metronidazole has been researched along with Syphilis in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Syphilis: A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of asymptomatic bacterial vaginosis or T." | 2.41 | Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy. ( Carey, JC; Klebanoff, MA, 2001) |
| " The recommended treatment for gonorrhea is ceftriaxone monotherapy given intramuscularly, with dosing based on the patient's body weight." | 1.72 | Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines. ( Dalby, J; Stoner, BP, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (76.19) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Dalby, J | 1 |
| Stoner, BP | 1 |
| Sherley, M | 1 |
| Martin, SJ | 1 |
| Tambe, S | 1 |
| Zambare, U | 1 |
| Nayak, C | 1 |
| Carey, JC | 1 |
| Klebanoff, MA | 1 |
| Davies, AH | 1 |
| Kang, JY | 1 |
| Stiel, D | 1 |
| Doe, WF | 1 |
| Shchutskiĭ, IV | 1 |
| Bratus', FF | 1 |
| Mel'nichenko, AI | 1 |
| Borovskiĭ, AV | 1 |
| Vinogradova, MP | 1 |
| McCormack, WM | 1 |
| Stern, MS | 1 |
| MacKenzie, RG | 1 |
| Rein, MF | 1 |
| Tyler, CW | 1 |
| Holm, SE | 1 |
| Mobacken, H | 1 |
| Knudsen, EA | 1 |
| Vasiliev, TV | 1 |
| Shibanov, VA | 1 |
| Shkolinik, MS | 1 |
| Ivakina, AIa | 1 |
| Shraĭber, VG | 1 |
| Bell, DR | 1 |
| Wilkinson, AE | 1 |
| Rodin, P | 1 |
| McFadzean, JA | 1 |
| Squires, S | 1 |
| Penza, J | 1 |
| Rankin, JS | 1 |
| Luger, A | 1 |
| Il'in, II | 1 |
| Rostova, RG | 1 |
| Pasechnik, VA | 1 |
5 reviews available for metronidazole and Syphilis
| Article | Year |
|---|---|
Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy.
Topics: Adult; Anti-Bacterial Agents; Chlamydia Infections; Comorbidity; Female; Gonorrhea; Humans; Incidenc | 2001 |
Management of sexually transmissible infections during pregnancy.
Topics: Anti-Bacterial Agents; Candidiasis; Chlamydia Infections; Coitus; Condylomata Acuminata; Corynebacte | 1975 |
Biopharmacology of syphilotherapy.
Topics: Aminoglycosides; Animals; Anterior Chamber; Anti-Bacterial Agents; Bacitracin; Cephalosporins; Chlor | 1976 |
The gynecologist's approach to sexually transmitted infections.
Topics: Ampicillin; Culture Techniques; Female; Gonorrhea; Humans; Metronidazole; Neisseria gonorrhoeae; Pen | 1975 |
Infectious vaginopathies in pregnancy.
Topics: Antifungal Agents; Candidiasis, Vulvovaginal; Female; Glucocorticoids; Gonorrhea; Haemophilus Infect | 1970 |
16 other studies available for metronidazole and Syphilis
| Article | Year |
|---|---|
Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines.
Topics: Adolescent; Ceftriaxone; Centers for Disease Control and Prevention, U.S.; Chlamydia Infections; Dox | 2022 |
Multiple simultaneous infections in a patient with well-controlled HIV: when Occam's razor fails.
Topics: Acquired Immunodeficiency Syndrome; Aftercare; AIDS-Related Opportunistic Infections; Anti-Retrovira | 2017 |
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre; | 2019 |
Metronidazole and syphilis.
Topics: Humans; Metronidazole; Syphilis | 1967 |
Metronidazole in human infections with syphilis.
Topics: Humans; Metronidazole; Syphilis; Treponema Immobilization Test | 1967 |
Gay bowel syndrome: syphilis association.
Topics: Colitis; Homosexuality; Humans; Male; Metronidazole; Proctocolitis; Syphilis | 1980 |
Drugs for sexually transmitted infections.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antitrichomonal Agents; Azithromycin; Chlamydia | 1999 |
[Experience with the overall treatment of urogenital trichomoniasis in combination with gonorrhea and syphilis].
Topics: Adult; Bacterial Infections; Bacterial Vaccines; Drug Therapy, Combination; Female; Gonorrhea; Hista | 1979 |
Venereal disease in adolescents.
Topics: Adolescent; Chlamydia Infections; Cytomegalovirus; Erythromycin; Female; Gonorrhea; Herpesviridae In | 1975 |
Influence of metronidazole on treponema pallidum in vivo and in vitro.
Topics: Animals; Bacteriological Techniques; Culture Media; In Vitro Techniques; Injections, Intraperitoneal | 1972 |
A clinical study on 29 cases of debatable STS and TPI seroreactions in Greenland.
Topics: Adolescent; Adult; Age Factors; Female; Gonorrhea; Greenland; Humans; Male; Metronidazole; Middle Ag | 1974 |
[Trichopol as one of the probable causes of atypical course and difficulties in the diagnosis of syphilis].
Topics: Adult; Female; Humans; Metronidazole; Middle Aged; Syphilis; Treponema pallidum; Trichomonas Infecti | 1972 |
Treatment of venereal diseases.
Topics: Chancroid; Drug Combinations; Erythromycin; Female; Gonorrhea; Granuloma Inguinale; Humans; Injectio | 1973 |
A note on the effect of metronidazole on the Nichols strain of Treponema pallidum in vitro and in vivo.
Topics: Adult; Female; Humans; Male; Metronidazole; Syphilis; Treponema Immobilization Test; Treponema palli | 1967 |
[Syphilis diagnosis in the age of antibiotics].
Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphe | 1971 |
[Metronidazole as a possible reason for difficulty in diagnosis of syphilis].
Topics: Adolescent; Adult; Diagnostic Errors; Female; Humans; Male; Metronidazole; Middle Aged; Syphilis; Tr | 1971 |