metronidazole has been researched along with Colorectal Cancer in 27 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of our study was to evaluate the impact of metronidazole (MTZ) on DLD-1 colorectal cancer cell (CRC) line." | 7.79 | Metronidazole decreases viability of DLD-1 colorectal cancer cell line. ( Car, H; Cechowska-Pasko, M; Krętowski, R; Sadowska, A; Szynaka, B, 2013) |
| "Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colorectal cancer, with the vast majority (80-90%) of liver metastases unresponsive to curative resection at first." | 7.30 | A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer. ( Dong, DH; Gao, RQ; Ji, G; Li, XH; Mo, ZC; Wang, WD; Yang, XS; Yu, PF; Zhou, HK, 2023) |
| "The aim of our study was to evaluate the impact of metronidazole (MTZ) on DLD-1 colorectal cancer cell (CRC) line." | 3.79 | Metronidazole decreases viability of DLD-1 colorectal cancer cell line. ( Car, H; Cechowska-Pasko, M; Krętowski, R; Sadowska, A; Szynaka, B, 2013) |
| "Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colorectal cancer, with the vast majority (80-90%) of liver metastases unresponsive to curative resection at first." | 3.30 | A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer. ( Dong, DH; Gao, RQ; Ji, G; Li, XH; Mo, ZC; Wang, WD; Yang, XS; Yu, PF; Zhou, HK, 2023) |
| "Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F." | 2.72 | Fusobacterium nucleatum and oral cancer: a critical review. ( Craig, SG; James, JA; Linden, GJ; Lundy, FT; McIlvanna, E, 2021) |
| "We compared postoperative wound infection rates in 221 colorectal surgery patients randomized to receive systemic gentamicin/metronidazole with (Group I, n = 107) or without (Group II, n = 114) the gentamicin-collagen sponge." | 2.68 | Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge. ( Nijhuis, PH; Rutten, HJ, 1997) |
| "The files of individuals who underwent colorectal cancer surgery at the University Hospital Brandenburg an der Havel (Germany) between 2009 and 2017 were analyzed." | 1.91 | Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients. ( Haller, IE; Heisler, S; Helmke, C; Hunger, R; Kirbach, J; Kobelt, E; Lünse, S; Mantke, R; Meyer, J; Paasch, C; Schildberg, C, 2023) |
| "OAs significantly reduce SSI in colorectal cancer surgery." | 1.91 | Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial a ( Arita, T; Fujiwara, H; Ikoma, H; Kiuchi, J; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Nanishi, K; Ohashi, T; Otsuji, E; Shimizu, H; Shiozaki, A; Takaki, W; Yamamoto, Y, 2023) |
| "Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery." | 1.72 | Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection. ( Araújo, A; Leão, P; Martins, A; Neves, NM; Oliveira, A; Reis, RL; Rodrigues, LC; Silva, CS, 2022) |
| " Severe obese patients need higher dosage of antibiotics." | 1.34 | [Use of antibiotics in colorectal surgery in Denmark]. ( Frimodt-Møller, N; Jensen, TG; Madsen, H; Pedersen, C; Qvist, N; Salomon, S, 2007) |
| "A model of colorectal cancer liver metastases in male inbred CBA mice was used." | 1.31 | Interstitial laser hyperthermia for colorectal liver metastases: the effect of thermal sensitization and the use of a cylindrical diffuser tip on tumor necrosis. ( Christophi, C; Malcontenti-Wilson, C; Muralidharan, V, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 11 (40.74) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 7 (25.93) | 2.80 |
| Authors | Studies |
|---|---|
| McIlvanna, E | 1 |
| Linden, GJ | 1 |
| Craig, SG | 1 |
| Lundy, FT | 1 |
| James, JA | 1 |
| Oliveira, A | 1 |
| Araújo, A | 1 |
| Rodrigues, LC | 1 |
| Silva, CS | 1 |
| Reis, RL | 1 |
| Neves, NM | 1 |
| Leão, P | 1 |
| Martins, A | 1 |
| Paasch, C | 1 |
| Schildberg, C | 1 |
| Lünse, S | 1 |
| Heisler, S | 1 |
| Meyer, J | 1 |
| Kirbach, J | 1 |
| Kobelt, E | 1 |
| Hunger, R | 1 |
| Haller, IE | 1 |
| Helmke, C | 1 |
| Mantke, R | 1 |
| Kiuchi, J | 1 |
| Kuriu, Y | 1 |
| Arita, T | 1 |
| Shimizu, H | 1 |
| Nanishi, K | 1 |
| Takaki, W | 1 |
| Ohashi, T | 1 |
| Konishi, H | 1 |
| Yamamoto, Y | 1 |
| Morimura, R | 1 |
| Shiozaki, A | 1 |
| Ikoma, H | 1 |
| Kubota, T | 1 |
| Fujiwara, H | 1 |
| Otsuji, E | 1 |
| Wang, M | 1 |
| Li, Y | 1 |
| Yang, X | 1 |
| Liu, Z | 1 |
| Wang, K | 1 |
| Gong, D | 1 |
| Li, J | 1 |
| Gao, RQ | 1 |
| Mo, ZC | 1 |
| Zhou, HK | 1 |
| Yu, PF | 1 |
| Wang, WD | 1 |
| Dong, DH | 1 |
| Yang, XS | 1 |
| Li, XH | 1 |
| Ji, G | 1 |
| Sethi, S | 1 |
| Puri, A | 1 |
| Sachdeva, S | 1 |
| Dalal, A | 1 |
| Bullman, S | 1 |
| Pedamallu, CS | 1 |
| Sicinska, E | 1 |
| Clancy, TE | 1 |
| Zhang, X | 1 |
| Cai, D | 1 |
| Neuberg, D | 1 |
| Huang, K | 1 |
| Guevara, F | 1 |
| Nelson, T | 1 |
| Chipashvili, O | 1 |
| Hagan, T | 1 |
| Walker, M | 1 |
| Ramachandran, A | 1 |
| Diosdado, B | 1 |
| Serna, G | 1 |
| Mulet, N | 1 |
| Landolfi, S | 1 |
| Ramon Y Cajal, S | 1 |
| Fasani, R | 1 |
| Aguirre, AJ | 1 |
| Ng, K | 1 |
| Élez, E | 1 |
| Ogino, S | 1 |
| Tabernero, J | 1 |
| Fuchs, CS | 1 |
| Hahn, WC | 1 |
| Nuciforo, P | 1 |
| Meyerson, M | 1 |
| Sadowska, A | 1 |
| Krętowski, R | 1 |
| Szynaka, B | 1 |
| Cechowska-Pasko, M | 1 |
| Car, H | 1 |
| Hata, H | 1 |
| Yamaguchi, T | 2 |
| Hasegawa, S | 1 |
| Nomura, A | 1 |
| Hida, K | 1 |
| Nishitai, R | 1 |
| Yamanokuchi, S | 1 |
| Yamanaka, T | 1 |
| Sakai, Y | 1 |
| Ikeda, A | 1 |
| Konishi, T | 1 |
| Ueno, M | 1 |
| Fukunaga, Y | 1 |
| Nagayama, S | 1 |
| Fujimoto, Y | 1 |
| Akiyoshi, T | 1 |
| Yabata, E | 1 |
| Okabe, S | 1 |
| Endo, M | 1 |
| Muralidharan, V | 1 |
| Malcontenti-Wilson, C | 1 |
| Christophi, C | 1 |
| Espin-Basany, E | 1 |
| Sanchez-Garcia, JL | 1 |
| Lopez-Cano, M | 1 |
| Lozoya-Trujillo, R | 1 |
| Medarde-Ferrer, M | 1 |
| Armadans-Gil, L | 1 |
| Alemany-Vilches, L | 1 |
| Armengol-Carrasco, M | 1 |
| Salomon, S | 1 |
| Jensen, TG | 1 |
| Qvist, N | 1 |
| Frimodt-Møller, N | 1 |
| Pedersen, C | 1 |
| Madsen, H | 1 |
| Rau, BK | 1 |
| Harikrishnan, KM | 1 |
| Krishna, S | 1 |
| AhChong, K | 1 |
| Yip, AW | 1 |
| Lee, FC | 1 |
| Chiu, KM | 1 |
| Menzel, J | 1 |
| Bauer, J | 1 |
| von Pritzbuer, E | 1 |
| Klempa, I | 1 |
| Rutten, HJ | 1 |
| Nijhuis, PH | 1 |
| Zelenitsky, SA | 1 |
| Silverman, RE | 1 |
| Duckworth, H | 1 |
| Harding, GK | 1 |
| Löhde, E | 1 |
| Scholz, L | 1 |
| Gemperle, A | 1 |
| Langmark, H | 1 |
| Hopfenmüller, W | 1 |
| Abri, O | 1 |
| Kraas, E | 1 |
| Lumley, JW | 1 |
| Siu, SK | 1 |
| Pillay, SP | 1 |
| Stitz, R | 1 |
| Kemp, RJ | 1 |
| Faoagali, J | 1 |
| Nathanson, LK | 1 |
| White, S | 1 |
| Pacelli, F | 1 |
| Brisinda, G | 1 |
| Bellantone, R | 1 |
| Doglietto, GB | 1 |
| Crucitti, F | 1 |
| Tsimoyiannis, EC | 1 |
| Paizis, JB | 1 |
| Kabbani, K | 1 |
| Lekkas, ET | 1 |
| Floras, GA | 1 |
| Boulis, SA | 1 |
| Nøhr, M | 1 |
| Andersen, JC | 1 |
| Juul-Jensen, KE | 1 |
| Sachar, DB | 1 |
| Lewis, RT | 1 |
| Goodall, RG | 1 |
| Marien, B | 1 |
| Lloyd-Smith, W | 1 |
| Park, M | 1 |
| Wiegand, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rectal Microbiome Variability Among Rectal Cancer Cohorts Including Complete Clinical Responders, Pathologic Responders, and Early Recurrence[NCT04223102] | 40 participants (Anticipated) | Interventional | 2020-02-18 | Active, not recruiting | |||
| PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090] | Phase 4 | 268 participants (Actual) | Interventional | 2020-10-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Colorectal Cancer
| Article | Year |
|---|---|
Fusobacterium nucleatum and oral cancer: a critical review.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Cell Movement; Cell Proliferation; Col | 2021 |
15 trials available for metronidazole and Colorectal Cancer
| Article | Year |
|---|---|
A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer.
Topics: Colorectal Neoplasms; Double-Blind Method; Humans; Incidence; Liver Neoplasms; Metronidazole; Prospe | 2023 |
Oral and Parenteral Versus Parenteral Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery (JMTO PREV 07-01): A Phase 3, Multicenter, Open-label, Randomized Trial.
Topics: Aged; Antibiotic Prophylaxis; Cefmetazole; Colorectal Neoplasms; Elective Surgical Procedures; Femal | 2016 |
Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Antib | 2016 |
A prospective, randomized clinical trial of preoperative bowel preparation for elective colorectal surgery--comparison among oral, systemic, and intraoperative luminal antibacterial preparations.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophy | 1997 |
Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics?
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic | 2005 |
Comparison of prophylactic ampicillin/sulbactam with gentamicin and metronidazole in elective colorectal surgery: a randomized clinical study.
Topics: Adult; Aged; Aged, 80 and over; Ampicillin; Colon; Colorectal Neoplasms; Colostomy; Drug Therapy, Co | 1994 |
[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].
Topics: Aged; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Cefoxitin; Colitis, Ulcerative; Colon | 1993 |
Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Collagen; Colorectal | 1997 |
A prospective, randomized, double-blind studyof single high dose versus multiple standard dose gentamicin both in combination withmetronidazole for colorectal surgicalprophylaxis.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Colorectal Neoplasms; Di | 2000 |
[Comparative analysis of mezlocillin/metronidazole and amoxicillin/clavulanic acid as "one shot" preventive antibiotic administration in colorectal interventions].
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Clavulanic Acid; Clavulanic Acid | 1992 |
Single dose ceftriaxone as prophylaxis for sepsis in colorectal surgery.
Topics: Cefazolin; Ceftriaxone; Colon; Colorectal Neoplasms; Double-Blind Method; Female; Humans; Male; Metr | 1992 |
Single dose imipenem-cilastatin compared with three doses of cefuroxime and metronidazole as prophylaxis in elective colorectal surgery: a prospective randomized study.
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Cefuroxime; Cilastatin; Colorectal Neoplasms; | 1991 |
Short-term antibiotic prophylaxis in elective colorectal surgery.
Topics: Aged; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Ceftriaxone; Colorectal Neoplasms; Cost | 1991 |
Prophylactic single-dose fosfomycin and metronidazole compared with neomycin, bacitracin, metronidazole and ampicillin in elective colorectal operations.
Topics: Adult; Aged; Aged, 80 and over; Ampicillin; Bacitracin; Colorectal Neoplasms; Dose-Response Relation | 1990 |
Is neomycin necessary for bowel preparation in surgery of the colon? Oral neomycin plus erythromycin versus erythromycin-metronidazole.
Topics: Administration, Oral; Aged; Bacteria, Anaerobic; Clinical Trials as Topic; Colon; Colorectal Neoplas | 1989 |
11 other studies available for metronidazole and Colorectal Cancer
| Article | Year |
|---|---|
Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection.
Topics: Anti-Bacterial Agents; Bacteria; Chitosan; Colorectal Neoplasms; Drug Delivery Systems; Escherichia | 2022 |
Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cefuroxime; Colorectal Neoplas | 2023 |
Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial a
Topics: Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Colorectal Neoplasms; Cross-Sec | 2023 |
Effects of metronidazole on colorectal cancer occurrence and colorectal cancer liver metastases by regulating Fusobacterium nucleatum in mice.
Topics: Animals; Colorectal Neoplasms; DNA; Fusobacterium Infections; Fusobacterium nucleatum; Ki-67 Antigen | 2023 |
Erythrophagocytosis in colonic mucosa: real-time amazing display.
Topics: Adult; Amebiasis; Antiprotozoal Agents; Colorectal Neoplasms; Gastrointestinal Hemorrhage; Humans; I | 2020 |
Analysis of
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Bacteroides; Carcinogenesis; Colorectal Neoplasms; F | 2017 |
Metronidazole decreases viability of DLD-1 colorectal cancer cell line.
Topics: Anti-Infective Agents; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Cell Survival | 2013 |
Interstitial laser hyperthermia for colorectal liver metastases: the effect of thermal sensitization and the use of a cylindrical diffuser tip on tumor necrosis.
Topics: Animals; Colorectal Neoplasms; Hyperthermia, Induced; Laser Therapy; Liver Neoplasms, Experimental; | 2002 |
[Use of antibiotics in colorectal surgery in Denmark].
Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cefuroxime; Colore | 2007 |
Nd-YAG laser therapy for palliation of obstructed colorectal carcinomas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Fema | 1994 |
1989 Henry Baker lecture. Inflammatory bowel disease: back to the future.
Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Awards and Prizes; Colorectal Neoplasms; Gastroentero | 1990 |