metronidazole has been researched along with MS (Multiple Sclerosis) in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mannioui, A | 1 |
| Zalc, B | 1 |
| De Bleecker, JL | 1 |
| Leroy, BP | 1 |
| Meire, VI | 1 |
| Savely, G | 1 |
| Boman, J | 1 |
| Roblin, PM | 1 |
| Sundström, P | 1 |
| Sandström, M | 1 |
| Hammerschlag, MR | 1 |
4 other studies available for metronidazole and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Conditional Demyelination and Remyelination in a Transgenic Xenopus laevis.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Disease Progression; Drug Evaluation | 2019 |
Reversible visual deficit and Corpus callosum lesions due to metronidazole toxicity.
Topics: Adult; Anti-Infective Agents; Colitis, Ulcerative; Corpus Callosum; Diagnosis, Differential; Evoked | 2005 |
Neuralgia and demyelinating plaques: MS or lyme disease?
Topics: Anti-Bacterial Agents; Antigens, Bacterial; Blotting, Western; Borrelia burgdorferi; Ceftriaxone; Di | 2005 |
Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibodies, Bacterial; Cerebrospinal Fluid; Chlamydophila pneumo | 2000 |