metronidazole has been researched along with Blood Pressure, High in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pylori-infected patients with endoscopically documented duodenal ulcer either currently or within the past year were randomized to 14 days of (1) lansoprazole, 30 mg bid, plus amoxicillin, 1 gm tid; (2) lansoprazole, 30 mg tid, plus amoxicillin, 1 gm tid; (3) lansoprazole, 30 mg tid alone; or (4) amoxicillin, 1 gm tid alone." | 5.08 | Double-blind, multicenter evaluation of lansoprazole and amoxicillin dual therapy for the cure of Helicobacter pylori infection. ( Arora, A; Graham, D; Haber, M; Harford, W; Lanza, F; Rose, P; Siepman, N; Weissfeld, A, 1996) |
| "Colonoscopy revealed a picture of pseudomembranous colitis, and Clostridium difficile toxin was positive." | 1.31 | Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction. ( Pauly, MP; Sheikh, RA; Trudeau, WL; Yasmeen, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SU | 1 |
| Jung, IE | 1 |
| Kim, HJ | 1 |
| Kim, JS | 1 |
| Khan, SH | 1 |
| Sanche, SE | 1 |
| Robinson, CA | 1 |
| Pirouzmand, F | 1 |
| Harford, W | 1 |
| Lanza, F | 1 |
| Arora, A | 1 |
| Graham, D | 1 |
| Haber, M | 1 |
| Weissfeld, A | 1 |
| Rose, P | 1 |
| Siepman, N | 1 |
| Sheikh, RA | 1 |
| Yasmeen, S | 1 |
| Pauly, MP | 1 |
| Trudeau, WL | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
1 trial available for metronidazole and Blood Pressure, High
| Article | Year |
|---|---|
Double-blind, multicenter evaluation of lansoprazole and amoxicillin dual therapy for the cure of Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Ulcer Agents; Clarithromycin; Diar | 1996 |
4 other studies available for metronidazole and Blood Pressure, High
| Article | Year |
|---|---|
Metronidazole-induced combined peripheral and central vestibulopathy.
Topics: Aged; Anti-Infective Agents; Diabetes Mellitus; Diabetic Foot; Humans; Hypertension; Male; Metronida | 2016 |
N. paucivorans infection presenting as a brain abscess.
Topics: Anti-Bacterial Agents; Brain Abscess; Brain Neoplasms; Diagnosis, Differential; Humans; Hypertension | 2006 |
Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction.
Topics: Aged; Anti-Infective Agents; Biopsy; Colonic Pseudo-Obstruction; Colonoscopy; Contrast Media; Diabet | 2001 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |