metronidazole has been researched along with Rhinophyma in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rhinophyma: A manifestation of severe ROSACEA resulting in significant enlargement of the NOSE and occurring primarily in men. It is caused by hypertrophy of the SEBACEOUS GLANDS and surrounding CONNECTIVE TISSUE. The nose is reddened and marked with TELANGIECTASIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rosacea is one of the most common chronic dermatological diseases." | 2.46 | [Rosacea: pathogenesis, clinical forms and therapy]. ( Kárpáti, S; Preisz, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gross, H | 1 |
| Preisz, K | 1 |
| Kárpáti, S | 1 |
1 review available for metronidazole and Rhinophyma
| Article | Year |
|---|---|
[Rosacea: pathogenesis, clinical forms and therapy].
Topics: Administration, Cutaneous; Administration, Oral; Anti-Infective Agents; Anti-Infective Agents, Local | 2010 |
1 other study available for metronidazole and Rhinophyma
| Article | Year |
|---|---|
[Sunscreen, antibiotics, laser. What can you do against rosacea?].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Child; Contraindications; Dermatologic Agents; Doxyc | 2009 |