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metronidazole and Leprosy

metronidazole has been researched along with Leprosy in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Research Excerpts

ExcerptRelevanceReference
"Thirty three leprosy patients in reaction were treated with a combination of Metronidazole--Diethyl carbamazine citrate--Chloroquin which was reinforced either with prednisolone and/or Clofazimine in some, depending on the clinical state."3.66Multi-drug treatment for reactions in leprosy. ( Razack, EM; Zahra, A, 1981)
"Traditionally, many of the chemotherapeutic agents used in tropical medicine have possessed limited efficacy and serious adverse effects."2.39Adverse effects of chemotherapeutic agents used in tropical medicine. ( Cook, GC, 1995)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Razack, EM1
Zahra, A1
Cook, GC1

Reviews

1 review available for metronidazole and Leprosy

ArticleYear
Adverse effects of chemotherapeutic agents used in tropical medicine.
    Drug safety, 1995, Volume: 13, Issue:1

    Topics: Anthelmintics; Antimalarials; Drug-Related Side Effects and Adverse Reactions; Humans; Leprosy; Metr

1995

Other Studies

1 other study available for metronidazole and Leprosy

ArticleYear
Multi-drug treatment for reactions in leprosy.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Child; Chloroquine; Clofazimine; Diethylcarbamazine; Drug Therapy, Combination; F

1981