Anterior Ischemic Optic Neuropathy

Synonym
Ischemic Optic Neuropathy
Nonarteritic Anterior Ischemic Optic Neuropathy
Optic Neuropathy, Anterior Ischemic
Optic Nerve Ischemia
Optic Neuropathy, Posterior Ischemic
Optic Ischaemic Neuropathy
Optic Ischemic Neuropathy
Anterior Ischemic Optic Neuropathy
Posterior Ischemic Optic Neuropathy
NAION

Excerpt	Reference
"Anterior ischemic optic neuropathy is the most common cause of persistent monocular visual loss in persons over the age of 50."	( Fern, R; Ransom, BR, 1997)
"Nonarteritic ischemic optic neuropathy is characterized by acute, unilateral visual loss that is usually complete at onset, with resolution of disk edema over several weeks."	( Fraunfelder, FT; Macaluso, DC; Shults, WT, 1999)
"The mechanism of ischemic optic neuropathy is not clear, but it could be related to the fact that the ophthalmic and central retinal arteries have an autoregulation of their own blood flow without any autonomic nerve supply; vasoreactivity could be lower albeit efficient, and therefore more vulnerable to systemic modifications of the circulation."	( Di Pietro, R; Fodale, V; Santamaria, S, 2007)
"NAION is the second most common acquired optic neuropathy in men aged 50 years and older."	( Bella, AJ; Brant, WO; Brock, GB; Lue, TF, 2006)
"Ischemic optic neuropathy is caused by ischemia of the optic nerve head in the region of the lamina cribrosa."	( Unsöld, R, 2008)
"Anterior ischemic optic neuropathy is an uncommon complication of interferon treatment."	( Amrani, N; Benaïssa, A; Kabbaj, N; Mohammadi, M; Sentissi, S, 2009)
"Non-arteritic ischemic optic neuropathy is still a relatively rare complication with a poor functional prognosis, often requiring discontinuation of treatment."	( Bargach, T; Chatioui, S; Elasri, F; Iferkhass, S; Khoyaali, A; Oubaaz, A; Reda, K, 2015)
"Non-arteritic anterior ischemic optic neuropathy is one of the most common conditions affecting the optic nerve in the elderly."	( Cerovski, B; Kordić, R; Mrazovac, D; Perić, S; Vidović, T, 2015)
"Ischemic optic neuropathy is a well-recognized cause of blindness in humans and should be included as a differential diagnosis for acute prechiasmatic blindness in dogs."	( De Risio, L; Dominguez, E; Mari, L; Oliver, J; Premont, J; Stavinohova, R, 2018)

Excerpt	Reference
"Anterior ischemic optic neuropathy has rarely been reported in this condition, and only in conjunction with other ophthalmic findings."	( Fox, AJ; Nicolle, DA; Schmidt, MH, 1997)
"Recently, NAION has been associated with the use of phosphodiesterase type 5 inhibitors (PDE5i) in men with erectile dysfunction (ED)."	( Hatzimouratidis, K, 2007)
"NAION has been associated with PDE5i therapy in adults, but to the best of our knowledge it is almost unheard of in children."	( Biban, P; Cristofaletti, A; Gaffuri, M; Mansoldo, C, 2014)

Excerpt	Reference
"Two patients with non-arteritic anterior ischemic optic neuropathy due to a high-grade ophthalmic artery stenosis were treated with HBO at 2 atm abs in an effort to increase oxygen delivery for the eye."	( Bojić, L; Gosović, G; Ivanisević, M, 2002)
"The visual outcome in untreated nonarteritic anterior ischemic optic neuropathy (NAION) is dismal."	( Avci, R; Gelisken, O; Guler, K; Kaderli, B; Yucel, A, 2007)
"Careful interdisciplinary work up in NAION frequently reveals previously unrecognized diseases requiring treatment according to internal medicine standards."	( Unsöld, R, 2008)
"We treated a patient with anterior ischemic optic neuropathy caused by peginterferon."	( Kitagawa, C; Kiuchi, K; Miyashiro, M, 2009)
"Bilateral anterior ischemic optic neuropathy caused by interferon therapy was diagnosed."	( Kitagawa, C; Kiuchi, K; Miyashiro, M, 2009)
"We identified 23 additional cases of NAION during interferon alpha therapy."	( Berg, KT; Harrison, AR; Lee, MS; McLoon, LK; Nelson, B, 2010)
"In non-arteritic anterior ischemic optic neuropathy (NA-AION), no treatments have demonstrated to be effective in recovering visual loss in randomized clinical trials."	( Arndt, C; Brugniart, C; Ducasse, A; Garcia, T; Radoi, C, 2014)
"Treatment within 15 days of onset of NAION with levodopa improved central visual acuity by an average of 6 lines on Snellen acuity chart."	( Johnson, LN; Lyttle, DP; Madsen, RW; Margolin, EA, 2016)
"The management of nonarteritic anterior ischemic optic neuropathy centers around prevention of second eye involvement, without a uniformly accepted therapy for the involved eye."	( Arnhold, E; Ávila, MP; McCulley, TJ; Paula, AC; Pereira, LS; Salustiano, LX, 2018)
"Under the impression of NAION with branch retinal artery occlusion, the patient was treated with intravenous and intravitreal injection of corticosteroids."	( He, MS; Yang, YY, 2019)
"Non-arteritic anterior ischemic optic neuropathy (NAION) causes a sudden loss of vision and lacks effective treatment."	( Kapupara, K; Lin, W; Liu, PK; Tai, M; Tsai, RK; Wen, YT, 2020)
"Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of vision loss but no treatment has demonstrated its efficiency."	( Arndt, C; Denoyer, A; Durbant, E; Garcia, T; Radoi, C, 2021)
"Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common type of ischemic optic neuropathy (ION); however, there are still no effective or safe treatment options to date."	( Chien, JY; Chou, YY; Ciou, JW; Huang, SP, 2022)
"Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of blindness in individuals over 50 years of age, with no available effective treatment."	( Chiquet, C; Flet, L; Gohier, P; Heron, E; Lehmann, A; Milea, D; Pepin, JL; Quesada, JL; Rougier, MB; Roustit, M; Thuret, G; Vignal, C, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	54 (12.83)	12.5806
2000's	193 (45.84)	18.1394
2010's	138 (32.78)	28.8240
2020's	36 (8.55)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
chlorine	low	1	0
salicylic acid	low	1	0
glycine	low	1	0
dalteparin	low	2	0
nitrates	low	1	0
nitrous oxide	low	2	0
pyridoxal phosphate	low	1	0
2,3-piperidinedicarboxylic acid	low	1	0
4-aminopyridine	low	1	0
acetazolamide	low	4	0
alfuzosin	low	1	0
pimagedine	low	1	0
amiodarone	low	12	0
amlodipine	low	3	0
aspirin	low	22	0
atenolol	low	1	0
betaxolol	low	2	0
candesartan	low	1	0
cyclofenil	low	1	0
dapsone	low	1	0
disulfiram	low	1	0
fentanyl	low	1	0
glyburide	low	1	0
1-(5-isoquinolinesulfonyl)-2-methylpiperazine	low	1	0
fasudil	low	1	0
ethidium	low	1	0
hydralazine	low	1	0
ibuprofen	low	1	0
amrinone	low	1	0
isoflurane	low	1	0
isoniazid	low	1	0
2-propanol	low	2	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	low	1	0
memantine	low	2	0
metronidazole	low	1	0
nifedipine	low	2	0
niflumic acid	low	1	0
omeprazole	low	4	0
oxymetazoline	low	1	0
pentoxifylline	medium	3	1
phenoxybenzamine	low	1	0
phentermine	low	1	0
4-phenylbutyric acid	low	1	0
potassium chloride	low	1	0
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	low	1	0
propidium	low	1	0
risperidone	low	1	0
succinylcholine	low	1	0
prednisolone	medium	28	4
prednisone	low	33	0
alanine	low	1	0
aspartic acid	low	1	0
adenosine diphosphate	low	1	0
phenylephrine	low	1	0
levodopa	medium	9	3
methicillin	low	1	0
methionine	low	1	0
threonine	low	1	0
arginine	low	1	0
perflutren	low	2	0
triamcinolone acetonide	medium	13	2
methylprednisolone	medium	40	2
quinoxalines	medium	8	1
ergotamine	low	1	0
fluocortolone	medium	1	1
quinazolines	low	1	0
fluorometholone	low	1	0
dihydroergotamine	low	1	0
methamphetamine	low	1	0
hematoporphyrin	low	1	0
erythromycin	low	1	0
cytidine diphosphate choline	medium	3	2
ethambutol	low	2	0
durapatite	low	1	0
arsenic trioxide	low	1	0
d-alpha tocopherol	low	2	0
vincamine	low	1	0
fluorescein	low	2	0
methylprednisolone hemisuccinate	low	1	0
fluorescein-5-isothiocyanate	low	1	0
iodinated glycerol	low	1	0
n-methylaspartate	low	1	0
gadolinium	low	1	0
trolamine salicylate	low	1	0
cresyl violet	low	1	0
triamcinolone	medium	4	1
glutamic acid	low	2	0
timolol	low	3	0
tramadol	low	2	0
ribavirin	low	9	0
diltiazem	low	1	0
propiconazole	low	16	0
simvastatin	low	2	0
finasteride	low	1	0
anisodamine	low	1	0
fluorodeoxyglucose f18	low	2	0
zoledronic acid	low	1	0
tocophersolan	low	1	0
fibrinogen	medium	3	2
homocysteine	low	5	0
carbidopa, levodopa drug combination	medium	1	1
vitamin b 6	low	1	0
bosentan anhydrous	medium	1	1
tadalafil	low	11	0
imatinib mesylate	low	1	0
anisodine	low	1	0
3-(2,2,2-trimethylhydrazine)propionate	low	1	0
methotrexate	low	5	0
dihydroethidium	low	1	0
tamsulosin	low	1	0
cinacalcet	low	1	0
biotin	low	1	0
carboplatin	low	1	0
elastin	low	1	0
pentazocine	low	1	0
vinpocetine	low	1	0
tacrolimus	low	4	0
prostaglandin d2	low	3	0
enclomiphene	low	1	0
D-fructopyranose	low	2	0
thiopental	low	1	0
u 0126	low	1	0
2',3'-dialdehyde atp	low	1	0
myelin basic protein	low	1	0
dinoprostone	low	1	0
dinoprost	low	1	0
alprostadil	low	2	0
9-deoxy-delta-9-prostaglandin d2	low	3	0
astaxanthine	low	1	0
coenzyme q10	low	1	0
uf 021	low	1	0
travoprost	low	1	0
topiramate	low	1	0
bimatoprost	low	1	0
cloprostenol	low	2	0
iloprost	low	1	0
latanoprost	low	1	0
ag-490	low	1	0
butylidenephthalide	low	1	0
arsenic	low	1	0
lisinopril	low	2	0
puerarin	low	1	0
cysteine	low	1	0
pregabalin	low	2	0
carbocyanines	low	1	0
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	low	1	0
tetrodotoxin	low	2	0
mocetinostat	low	1	0
arl-67156	low	1	0
cystathionine	low	1	0
phenobarbital sodium	low	1	0
brimonidine tartrate	medium	9	1
losartan potassium	medium	8	2
indocyanine green	low	4	0
pituitrin	low	1	0
jaw	low	1	0
angiotensinogen	low	1	0
endothelin-1	low	17	0
ubiquinone	low	1	0
sodium nitrite	low	1	0
cardiovascular agents	low	1	0
piperidines	low	1	0
interleukin-8	low	1	0
fosinopril	low	1	0
minocycline	low	1	0
salicylates	low	1	0
mobic	low	2	0
warfarin	low	1	0
phenprocoumon	low	1	0
epidermal growth factor	low	1	0
epoetin alfa	medium	2	1
vitamin b 12	medium	3	1
cyclosporine	low	1	0
folic acid	low	3	0
sildenafil citrate	low	38	0
da 8159	low	1	0
vardenafil dihydrochloride	low	5	0
eye	low	40	0
carbidopa	medium	3	3

Protein Targets (1,749)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	32	0	0	32
thioredoxin reductase	33	0	0	33
ATAD5 protein, partial	18	0	0	18
GLS protein	20	0	0	20
TDP1 protein	52	0	0	52
regulator of G-protein signaling 4	20	0	0	20
67.9K protein	14	0	0	14
Parkin	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	12	0	0	12
IDH1	17	0	0	17
euchromatic histone-lysine N-methyltransferase 2	47	0	0	47
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
huntingtin isoform 2	10	0	0	10
ras-related protein Rab-9A	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
survival motor neuron protein isoform d	22	0	0	22
D(1A) dopamine receptor	3	1	0	4
Ataxin-2	23	0	0	23
ATP-dependent phosphofructokinase	21	0	0	21
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, HADH2 protein	17	0	0	17
Chain B, HADH2 protein	17	0	0	17
Chain A, 2-oxoglutarate Oxygenase	20	0	0	20
Chain A, Cruzipain	4	0	0	4
Chain A, Methyltransferase Wbdd	0	1	0	1
15-lipoxygenase, partial	7	0	0	7
NFKB1 protein, partial	13	0	0	13
Thrombopoietin	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	32	0	0	32
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	15	0	0	15
thyroid stimulating hormone receptor	23	0	0	23
EWS/FLI fusion protein	29	0	0	29
cytochrome P450 2D6 isoform 1	13	0	0	13
cellular tumor antigen p53 isoform a	8	0	0	8
cytochrome P450 2C19 precursor	13	0	0	13
cytochrome P450 2C9 precursor	10	0	0	10
chromobox protein homolog 1	24	0	0	24
flap endonuclease 1	13	0	0	13
cytochrome P450 3A4 isoform 1	21	0	0	21
M-phase phosphoprotein 8	9	0	0	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	4	0	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	21	4	3	28
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Bromodomain-containing protein 4	0	1	0	1
5-hydroxytryptamine receptor 4	0	18	0	18
cGMP-specific 3',5'-cyclic phosphodiesterase	0	7	1	8
Integrin beta-3	6	1	1	8
Cytochrome P450 1A2	0	5	0	6
Integrin alpha-IIb	6	1	1	8
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Serine/threonine-protein kinase pim-1	0	1	1	2
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit beta-1	21	4	3	28
Gamma-aminobutyric acid receptor subunit delta	21	4	3	28
Gamma-aminobutyric acid receptor subunit gamma-2	21	4	4	29
Casein kinase II subunit alpha'	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	21	4	3	28
Gamma-aminobutyric acid receptor subunit alpha-3	21	4	3	28
Gamma-aminobutyric acid receptor subunit gamma-1	21	4	3	28
Gamma-aminobutyric acid receptor subunit alpha-2	21	4	3	28
Proteinase-activated receptor 1	0	0	0	1
Bromodomain-containing protein 2	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	2
5-hydroxytryptamine receptor 2A	0	16	0	16
5-hydroxytryptamine receptor 2C	0	19	0	19
Gamma-aminobutyric acid receptor subunit alpha-4	21	4	3	28
Gamma-aminobutyric acid receptor subunit gamma-3	21	4	3	28
Gamma-aminobutyric acid receptor subunit alpha-6	21	4	3	28
Sodium-dependent serotonin transporter	0	5	0	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Type-1 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	16	0	16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	3
Serine/threonine-protein kinase mTOR	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Histamine H2 receptor	14	0	0	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	2
Glycogen synthase kinase-3 beta	0	1	1	2
Serine/threonine-protein kinase PLK1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	21	5	4	30
Gamma-aminobutyric acid receptor subunit beta-3	21	4	3	28
Gamma-aminobutyric acid receptor subunit beta-2	21	4	4	29
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mu-type opioid receptor	0	6	0	6
Serine-protein kinase ATM	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	5	0	5
Serine/threonine-protein kinase ATR	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	6	0	6
Bromodomain-containing protein 3	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
GABA theta subunit	21	4	3	28
Gamma-aminobutyric acid receptor subunit epsilon	21	4	3	28
Serine/threonine-protein kinase PLK3	0	2	0	2
Serine/threonine-protein kinase PLK2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	31	0	0	31
GLI family zinc finger 3	34	0	0	34
AR protein	57	0	0	57
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
retinoid X nuclear receptor alpha	32	0	0	32
estrogen nuclear receptor alpha	63	0	0	63
peroxisome proliferator-activated receptor delta	26	0	0	26
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	24	0	0	24
activating transcription factor 6	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
Histone H2A.x	17	0	0	17
thyroid hormone receptor beta isoform a	10	0	0	10
heat shock protein beta-1	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
lamin isoform A-delta10	35	0	0	35
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Glutamate receptor 2	17	3	1	21
Gamma-butyrobetaine dioxygenase	0	2	0	2
USP1 protein, partial	23	0	0	23
Microtubule-associated protein tau	20	0	0	20
estrogen receptor 2 (ER beta)	20	0	0	20
cytochrome P450 family 3 subfamily A polypeptide 4	34	0	0	34
glucocorticoid receptor [Homo sapiens]	39	0	0	39
cytochrome P450 2D6	26	0	0	26
glucocerebrosidase	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
transcriptional regulator ERG isoform 3	5	0	0	5
thyroid hormone receptor beta isoform 2	32	0	0	32
mitogen-activated protein kinase 1	10	0	0	10
geminin	39	0	0	39
peripheral myelin protein 22	24	0	0	24
lethal factor (plasmid)	11	0	0	11
Potassium channel subfamily K member 2	0	1	4	5
Rap guanine nucleotide exchange factor 3	5	0	0	5
Cellular tumor antigen p53	35	0	0	35
Potassium voltage-gated channel subfamily A member 3	0	0	1	1
Acetylcholinesterase	0	2	0	2
Pteridine reductase 1	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Histone deacetylase 3	0	5	0	5
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	4	0	4
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	4	0	4
vitamin D3 receptor isoform VDRA	20	0	0	20
Ubiquitin carboxyl-terminal hydrolase isozyme L3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	22	0	0	22
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	14	0	0	14
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
GALC protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	29	0	0	29
estrogen-related nuclear receptor alpha	44	0	0	44
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	17	0	0	17
Carbonic anhydrase	0	2	0	2
Bloom syndrome protein isoform 1	17	0	0	17
muscleblind-like protein 1 isoform 1	12	0	0	12
ATP-binding cassette sub-family C member 3	0	45	0	45
Multidrug resistance-associated protein 4	0	45	0	49
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	6
Carbonic anhydrase 12	0	5	1	11
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	56	0	56
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	13	1	24
Carbonic anhydrase 2	0	13	3	25
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase 3	0	4	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	17	1	22
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	7	0	8
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	4	0	5
Cytochrome P450 2D6	0	8	0	9
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	17	0	17
5-hydroxytryptamine receptor 2A	0	9	0	9
Androgen receptor	0	9	0	9
Translocator protein	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	3	0	3
Carbonic anhydrase 4	0	8	1	13
Carbonic anhydrase 6	0	4	1	9
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	3	0	4
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	4	0	5
5-hydroxytryptamine receptor 2B	0	5	0	5
Delta-type opioid receptor	0	4	0	4
Cytochrome P450 2C19	0	6	0	7
Delta-type opioid receptor	0	5	0	5
Mu-type opioid receptor	0	6	1	7
Carbonic anhydrase 5A, mitochondrial	0	6	2	13
Carbonic anhydrase	0	5	0	6
Kappa-type opioid receptor	0	3	0	3
Carbonic anhydrase 7	0	4	1	9
Carbonic anhydrase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
D(2) dopamine receptor	0	7	0	7
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	13	3	18
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	6	1	12
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Canalicular multispecific organic anion transporter 1	0	41	0	41
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase 15	0	5	0	7
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	8
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	5	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	10
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
Chain A, Ferritin light chain	18	0	0	18
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	24	0	0	24
Smad3	14	0	0	14
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	7	0	11
Bile salt export pump	0	12	0	12
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2J2	0	9	0	9
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	6
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	6
Thymidine kinase	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	8	4	12
Delta-type opioid receptor	0	5	2	7
Kappa-type opioid receptor	0	8	2	10
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	2	2
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	1	3	4
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	1	1	2
P2X purinoceptor 1	0	1	1	2
P2X purinoceptor 4	0	1	3	4
P2X purinoceptor 5	0	0	2	2
P2X purinoceptor 6	0	1	2	3
P2X purinoceptor 3	0	1	2	3
Inositol monophosphatase 1	7	0	0	7
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	2	2
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	1	2	3
Chain A, JmjC domain-containing histone demethylation protein 3A	11	0	0	11
Luciferase	17	0	0	17
endonuclease IV	3	0	0	3
WRN	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
apical membrane antigen 1, AMA1	5	0	0	5
nonstructural protein 1	9	0	0	9
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	6	0	0	6
peripheral myelin protein 22 isoform 1	12	0	0	12
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	18	0	0	18
DNA polymerase kappa isoform 1	13	0	0	13
muscarinic acetylcholine receptor M1	16	0	0	16
pyruvate kinase PKM isoform b	4	0	0	4
Tyrosine-protein kinase JAK2	0	1	0	1
Epidermal growth factor receptor	0	8	1	9
Receptor tyrosine-protein kinase erbB-2	0	4	0	4
Ornithine decarboxylase	4	0	0	4
Tyrosine-protein kinase JAK1	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	12	3	17
Tyrosine-protein kinase JAK3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	11	3	16
Glutamate receptor ionotropic, NMDA 2C	0	11	3	16
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
large T antigen	0	2	0	2
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	4	1	8
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
alpha-galactosidase	7	0	0	7
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Alpha-1A adrenergic receptor	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	5
Alpha-2B adrenergic receptor	0	7	3	10
Alpha-2C adrenergic receptor	0	6	3	9
Acetylcholinesterase	0	7	0	7
Alpha-2A adrenergic receptor	0	6	3	9
Alpha-1D adrenergic receptor	0	7	1	8
Alpha-1D adrenergic receptor	0	16	3	19
Alpha-1A adrenergic receptor	0	11	5	16
Alpha-1B adrenergic receptor	0	9	5	14
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	1	12
Sodium channel protein type 5 subunit alpha	0	6	0	6
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
peroxisome proliferator activated receptor gamma	26	0	0	26
Thromboxane-A synthase	0	4	0	4
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	7	3	10
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	2	0	6
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	3	0	7
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Solute carrier organic anion transporter family member 3A1	0	0	0	1
acetylcholinesterase	13	0	0	13
SMAD family member 2	15	0	0	15
Fumarate hydratase	7	0	0	7
PPM1D protein	6	0	0	6
SMAD family member 3	15	0	0	15
caspase 7, apoptosis-related cysteine protease	4	0	0	4
progesterone receptor	27	0	0	27
farnesoid X nuclear receptor	18	0	0	18
pregnane X nuclear receptor	35	0	0	35
G	24	0	0	24
polyprotein	7	0	0	7
caspase-3	4	0	0	4
thyroid stimulating hormone receptor	12	0	0	12
D(1A) dopamine receptor	10	0	0	10
nuclear receptor ROR-gamma isoform 1	22	0	0	22
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	7	1	8
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	28	0	0	28
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
Thyroid hormone receptor alpha	0	1	0	1
Tyrosine-protein kinase Fyn	0	4	1	5
ATP-dependent translocase ABCB1	0	5	0	5
Aldo-keto reductase family 1 member B1	0	9	0	9
Muscarinic acetylcholine receptor M2	0	7	1	12
Muscarinic acetylcholine receptor M4	0	9	1	13
ATP-dependent translocase ABCB1	0	12	1	14
Beta-1 adrenergic receptor	0	9	3	12
Muscarinic acetylcholine receptor M5	0	9	1	13
Alpha-2A adrenergic receptor	0	18	2	20
Adenosine receptor A3	0	11	0	11
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	7	1	12
Beta-3 adrenergic receptor	0	8	2	10
D(2) dopamine receptor	0	13	0	13
Alpha-1B adrenergic receptor	0	14	1	15
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	17	0	17
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M3	0	8	1	12
ATP-dependent translocase ABCB1	0	5	0	5
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	10	0	10
D(4) dopamine receptor	0	6	0	6
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	12	1	13
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	5	0	5
Lysine-specific demethylase 5A	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	7	1	8
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	2	0	2
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	14	0	14
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	3
Squalene synthase	0	1	0	1
C-C chemokine receptor type 2	0	7	0	7
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	16	1	17
5-hydroxytryptamine receptor 6	0	16	0	16
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	4	0	4
Spike glycoprotein	17	1	1	19
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	7	1	8
Sodium-dependent dopamine transporter	0	10	0	10
Voltage-dependent L-type calcium channel subunit alpha-1S	0	7	1	8
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	4	0	4
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	24	0	0	24
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	10	1	11
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	3	0	3
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	3	0	3
cytochrome P450 2C9, partial	24	0	0	24
acid sphingomyelinase	4	0	0	4
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
histone acetyltransferase KAT2A isoform 1	16	0	0	16
Alpha-2C adrenergic receptor	0	14	1	15
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Potassium channel subfamily K member 2	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
MPI protein	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
hypothetical protein, conserved	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
aryl hydrocarbon receptor	19	0	0	19
perilipin-5	0	3	0	3
perilipin-1	0	3	0	3
serine/threonine-protein kinase PLK1	6	0	0	6
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
caspase-1 isoform alpha precursor	3	0	0	3
Aurora kinase A	0	1	1	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Dual specificity protein kinase TTK	0	1	1	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	5	0	5
Aurora kinase B	0	1	1	2
Inner centromere protein	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
Monoglyceride lipase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	10	3	15
Glutamate receptor ionotropic, NMDA 3B	0	10	3	15
Glutamate receptor ionotropic, NMDA 3A	0	10	3	15
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	4	0	4
Fatty acid-binding protein, liver	0	4	0	4
Myeloperoxidase	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	8	0	8
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	9	0	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	7	0	0	7
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	1	1	2
Beta-1 adrenergic receptor	0	0	3	3
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	6	2	8
5-hydroxytryptamine receptor 1A	0	16	5	21
TAR DNA-binding protein 43	11	0	0	11
Beta-2 adrenergic receptor	0	0	3	4
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	4	0	4
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	2	1	3
P53	1	0	0	1
ATPase family AAA domain-containing protein 5	17	0	0	17
Protein-arginine deiminase type-4	0	4	0	4
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-1 adrenergic receptor	0	3	1	4
Beta-2 adrenergic receptor	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	2	1	3
Endothelin-1 receptor	0	2	1	3
Endothelin receptor type B	0	0	1	1
Deoxyhypusine synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Alpha-mannosidase	0	1	0	1
Alpha-glucosidase MAL62	0	2	0	2
Oligo-1,6-glucosidase IMA1	0	2	0	2
Tissue alpha-L-fucosidase	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Type-1A angiotensin II receptor	0	1	1	2
Type-1 angiotensin II receptor	0	2	0	3
Type-2 angiotensin II receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Leukotriene B4 receptor 2	0	1	1	3
PINK1	2	0	0	2
Glycine receptor subunit alpha-1	0	0	3	3
Extracellular calcium-sensing receptor	0	0	1	1
Angiotensin-converting enzyme 2	0	2	1	3
Thromboxane A2 receptor	0	2	2	4
Prostaglandin E2 receptor EP1 subtype	0	4	4	8
Prostaglandin E2 receptor EP4 subtype	0	4	1	5
Prostaglandin F2-alpha receptor	0	4	3	7
Prostaglandin E2 receptor EP3 subtype	0	5	3	8
Prostaglandin E2 receptor EP2 subtype	0	4	2	6
Prostaglandin D2 receptor	0	2	1	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	2	1	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
D	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
5-hydroxytryptamine receptor 1B	0	13	1	14
5-hydroxytryptamine receptor 1D	0	2	2	4
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	3	0	3
Estrogen receptor	0	5	1	6
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Dihydrofolate reductase	0	3	0	3
dopamine D1 receptor	5	0	0	5
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Solute carrier family 22 member 2	0	3	0	6
Replicase polyprotein 1ab	0	3	1	4
Replicase polyprotein 1ab	0	3	1	4
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Chain A, HTH-type transcriptional regulator qacR	0	0	1	1
Chain B, HTH-type transcriptional regulator qacR	0	0	1	1
Chain A, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Chain B, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	0	1	1
Solute carrier family 22 member 7	0	1	0	4
Solute carrier organic anion transporter family member 2A1	0	2	0	2
Solute carrier family 22 member 11	0	0	0	3
Solute carrier family 22 member 7	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
pyruvate kinase	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
thyrotropin-releasing hormone receptor	3	0	0	3
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
beta-2 adrenergic receptor	4	0	0	4
type-1 angiotensin II receptor	0	1	0	1
runt-related transcription factor 1 isoform AML1b	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
Vpr	2	0	0	2
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
neuropeptide S receptor isoform A	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Procathepsin L	0	1	1	2
Fructose-1,6-bisphosphatase 1	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Amine oxidase [flavin-containing] A	0	2	0	2
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	1	2
Protein-lysine 6-oxidase	0	1	0	1
Caspase-1	0	2	0	2
Alpha-synuclein	4	0	0	4
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	2	0	2
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
heat shock protein 90, putative	0	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
glp-1 receptor, partial	9	0	0	9
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	1	3
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 5A	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	2	4	6
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	1	1	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	2	0	2
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	0	1	0	1
Chain B, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1	0	0	0	1
serine/threonine-protein kinase 33 isoform a	0	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	2	1	3
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	1	1	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	3	4
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
C-C motif chemokine 2	0	1	0	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	2	1	3
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	2	1	3
cAMP-dependent protein kinase catalytic subunit beta	0	2	1	3
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Cyclin-dependent kinase 2	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Protein kinase C epsilon type	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	1	2
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Myotonin-protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	2	1	3
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	3	1	4
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	1	1	2
Serine/threonine-protein kinase N2	0	1	1	2
Mitogen-activated protein kinase 14	0	1	1	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
Rho-associated protein kinase 2	0	1	0	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	1	1	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	3	0	3
Mu-type opioid receptor	0	1	0	1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	3	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
Glucocorticoid receptor	0	12	2	19
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
pregnane X receptor	4	0	0	4
Solute carrier family 22 member 8	0	1	0	2
Thymidylate synthase	0	4	0	4
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	5	0	5
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	3	1	4
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	3	1	4
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	3	0	3
Glutamate carboxypeptidase 2	0	3	2	5
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	1	0	1
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	1	2
Cholesteryl ester transfer protein	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
N-glycosylase/DNA lyase	0	2	0	2
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Albumin	0	1	1	2
Albumin	0	0	3	3
Cholinesterase	0	4	0	4
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostacyclin receptor	0	1	1	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Polyphenol oxidase 2	0	2	0	4
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Plasma kallikrein	0	0	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Angiotensin-converting enzyme	0	4	0	4
Type-2 angiotensin II receptor	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Type-1 angiotensin II receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
tumor necrosis factor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Transthyretin	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
Transcription factor SOX-18	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Transcriptional enhancer factor TEF-3	0	1	1	2
G-protein coupled receptor 35	0	2	1	3
Sodium/iodide cotransporter	0	1	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
chaperonin GroEL	1	0	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
Tumor necrosis factor	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Glutamate carboxypeptidase 2	0	2	0	2
N-acetylated-alpha-linked acidic dipeptidase 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
D(3) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
Alpha-1B adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Neutrophil elastase	0	1	0	1
Complement C1s subcomponent	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 3	0	1	0	1
P2X purinoceptor 1	0	1	0	1
P2Y purinoceptor 4	0	0	1	1
P2X purinoceptor 7	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	0	1	0	1
P2X purinoceptor 5	0	1	0	1
P2X purinoceptor 4	0	1	1	2
P2X purinoceptor 7	0	1	0	1
P2X purinoceptor 4	0	1	0	1
NS5	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	4	3	7
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Anterior Ischemic Optic Neuropathy

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (421)

Protein Targets (1,749)

Anterior Ischemic Optic Neuropathy

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (421)

Drugs Studied (202)

Protein Targets (1,749)