | 1984 |
Metronidazole prophylaxis in abdominal hysterectomy. A double-blind controlled trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Fever; Humans; Hysterectomy; Metronidazole; P | 1982 |
Prophylactic single-dose metronidazole before abdominal hysterectomy.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Fever; Humans; Hysterectomy; Metronidazole; P | 1982 |
Intravenous prophylactic antimicrobial drugs in elective colorectal operations.
Topics: Anti-Bacterial Agents; Double-Blind Method; Drug Therapy, Combination; Erythromycin; Female; Humans; | 1983 |
The influence of oral versus parenteral preoperative metronidazole on sepsis following colon surgery.
Topics: Administration, Oral; Ascitic Fluid; Bacteria; Bacteroides; Clinical Trials as Topic; Colon; Double- | 1980 |
Prophylactic metronidazole in prevention of infection after appendicectomy: report of a double-blind trial.
Topics: Adolescent; Adult; Appendectomy; Appendicitis; Bacterial Infections; Bacteroides fragilis; Child; Cl | 1980 |
The prophylactic use of metronidazole in caesarean section.
Topics: Bacterial Infections; Cesarean Section; Clinical Trials as Topic; Double-Blind Method; Female; Human | 1980 |
[Antibiotic preparation of the colon or preoperative parenteral prophylaxis in colon surgery. A randomized study].
Topics: Clinical Trials as Topic; Colonic Diseases; Double-Blind Method; Humans; Kanamycin; Metronidazole; P | 1980 |
Preventing anaerobic infection in surgery of the colon.
Topics: Administration, Oral; Aged; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides I | 1981 |
Importance of adding neomycin to metronidazole for bowel preparation.
Topics: Administration, Oral; Aged; Clinical Trials as Topic; Colon; Double-Blind Method; Drug Therapy, Comb | 1980 |
Comparison of systemic prophylaxis with metronidazole-fosfomycin and metronidazole-cephalothin in elective colorectal surgery.
Topics: Anti-Bacterial Agents; Bacterial Infections; Bacteroides; Cephalothin; Clinical Trials as Topic; Col | 1981 |
The management of the perforated appendix: a controlled clinical trial.
Topics: Adult; Aged; Appendectomy; Appendicitis; Clinical Trials as Topic; Drug Administration Schedule; Hum | 1982 |
[Metronidazole prophylaxis in excision of the appendix].
Topics: Appendectomy; Humans; Metronidazole; Postoperative Complications | 1982 |
[Single dose of tinidazole in prevention of post-hysterectomy infections].
Topics: Adult; Bacterial Infections; Drug Resistance, Microbial; Female; Humans; Hysterectomy; Metronidazole | 1980 |
Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery.
Topics: Adult; Aged; Colon; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Metronida | 1980 |
Extraperitonealization for sigmoid volvulus: a reappraisal.
Topics: Adolescent; Adult; Aged; Ampicillin; Colectomy; Drug Therapy, Combination; Elective Surgical Procedu | 1995 |
Topical metronidazole treatment in pouchitis.
Topics: Adenomatous Polyposis Coli; Administration, Topical; Adolescent; Adult; Colitis, Ulcerative; Fatty A | 1994 |
Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis.
Topics: C-Reactive Protein; Chronic Disease; Colitis, Ulcerative; Defecation; Double-Blind Method; Humans; I | 1994 |
Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial.
Topics: Aged; Aged, 80 and over; Bacteria; Ceftriaxone; Drug Therapy, Combination; Female; Gentamicins; Huma | 1993 |
Imipenem prophylaxis in elective colorectal surgery.
Topics: Aged; Bacterial Infections; Cefuroxime; Colon; Female; Humans; Imipenem; Male; Metronidazole; Postop | 1993 |
A prospective randomized study comparing amoxycillin/clavulanate with cefuroxime plus metronidazole for perioperative prophylaxis in gynaecological surgery.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Bacterial Infections; Cefuroxime; | 1993 |
Prophylactic antibiotics in uncomplicated appendicitis during childhood--a prospective randomised study.
Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendicitis; Appendix; Bacterial Infecti | 1995 |
Metronidazole prophylaxis to prevent infections after total abdominal hysterectomy.
Topics: Anti-Infective Agents; Bacterial Infections; Double-Blind Method; Female; Humans; Hysterectomy; Infu | 1998 |
The effect of ranitidine on postoperative infectious complications following emergency colorectal surgery: a randomized, placebo-controlled, double-blind trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cefuroxime; Colonic Diseases; Double-Blind Method; Femal | 1998 |
A brief course of colon preparation with oral antibiotics.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Bacteria; Bacterial Infections; Colectomy; Col | 2000 |
Adjunctive intravaginal metronidazole for the prevention of postcesarean endometritis: a randomized controlled trial.
Topics: Administration, Intravaginal; Adult; Anti-Infective Agents; Cesarean Section; Double-Blind Method; E | 2001 |
[Perioperative antimicrobial prophylaxis for colonic surgery: Present status in Germany. A prospective multicenter study with and without Metronidazole].
Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Bacterial Infections; Ceftriaxone; Cephalospori | 2001 |
Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery.
Topics: Bacterial Infections; Bacteroides Infections; Clinical Trials as Topic; Colon; Gram-Negative Anaerob | 1977 |
Role of intestinal microflora in colonic pseudoobstruction complicating jejunoileal bypass.
Topics: Bacteria; Clinical Trials as Topic; Colonic Diseases; Dilatation, Pathologic; Drug Therapy, Combinat | 1977 |
Multicentre study of 'Flagyl' suppositories in the prevention of post-operative anaerobic infection.
Topics: Abdomen; Adolescent; Adult; Aged; Anaerobiosis; Bacterial Infections; Child; Clinical Trials as Topi | 1978 |
Metronidazole in the prophylaxis of anaerobic infections in gynaecological surgery: a trial.
Topics: Anaerobiosis; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Ge | 1979 |
Single dose metronidazole prophylaxis in gynaecological surgery.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Genital Diseases, Female; Human | 1979 |
Metronidazole in the prevention and treatment of anaerobic sepsis.
Topics: Anaerobiosis; Appendectomy; Bacterial Infections; Cesarean Section; Clinical Trials as Topic; Colon; | 1979 |
Fosfomycin/metronidazole compared with doxycycline/metronidazole for the prophylaxis of infection after elective colorectal surgery. A randomised double-blind multicentre trial in 517 patients.
Topics: Aged; Colon; Double-Blind Method; Doxycycline; Drug Therapy, Combination; Female; Fosfomycin; Humans | 1992 |
Amikacin once daily plus metronidazole versus amikacin twice daily plus metronidazole in colorectal surgery.
Topics: Adult; Aged; Amikacin; Bacterial Infections; Colon; Drug Administration Schedule; Drug Therapy, Comb | 1992 |
Antibiotic prophylaxis for cold coagulation of the cervix?
Topics: Cryosurgery; Female; Humans; Metronidazole; Postoperative Complications; Sulfonamides; Uterine Cervi | 1992 |
Prevention of postcesarean infectious morbidity with a single dose of intravenous metronidazole.
Topics: Adult; Cesarean Section; Endometritis; Female; Humans; Infusions, Intravenous; Metronidazole; Postop | 1991 |
Single dose imipenem-cilastatin compared with three doses of cefuroxime and metronidazole as prophylaxis in elective colorectal surgery: a prospective randomized study.
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Cefuroxime; Cilastatin; Colorectal Neoplasms; | 1991 |
[Comparison of 2 antibiotic combinations used for peritonitis. Cefotaxime-clindamycin versus cefotaxime-metronidazole].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cefotaxime; Clindamycin; Drug Therapy, Combination; Fema | 1991 |
Single-dose prophylaxis in hysterectomies. An interim analysis.
Topics: Anti-Bacterial Agents; Cefuroxime; Double-Blind Method; Drug Administration Schedule; Female; Fever; | 1990 |
Vaginal hysterectomy: cefuroxime, metronidazole or both?
Topics: Adult; Aged; Bacterial Infections; Bacteriuria; Body Fluids; Cefuroxime; Double-Blind Method; Drug T | 1990 |
Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis.
Topics: Adult; Anti-Bacterial Agents; Cefuroxime; Drug Administration Schedule; Drug Therapy, Combination; F | 1990 |
Antibiotic prophylaxis in vaginal hysterectomy. Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin.
Topics: Adult; Aged; Aged, 80 and over; Cefuroxime; Ciprofloxacin; Drug Administration Schedule; Drug Therap | 1990 |
Single dose cefotaxime plus metronidazole versus three dose cefuroxime plus metronidazole as prophylaxis against wound infection in colorectal surgery: multicentre prospective randomised study.
Topics: Adolescent; Adult; Aged; Cefotaxime; Cefuroxime; Colon; Dose-Response Relationship, Drug; Female; Hu | 1990 |
A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover.
Topics: Aztreonam; Bacterial Infections; Cefotaxime; Colon; Drug Therapy, Combination; Gram-Positive Bacteri | 1990 |
Comparison of one dose versus three doses of prophylactic antibiotics, and the influence of blood transfusion, on infectious complications in acute and elective colorectal surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; | 1990 |
Short-term chemoprophylaxis with ceftizoxime vs. five-day aminoglycoside with metronidazole in 'contaminated' lower gastrointestinal surgery.
Topics: Aminoglycosides; Bacterial Infections; Ceftizoxime; Drug Administration Schedule; Humans; Incidence; | 1990 |
Chest infection following head and neck surgery: a pilot study.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Clavulanic Acids; Drug Thera | 1990 |
Prophylactic short course rectal metronidazole for cesarean section. A double-blind controlled trial of a simple low cost regimen.
Topics: Adult; Cesarean Section; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infection Co | 1989 |
Piperacillin for prophylaxis in gynecological surgery.
Topics: Bacterial Infections; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gentamicins; Huma | 1989 |
Design and trial of a metronidazole loading dose regimen for patients undergoing emergency surgery.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Clinical Trials | 1989 |
A randomized trial to compare amoxycillin/clavulanate with metronidazole plus gentamicin in prophylaxis in elective colorectal surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combinati | 1989 |
Effectiveness of two therapeutic antibiotic regimens in the treatment of serious post-operative infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combinati | 1989 |
Single dose prophylactic antibiotics in caesarean sections.
Topics: Adult; Ampicillin; Cesarean Section; Double-Blind Method; Female; Humans; Maternal Age; Metronidazol | 1989 |
Serious postoperative bleeding associated with a single intravenous dose of cefuroxime and metronidazole.
Topics: Aged; Cefuroxime; Cephalosporins; Colonic Neoplasms; Drug Combinations; Female; Gastrointestinal Hem | 1986 |
Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ileostom | 1986 |
A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy.
Topics: Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Cellulitis; Clinical Trials as Topic; Double-Bl | 1987 |
Metronidazole prophylaxis in acute mural appendicitis: failure of a single intra-operative infusion to reduce wound infection.
Topics: Adolescent; Adult; Appendectomy; Child; Drug Evaluation; Female; Humans; Infusions, Intravenous; Int | 1987 |
A multicentre study to compare piperacillin with the combination of netilmicin and metronidazole for prophylaxis in elective colorectal surgery undertaken in district general hospitals.
Topics: Adult; Aged; Bacterial Infections; Colon; Drug Therapy, Combination; Female; Humans; Male; Metronida | 1988 |
Metronidazole vs. erythromycin, neomycin, and cefazolin in prophylaxis for colonic surgery.
Topics: Cefazolin; Colon; Double-Blind Method; Drug Therapy, Combination; Erythromycin; Humans; Injections, | 1989 |
Cefoxitin for one day vs. ampicillin and metronidazole for three days in elective colorectal surgery. A prospective, randomized, multicenter study.
Topics: Aged; Ampicillin; Bacterial Infections; Cefoxitin; Colon; Drug Administration Schedule; Drug Therapy | 1988 |
Comparative clinical and pharmacokinetic aspects of cefotetan versus cefoxitin plus metronidazole in vaginal hysterectomy.
Topics: Adult; Aged; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Cefotetan; Cefoxitin; Cli | 1988 |
Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery.
Topics: Administration, Oral; Bacteroides fragilis; Ceftriaxone; Clinical Trials as Topic; Clostridium; Colo | 1986 |
[Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery].
Topics: Adult; Aged; Bacterial Infections; Female; Humans; Intraoperative Period; Laryngectomy; Male; Metron | 1987 |
A new bowel preparation for elective colon and rectal surgery. A prospective, randomized clinical trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cathartics; Clinical Trials as Topic; Colon; Diet; Enema | 1988 |
[Prevention of postoperative anaerobic bacterial infections in abdominal surgery with metronidazole suppositories].
Topics: Abdomen; Adult; Aged; Bacteria, Anaerobic; Bacterial Infections; Emergencies; Female; Humans; Male; | 1985 |
Failure of single-dose metronidazole prophylaxis in colorectal surgery. No benefit from high dosage or combination with nalidixic acid.
Topics: Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Colon; Drug Therapy, Combination; Femal | 1988 |
Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery. Metronidazole-fosfomycin vs. metronidazole-gentamicin in 381 patients.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Appendicitis; Cholecystitis; Clinical Trials as Topic; Drug | 1987 |
Prophylactic antibiotics in women with a history of pelvic inflammatory disease undergoing first-trimester abortion.
Topics: Abortion, Induced; Anti-Bacterial Agents; Clinical Trials as Topic; Double-Blind Method; Female; Hum | 1987 |
Single-shot antibiotic prophylaxis in colon surgery.
Topics: Bacteria; Ceftizoxime; Clinical Trials as Topic; Colonic Neoplasms; Diverticulitis; Humans; Metronid | 1987 |
One versus three doses of metronidazole/mezlocillin for antibiotic prophylaxis in colon surgery.
Topics: Clinical Trials as Topic; Colonic Diseases; Drug Administration Schedule; Drug Therapy, Combination; | 1987 |
Metronidazole versus placebo in the treatment of gaseous discomfort in patients having an ileostomy. A double-blind cross-over investigation.
Topics: Adult; Colectomy; Double-Blind Method; Female; Flatulence; Humans; Ileostomy; Male; Metronidazole; M | 1988 |
Antibiotics in acute abdominal surgery. A clinical trial comparing the combination of ampicillin, mecillinam and metronidazole with cefoxitin alone.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Amdinocillin; Ampicillin; Cefoxitin; Clinical Trials as Top | 1986 |
A comparison between netilmicin with metronidazole and doxycycline as prophylaxis in elective colorectal surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Colon; Doxycycline; Female; Humans; Male; Metronidazole; | 1986 |
Randomized study of minocycline + gentamicin compared with metronidazole + gentamicin for prophylaxis or treatment of mixed infections in abdominal surgery.
Topics: Abdomen; Adult; Aged; Bacterial Infections; Drug Therapy, Combination; Female; Gentamicins; Humans; | 1986 |
Prophylaxis with whole gut irrigation and antimicrobials in colorectal surgery. A prospective, randomized double-blind clinical trial.
Topics: Adult; Aged; Ampicillin; Anti-Infective Agents; Bacterial Infections; Clinical Trials as Topic; Colo | 1985 |
[Comparative clinical study between Rocephin (Roche) and doxycycline, amoxycillin, erythromycin and amoxycillin + metronidazole combination in gynecology].
Topics: Abscess; Adult; Aged; Amoxicillin; Breast Diseases; Cefotaxime; Ceftriaxone; Clinical Trials as Topi | 1985 |
Peroperative systemic prophylaxis in colorectal surgery.
Topics: Cefuroxime; Cephalosporins; Clinical Trials as Topic; Colon; Double-Blind Method; Drug Evaluation; D | 1985 |
[Rectal versus intravenous metronidazole treatment following perforated appendicitis. A randomized study].
Topics: Adolescent; Aged; Appendectomy; Appendicitis; Child; Child, Preschool; Humans; Injections, Intraveno | 1985 |
160 other studies available for metronidazole and Complication, Postoperative
| Article | Year |
|---|---|
Clinical Significance of Postoperative Antibiotic Treatment for Positive Islet Cultures After Total Pancreatectomy With Islet Autotransplantation.
Topics: Administration, Intravenous; Adult; Anti-Bacterial Agents; Bacterial Infections; Ceftriaxone; Cells, | 2021 |
Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis.
Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Humans; Metronidazole; Pipera | 2022 |
[The importance of microbiological results for the treatment of complicated appendicitis-a monocentric case-control study].
Topics: Ampicillin; Anti-Bacterial Agents; Appendicitis; Case-Control Studies; Cephalosporins; Escherichia c | 2022 |
Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients.
Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; A | 2022 |
Reduction in Rates of Symptomatic Urinary Tract Infection After Pelvic Reconstructive Surgery: A Quality Improvement Analysis.
Topics: Cefazolin; Female; Humans; Metronidazole; Pelvic Organ Prolapse; Plastic Surgery Procedures; Postope | 2022 |
Preventive effect of metronidazole vaginal tablets on vaginal bacteria-related postoperative complications with total laparoscopic hysterectomy.
Topics: Bacteria; Female; Humans; Hysterectomy; Laparoscopy; Metronidazole; Postoperative Complications; Ret | 2023 |
Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole.
Topics: Abdominal Abscess; Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxo | 2023 |
Effect of Augmented Antimicrobial Prophylaxis and Rectal Swab Culture-guided Targeted Prophylaxis on the Risk of Sepsis Following Transrectal Prostate Biopsy.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteriological Techniques; Biopsy; Ciprofloxacin; Ge | 2020 |
Evaluation of prophylactic antibiotics in penetrating brain injuries at an academic level 1 trauma center.
Topics: Academic Medical Centers; Adolescent; Adult; Antibiotic Prophylaxis; Cefazolin; Ceftriaxone; Concurr | 2020 |
Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Carbapenems; | 2020 |
Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment.
Topics: Acute Disease; Advisory Committees; Algorithms; Anti-Bacterial Agents; Biological Products; Budesoni | 2020 |
Intracranial abscess due to Prevotella bivia: First case report from India.
Topics: Anti-Bacterial Agents; Bacteroidaceae Infections; Brain Abscess; Combined Modality Therapy; Humans; | 2020 |
Medication-related osteonecrosis of the jaw: risk factors in patients under biphosphonate versus patients under antiresorptive-antiangiogenic drugs.
Topics: Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Angiogenesis Inhibitors; Ant | 2017 |
Preoperative Vaginal Metronidazole Decreases the Risk of Pelvic Infections After Radical Robotic Hysterectomy.
Topics: Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Female; Female Urogenital Diseases; Genital Ne | 2017 |
The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Appendicitis; Child, Preschool; Combined | 2017 |
Simplification of first-line antibacterial regimen for complicated appendicitis in children is associated with better adherence to guidelines and reduced use of antibiotics.
Topics: Adolescent; Anti-Bacterial Agents; Appendicitis; Cefotaxime; Child; Drug Therapy, Combination; Femal | 2018 |
Calvarial osteomyelitis and intracranial extension post-Mohs micrographic surgery.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Basal Cell; Diagnosis, Differential; Female; Humans; Magneti | 2018 |
Stump Appendicitis Management.
Topics: Administration, Oral; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ciprofloxacin; Female; Huma | 2018 |
Incidence and microbiology of post-operative infections after radical cystectomy and ureteral stent removal; a retrospective cohort study.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Cefazolin; Cystectomy; Enter | 2019 |
Secondary haemophagocytic lymphohistiocytosis associated with metronidazole.
Topics: Abdominal Abscess; Appendectomy; Appendicitis; Child; Dexamethasone; Female; Follow-Up Studies; Huma | 2019 |
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; | 2019 |
Clostridium difficile: A Frequent Infection in Children After Intestinal Transplantation.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Clostridioides difficile; Clostridium In | 2020 |
[Epidemiology of Clostridium difficile-associated disease (CDAD) in Salamanca].
Topics: Aged; Aged, 80 and over; Antacids; Anti-Bacterial Agents; Antineoplastic Agents; Clostridioides diff | 2014 |
[Ameboma: possible therapeutic decisions in an amebiasis-endemic region].
Topics: Abdomen, Acute; Adult; Aged; Appendectomy; Cecal Neoplasms; Colectomy; Combined Modality Therapy; Di | 2015 |
Refractory giardiasis in renal transplantation: a case report.
Topics: Adult; Antiprotozoal Agents; Doxycycline; Drug Therapy, Combination; Giardiasis; Humans; Kidney Tran | 2015 |
Experiences with LESS-appendectomy in Children.
Topics: Abdominal Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefuroxime; Child; | 2016 |
[Fulminant Clostridium difficile colitis].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficile; Colectomy; Enterocol | 2016 |
Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible?
Topics: Anastomotic Leak; Anti-Bacterial Agents; Combined Modality Therapy; Conservative Treatment; Hemorrho | 2016 |
Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion.
Topics: Abscess; Cefotaxime; Child; Dermoid Cyst; Drug Therapy, Combination; Follow-Up Studies; Gram-Negativ | 2008 |
Antibiotics and postoperative abscesses in complicated appendicitis: is there any association?
Topics: Abdominal Abscess; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Female; Hu | 2008 |
Dose related effect of systemic antibiotics in prevention of postoperative intra-abdominal adhesion formation in experimental animals.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Cricetinae; Disease Models, Animal; Inject | 2008 |
[Perianal fistulas in Crohn's disease: treatment results at an interdisciplinary unit].
Topics: Abscess; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; | 2009 |
Clostridium difficile-associated diarrhea in Crohn's disease patients with ostomy.
Topics: Adult; Clostridioides difficile; Colectomy; Crohn Disease; Diarrhea; Enterocolitis, Pseudomembranous | 2010 |
Enteral Clostridium difficile, an emerging cause for high-output ileostomy.
Topics: Adult; Aged; Anti-Bacterial Agents; Clostridioides difficile; Crohn Disease; Enterocolitis, Pseudome | 2009 |
Recurrent cytomegalovirus infection in ileal pouch-anal anastomosis for ulcerative colitis.
Topics: Ciprofloxacin; Colitis, Ulcerative; Colonic Pouches; Cytomegalovirus Infections; Dietary Supplements | 2010 |
[Perioperative acquired long QT syndrome: a case report].
Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Amoxicillin-Potassium Clavulanate Combination; A | 2010 |
Pulmonary toxicity associated with sirolimus following kidney transplantation: computed tomography findings.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bronchoalveolar Lavage Fluid; Diagnosis, Differential; | 2010 |
Lingua villosa nigra.
Topics: Anti-Infective Agents; Antifungal Agents; Candidiasis; Clavulanic Acid; Female; Fluconazole; Humans; | 2011 |
Concurrent postpartum uterine and abdominal wall dehiscence and Streptococcus anginosus infection.
Topics: Abdominal Wall; Acute Disease; Adolescent; Anti-Bacterial Agents; Ascitic Fluid; Cefazolin; Cesarean | 2011 |
Streptococcus milleri in intraabdominal abscesses in children after appendectomy: incidence and course.
Topics: Abdominal Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefuroxime; Child; | 2012 |
Metronidazole prophylaxis before surgical abortion: retrospective review of 51 330 cases.
Topics: Abortion, Induced; Anti-Infective Agents; Antibiotic Prophylaxis; Canada; Chlamydia Infections; Chla | 2012 |
Clinical features and management of pouchitis in Japanese ulcerative colitis patients.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Age of Onset; Aged; Anti-Bacterial Agents; Asian Peop | 2013 |
Appendicitis in children: a ten-year update of therapeutic recommendations.
Topics: Abdominal Abscess; Acute Disease; Adolescent; Ampicillin; Antibiotic Prophylaxis; Appendectomy; Appe | 2003 |
Pharmacokinetics and tissue penetration of pefloxacin plus metronidazole after administration as surgical prophylaxis in colorectal surgery.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteroides fragilis; | 2003 |
Acute appendicitis with fulminant necrotizing fasciitis in a neonate.
Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug | 2003 |
Blastocystis hominis--an emerging cause of diarrhoea in renal transplant recipients.
Topics: Adult; Animals; Anti-Infective Agents; Blastocystis hominis; Blastocystis Infections; Diarrhea; Fece | 2003 |
D-lactic acidosis in a patient after subtotal colectomy.
Topics: Acidosis, Lactic; Adenocarcinoma; Aged; Aged, 80 and over; Anti-Bacterial Agents; Colectomy; Colonic | 2003 |
Fibrin glue treatment of low rectal and pouch-anal anastomotic sinuses.
Topics: Adult; Anastomosis, Surgical; Anti-Infective Agents; Female; Fibrin Tissue Adhesive; Humans; Male; M | 2004 |
Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients.
Topics: Alcoholism; Antibiotic Prophylaxis; Cefuroxime; Cytokines; Female; Humans; Immunity, Cellular; Male; | 2004 |
Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Clinical Com | 2004 |
Thoracic spondylitis from a mycotic (Streptococcus pneumoniae) aortic aneurysm: a case report.
Topics: Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implan | 2004 |
Subdural empyema due to spinal anesthesia.
Topics: Adult; Anesthesia, Spinal; Anti-Bacterial Agents; Anti-Infective Agents; Brain; Ceftriaxone; Cesarea | 2005 |
[Management of perianal fistulizing Crohn's disease: a conservative approach].
Topics: Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Crohn Disease; Fecal Incontinence; | 2005 |
[Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria].
Topics: Aeromonas; Anti-Bacterial Agents; Carcinoma, Signet Ring Cell; Cefotaxime; Gram-Negative Bacterial I | 2006 |
A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient.
Topics: Adult; Antifungal Agents; Brain Abscess; Female; Humans; Immunosuppressive Agents; Kidney Failure, C | 2006 |
Anterior necrotizing scleritis after strabismus surgery in a child.
Topics: Animals; Antiprotozoal Agents; Chloramphenicol; Drug Therapy, Combination; Dysentery, Amebic; Entamo | 2007 |
Clostridium difficile small-bowel enteritis after total proctocolectomy: a rare but fatal, easily missed diagnosis. Report of a case.
Topics: Aged; Anti-Infective Agents; Clostridioides difficile; Enteritis; Enterocolitis, Pseudomembranous; F | 2007 |
Post-appendectomy intra-abdominal abscesses--can they successfully be managed with the sole use of antibiotic therapy?
Topics: Abdominal Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Cefotaxime; Child; Child, Presch | 2007 |
Are routine peritoneal fluid cultures during appendicectomy justified?
Topics: Abdominal Abscess; Abdominal Cavity; Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxi | 2007 |
Polybacterial pyomyositis following laparoscopic colectomy for complicated diverticulosis.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ceftriaxone; Colectomy; Colon, Sigmoid; Diverticulit | 2007 |
Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis | 2007 |
Microbial flora alterations in jejunum and colon after chemical bowel preparation before Kasai hepatoportojejunostomy.
Topics: Anti-Infective Agents; Biliary Atresia; Cholangitis; Colon; Colony Count, Microbial; Drug Therapy, C | 2007 |
Clostridium difficile-associated disease with lethal outcome in a 77-year-old woman. A case report.
Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Cholecy | 2007 |
Amebic appendicitis associated with hepatic abscess.
Topics: Amebiasis; Appendectomy; Appendicitis; Entamoeba histolytica; Entamoebiasis; Humans; Liver Abscess, | 1984 |
Metronidazole and prostaglandin induced abortion.
Topics: Abortion, Induced; Adult; Dilatation and Curettage; Dinoprostone; Female; Humans; Metronidazole; Pos | 1981 |
Pelvic abscess in gynecologic patients.
Topics: Abortion, Induced; Abortion, Spontaneous; Abscess; Adolescent; Adult; Anti-Bacterial Agents; Female; | 1981 |
[Diagnosis and therapy of cancer of the large intestine (author's transl)].
Topics: Aged; Colonic Neoplasms; Colostomy; Female; Humans; Intestinal Obstruction; Male; Metronidazole; Mid | 1982 |
Perioperative antibiotics.
Topics: Administration, Oral; Anti-Bacterial Agents; Cephalosporins; Colon; Humans; Injections, Intradermal; | 1983 |
Rheumatoid arthritis associated with jejunoileal bypass.
Topics: Adult; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Ileum; Jejunum; Metronidazole | 1984 |
[Prevention of serious anaerobic infections].
Topics: Bacteria, Anaerobic; Bacterial Infections; Humans; Intestine, Large; Metronidazole; Postoperative Co | 1984 |
Microbial spectrum and antimicrobial susceptibility in infections after gastrointestinal surgery.
Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Digestive System Surgical Procedures; Doxyc | 1984 |
Management of surgical infections.
Topics: Abscess; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clindamycin; Drainage; Drug T | 1984 |
[Pharmacokinetics of metronidazole during perioperative short-term prophylaxis in cesarean section].
Topics: Bacteroides Infections; Cesarean Section; Female; Humans; Kinetics; Metronidazole; Postoperative Com | 1983 |
[Therapeutic routines in appendectomy. How are they followed in practice?].
Topics: Anti-Bacterial Agents; Appendectomy; Humans; Metronidazole; Postoperative Care; Postoperative Compli | 1984 |
[Neomycin versus plus metronidazol for large bowel preparation in elective colon surgery].
Topics: Colonic Diseases; Drug Therapy, Combination; Female; Humans; Infection Control; Intestine, Large; Ma | 1980 |
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida | 1982 |
Metronidazole and breast feeding.
Topics: Breast Feeding; Cesarean Section; Diarrhea, Infantile; Female; Humans; Infant; Infant, Newborn; Lact | 1980 |
Prospective comparative trial of tinidazole and metronidazole as prophylaxis for elective hysterectomy.
Topics: Adult; Aged; Female; Humans; Hysterectomy; Metronidazole; Middle Aged; Nitroimidazoles; Postoperativ | 1981 |
Symposium on infective endocarditis. III. Endocarditis due to gram-negative bacteria. Report of 56 cases.
Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Valve Prosthesis; H | 1982 |
[Metronidazole in perforated appendicitis. A retrospective study on the effect of metronidazole administered peroperatively].
Topics: Adolescent; Adult; Aged; Appendectomy; Appendicitis; Bacterial Infections; Child; Child, Preschool; | 1982 |
Double-blind trial of perioperative intravenous metronidazole prophylaxis for abdominal hysterectomy.
Topics: Adult; Bacterial Infections; Double-Blind Method; Drug Evaluation; Female; Fever; Humans; Hysterecto | 1982 |
Chemoprophylaxis for major gynaecological and obstetric surgery.
Topics: Bacterial Infections; Cesarean Section; Female; Genitalia, Female; Humans; Metronidazole; Postoperat | 1982 |
Metronidazole treatment of bypass-enteropathy after jejunoileal shunt-operation for obesity.
Topics: Adult; Bacteroides Infections; Enterobacteriaceae Infections; Female; Humans; Ileum; Jejunum; Male; | 1982 |
The aetiology of scrotal sepsis.
Topics: Abscess; Adult; Aged; Bacteria; Genital Diseases, Male; Humans; Male; Metronidazole; Middle Aged; Po | 1982 |
[Preventive administration of metronidazole in gynecologic operations].
Topics: Anaerobiosis; Bacterial Infections; Bacteroides Infections; Female; Humans; Hysterectomy; Metronidaz | 1980 |
Pros and cons of antimicrobial prophylaxis in surgery.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Humans; Metronidazole; Postope | 1981 |
Cefuroxime and metronidazole in gynaecological surgery.
Topics: Bacteria; Cefuroxime; Cephalosporins; Female; Genitalia, Female; Humans; Metronidazole; Postoperativ | 1981 |
[Prevention of anaerobic infections with metronidazole (Klion) in colon surgery].
Topics: Bacterial Infections; Colonic Diseases; Female; Humans; Male; Metronidazole; Middle Aged; Postoperat | 1981 |
Rectal administration of metronidazole provides therapeutic plasma levels in postoperative patients.
Topics: Abdomen; Adult; Aged; Bacterial Infections; Half-Life; Humans; Infusions, Parenteral; Intestinal Abs | 1981 |
Experiences with the EEA stapling instrument for colorectal anastomosis.
Topics: Adult; Aged; Clindamycin; Colectomy; Colon; Colonic Neoplasms; Disposable Equipment; Female; Gentami | 1980 |
Sepsis after bowel surgery.
Topics: Humans; Intestines; Metronidazole; Postoperative Complications; Surgical Wound Infection | 1980 |
Prophylaxis of infection after appendicectomy: a survey of current surgical practice.
Topics: Administration, Topical; Anti-Bacterial Agents; Appendectomy; Bacterial Infections; Drainage; Drug U | 1980 |
[Surgical revision of the pilonidal sinus with single shot antibiosis].
Topics: Abscess; Adult; Bacterial Infections; Drug Therapy, Combination; Humans; Infusions, Intravenous; Mal | 1995 |
[Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases].
Topics: Adult; Aged; Ampicillin; Anastomosis, Surgical; Cameroon; Chloramphenicol; Colon; Combined Modality | 1994 |
Postappendectomy intra-abdominal abscess: a therapeutic approach.
Topics: Abdomen; Abscess; Adolescent; Ampicillin; Appendectomy; Child; Child, Preschool; Drainage; Female; G | 1994 |
Incidence and characteristics of pouchitis in the Kock continent ileostomy and the pelvic pouch.
Topics: Adult; Female; Follow-Up Studies; Humans; Incidence; Inflammation; Intestinal Mucosa; Male; Metronid | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Significant decrease of gram-negative anaerobic bacteremia in a major hospital from 1967-73 to 1981-89: an effect of the introduction of metronidazole?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacteremia; Denmark; Female; Gram-Negative Anaerobic Bac | 1993 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study.
Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infe | 1996 |
[Puerperal ovarian vein thrombosis in a 14-year-old patient after cesarean section for twin pregnancy].
Topics: Adolescent; Cefotiam; Cesarean Section; Combined Modality Therapy; Drug Therapy, Combination; Female | 1996 |
First report of invasive amebiasis in an organ transplant recipient.
Topics: Adult; Animals; Antiprotozoal Agents; Colon; Colonoscopy; Dysentery, Amebic; Entamoeba histolytica; | 1997 |
Postoperative urinary tract infections (UTIs) following single-dose intraoperative antibiotic prophylaxis in colposuspension patients.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Antibiotic Prophylaxi | 1998 |
Early discharge after appendicectomy in children.
Topics: Adolescent; Anti-Infective Agents; Appendectomy; Brazil; Child; Child, Preschool; Female; Humans; Le | 1999 |
[Intra- and peri-renal gas formation. Bilateral emphysematous pyelonephritis].
Topics: Aged; Combined Modality Therapy; Fatal Outcome; Female; Humans; Imipenem; Kidney; Lumbar Vertebrae; | 1999 |
[Conservative therapy of fistulas of the anorectal area in Crohn disease].
Topics: Crohn Disease; Humans; Immunosuppressive Agents; Metronidazole; Postoperative Complications; Prognos | 1999 |
Trimethoprim-sulphamethoxazole and metronidazole as prophylaxis in colorectal surgery: a study of bioavailability after an oral single dose.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Biological Availability; Colorectal Surger | 2001 |
Infectious complications following abdominal hysterectomy in Karachi, Pakistan.
Topics: Anti-Infective Agents; Antibiotic Prophylaxis; Cefazolin; Cephalosporins; Communicable Diseases; Fem | 2001 |
Bacteroides fragilis vertebral osteomyelitis secondary to anal dilatation.
Topics: Adolescent; Bacteroides fragilis; Bacteroides Infections; Dilatation; Fissure in Ano; Humans; Low Ba | 2001 |
[Pseudomembranous colitis after pristinamycin].
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Enterocolitis, Pseudomembrano | 2001 |
[Current principles of the use of laparoscopic surgery in gastroduodenal ulcer].
Topics: Antacids; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; Duode | 2001 |
The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model.
Topics: Animals; Anti-Infective Agents; Cefepime; Cephalosporins; Fibrosis; Injections, Intramuscular; Metro | 2001 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
Retroperitoneal sepsis complicating stapled hemorrhoidectomy: report of a case and review of the literature.
Topics: Adult; Anti-Infective Agents; Cefuroxime; Cephalosporins; Hemorrhoids; Humans; Male; Metronidazole; | 2002 |
[Bacteroides fragilis septicemia].
Topics: Adult; Aged; Bacteroides fragilis; Bacteroides Infections; Female; Humans; Male; Metronidazole; Midd | 1977 |
Simplified antibiotic prophylaxis for vaginal hysterectomy.
Topics: Adult; Aged; Ampicillin; Bacterial Infections; Female; Fever; Humans; Hysterectomy; Hysterectomy, Va | 1979 |
[Anaerobic septicemia in surgery].
Topics: Adult; Aged; Bacterial Infections; Digestive System Surgical Procedures; Drug Resistance, Microbial; | 1979 |
Treatment of infections due to nonsporing anaerobes.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Brain Diseases; Cefoxitin; Clindamycin; G | 1979 |
The use of metronidazole in the preparation of the bowel for surgery.
Topics: Colon; Drug Therapy, Combination; Humans; Metronidazole; Postoperative Complications; Preoperative C | 1977 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
Pelvic sepsis after hysterectomy.
Topics: Bacterial Infections; Female; Humans; Hysterectomy; Hysterectomy, Vaginal; Metronidazole; Pelvis; Po | 1977 |
Colonic pseudo-obstruction: a new complication of jejunoileal bypass.
Topics: Adult; Clindamycin; Colon; Colonic Diseases; Diagnosis, Differential; Dilatation, Pathologic; Humans | 1975 |
Pseudomembranous colitis following resection for Hirschsprung's disease.
Topics: Administration, Rectal; Child, Preschool; Clostridioides difficile; Enterocolitis, Pseudomembranous; | 1992 |
[Experience with rectal application of Klion in man].
Topics: Appendectomy; Drug Industry; Humans; Hungary; Metronidazole; Postoperative Complications; Suppositor | 1992 |
[Acanthamoeba keratitis caused by extended wear contact lenses].
Topics: Acanthamoeba Keratitis; Administration, Oral; Aged; Cataract Extraction; Contact Lenses, Extended-We | 1992 |
Contaminated fistula following J-pouch ileoanal reservoir. Treatment with a collagen sponge containing gentamicin and metronidazole. Case report.
Topics: Anal Canal; Anastomosis, Surgical; Bacterial Infections; Bone Diseases; Collagen; Female; Gentamicin | 1991 |
Fibrin adhesive in the treatment of perineal fistulas.
Topics: Administration, Topical; Adult; Aged; Cefotaxime; Drug Therapy, Combination; Female; Fibrin Tissue A | 1991 |
Klion infusion for controlling surgical and other bacterial gynaecological febrile complications.
Topics: Adult; Bacterial Infections; Female; Genital Diseases, Female; Humans; Hungary; Incidence; Infusions | 1991 |
Management of focal intracranial infections: is medical treatment better than surgery?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Brain Abscess; Cause of Death; Ceftriaxone; Combined Modal | 1990 |
[Perioperative prophylaxis in patients with head and neck tumors].
Topics: Bacterial Infections; Cefuroxime; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans | 1991 |
[Surgical treatment of amebic liver abscess].
Topics: Combined Modality Therapy; Drainage; Emetine; Humans; Liver Abscess, Amebic; Metronidazole; Mexico; | 1990 |
Pouchitis and gastric hyposecretion: cause or effect?
Topics: Adenomatous Polyposis Coli; Adult; Anal Canal; Anastomosis, Surgical; Cimetidine; Colitis, Ulcerativ | 1990 |
Typhoid perforation: further experience with end-to-side ileotransverse colostomy.
Topics: Adult; Colostomy; Female; Humans; India; Intestinal Perforation; Male; Metronidazole; Postoperative | 1990 |
[Prophylactic administration of Klion in acute appendicitis].
Topics: Acute Disease; Appendicitis; Child; Female; Humans; Male; Metronidazole; Postoperative Complications | 1990 |
[Single preoperative intravenous dose of metronidazole for appendectomy in children].
Topics: Appendectomy; Child; Female; Humans; Infections; Infusions, Intravenous; Male; Metronidazole; Postop | 1990 |
[Ofloxacin and metronidazole in short-term prophylaxis of septic complications after hepatocholedochal surgery].
Topics: Aged; Aged, 80 and over; Biliary Tract Surgical Procedures; Drug Therapy, Combination; Female; Human | 1989 |
Use of cefuroxime in preventing postcesarean infection in high-risk patients.
Topics: Bacterial Infections; Cefadroxil; Cefuroxime; Cephalosporins; Cesarean Section; Drug Therapy, Combin | 1989 |
Single dose mezlocillin versus three dose cefuroxime plus metronidazole for prophylaxis in large bowel surgery.
Topics: Cefotaxime; Colon; Drug Therapy, Combination; Humans; Infection Control; Metronidazole; Mezlocillin; | 1988 |
[The role of metronidazole in the treatment of anaerobic infections].
Topics: Bacteria, Anaerobic; Bacterial Infections; Humans; Metronidazole; Microbial Sensitivity Tests; Posto | 1988 |
Clinical studies of 4 methods of bowel preparation in colorectal surgery.
Topics: Adult; Child; Child, Preschool; Colon; Humans; Infant; Infection Control; Infections; Metronidazole; | 1986 |
[Comparison of a combination of clindamycin/gentamycin with metronidazole/gentamycin in surgery of the head and neck].
Topics: Clindamycin; Drug Therapy, Combination; Gentamicins; Head and Neck Neoplasms; Humans; Infection Cont | 1988 |
[Long-term experience with rectal administration of metronidazole in the treatment of perforated appendicitis].
Topics: Abdomen; Abscess; Adolescent; Adult; Appendicitis; Child; Female; Humans; Intestinal Perforation; Ma | 1988 |
Clinical implications of metronidazole antianaerobic prophylaxis in major head and neck surgical procedures.
Topics: Bacteria, Anaerobic; Bacterial Infections; Head; Humans; Metronidazole; Neck; Postoperative Complica | 1988 |
Chlamydia trachomatis: is it possible to reduce the number of infections after abortions?
Topics: Abortion, Induced; Adult; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, C | 1988 |
Disulfiram-like reaction associated with intravenous trimethoprim-sulfamethoxazole and metronidazole.
Topics: Adolescent; Disulfiram; Drug Combinations; Drug Interactions; Humans; Male; Metronidazole; Postopera | 1986 |
Open study of different perioperative prophylactic regimens with mezlocillin/metronidazole in proctectomy.
Topics: Aged; Drug Therapy, Combination; Female; Humans; Male; Metronidazole; Mezlocillin; Postoperative Com | 1987 |
Dip slide culture of intraoperative peritoneal irrigation fluid for prediction of septic complication in elective colorectal surgery.
Topics: Bacteria; Bacterial Infections; Bacteriological Techniques; Bacteroidaceae; Colon; Enterobacteriacea | 1986 |
Tobramycin dosing in the puerperal patient.
Topics: Cesarean Section; Drug Therapy, Combination; Endometritis; Female; Humans; Kinetics; Metronidazole; | 1987 |
Ceftriaxone and metronidazole as single-dose prophylaxis in colorectal surgery.
Topics: Administration, Oral; Bacterial Infections; Ceftriaxone; Colon; Drug Therapy, Combination; Erythromy | 1987 |
Microbial flora in the bypassed jejunum of patients with biliopancreatic bypass for obesity.
Topics: Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Diarrhea; Female; Humans; Jejunoileal Bypass; Jejunum | 1987 |
[Rectal administration of metronidazole in the prevention of suppurative complications after appendectomy].
Topics: Adolescent; Adult; Appendectomy; Bacteria, Anaerobic; Bacterial Infections; Humans; Metronidazole; M | 1986 |
Abdominal actinomycosis.
Topics: Abscess; Actinomycosis; Appendectomy; Appendicitis; Child; Combined Modality Therapy; Humans; Male; | 1986 |
One row anastomosis in colonic operations with antibiotic prophylaxis.
Topics: Adolescent; Adult; Aged; Colon; Colonic Neoplasms; Diverticulitis, Colonic; Humans; Metronidazole; M | 1985 |
Aseptic rituals unmasked.
Topics: Cesarean Section; Female; Humans; Metronidazole; Postoperative Complications; Pregnancy | 1985 |
[Antibiotic prophylaxis in biliary surgery. Indications and results].
Topics: Bacterial Infections; Biliary Tract Surgical Procedures; Cholecystitis; Cholestasis; Drug Administra | 1985 |
Absorption of metronidazole suppositories in patients with postoperative ileus.
Topics: Absorption; Adult; Aged; Bacterial Infections; Female; Humans; Intestinal Obstruction; Male; Metroni | 1985 |
Clostridium difficile colitis following head and neck surgery. Report of cases.
Topics: Aged; Anti-Bacterial Agents; Clostridium Infections; Diarrhea; Enterocolitis, Pseudomembranous; Head | 1985 |
Comparative pharmacokinetics of metronidazole and tinidazole and their tissue penetration.
Topics: Adult; Aged; Colonic Diseases; Humans; Infusions, Parenteral; Metronidazole; Middle Aged; Nitroimida | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis.
Topics: Administration, Oral; Bacteroides; Bacteroides Infections; Carrier State; Female; Follow-Up Studies; | 1974 |