metronidazole has been researched along with Rhabdomyosarcoma in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination of the radiosensitizer, metronidazole, and the radioprotector, dimethyl sulfoxide (DMSO), was tested for its effects on the radiation tolerance of rat skin and on the radiosensitivity of the BA1112 rhabdomyosarcoma." | 3.66 | Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat. ( Fischer, JJ; Lo, PS; Moulder, JE, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Theys, J | 1 |
| Landuyt, W | 1 |
| Nuyts, S | 1 |
| Van Mellaert, L | 1 |
| Bosmans, E | 1 |
| Rijnders, A | 1 |
| Van Den Bogaert, W | 1 |
| van Oosterom, A | 1 |
| Anné, J | 1 |
| Lambin, P | 1 |
| Moulder, JE | 1 |
| Lo, PS | 1 |
| Fischer, JJ | 1 |
2 other studies available for metronidazole and Rhabdomyosarcoma
| Article | Year |
|---|---|
Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bacterial; Clostridium; Clostridi | 2001 |
Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat.
Topics: Animals; Dimethyl Sulfoxide; Metronidazole; Radiation Dosage; Radiation Tolerance; Rats; Rhabdomyosa | 1978 |