metronidazole has been researched along with Shock, Septic in 25 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was withdrawn and agranulocytosis improved within three days." | 5.27 | [Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985) |
| " in cases of abdominal and puerperal sepsis necessitates addition of a lincomycin or metronidazole." | 3.65 | Septicaemia. ( , 1975) |
| "Septic shock was defined as the presence of severe sepsis plus hypotension not reversed with fluid resuscitation." | 2.77 | Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome. ( Conti-Patara, A; Cortopassi, SR; de Araújo Caldeira, J; de Carvalho, Hda S; de Mattos-Junior, E; de Oliveira, CM; Faustino, M; Francisco Talib, MS; Patara, M; Pedron, BG; Reinoldes, A, 2012) |
| "Various complications are reported with Clostridium difficile infection (CDI), including fulminant CDI." | 1.46 | Cecal Perforation Associated with Clostridium difficile Infection: A Case Report. ( Luthe, SK; Sato, R, 2017) |
| "Severe and severe/complicated Clostridium difficile infection (CDI) can result in ICU admission, sepsis, toxic megacolon and death." | 1.42 | Faecal microbiota transplantation plus selected use of vancomycin for severe-complicated Clostridium difficile infection: description of a protocol with high success rate. ( Cook, GK; Fischer, M; Rex, DK; Robb, BW; Rogers, NA; Sipe, BW; Vuppalanchi, R, 2015) |
| "Lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels." | 1.36 | [Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome]. ( Braunbeck, A; Daecke, W; Fiebig, C; Geiger, EV; Maier, M; Marzi, I; Weber, R, 2010) |
| "Histologic examination confirmed Crohn's disease that was associated with vasculitis and, in particular, with thrombophlebitis and subsequent transmural bowel necrosis." | 1.32 | [Pylephlebitis with air in the portal vein system. An unusual focus in a patient with sepsis]. ( Gocht, A; Hahn, KE; Kluge, S; Kreymann, G; Lund, CH, 2003) |
| "We present three cases of toxic shock syndrome secondary to (GAS) myositis demonstrating the importance of early recognition and provision of intensive care management." | 1.31 | Toxic shock syndrome and streptococcal myositis: three case reports. ( Vyas, H; Watkins, R, 2002) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| "There seems to be an increase in septicemia and the development of shock after infection by streptococci." | 1.28 | [Gram positive septicemia]. ( Dahl, V; Johnstad, B, 1990) |
| "Metronidazole was withdrawn and agranulocytosis improved within three days." | 1.27 | [Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goret, NE | 1 |
| Goret, CC | 1 |
| Kulkarni, SS | 1 |
| Teoh, WH | 1 |
| Sia, AT | 1 |
| Nair, S | 1 |
| Lai, MJ | 1 |
| Chiueh, TS | 1 |
| Huang, ZY | 1 |
| Lin, JC | 1 |
| Fischer, M | 2 |
| Sipe, BW | 1 |
| Rogers, NA | 1 |
| Cook, GK | 1 |
| Robb, BW | 1 |
| Vuppalanchi, R | 1 |
| Rex, DK | 1 |
| Kerhuel, L | 1 |
| Valade, S | 1 |
| Donay, JL | 1 |
| Canet, E | 1 |
| Luthe, SK | 1 |
| Sato, R | 1 |
| Braunbeck, A | 1 |
| Geiger, EV | 1 |
| Weber, R | 1 |
| Maier, M | 1 |
| Daecke, W | 1 |
| Fiebig, C | 1 |
| Marzi, I | 1 |
| Harji, DP | 1 |
| Rastall, S | 1 |
| Catchpole, C | 1 |
| Bright-Thomas, R | 1 |
| Thrush, S | 1 |
| Lee, JW | 1 |
| Kim, TS | 1 |
| Jung, JW | 1 |
| Park, SB | 1 |
| Lee, HJ | 1 |
| Lee, DG | 1 |
| Lee, JN | 1 |
| Lee, SH | 1 |
| Conti-Patara, A | 1 |
| de Araújo Caldeira, J | 1 |
| de Mattos-Junior, E | 1 |
| de Carvalho, Hda S | 1 |
| Reinoldes, A | 1 |
| Pedron, BG | 1 |
| Patara, M | 1 |
| Francisco Talib, MS | 1 |
| Faustino, M | 1 |
| de Oliveira, CM | 1 |
| Cortopassi, SR | 1 |
| Watkins, R | 1 |
| Vyas, H | 1 |
| Kluge, S | 1 |
| Hahn, KE | 1 |
| Lund, CH | 1 |
| Gocht, A | 1 |
| Kreymann, G | 1 |
| Lodha, A | 1 |
| Wales, PW | 1 |
| James, A | 1 |
| Smith, CR | 1 |
| Langer, JC | 1 |
| Serra, T | 1 |
| González de Cárdenas, M | 1 |
| Plovins, J | 1 |
| Ballesteros, A | 1 |
| Vindel, A | 1 |
| Sáez-Nieto, JA | 1 |
| Karjagin, J | 1 |
| Pähkla, R | 1 |
| Karki, T | 1 |
| Starkopf, J | 1 |
| Kim, KA | 1 |
| Wry, P | 1 |
| Hughes, E | 1 |
| Butcher, J | 1 |
| Barbot, D | 1 |
| Vallent, K | 1 |
| Bodnár, A | 1 |
| Weltner, J | 1 |
| Schneider, GT | 1 |
| Stern, M | 1 |
| Althoff, PH | 1 |
| Zeitoun, IM | 1 |
| Dhanarajani, PJ | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Johnstad, B | 1 |
| Dahl, V | 1 |
| Martin, C | 1 |
| Ruperti, A | 1 |
| Saux, P | 1 |
| Brioche, MI | 1 |
| Gouin, F | 1 |
3 reviews available for metronidazole and Shock, Septic
| Article | Year |
|---|---|
Splenic abscess is extremely rare after amoebic dysentery. A case report and review of the literature.
Topics: Abscess; Adult; Amebicides; Anti-Bacterial Agents; Bacteremia; Combined Modality Therapy; Cross Infe | 2019 |
Pseudomonal breast infection.
Topics: Abscess; Anti-Bacterial Agents; Ciprofloxacin; Drug Therapy, Combination; Female; Humans; Mastitis; | 2010 |
Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature.
Topics: Adult; Amikacin; Fatal Outcome; Focal Infection, Dental; Humans; Ludwig's Angina; Male; Mediastinal | 1995 |
2 trials available for metronidazole and Shock, Septic
| Article | Year |
|---|---|
Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cephalothin; Dog Diseases; Dogs; Dopamine; Female; Fluid | 2012 |
[Experience with intravenous metronidazole administration in the preoperative care of surgery of the large intestine].
Topics: Colon; Drug Therapy, Combination; Gentamicins; Humans; Infusions, Parenteral; Metronidazole; Premedi | 1983 |
20 other studies available for metronidazole and Shock, Septic
| Article | Year |
|---|---|
Ruptured uterine artery pseudoaneurysm: an overlooked cause of late postpartum haemorrhage.
Topics: Aneurysm, False; Aneurysm, Ruptured; Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Cesa | 2013 |
The first Clostridium difficile ribotype 027 strain isolated in Taiwan.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Chemoradiotherapy; Clostridioides difficile; | 2016 |
Faecal microbiota transplantation plus selected use of vancomycin for severe-complicated Clostridium difficile infection: description of a protocol with high success rate.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infecti | 2015 |
Angina, back pain and septic shock.
Topics: Amoxicillin; Angina, Unstable; Anti-Bacterial Agents; Back Pain; Fusobacterium necrophorum; Humans; | 2017 |
Cecal Perforation Associated with Clostridium difficile Infection: A Case Report.
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Colectomy; Colon; Con | 2017 |
[Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome].
Topics: Abscess; Acromioclavicular Joint; Anti-Bacterial Agents; Cellulitis; Combined Modality Therapy; Diag | 2010 |
[A case of liver abscess and bacteremia caused by Vibrio cholerae non-O1].
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Ceftriaxone; Humans; Liver Abscess; Male; Metronidazole; Sh | 2011 |
Toxic shock syndrome and streptococcal myositis: three case reports.
Topics: Anti-Bacterial Agents; Child, Preschool; Clindamycin; Critical Care; Female; Humans; Immunoglobulins | 2002 |
[Pylephlebitis with air in the portal vein system. An unusual focus in a patient with sepsis].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anticoagulants; Cefotaxime; Crohn Disease; Diag | 2003 |
Acute appendicitis with fulminant necrotizing fasciitis in a neonate.
Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug | 2003 |
[Three cases of Yersinia pseudotuberculosis gastrointestinal infection having no apparent epidemiological relationship, caused by identical strains].
Topics: Abdominal Pain; Adult; Amoxicillin; Bacterial Typing Techniques; Child; Diarrhea; Doxycycline; Drug | 2005 |
Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro.
Topics: Adult; Aged; Area Under Curve; Bacteroides fragilis; Humans; Male; Metronidazole; Microdialysis; Mid | 2005 |
Clostridium difficile small-bowel enteritis after total proctocolectomy: a rare but fatal, easily missed diagnosis. Report of a case.
Topics: Aged; Anti-Infective Agents; Clostridioides difficile; Enteritis; Enterocolitis, Pseudomembranous; F | 2007 |
Vaginal infections. How to identify and treat them.
Topics: Adolescent; Adult; Candidiasis; Child; Chlamydia Infections; Female; Haemophilus Infections; Herpes | 1983 |
[Severe infection by methicillin-resistant staphylococci after insertion of PEG].
Topics: Aged; Aged, 80 and over; Enteral Nutrition; Female; Gastrostomy; Gentamicins; Humans; Injections, In | 1995 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
Septicaemia.
Topics: Cefazolin; Cephaloridine; Cephalothin; Cephradine; Clindamycin; Drug Resistance, Microbial; Flucytos | 1975 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
[Gram positive septicemia].
Topics: Adolescent; Adult; Female; Humans; Metronidazole; Norway; Penicillins; Sepsis; Shock, Septic; Strept | 1990 |
[Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole].
Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Bone Marrow Examination; Drug Therapy, Combination; F | 1985 |