metronidazole has been researched along with Multiple Myeloma in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant." | 9.09 | Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999) |
| "We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy." | 7.83 | Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016) |
| "In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant." | 5.09 | Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999) |
| "We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy." | 3.83 | Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016) |
| " We herein report the findings of a 53-year-old woman who was receiving lenalidomide for multiple myeloma and subsequently developed multiple amoebic abscesses." | 3.83 | Multiple Medium Amoebic Liver Abscesses Successfully Treated with Medication and Comprehensive Percutaneous Catheter Drainage. ( Goto, T; Iida, K; Kasamatsu, Y; Shimizu, S; Shirano, M, 2016) |
| "Pseudomembranous colitis was seen in the first patient during endoscopy but an enzyme immunoassay of the faeces was false negative for Clostridium difficile enterotoxin." | 2.41 | [Diarrhea due to Clostridium difficile toxin in hemato-oncological patients]. ( Kerst, JM; Kuijper, EJ; van der Lelie, J, 2001) |
| "We present a case of extragenitourinary malakoplakia, developing in a patient with a history of plasma cell myeloma, which clinically mimicked recurrent extramedullary myelomatous involvement." | 1.37 | Extragenitourinary malakoplakia in a patient with myeloma clinically mimicking extramedullary myelomatous disease. ( Cox, RM; El Jamal, SM; Lorsbach, RB; Malak, SF, 2011) |
| "Bortezomib has the boronic acid moiety which improves the specificity of proteasome inhibition and can be used as non-beta-lactam-based beta-lactamase inhibitors." | 1.34 | Pseudomembranous colitis following bortezomib therapy in a myeloma patient. ( Kim, CC; Kim, M; Kim, Y; Lee, DG; Lee, JW; Lee, S; Min, CK; Min, WS; Moon, SJ; Park, G, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrini, S | 1 |
| Bucalossi, A | 1 |
| Cioffi Squitieri, N | 1 |
| Mazzei, FG | 1 |
| Volterrani, L | 1 |
| Mazzei, MA | 1 |
| Kasamatsu, Y | 1 |
| Shirano, M | 1 |
| Iida, K | 1 |
| Shimizu, S | 1 |
| Goto, T | 1 |
| El Jamal, SM | 1 |
| Malak, SF | 1 |
| Cox, RM | 1 |
| Lorsbach, RB | 1 |
| Moon, SJ | 1 |
| Min, CK | 1 |
| Lee, DG | 1 |
| Lee, S | 1 |
| Lee, JW | 1 |
| Min, WS | 1 |
| Kim, CC | 1 |
| Kim, M | 1 |
| Park, G | 1 |
| Kim, Y | 1 |
| Beelen, DW | 1 |
| Elmaagacli, A | 1 |
| Müller, KD | 1 |
| Hirche, H | 1 |
| Schaefer, UW | 1 |
| Kerst, JM | 1 |
| van der Lelie, J | 1 |
| Kuijper, EJ | 1 |
1 review available for metronidazole and Multiple Myeloma
| Article | Year |
|---|---|
[Diarrhea due to Clostridium difficile toxin in hemato-oncological patients].
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficil | 2001 |
1 trial available for metronidazole and Multiple Myeloma
| Article | Year |
|---|---|
Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bone Marrow Transplantation; Ciprofloxacin; Drug Therapy, | 1999 |
4 other studies available for metronidazole and Multiple Myeloma
| Article | Year |
|---|---|
Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma.
Topics: Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Colitis, Ischemic; Combined M | 2016 |
Multiple Medium Amoebic Liver Abscesses Successfully Treated with Medication and Comprehensive Percutaneous Catheter Drainage.
Topics: Catheterization; Drainage; Female; Humans; Immunologic Factors; Lenalidomide; Liver Abscess, Amebic; | 2016 |
Extragenitourinary malakoplakia in a patient with myeloma clinically mimicking extramedullary myelomatous disease.
Topics: Aged; Anti-Bacterial Agents; Cefepime; Cephalosporins; Escherichia coli Infections; Humans; Malacopl | 2011 |
Pseudomembranous colitis following bortezomib therapy in a myeloma patient.
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Enterocolitis, Pseudo | 2007 |