metronidazole has been researched along with Bilharziasis in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 7.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 3.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "Metronidazole administered orally in doses of 20 and 200 mg/kg daily suppressed granuloma formation around Schistosoma mansoni eggs which were injected intravenously and lodged in the pulmonary microvasculature of mice." | 3.65 | Suppression of cell-mediated immunity by metronidazole. ( Grove, DI; Mahmound, AA; Warren, KS, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Werf, MJ | 1 |
| de Vlas, SJ | 1 |
| Landouré, A | 1 |
| Bosompem, KM | 1 |
| Habbema, JD | 1 |
| Trussell, RR | 1 |
| Beeley, L | 1 |
| Daneshmend, TK | 1 |
| Homeida, M | 1 |
| Kaye, CM | 1 |
| Elamin, AA | 1 |
| Roberts, CJ | 1 |
| Grove, DI | 1 |
| Mahmound, AA | 1 |
| Warren, KS | 1 |
| Most, H | 1 |
| Shlansky, E | 1 |
| Knight, R | 1 |
| Schultz, MG | 1 |
| Hoskins, DW | 1 |
| Marsden, PD | 1 |
| Radermecker, M | 1 |
| Bekhti, A | 1 |
| Poncelet, E | 1 |
| Salmon, J | 1 |
| Sherif, SM | 1 |
3 reviews available for metronidazole and Bilharziasis
| Article | Year |
|---|---|
Prescribing in pregnancy. Infestations.
Topics: Animals; Anthelmintics; Antiprotozoal Agents; Bephenium Compounds; Cestode Infections; Female; Fetus | 1981 |
Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2.
Topics: Amebiasis; Amebicides; Anthelmintics; Antimalarials; Antimony; Benzenesulfonates; Chloroquine; Clono | 1972 |
Intestinal parasites.
Topics: Animals; Anthelmintics; Antimony; Chloroquine; Coccidiosis; Diphyllobothriasis; Dysentery, Amebic; E | 1973 |
6 other studies available for metronidazole and Bilharziasis
| Article | Year |
|---|---|
Measuring schistosomiasis case management of the health services in Ghana and Mali.
Topics: Adult; Analysis of Variance; Anthelmintics; Anti-Bacterial Agents; Case Management; Child; Delivery | 2004 |
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Kinetics; Liver Cirrhosis; Liver Diseases, Parasi | 1982 |
Suppression of cell-mediated immunity by metronidazole.
Topics: Animals; Female; Graft Survival; Granuloma; Hypersensitivity, Delayed; Immunity, Cellular; Metronida | 1977 |
Treatment of common enteric parasites.
Topics: Amebiasis; Amoeba; Ascariasis; Benzenesulfonates; Bephenium Compounds; Feces; Hookworm Infections; H | 1974 |
Serum IgE levels in protozoal and helminthic infections.
Topics: Adolescent; Adult; Amebiasis; Ascariasis; Child; Child, Preschool; Echinococcosis; Female; Filariasi | 1974 |
Malabsorption and schistosomal involvement of jejunum.
Topics: Adult; Diet Therapy; Humans; Intestine, Small; Intestines; Jejunum; Malabsorption Syndromes; Male; M | 1970 |