metronidazole has been researched along with Adult Periodontitis in 72 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim is to explore the optimal drug dose and duration of adjunctive Amoxicillin-plus-Metronidazole (AMX/MET) to full-mouth scaling and planing (FMSRP) in periodontitis." | 9.12 | The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis. ( Hu, J; Zhao, H; Zhao, L, 2021) |
| " In a single-center, randomized, placebo-controlled, and double-masked clinical trial, 80 patients with chronic or aggressive periodontitis were randomized into 2 treatment groups: group A, receiving systemic amoxicillin and metronidazole during the first, nonsurgical phase of periodontal therapy (phase 1), and group B, receiving the antibiotics during the second, surgical phase (phase 2)." | 5.22 | Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial. ( Almaghlouth, A; Cancela, J; Cionca, N; Courvoisier, DS; Giannopoulou, C; Mombelli, A, 2016) |
| "The aim is to explore the optimal drug dose and duration of adjunctive Amoxicillin-plus-Metronidazole (AMX/MET) to full-mouth scaling and planing (FMSRP) in periodontitis." | 5.12 | The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis. ( Hu, J; Zhao, H; Zhao, L, 2021) |
| "Eighty patients with chronic or aggressive periodontitis received periodontal treatment supplemented with 375 mg amoxicillin plus 500 mg metronidazole, three times daily for 7 days." | 3.85 | Microbiologic Response to Periodontal Therapy and Multivariable Prediction of Clinical Outcome. ( Almaghlouth, A; Cancela, J; Cionca, N; Courvoisier, DS; Giannopoulou, C; Mombelli, A, 2017) |
| "This study assessed the subgingival occurrence of the flagellated, Gram-negative, anaerobic rod Centipeda periodontii in chronic periodontitis and periodontal health/gingivitis with species-specific nucleic acid probes, and evaluated the in vitro resistance of subgingival isolates to therapeutic levels of amoxicillin, metronidazole, and doxycycline." | 3.81 | Centipeda periodontii in human periodontitis. ( Degener, JE; Hawley, CE; Rams, TE; van Winkelhoff, AJ; Whitaker, EJ, 2015) |
| "One hundred and two patients with severe chronic periodontitis [e." | 2.82 | Non-surgical periodontal treatment in conjunction with 3 or 7 days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study. ( Arweiler, N; Cosgarea, R; Heumann, C; Juncar, R; Lascu, L; Sculean, A; Stavropoulos, A; Tristiu, R, 2016) |
| "Adult patients with chronic periodontitis (n = 90) underwent non-surgical periodontal treatment (zero-day) and then randomly divided into three groups." | 2.82 | Comparison of cefixime and amoxicillin plus metronidazole in the treatment of chronic periodontitis. ( Cutović, T; Daković, D; Dukić, S; Matijević, S, 2016) |
| "For patients with severe chronic periodontitis, it is safe and feasible to receive full-mouth SRP by 2 times within 1 week." | 2.80 | [Clinical effect of different sequences of debridement-antibiotic therapy in treatment of severe chronic periodontitis]. ( An, YB; Li, Y; Lu, RF; Meng, HX; Song, WL; Wang, XE; Xu, L, 2015) |
| "In this study, 178 chronic periodontitis subjects were recruited and clinically monitored at baseline, 3, 6, 12, 18 and 24 months after therapy." | 2.78 | Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change. ( Bogren, A; Goodson, JM; Haffajee, AD; Hasturk, H; Lindhe, J; Socransky, SS; Teles, R; van Dyke, T; Wang, X; Wennstrom, JL, 2013) |
| "Twenty-seven chronic periodontitis (CP) patients were randomly divided into three parallel groups each comprising nine individuals with at least four teeth having at least one approximal site with a probing depth (PD) of ≥5 mm and gingival index (GI) of ≥2 in each quadrant." | 2.77 | Er:YAG laser versus systemic metronidazole as an adjunct to nonsurgical periodontal therapy: a clinical and microbiological study. ( Eren-Kuru, B; Gursoy, H; Kadir, T; Kut, B; Noyan, U; Yilmaz, S, 2012) |
| "Periodontitis is one of the most prevalent inflammatory diseases in humans." | 2.66 | Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis. ( da Rocha, TE; Ervolino, E; Garcia, VG; Guiati, IZ; Souza, EQM; Theodoro, LH; Toro, LF; Wainwright, M, 2020) |
| "Metronidazole (MET) has been suggested as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis." | 2.50 | Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. ( Gatto, R; Monaco, A; Petrucci, A; Severino, M; Sgolastra, F, 2014) |
| " Volunteers answered an adverse event questionnaire." | 1.72 | Adverse events of metronidazole and amoxicillin: Retrospective analysis of a large data set of five randomized clinical trials. ( Borges, I; Castro Dos Santos, N; Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Giudicissi, M; Graças, YTD; Mestnik, MJ; Miranda, TS; Monique, S; Pannuti, CM; Pereira da Silva, HD; Retamal-Valdes, B; Romito, GA; Saraiva, L; Soares, GMS; Souto, MLS; Tavares, APL, 2022) |
| "Eleven studies were performed in chronic periodontitis patients and six in aggressive periodontitis patients." | 1.51 | No evidence to support benefit of 14-day courses of amoxicillin-plus-metronidazole as adjunct to non-surgical periodontal treatment at three months. ( Huck, O; Martín-Cabezas, R, 2019) |
| "Nineteen patients with chronic periodontitis were qualified to the study." | 1.46 | The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients. ( Dolińska, E; Dymicka-Piekarska, V; Milewski, R; Pietruska, M; Pietruski, J; Sculean, A; Skurska, A, 2017) |
| "Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP." | 1.43 | Nonsurgical therapy of chronic periodontitis with adjunctive systemic azithromycin or amoxicillin/metronidazole. ( Buchmann, A; Eick, S; Friedrich, A; Jentsch, HF, 2016) |
| "Gingiva samples from untreated chronic periodontitis patients revealed a diffuse positive reaction for MMP-2 in the epithelium and also in fibroblasts and macrophages from the lamina propria." | 1.42 | Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis. ( BaniŢă, IM; Bătăiosu, M; Dăguci, C; Dăguci, L; Pascu, EI; Pisoschi, CG; Taisescu, CI; Ţuculină, MJ, 2015) |
| "Patients with chronic periodontitis (CP) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility." | 1.40 | Antibiotic resistance in human chronic periodontitis microbiota. ( Degener, JE; Rams, TE; van Winkelhoff, AJ, 2014) |
| "gingivalis in patients with chronic periodontitis and to assess antimicrobial susceptibility in terms of minimum inhibitory concentration (MIC) of clinical isolates to metronidazole and tetracycline." | 1.40 | Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis. ( Acosta, A; Araya, N; Gamboa, F; García, DA; Ledergerber, R; Velosa, J, 2014) |
| "Individuals with chronic periodontitis were classified as RP (n = 17) based on mean attachment loss (AL) and/or >3 sites with AL ≥2." | 1.38 | Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. ( Bennet, S; Colombo, AP; Cotton, SL; Dewhirst, FE; Goodson, JM; Haffajee, AD; Hasturk, H; Kent, R; Paster, BJ; Socransky, SS; Van Dyke, TE, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (8.33) | 29.6817 |
| 2010's | 57 (79.17) | 24.3611 |
| 2020's | 9 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Baghani, Z | 1 |
| Basir Shabestari, S | 1 |
| Karrabi, M | 1 |
| Retamal-Valdes, B | 4 |
| Tavares, APL | 1 |
| Monique, S | 1 |
| Pereira da Silva, HD | 1 |
| Mestnik, MJ | 1 |
| Duarte, PM | 6 |
| Miranda, TS | 3 |
| Borges, I | 2 |
| Soares, GMS | 2 |
| Faveri, M | 10 |
| Castro Dos Santos, N | 1 |
| Graças, YTD | 1 |
| Souto, MLS | 1 |
| Giudicissi, M | 1 |
| Romito, GA | 1 |
| Saraiva, L | 1 |
| Pannuti, CM | 1 |
| Figueiredo, LC | 10 |
| Feres, M | 11 |
| Ye, Z | 1 |
| Cao, Y | 1 |
| Miao, C | 1 |
| Liu, W | 1 |
| Dong, L | 1 |
| Lv, Z | 1 |
| Iheozor-Ejiofor, Z | 1 |
| Li, C | 1 |
| Goyal, L | 1 |
| Gupta, S | 1 |
| Dewan, M | 1 |
| Singla, M | 1 |
| Liaw, A | 2 |
| Miller, C | 2 |
| Nimmo, A | 2 |
| El-Makaky, Y | 1 |
| Shalaby, HK | 1 |
| Souza, EQM | 1 |
| da Rocha, TE | 1 |
| Toro, LF | 1 |
| Guiati, IZ | 1 |
| Ervolino, E | 1 |
| Garcia, VG | 3 |
| Wainwright, M | 1 |
| Theodoro, LH | 3 |
| Zhao, H | 1 |
| Hu, J | 1 |
| Zhao, L | 1 |
| Teughels, W | 1 |
| Oliveira, LM | 1 |
| da Silva, RN | 1 |
| Fritoli, A | 1 |
| Gomes, P | 1 |
| Temporão, N | 1 |
| Furquim, CP | 1 |
| Doyle, H | 1 |
| Qureshi, A | 1 |
| Bokhari, SAH | 1 |
| Haque, Z | 1 |
| Baloch, AA | 1 |
| Zaheer, S | 1 |
| Rams, TE | 6 |
| Loesche, WJ | 1 |
| Mei, L | 1 |
| Huang, X | 1 |
| Xie, Y | 1 |
| Chen, J | 1 |
| Huang, Y | 1 |
| Wang, B | 1 |
| Wang, H | 1 |
| Pan, X | 1 |
| Wu, C | 1 |
| Mombelli, A | 6 |
| Almaghlouth, A | 3 |
| Cionca, N | 5 |
| Cancela, J | 2 |
| Courvoisier, DS | 2 |
| Giannopoulou, C | 4 |
| Lopes, AB | 1 |
| Nuernberg, MAA | 1 |
| Cláudio, MM | 1 |
| Miessi, DMJ | 1 |
| Alves, MLF | 2 |
| Duque, C | 2 |
| Assem, NZ | 1 |
| Longo, M | 1 |
| Stipp, RN | 1 |
| Vizoto, NL | 1 |
| Hagenfeld, D | 1 |
| Koch, R | 1 |
| Jünemann, S | 1 |
| Prior, K | 1 |
| Harks, I | 1 |
| Eickholz, P | 1 |
| Hoffmann, T | 1 |
| Kim, TS | 1 |
| Kocher, T | 1 |
| Meyle, J | 1 |
| Kaner, D | 1 |
| Schlagenhauf, U | 1 |
| Ehmke, B | 1 |
| Harmsen, D | 1 |
| Ramiro, FS | 1 |
| de Lira, E | 1 |
| Soares, G | 1 |
| Martín-Cabezas, R | 1 |
| Huck, O | 1 |
| Sgolastra, F | 2 |
| Severino, M | 1 |
| Petrucci, A | 2 |
| Gatto, R | 2 |
| Monaco, A | 2 |
| Degener, JE | 5 |
| van Winkelhoff, AJ | 5 |
| Socransky, SS | 5 |
| Haffajee, AD | 3 |
| Teles, R | 3 |
| Wennstrom, JL | 1 |
| Lindhe, J | 1 |
| Bogren, A | 1 |
| Hasturk, H | 3 |
| van Dyke, T | 1 |
| Wang, X | 2 |
| Goodson, JM | 4 |
| Powell, LV | 1 |
| Albandar, JM | 1 |
| Rebello, A | 1 |
| de Oliveira Dias, R | 1 |
| Borges-Junior, I | 1 |
| Preus, HR | 4 |
| Scheie, AA | 2 |
| Baelum, V | 3 |
| Zandbergen, D | 2 |
| Slot, DE | 2 |
| Cobb, CM | 2 |
| Van der Weijden, FA | 2 |
| Soares, GM | 3 |
| Mendes, JA | 3 |
| Silva, MP | 3 |
| Perez-Chaparro, PJ | 1 |
| Tamashiro, NS | 1 |
| Bastos, MF | 1 |
| Hawley, CE | 1 |
| Whitaker, EJ | 1 |
| Feik, D | 2 |
| Mortensen, JE | 2 |
| Gillam, DG | 1 |
| Turner, W | 1 |
| Kolakovic, M | 1 |
| Held, U | 1 |
| Schmidlin, PR | 1 |
| Sahrmann, P | 1 |
| Gamboa, F | 1 |
| Acosta, A | 1 |
| García, DA | 1 |
| Velosa, J | 1 |
| Araya, N | 1 |
| Ledergerber, R | 1 |
| Gjermo, P | 2 |
| Li, Y | 1 |
| Xu, L | 1 |
| Lu, RF | 1 |
| An, YB | 1 |
| Wang, XE | 1 |
| Song, WL | 1 |
| Meng, HX | 1 |
| Dahlen, G | 2 |
| Bătăiosu, M | 1 |
| Taisescu, CI | 1 |
| Pisoschi, CG | 1 |
| Pascu, EI | 1 |
| Ţuculină, MJ | 1 |
| Dăguci, L | 1 |
| Dăguci, C | 1 |
| BaniŢă, IM | 1 |
| Bergamaschi, CC | 1 |
| Santamaria, MP | 1 |
| Berto, LA | 1 |
| Cogo-Müller, K | 1 |
| Motta, RH | 1 |
| Salum, EA | 1 |
| Nociti Júnior, FH | 1 |
| Groppo, FC | 1 |
| Jentsch, HF | 1 |
| Buchmann, A | 1 |
| Friedrich, A | 1 |
| Eick, S | 1 |
| Saleh, A | 1 |
| Rincon, J | 1 |
| Tan, A | 1 |
| Firth, M | 1 |
| Cosgarea, R | 1 |
| Juncar, R | 1 |
| Heumann, C | 1 |
| Tristiu, R | 1 |
| Lascu, L | 1 |
| Arweiler, N | 1 |
| Stavropoulos, A | 1 |
| Sculean, A | 3 |
| Dukić, S | 1 |
| Matijević, S | 1 |
| Daković, D | 1 |
| Cutović, T | 1 |
| Dolińska, E | 1 |
| Skurska, A | 1 |
| Pietruska, M | 1 |
| Dymicka-Piekarska, V | 1 |
| Milewski, R | 1 |
| Pietruski, J | 1 |
| Oh, TJ | 1 |
| Montenegro, SCL | 1 |
| Matarazzo, F | 1 |
| Cruz, SE | 1 |
| Knöfler, G | 1 |
| Purschwitz, R | 1 |
| Jentsch, H | 1 |
| Birkenmeier, G | 1 |
| Schmidt, H | 1 |
| Ugolotti, G | 2 |
| Romeo, E | 1 |
| Lops, D | 1 |
| Storelli, S | 1 |
| Ghisolfi, M | 1 |
| Ribeiro, Edel P | 1 |
| Bittencourt, S | 1 |
| Zanin, IC | 1 |
| Bovi Ambrosano, GM | 1 |
| Sallum, EA | 1 |
| Nociti, FH | 1 |
| Gonçalves, RB | 1 |
| Casati, MZ | 1 |
| Colombo, AP | 2 |
| Boches, SK | 1 |
| Cotton, SL | 2 |
| Kent, R | 2 |
| Van Dyke, TE | 2 |
| Dewhirst, F | 1 |
| Paster, BJ | 2 |
| Buchmann, R | 1 |
| Conrads, G | 1 |
| Leininger, M | 1 |
| Tenenbaum, H | 1 |
| Davideau, JL | 1 |
| Ardila, CM | 1 |
| Granada, MI | 1 |
| Guzmán, IC | 1 |
| Gazhva, SI | 1 |
| Voronina, AI | 1 |
| Shkarednaia, OV | 1 |
| Décaillet, F | 1 |
| Wick, P | 1 |
| Bono, A | 1 |
| Brunotto, M | 1 |
| Sirotto, TA | 1 |
| Miani, PK | 1 |
| do Nascimento, C | 1 |
| Sato, S | 1 |
| Filho, AV | 1 |
| da Fonseca, MJ | 1 |
| Pedrazzi, V | 1 |
| Iordanishvili, AK | 1 |
| Soldatov, SV | 1 |
| Moskalev, AV | 1 |
| Soldatova, LN | 1 |
| Ryzhak, GA | 1 |
| Bennet, S | 1 |
| Dewhirst, FE | 1 |
| Mendonça, AC | 1 |
| Santos, VR | 1 |
| Ribeiro, FV | 1 |
| Lima, JA | 1 |
| Yilmaz, S | 1 |
| Kut, B | 1 |
| Gursoy, H | 1 |
| Eren-Kuru, B | 1 |
| Noyan, U | 1 |
| Kadir, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With Periodontitis[NCT04305171] | 28 participants (Actual) | Observational [Patient Registry] | 2018-04-06 | Completed | |||
| A Randomized Control Trial of Comprehensive Oral Intervention in Patients With Acute Myocardial Infarction: a Pilot Study[NCT04012541] | 68 participants (Anticipated) | Interventional | 2019-07-05 | Recruiting | |||
| Systemic Effects of Periodontal Therapy on Patients With Ischemic Stroke. A Pilot Randomized Controlled Clinical Trial[NCT04956211] | 60 participants (Anticipated) | Interventional | 2021-09-29 | Enrolling by invitation | |||
| The Effects of Non-Surgical Periodontal Therapy on Neutrophil Elastase and Elastase Alpha-1 Proteinase Inhibitor Levels in GCF in Periodontitis Patients With or Without Acute Coronary Syndrome[NCT04785235] | 43 participants (Actual) | Observational [Patient Registry] | 2007-10-15 | Completed | |||
| Clinical, Microbiological and Immunological Evaluation of the Effects of Systemic Probiotics in the Periodontal Treatment[NCT03733379] | Phase 3 | 176 participants (Anticipated) | Interventional | 2018-11-05 | Recruiting | ||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation[NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial[NCT02911766] | Phase 4 | 59 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study[NCT02884817] | Phase 4 | 59 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Pharmacokinetic Considerations and Dosing Strategies of Amoxicillin and Metronidazole or Azithromycin as Adjunct to Non-surgical Periodontal Therapy. A Randomized,6-month, Parallel-group, Clinical Trial.[NCT04669717] | Phase 4 | 45 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response[NCT02197260] | Phase 4 | 80 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study[NCT03043066] | 30 participants (Actual) | Interventional | 2016-03-01 | Completed | |||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial[NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study[NCT04830969] | Phase 2 | 116 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial[NCT03508999] | Phase 4 | 63 participants (Actual) | Interventional | 2018-05-23 | Completed | ||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial.[NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in Moderate Periodontitis Patients[NCT04605289] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2020-01-13 | Completed | ||
| Single Arm Pilot Study of Antimicrobial Treatment of Active Rheumatoid Arthritis Associated With Manifest Periodontitis (Translated From German: Anti-mikrobielle Behandlung Der Aktiven Rheumatoiden Arthritis Bei Manifester Parodontitis - Eine Unkontrollie[NCT02096120] | 8 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Analysis of microbiome community changes using the healthy plane (HP) as a reference. A healthy plane was calculated by fitting a plane that minimizes the sum of squares of distances from HC samples to the nearest point on the plane. The distance of each sample to the HP was then calculated. Higher values of distance to HP mean microbiome community changes towards disease status (NCT04830969)
Timeframe: Baseline to 6 Months
| Intervention | distance to the healthy plane (Mean) |
|---|---|
| Group A: SRP + SPT | -2.16 |
| Group B: SRP | -1.26 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Group A: SRP + SPT | -0.33 |
| Group B: SRP | -1.25 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Diabetic + SRP + SPT | 0.23 |
| Diabetic + SRP | -2.23 |
| Non-Diabetic + SRP + SPT | -0.41 |
| Non-Diabetic + SRP | 0.01 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 3 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.31 |
| Group B: SRP | -0.21 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.25 |
| Group B: SRP | -0.18 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Group A: SRP + SPT | -2.13 |
| Group B: SRP | 1.85 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Diabetic + SRP + SPT | -5.05 |
| Diabetic + SRP | 2.74 |
| Non-Diabetic + SRP + SPT | 0.42 |
| Non-Diabetic + SRP | 0.72 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Group A: SRP + SPT | -0.01 |
| Group B: SRP | 0.14 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Diabetic + SRP + SPT | -0.04 |
| Diabetic + SRP | 0.30 |
| Non-Diabetic + SRP + SPT | 0.01 |
| Non-Diabetic + SRP | -0.07 |
The analysis is based on the measures of each participant. Participant instead of site is used as unite for arm/group. The measure, % sites with probing pocket depth >= 4 mm within each participant, indicates the portion of deep pocket in a participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm within each participant was compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -8.71 | -7.03 |
| Group B: SRP | -4.74 | -4.73 |
The analysis is based on the measure of each participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm per participant is compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -4.22 | 4.12 |
| Diabetic + SRP + SPT | -10.23 | -7.85 |
| Non-Diabetic + SRP | -5.4 | -5.52 |
| Non-Diabetic + SRP + SPT | -7.39 | -6.3 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -14.76 | 9.68 |
| Group B: SRP | -7.7 | -5.19 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -7.67 | -4.97 |
| Diabetic + SRP + SPT | -17.46 | -12.11 |
| Non-Diabetic + SRP | -7.75 | -5.48 |
| Non-Diabetic + SRP + SPT | -12.4 | -7.56 |
Probing depth (PD) or probing pocket depth (PPD), measured on six surfaces/tooth, is the distance in millimeters (mm) from the gingival margin to the base of the gingival pocket (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -0.17 | -0.12 |
| Diabetic + SRP + SPT | -0.36 | -0.27 |
| Non-Diabetic + SRP | -0.27 | -0.26 |
| Non-Diabetic + SRP + SPT | -0.26 | -0.24 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -13.24 | -8.93 |
| Group B: SRP | -5.57 | -4.09 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -4.35 | -1.95 |
| Diabetic + SRP + SPT | -13.45 | -9.62 |
| Non-Diabetic + SRP | -7.13 | -6.82 |
| Non-Diabetic + SRP + SPT | -13.06 | -8.32 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months;Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -0.1 | -0.1 |
| Group B: SRP | -0.2 | -0.12 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -0.17 | -0.06 |
| Diabetic + SRP + SPT | -0.11 | -0.14 |
| Non-Diabetic + SRP | -0.23 | -0.19 |
| Non-Diabetic + SRP + SPT | -0.1 | -0.07 |
Shannon index represents mean species diversity in a site at a local scale. Shannon index quantifies the uncertainty in predicting the species identity of an individual that is taken at random from the dataset. The minimum value is 0 and there is no maximum value. High values mean high species diversities. (NCT04830969)
Timeframe: Baseline; 6 Months
| Intervention | Shannon index value (Mean) | |
|---|---|---|
| Baseline | 6 Months | |
| Group A: SRP + SPT | 5.31 | 5.2 |
| Group B: SRP | 5.27 | 5.34 |
11 reviews available for metronidazole and Adult Periodontitis
| Article | Year |
|---|---|
Clinical attachment loss in the use of adjunctive antimicrobial photodynamic therapy in Stages II-IV Grade C molar-incisor periodontitis: A systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Humans; Incisor; M | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Cardiovascular Diseases; Chronic Periodontitis; Humans; Metaboli | 2022 |
Is periodontal therapy an effective treatment modality for preventing or managing cardiovascular disease in patients with periodontitis?
Topics: Amoxicillin; Cardiovascular Diseases; Chronic Periodontitis; Female; Humans; Lactation; Metronidazol | 2023 |
Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Dent | 2020 |
The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole; Pe | 2021 |
Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Humans; Met | 2014 |
An estimate of pocket closure and avoided needs of surgery after scaling and root planing with systemic antibiotics: a systematic review.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modali | 2014 |
[Efficient, minimally invasive periodontal therapy. An evidence based treatment concept].
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2011 |
Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Dental Plaque Inde | 2010 |
Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Administration, Oral; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chi-Square Distrib | 2012 |
Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Administration, Oral; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chi-Square Distrib | 2012 |
Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Administration, Oral; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chi-Square Distrib | 2012 |
Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Administration, Oral; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chi-Square Distrib | 2012 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.
Topics: Administration, Oral; Adult; Amoxicillin; Anti-Infective Agents; Chemotherapy, Adjuvant; Chronic Per | 2013 |
34 trials available for metronidazole and Adult Periodontitis
| Article | Year |
|---|---|
The effects of non-surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Blood Glucose; Chronic Periodontitis; Dental Scaling; Diabetes M | 2020 |
Clinical, microbiological, and immunological effects of systemic probiotics in periodontal treatment: study protocol for a randomized controlled trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Double-Blind Method; Huma | 2021 |
Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial.
Topics: Blood Glucose; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole; Periodontal Attachment | 2021 |
Comparison of repeated applications of aPDT with amoxicillin and metronidazole in the treatment of chronic periodontitis: A short-term study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Female; Humans; Male; Metron | 2017 |
Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Infective Agents; Chronic Periodontitis; Drug Therapy, Combination; F | 2018 |
Do we treat our patients or rather periodontal microbes with adjunctive antibiotics in periodontal therapy? A 16S rDNA microbial community analysis.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; DNA, Ribosomal; Female; Gingiva; H | 2018 |
Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial.
Topics: Adult; Amoxicillin; Archaea; Biofilms; Chronic Periodontitis; Combined Modality Therapy; Dental Plaq | 2018 |
Comparing the periodontal tissue response to non-surgical scaling and root planing alone, adjunctive azithromycin, or adjunctive amoxicillin plus metronidazole in generalized chronic moderate-to-severe periodontitis: a preliminary randomized controlled tr
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Azithromycin; Chronic Periodontitis; Dental Scaling; Fema | 2019 |
Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change.
Topics: Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Bacteroides; Biofilms; Capnocytophaga; Chronic P | 2013 |
Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers.
Topics: Actinomyces; Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cohort Studies; Combi | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Chronic Periodonti | 2014 |
The effect of metronidazole on the presence of P. gingivalis and T. forsythia at 3 and 12 months after different periodontal treatment strategies evaluated in a randomized, clinical trial.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Anti-Infective Agents, Lo | 2015 |
[Clinical effect of different sequences of debridement-antibiotic therapy in treatment of severe chronic periodontitis].
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debride | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study.
Topics: Chronic Periodontitis; Dental Scaling; Follow-Up Studies; Humans; Metronidazole; Periodontal Attachm | 2016 |
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial.
Topics: Acute-Phase Proteins; Adult; Aged; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bio | 2016 |
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial.
Topics: Acute-Phase Proteins; Adult; Aged; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bio | 2016 |
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial.
Topics: Acute-Phase Proteins; Adult; Aged; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bio | 2016 |
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial.
Topics: Acute-Phase Proteins; Adult; Aged; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bio | 2016 |
Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Azithromycin; Chronic Periodontitis; Dental Scaling; Doub | 2016 |
Non-surgical periodontal treatment in conjunction with 3 or 7 days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole; Ro | 2016 |
Comparison of cefixime and amoxicillin plus metronidazole in the treatment of chronic periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Cefixime; Chronic Periodontitis; Drug The | 2016 |
Low antibiotic resistance among anaerobic Gram-negative bacteria in periodontitis 5 years following metronidazole therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Clindamycin; Drug | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling | 2017 |
Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Infective Agents; Bacteria; Chronic Periodontitis; Colony Count, Microbial; | 2008 |
Gingival crevicular fluid levels of aspartate aminotransferase and alpha2-macroglobulin before and after topical application of metronidazole or scaling and root planing.
Topics: Adult; alpha-Macroglobulins; Anti-Infective Agents, Local; Aspartate Aminotransferases; Chronic Peri | 2008 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacteroides; | 2009 |
Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis.
Topics: Adult; Amoxicillin; Anti-Infective Agents; Antibiotic Prophylaxis; Bacteria; Chronic Periodontitis; | 2010 |
Short-term effects of systemic antibiotics during periodontal healing.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; A | 2010 |
[Efficient, minimally invasive periodontal therapy. An evidence based treatment concept].
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
In vivo evaluation of a metronidazole-containing gel for the adjuvant treatment of chronic periodontitis: preliminary results.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Bacterial Load; Chemot | 2012 |
Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cytokines; Dental Scaling; D | 2012 |
Er:YAG laser versus systemic metronidazole as an adjunct to nonsurgical periodontal therapy: a clinical and microbiological study.
Topics: Administration, Oral; Adult; Aged; Chronic Periodontitis; Combined Modality Therapy; Dental Plaque I | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
28 other studies available for metronidazole and Adult Periodontitis
| Article | Year |
|---|---|
Adverse events of metronidazole and amoxicillin: Retrospective analysis of a large data set of five randomized clinical trials.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Diarrhea; Double-Blind Me | 2022 |
Response to Letter to the Editor.
Topics: Amoxicillin; Azithromycin; Chronic Periodontitis; Humans; Metronidazole; Root Planing | 2019 |
Relationship Between Periodontal Screening and Recording Index Scores and Need for Periodontal Access Surgery.
Topics: Adult; Aged; Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Doxycycline; F | 2017 |
An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis.
Topics: Chronic Periodontitis; Drug Liberation; Humans; Metronidazole; Nanostructures; Periodontal Pocket | 2017 |
Microbiologic Response to Periodontal Therapy and Multivariable Prediction of Clinical Outcome.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Infe | 2017 |
No evidence to support benefit of 14-day courses of amoxicillin-plus-metronidazole as adjunct to non-surgical periodontal treatment at three months.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Humans; Metroni | 2019 |
Antibiotic resistance in human chronic periodontitis microbiota.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Lo | 2014 |
Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis.
Topics: Amoxicillin; Anti-Infective Agents; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole | 2013 |
The 1-year treatment outcome of generalized chronic periodontitis may be enhanced by the systemic use of metronidazole alone or in combination with amoxicillin as adjuncts to scaling and root planing.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Female; Humans; Male; Metronidazole | 2013 |
Letter to the editor: Re: The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review; Re: Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to s
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodo | 2014 |
Letter to the editor: Authors' response.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodo | 2014 |
Centipeda periodontii in human periodontitis.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Biofilms; Chronic Periodontitis; DNA, Bacterial; Doxycycl | 2015 |
Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Azithromycin; Bacteriological Techniques; Chronic P | 2014 |
Antibiotics in the treatment of periodontal disease: a guide for the general dental practitioner.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Biofilms; Chronic Periodontitis | 2014 |
Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Load; Bacteriological Techniques; Chronic | 2014 |
Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Drug Therapy, Combination; F | 2015 |
Nonsurgical therapy of chronic periodontitis with adjunctive systemic azithromycin or amoxicillin/metronidazole.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Chemotherapy, Adjuva | 2016 |
The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients.
Topics: alpha-Defensins; Amoxicillin; Anti-Infective Agents; Chronic Periodontitis; Defensins; Dental Scalin | 2017 |
Adjunctive Use of Systemic Antibiotics (Amoxicillin 500 MG plus Metronidazole 500 MG 3 times a Day for 3 or 7 Days) to Nonsurgical Periodontal Therapy may Improve Clinical Outcomes in Treating Severe Chronic Periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Double-Blind Method; Humans; Metronidazol | 2017 |
Clinical peri-implant sounding accuracy in the presence of chronic inflammation of peri-implant tissues. Clinical observation study.
Topics: Alveolar Bone Loss; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debride | 2009 |
Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacteroides; Bacteroidetes; Campylobacter; Chro | 2009 |
Modified periodontal risk assessment score: long-term predictive value of treatment outcomes. A retrospective study.
Topics: Aggressive Periodontitis; Anti-Infective Agents, Local; Chronic Periodontitis; Dental Scaling; Disea | 2010 |
Antibiotic resistance of subgingival species in chronic periodontitis patients.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate C | 2010 |
[Analysis of the oral cavity clinical immunological status in patients with chronic generalized mild and moderate parodontitis when treated with antibacterial means].
Topics: Adult; Anti-Bacterial Agents; Chlorhexidine; Chronic Periodontitis; Drug Combinations; Female; Human | 2010 |
[Methodic approaches to treatment of the chronic generalized parodontitis in elderly and senile patients].
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Chron | 2011 |
Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray.
Topics: Amoxicillin; Anti-Infective Agents; Bacteria; Chi-Square Distribution; Chronic Periodontitis; Dental | 2012 |
Antibiotic susceptibility of periodontal Enterococcus faecalis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Anti- | 2013 |
Prevalence of β-lactamase-producing bacteria in human periodontitis.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bac | 2013 |