metronidazole has been researched along with Hemorrhage in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metronidazole and fluconazole inhibit the metabolism of warfarin by blocking cytochrome P-450 2C9 (CYP-2C9), the major metabolic pathway of warfarin, with the end result being dramatic increases in patients' international normalized ratios (INRs) and potentially fatal bleeding." | 4.91 | Three Serious Drug Interactions that Every Dentist Should Know About. ( Hersh, EV; Moore, PA, 2015) |
| "Fingating wounds always present a management challenge." | 2.43 | Assessment and management of fungating wounds: a review. ( Wilson, V, 2005) |
| "Various complications are reported with Clostridium difficile infection (CDI), including fulminant CDI." | 1.46 | Cecal Perforation Associated with Clostridium difficile Infection: A Case Report. ( Luthe, SK; Sato, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Powers, A | 1 |
| Loesch, EB | 1 |
| Weiland, A | 1 |
| Fioravanti, N | 1 |
| Lucius, D | 1 |
| Tanaka, K | 1 |
| Fujiya, M | 1 |
| Sakatani, A | 1 |
| Fujibayashi, S | 1 |
| Nomura, Y | 1 |
| Ueno, N | 1 |
| Kashima, S | 1 |
| Goto, T | 1 |
| Sasajima, J | 1 |
| Moriichi, K | 1 |
| Okumura, T | 1 |
| Hersh, EV | 1 |
| Moore, PA | 1 |
| Luthe, SK | 1 |
| Sato, R | 1 |
| Amini, M | 1 |
| Tajik, A | 1 |
| Norhafizah, M | 1 |
| Malina, O | 1 |
| Rukman, AH | 1 |
| Lee, BR | 1 |
| Ngah, ZY | 1 |
| Wan, OA | 1 |
| Jamal, F | 1 |
| Wilson, V | 1 |
| Gray, B | 1 |
| Harper, WF | 1 |
| Still, RM | 1 |
| Morris, DL | 1 |
| Fabricius, PJ | 1 |
| Ambrose, NS | 1 |
| Scammell, B | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 1 |
| Kolko, A | 1 |
| Kiselman, R | 1 |
| Russ, G | 1 |
| Bacques, O | 1 |
| Kleinknecht, D | 1 |
| Vaughan-Scott, T | 1 |
| Lobetti, RG | 1 |
| Bates, G | 1 |
| Tucker, RL | 1 |
| Ford, S | 1 |
| Mattix, ME | 1 |
| Kazmier, FJ | 1 |
2 reviews available for metronidazole and Hemorrhage
| Article | Year |
|---|---|
Three Serious Drug Interactions that Every Dentist Should Know About.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Cytochrome P-450 | 2015 |
Assessment and management of fungating wounds: a review.
Topics: Administration, Topical; Alginates; Anti-Infective Agents; Bandages; Charcoal; Community Health Nurs | 2005 |
1 trial available for metronidazole and Hemorrhage
| Article | Year |
|---|---|
A high incidence of bleeding is observed in a trial to determine whether addition of metronidazole is needed with latamoxef for prophylaxis in colorectal surgery.
Topics: Adult; Aged; Clinical Trials as Topic; Colon; Drug Therapy, Combination; Hemorrhage; Humans; Metroni | 1984 |
10 other studies available for metronidazole and Hemorrhage
| Article | Year |
|---|---|
Preemptive warfarin dose reduction after initiation of sulfamethoxazole-trimethoprim or metronidazole.
Topics: Adult; Aged; Aged, 80 and over; Female; Hemorrhage; Humans; International Normalized Ratio; Male; Me | 2017 |
Second-line therapy for Helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis.
Topics: Abdominal Pain; Aged; Amoxicillin; Biopsy; Colitis; Colon; Colonoscopy; Female; Gastrointestinal Hem | 2017 |
Cecal Perforation Associated with Clostridium difficile Infection: A Case Report.
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Colectomy; Colon; Con | 2017 |
Oral and intravenous eradication of Helicobacter pylori.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Bismuth; Female; Helicobacter Infec | 2009 |
Oh dear ... it's amoebic colitis.
Topics: Adult; Antiprotozoal Agents; Dysentery, Amebic; Female; Hemorrhage; Humans; Metronidazole; Middle Ag | 2011 |
The effect of metronidazole therapy on cervical histology in trichomoniasis.
Topics: Edema; Epithelium; Female; Hemorrhage; Humans; Hyperplasia; Leukocytes; Metronidazole; Trichomonas V | 1967 |
Acute renal failure due to bilateral ureteral hematomas complicating anticoagulant therapy.
Topics: Acute Kidney Injury; Aged; Female; Hematoma; Hemorrhage; Humans; Metronidazole; Ureteral Diseases; W | 1993 |
Boomslang envenomation in a dog.
Topics: Amoxicillin; Animals; Antivenins; Dog Diseases; Dogs; Hemorrhage; Male; Metronidazole; Penicillins; | 1995 |
Thyroid adenocarcinoma in a bald eagle (Haliaeetus leukocephalus).
Topics: Adenocarcinoma; Animals; Antitrichomonal Agents; Bird Diseases; Eagles; Female; Hemorrhage; Metronid | 1999 |
A significant interaction between metronidazole and warfarin.
Topics: Adult; Drug Interactions; Female; Hemorrhage; Humans; Metronidazole; Warfarin | 1976 |