metronidazole has been researched along with Leprosy in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty three leprosy patients in reaction were treated with a combination of Metronidazole--Diethyl carbamazine citrate--Chloroquin which was reinforced either with prednisolone and/or Clofazimine in some, depending on the clinical state." | 3.66 | Multi-drug treatment for reactions in leprosy. ( Razack, EM; Zahra, A, 1981) |
| "Traditionally, many of the chemotherapeutic agents used in tropical medicine have possessed limited efficacy and serious adverse effects." | 2.39 | Adverse effects of chemotherapeutic agents used in tropical medicine. ( Cook, GC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Razack, EM | 1 |
| Zahra, A | 1 |
| Cook, GC | 1 |
1 review available for metronidazole and Leprosy
| Article | Year |
|---|---|
Adverse effects of chemotherapeutic agents used in tropical medicine.
Topics: Anthelmintics; Antimalarials; Drug-Related Side Effects and Adverse Reactions; Humans; Leprosy; Metr | 1995 |
1 other study available for metronidazole and Leprosy
| Article | Year |
|---|---|
Multi-drug treatment for reactions in leprosy.
Topics: Adolescent; Adult; Child; Chloroquine; Clofazimine; Diethylcarbamazine; Drug Therapy, Combination; F | 1981 |