metronidazole has been researched along with Obesity in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The influence of obesity on the pharmacokinetics of metronidazole was similar (Cmax 8." | 4.02 | Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid. ( Dietrich, A; Dorn, C; Kees, F; Kees, MG; Kloft, C; Kratzer, A; Petroff, D; Simon, P; Stoelzel, M; Wrigge, H; Zeitlinger, M, 2021) |
| "Surgical site infection was diagnosed in 13 women (6." | 2.84 | Effect of Post-Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial. ( Boldt, M; DeArmond, C; DeFranco, E; Evans, AT; Gold, A; Houston, JM; Masters, HR; Reddy, S; Valent, AM; Warshak, CR, 2017) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| You, Y | 1 |
| Wang, L | 1 |
| Ai, C | 1 |
| Huang, L | 1 |
| Wang, S | 1 |
| Wang, Z | 1 |
| Song, S | 1 |
| Zhu, B | 1 |
| Tara, F | 2 |
| Danesteh, S | 2 |
| Rezaee, M | 2 |
| Geraylow, KR | 2 |
| Moodi Ghalibaf, A | 2 |
| Moeindarbari, S | 2 |
| Laudanno, O | 1 |
| Ahumarán, G | 1 |
| Gollo, P | 1 |
| Khoury, M | 1 |
| Thomé, M | 1 |
| González, P | 1 |
| Dorn, C | 1 |
| Petroff, D | 1 |
| Stoelzel, M | 1 |
| Kees, MG | 1 |
| Kratzer, A | 1 |
| Dietrich, A | 1 |
| Kloft, C | 1 |
| Zeitlinger, M | 1 |
| Kees, F | 1 |
| Wrigge, H | 1 |
| Simon, P | 1 |
| Valent, AM | 1 |
| DeArmond, C | 1 |
| Houston, JM | 1 |
| Reddy, S | 1 |
| Masters, HR | 1 |
| Gold, A | 1 |
| Boldt, M | 1 |
| DeFranco, E | 1 |
| Evans, AT | 1 |
| Warshak, CR | 1 |
| Soto, M | 1 |
| Herzog, C | 1 |
| Pacheco, JA | 1 |
| Fujisaka, S | 1 |
| Bullock, K | 1 |
| Clish, CB | 1 |
| Kahn, CR | 1 |
| Zarrinpar, A | 1 |
| Chaix, A | 1 |
| Xu, ZZ | 1 |
| Chang, MW | 1 |
| Marotz, CA | 1 |
| Saghatelian, A | 1 |
| Knight, R | 1 |
| Panda, S | 1 |
| Batista, N | 1 |
| Fernández, MP | 1 |
| Gambra, ML | 1 |
| Rodríguez, L | 1 |
| López, NJ | 1 |
| Quintero, A | 1 |
| Casanova, PA | 1 |
| Ibieta, CI | 1 |
| Baelum, V | 1 |
| López, R | 1 |
| Selgrad, M | 1 |
| Bornschein, J | 1 |
| Malfertheiner, P | 1 |
| Lo, M | 1 |
| Reid, M | 1 |
| Brokenshire, M | 1 |
| Drenick, EJ | 5 |
| Bassett, LW | 1 |
| Stanley, TM | 1 |
| Fisler, J | 1 |
| Johnson, D | 1 |
| Paerregaard, A | 1 |
| Justesen, T | 1 |
| Prytz, H | 1 |
| Andersen, B | 1 |
| Gudmand-Hoeyer, E | 1 |
| Wollman, JS | 1 |
| Ament, ME | 1 |
| Finegold, SM | 2 |
| Passaro, E | 1 |
| Barry, RE | 1 |
| Benfield, JR | 1 |
| Nicell, P | 1 |
| Bray, GA | 1 |
| Prakash, G | 1 |
| Wexler, H | 1 |
| DeLucia, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery[NCT01194115] | 475 participants (Anticipated) | Interventional | 2010-09-30 | Enrolling by invitation | |||
| Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients[NCT04179006] | 120 participants (Anticipated) | Interventional | 2019-11-14 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Obesity
| Article | Year |
|---|---|
[Helicobacter pylori: an infection with local complications and systemic effects].
Topics: Amoxicillin; Anemia, Iron-Deficiency; Anti-Bacterial Agents; Asthma; Clarithromycin; Cross-Sectional | 2011 |
3 trials available for metronidazole and Obesity
14 other studies available for metronidazole and Obesity
| Article | Year |
|---|---|
Anti-obesity effects of
Topics: Animals; Bacteroidetes; Diet, High-Fat; Gastrointestinal Microbiome; Laminaria; Metronidazole; Mice; | 2022 |
Tailored Helicobacter pylori eradication therapy in obese patients undergoing bariatric surgery.
Topics: Amoxicillin; Anti-Bacterial Agents; Bariatric Surgery; Drug Therapy, Combination; Helicobacter Infec | 2021 |
Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Extracellular Fluid; Humans; Metronidazole | 2021 |
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.
Topics: Animals; Anti-Bacterial Agents; Anxiety; Brain; Diet, High-Fat; Gastrointestinal Microbiome; Inflamm | 2018 |
Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.
Topics: Amphotericin B; Ampicillin; Animals; Anti-Bacterial Agents; Bile Acids and Salts; Blood Glucose; Bod | 2018 |
[Fournier's gangrene caused by Streptococcus agalactiae in a non-pregnant woman].
Topics: Adult; Anti-Bacterial Agents; Clindamycin; Combined Modality Therapy; Debridement; Diabetes Mellitus | 2009 |
Resistance of Trichomonas vaginalis infections to metronidazole in Auckland sexual health clinics: report of two cases.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Ambulatory Care Facilities; Animals; Anti | 2002 |
Rheumatoid arthritis associated with jejunoileal bypass.
Topics: Adult; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Ileum; Jejunum; Metronidazole | 1984 |
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida | 1982 |
Metronidazole treatment of bypass-enteropathy after jejunoileal shunt-operation for obesity.
Topics: Adult; Bacteroides Infections; Enterobacteriaceae Infections; Female; Humans; Ileum; Jejunum; Male; | 1982 |
Treatment of proctitis after jejunoileal bypass operations.
Topics: Diarrhea; Female; Humans; Ileum; Jejunum; Male; Metronidazole; Obesity; Proctitis | 1980 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
Colonic pseudo-obstruction: a new complication of jejunoileal bypass.
Topics: Adult; Clindamycin; Colon; Colonic Diseases; Diagnosis, Differential; Dilatation, Pathologic; Humans | 1975 |
Microbial flora in the bypassed jejunum of patients with biliopancreatic bypass for obesity.
Topics: Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Diarrhea; Female; Humans; Jejunoileal Bypass; Jejunum | 1987 |