| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Congenital Zika Syndrome
[description not available] | 0 | 2.25 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.28 | 5 | 0 |
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME. | 0 | 2.25 | 1 | 0 |
Bovine Diseases
[description not available] | 0 | 3.8 | 1 | 1 |
Innate Inflammatory Response
[description not available] | 0 | 3.8 | 1 | 1 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 3.8 | 1 | 1 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 7.76 | 16 | 4 |
Amino Acid Metabolism Disorders, Inborn
[description not available] | 0 | 8.05 | 13 | 3 |
Hyperammonemia
Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA. | 1 | 12.7 | 56 | 2 |
Fetal Growth Restriction
[description not available] | 0 | 3.68 | 8 | 0 |
Ovine Diseases
[description not available] | 0 | 2.59 | 2 | 0 |
Fetal Growth Retardation
Failure of a FETUS to attain expected GROWTH. | 0 | 3.68 | 8 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 4.77 | 3 | 2 |
Inborn Urea Cycle Disorder
[description not available] | 0 | 6.13 | 10 | 0 |
Urea Cycle Disorders, Inborn
Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, NEONATAL HYPOTONIA; RESPIRATORY ALKALOSIS; HYPERAMMONEMIA; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for ENCEPHALOPATHIES, METABOLIC, INBORN; and RESPIRATORY ALKALOSIS due to HYPERAMMONEMIA. | 0 | 6.13 | 10 | 0 |
Coma
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION. | 0 | 2.72 | 3 | 0 |
Chronic Illness
[description not available] | 0 | 3.09 | 1 | 0 |
Acidemia Propionic
[description not available] | 0 | 9.74 | 14 | 4 |
Child Development Deviations
[description not available] | 0 | 3.09 | 1 | 0 |
Developmental Disabilities
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed) | 0 | 3.09 | 1 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 3.09 | 1 | 0 |
Propionic Acidemia
Autosomal recessive metabolic disorder caused by mutations in PROPIONYL-COA CARBOXYLASE genes that result in dysfunction of branch chain amino acids and of the metabolism of certain fatty acids. Neonatal clinical onset is characterized by severe metabolic acidemia accompanied by hyperammonemia, HYPERGLYCEMIA, lethargy, vomiting, HYPOTONIA; and HEPATOMEGALY. Survivors of the neonatal onset propionic acidemia often show developmental retardation, and intolerance to dietary proteins. Late-onset form of the disease shows mild mental and/or developmental retardation, sometimes without metabolic acidemia. | 1 | 11.74 | 14 | 4 |
Birth Weight
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms. | 0 | 5.1 | 3 | 1 |
Malnourishment
[description not available] | 0 | 2.17 | 1 | 0 |
Malnutrition
An imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement. | 0 | 2.17 | 1 | 0 |
Fish Diseases
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates). | 0 | 2.21 | 1 | 0 |
Liver Dysfunction
[description not available] | 0 | 2.45 | 2 | 0 |
Diseases, Metabolic
[description not available] | 0 | 4.8 | 2 | 1 |
Liver Diseases
Pathological processes of the LIVER. | 0 | 2.45 | 2 | 0 |
Metabolic Diseases
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed) | 0 | 4.8 | 2 | 1 |
Deficiency Disease, Ornithine Carbamoyltransferase
[description not available] | 0 | 2.42 | 2 | 0 |
Lethargy
A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION. | 0 | 2.08 | 1 | 0 |
Emesis
[description not available] | 0 | 2.43 | 2 | 0 |
Vomiting
The forcible expulsion of the contents of the STOMACH through the MOUTH. | 0 | 2.43 | 2 | 0 |
Ornithine Carbamoyltransferase Deficiency Disease
An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50) | 0 | 2.42 | 2 | 0 |
E coli Infections
[description not available] | 0 | 2.08 | 1 | 0 |
Swine Diseases
Diseases of domestic swine and of the wild boar of the genus Sus. | 0 | 2.08 | 1 | 0 |
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI. | 0 | 2.08 | 1 | 0 |
Carbamoyl Phosphate Synthase (Ammonia) Deficiency Disease
[description not available] | 0 | 5.12 | 3 | 1 |
Carbamoyl-Phosphate Synthase I Deficiency Disease
A urea cycle disorder manifesting in infancy as lethargy, emesis, seizures, alterations of muscle tone, abnormal eye movements, and an elevation of serum ammonia. The disorder is caused by a reduction in the activity of hepatic mitochondrial CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA). (Menkes, Textbook of Child Neurology, 5th ed, pp50-1) | 0 | 5.12 | 3 | 1 |
Fetal Resorption
The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS). | 0 | 2.11 | 1 | 0 |
Disbacteriosis
[description not available] | 0 | 2.13 | 1 | 0 |
Orphan Diseases
Rare diseases that have not been well studied. | 0 | 2.49 | 2 | 0 |
Metabolic Acidosis
[description not available] | 0 | 2.05 | 1 | 0 |
BCKD Deficiency
[description not available] | 0 | 2.05 | 1 | 0 |
Acidosis
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up. | 0 | 2.05 | 1 | 0 |
Maple Syrup Urine Disease
An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a maple syrup odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936) | 0 | 2.05 | 1 | 0 |
Deficiency, Vitamin B 12
[description not available] | 0 | 2.05 | 1 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 2.73 | 3 | 0 |
Vitamin B 12 Deficiency
A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848) | 0 | 2.05 | 1 | 0 |
Hepatic Failure
[description not available] | 0 | 2.06 | 1 | 0 |
Liver Failure
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed) | 0 | 2.06 | 1 | 0 |
Brain Diseases, Metabolic, Familial
[description not available] | 0 | 2.01 | 1 | 0 |
Psychoses
[description not available] | 0 | 2.01 | 1 | 0 |
Psychotic Disorders
Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994) | 0 | 2.01 | 1 | 0 |
Infant, Newborn, Diseases
Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts. | 0 | 2.02 | 1 | 0 |
Inborn Errors of Metabolism
[description not available] | 0 | 2.41 | 2 | 0 |
Metabolism, Inborn Errors
Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero. | 1 | 4.41 | 2 | 0 |
Weight Gain
Increase in BODY WEIGHT over existing weight. | 0 | 3.42 | 1 | 1 |
Compensatory Hyperinsulinemia
A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin. | 0 | 1.99 | 1 | 0 |
Fasting Hypoglycemia
HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast. | 0 | 1.99 | 1 | 0 |
Hyperinsulinism
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS. | 0 | 1.99 | 1 | 0 |
Hypoglycemia
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH. | 0 | 1.99 | 1 | 0 |
Brain Disorders
[description not available] | 0 | 2.94 | 4 | 0 |
Pyrexia
[description not available] | 0 | 1.99 | 1 | 0 |
Paralysis, Legs
[description not available] | 0 | 1.99 | 1 | 0 |
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. | 0 | 2.94 | 4 | 0 |
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process. | 0 | 1.99 | 1 | 0 |
Paraplegia
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness. | 0 | 1.99 | 1 | 0 |
Cirrhosis, Liver
[description not available] | 0 | 2 | 1 | 0 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 2 | 1 | 0 |
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure. | 0 | 2 | 1 | 0 |
Complication, Postoperative
[description not available] | 0 | 2.25 | 1 | 0 |
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. | 0 | 2.25 | 1 | 0 |
Argininosuccinate Synthase Deficiency Disease
[description not available] | 0 | 2.17 | 1 | 0 |
Citrullinemia
A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49) | 0 | 7.17 | 1 | 0 |
Encephalopathy, Toxic
[description not available] | 0 | 3.44 | 2 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 2.17 | 1 | 0 |
Absence Seizure
[description not available] | 0 | 2.1 | 1 | 0 |
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. | 0 | 2.1 | 1 | 0 |