6th Nerve Palsy

Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.

Synonym
Cranial Nerve VI Palsy
Benign Recurrent Abducens Palsy, Children
Benign Recurrent Abducens Palsy of Childhood
Cranial Nerve VI Diseases
Abducens Nerve Diseases
Lateral Rectus Palsy
VI Nerve Palsy
Sixth Nerve Palsy
Abducens Palsy, Childhood, Benign Recurrent
Abducens Nerve Palsy
Sixth Cranial Nerve Palsy
Sixth Cranial Nerve Disorders
6th Nerve Palsy
Sixth Cranial Nerve Diseases
Abducens Palsy
VIth Cranial Nerve Diseases

Excerpt	Reference
"Proptosis and 6th nerve palsy is very uncommon presentation."	( Multani, LS; Neki, NS; Sharma, N; Sharma, RK, 2001)
"Bilateral sixth nerve palsy is a known though uncommon complication following dural puncture."	( Arcand, G; Boudreault, D; Chouinard, P; Girard, F; McCormack, M; Williams, S, 2004)
"Isolated abducens nerve palsy is a rare complication of treatment with various drugs."	( Alemdar, M; Iseri, P; Komsuoglu, SS; Selekler, HM; Serbest, AS, 2005)
"A bilateral sixth nerve palsy is rarely seen after a head trauma without cranial pathologic findings, and corticosteroid therapy may have beneficial effects during treatment besides spontaneous resolution."	( Acioglu, E; Eltutar, K; Ogreden, S; Sisman, AS; Taskin, U; Yigit, O, 2009)
"Sixth nerve palsy is a common complication of endovascular treatment for carotid-cavernous fistulas (CCF)."	( Blanc, R; Ciccio, G; Piotin, M; Redjem, H; Robert, T; Smajda, S; Sylvestre, P; Valsecchi, D, 2018)
"Recovery from sixth nerve palsy is possible with this approach."	( Ambrosiani, J; Arraez, MA; Cárdenas Ruiz-Valdepeñas, E; Kaen, A; Martin Schrader, I; Pérez Prat, G; Simal Julián, JA; Soto Moreno, A, 2022)

Excerpt	Reference
"We present here a patient with sixth cranial nerve palsy that occurred during treatment for brucellosis, a form of presentation rarely been reported in English-language literature."	( Mert, A; Ozaras, R; Ozturk, R; Tabak, F; Yilmaz, M, 2003)
"Isolated abducens nerve palsy is a rare complication of treatment with various drugs."	( Alemdar, M; Iseri, P; Komsuoglu, SS; Selekler, HM; Serbest, AS, 2005)
"The left abducens palsy completely improved after treatment with intravenous methylprednisolone."	( Ergan, S; Kocer, B; Nazliel, B, 2009)
"We report a case of transient sixth nerve palsy after systemic administration of bevacizumab."	( Momeni, M; Veras, L; Zakashansky, K, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	18 (9.57)	23.3326
1990's	2 (1.06)	12.5806
2000's	70 (37.23)	18.1394
2010's	76 (40.43)	28.8240
2020's	22 (11.70)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	2
dalteparin	low	1
thiamine	low	3
n-methyl-3,4-methylenedioxyamphetamine	low	1
4-aminopyridine	low	1
phenytoin	low	1
acetaminophen	low	1
acetazolamide	low	6
albendazole	low	2
theophylline	low	1
aspirin	low	3
azathioprine	low	2
baclofen	low	1
bupivacaine	low	4
verapamil	low	1
carbamazepine	low	4
carmustine	low	1
celecoxib	low	1
chloroquine	low	1
ciprofloxacin	low	1
valproic acid	low	1
brl 42810	low	1
fentanyl	low	2
fluconazole	low	2
fluorouracil	low	1
gabapentin	low	1
hydroxychloroquine	low	1
lidocaine	low	4
isoniazid	low	1
mechlorethamine	low	1
metronidazole	low	2
ofloxacin	low	2
phenylbutazone	low	1
propofol	low	1
thalidomide	low	2
ticlopidine	low	1
prednisolone	low	14
dextroamphetamine	low	1
prednisone	low	4
amifampridine	low	1
chloramphenicol	low	1
kanamycin a	low	1
colchicine	low	1
ampicillin	low	1
mannitol	low	1
methylprednisolone	low	16
thiazoles	low	1
2-aminopurine	low	1
hydantoins	low	1
deoxycytidine	low	1
streptomycin	low	2
floxacillin	low	1
tantalum	low	1
gadolinium	low	11
magnesium sulfate	low	1
trolamine salicylate	low	2
carticaine	low	1
amoxicillin	low	2
etoposide	low	2
ribavirin	low	2
propiconazole	low	19
nicorandil	low	1
fomesafen	low	2
cabergoline	low	1
clopidogrel	low	1
gemcitabine	low	1
chloroquine diphosphate	low	1
triazoles	low	1
fluorodeoxyglucose f18	low	2
zoledronic acid	low	1
voriconazole	low	2
homocysteine	low	1
methotrexate	low	3
sulbactam	low	1
carbapenems	low	1
dabigatran	low	1
cortisone	low	1
carboplatin	low	3
rocuronium	low	1
sultamicillin	low	1
tretinoin	low	1
retinol	low	2
zithromax	low	1
bromochloroacetic acid	low	1
quinine	low	1
clavulanic acid	low	1
phenylephrine hydrochloride	low	2
acitretin	low	1
nitrofurazone	low	1
beryllium	low	1
pregabalin	low	2
cefotaxime	low	1
gadolinium dtpa	low	2
ergoline	low	1
g(m2) ganglioside	low	1
edoxaban	low	1
oligonucleotides	low	1
ro13-9904	low	6
cardiovascular agents	low	1
phosphinothricin	low	1
vitamin b 12	low	2
cyclosporine	low	3
nusinersen	low	1
acyclovir	low	7
rifampin	low	2
ganciclovir	low	2
eye	low	8
gq1b ganglioside	low	8

Protein Targets (1,107)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	12	0	0	12
thioredoxin reductase	23	0	0	23
aldehyde dehydrogenase 1 family, member A1	31	0	0	31
IDH1	15	0	0	15
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
TAR DNA-binding protein 43	11	0	0	11
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	19	0	0	19
Chain A, Cruzipain	9	0	0	9
RAR-related orphan receptor gamma	29	0	0	29
USP1 protein, partial	14	0	0	14
Microtubule-associated protein tau	15	0	0	15
thyroid stimulating hormone receptor	18	0	0	18
estrogen receptor 2 (ER beta)	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	26	0	0	26
glucocorticoid receptor [Homo sapiens]	33	0	0	33
cytochrome P450 2D6	14	0	0	14
glucocerebrosidase	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
cytochrome P450 2D6 isoform 1	4	0	0	4
chromobox protein homolog 1	22	0	0	22
transcriptional regulator ERG isoform 3	9	0	0	9
thyroid hormone receptor beta isoform 2	29	0	0	29
mitogen-activated protein kinase 1	8	0	0	8
geminin	36	0	0	36
peripheral myelin protein 22	20	0	0	20
survival motor neuron protein isoform d	15	0	0	15
lethal factor (plasmid)	6	0	0	6
lamin isoform A-delta10	29	0	0	29
Potassium channel subfamily K member 2	0	2	3	5
Rap guanine nucleotide exchange factor 3	4	0	0	4
Cellular tumor antigen p53	31	0	0	31
Potassium voltage-gated channel subfamily A member 3	0	1	1	2
Acetylcholinesterase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	13	0	14
ATP-dependent phosphofructokinase	13	0	0	13
ATAD5 protein, partial	10	0	0	10
GLS protein	15	0	0	15
Smad3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	24	0	0	24
progesterone receptor	20	0	0	20
EWS/FLI fusion protein	29	0	0	29
retinoic acid nuclear receptor alpha variant 1	31	0	0	31
retinoid X nuclear receptor alpha	26	0	0	26
estrogen-related nuclear receptor alpha	33	0	0	33
estrogen nuclear receptor alpha	50	0	0	50
peroxisome proliferator activated receptor gamma	27	0	0	27
aryl hydrocarbon receptor	14	0	0	14
cytochrome P450 3A4 isoform 1	19	0	0	19
Gamma-aminobutyric acid receptor subunit pi	19	7	1	27
ATP-binding cassette sub-family C member 3	0	42	0	42
Multidrug resistance-associated protein 4	0	42	0	43
Solute carrier family 22 member 6	0	4	0	5
Carbonic anhydrase 12	0	5	1	8
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	17	0	17
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Bile salt export pump	0	51	0	51
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	11	1	16
Carbonic anhydrase 2	0	11	2	16
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	3	1	5
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 3	0	4	1	7
Cytochrome P450 3A4	0	13	1	14
Cytochrome P450 2D6	0	8	1	10
Cytochrome P450 2C9	0	17	1	18
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	19	7	1	27
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	19	7	1	27
Gamma-aminobutyric acid receptor subunit gamma-2	19	7	3	29
UDP-glucuronosyltransferase 1-6	0	0	0	2
Glutamate receptor 2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-5	19	7	1	27
Gamma-aminobutyric acid receptor subunit alpha-3	19	7	1	27
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	2
Carbonic anhydrase 4	0	4	1	6
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase 6	0	5	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	19	7	1	27
Gamma-aminobutyric acid receptor subunit alpha-2	19	7	1	27
Gamma-aminobutyric acid receptor subunit alpha-4	19	7	1	27
Gamma-aminobutyric acid receptor subunit gamma-3	19	7	1	27
Gamma-aminobutyric acid receptor subunit alpha-6	19	7	1	27
Carbonic anhydrase 5A, mitochondrial	0	4	1	7
Prostaglandin G/H synthase 2	0	6	1	9
Carbonic anhydrase 7	0	4	1	6
Nuclear receptor ROR-gamma	14	1	1	16
Cytochrome P450 2J2	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	19	9	3	31
Gamma-aminobutyric acid receptor subunit beta-3	19	7	1	27
Gamma-aminobutyric acid receptor subunit beta-2	19	7	3	29
Carbonic anhydrase 9	0	6	1	9
GABA theta subunit	19	7	1	27
Canalicular multispecific organic anion transporter 1	0	41	0	42
Carbonic anhydrase 15	0	3	0	4
Carbonic anhydrase 13	0	3	0	4
Gamma-aminobutyric acid receptor subunit epsilon	19	7	1	27
Carbonic anhydrase 14	0	5	1	8
Carbonic anhydrase 5B, mitochondrial	0	4	1	7
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	3	0	0	3
GLI family zinc finger 3	34	0	0	34
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	12	0	0	12
Carbonic anhydrase	0	2	0	2
Bloom syndrome protein isoform 1	17	0	0	17
thyroid hormone receptor beta isoform a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	31	0	0	31
muscleblind-like protein 1 isoform 1	9	0	0	9
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	3	0	3
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	1	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	5	0	5
Cytochrome P450 2A6	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	1	3
Androgen receptor	0	4	0	4
Translocator protein	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	6	2	8
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	0	6
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	3	0	5
5-hydroxytryptamine receptor 2B	0	1	1	2
Sodium-dependent serotonin transporter	0	2	3	5
Delta-type opioid receptor	0	5	0	5
Cytochrome P450 2C19	0	7	1	8
Delta-type opioid receptor	0	5	0	5
Mu-type opioid receptor	0	6	1	7
Carbonic anhydrase	0	2	0	2
Kappa-type opioid receptor	0	4	0	6
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	5	0	5
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	4	0	4
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	11	0	0	11
TDP1 protein	41	0	0	41
AR protein	38	0	0	38
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
vitamin D3 receptor isoform VDRA	11	0	0	11
flap endonuclease 1	9	0	0	9
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	11	0	0	11
Thymidine kinase	0	2	0	2
phosphopantetheinyl transferase	11	0	0	11
activating transcription factor 6	13	0	0	13
Histone H2A.x	13	0	0	13
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Solute carrier family 22 member 1	0	6	0	9
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	1	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Thymidine kinase	0	1	0	1
glp-1 receptor, partial	10	0	0	10
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
Fumarate hydratase	6	0	0	6
caspase 7, apoptosis-related cysteine protease	5	0	0	5
farnesoid X nuclear receptor	18	0	0	18
pregnane X nuclear receptor	31	0	0	31
polyprotein	6	0	0	6
67.9K protein	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	22	0	0	22
caspase-3	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
cellular tumor antigen p53 isoform a	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	11	0	0	11
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
Vif	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
neuropeptide S receptor isoform A	4	0	0	4
Interferon beta	24	0	0	24
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	1	0	4
Methionine aminopeptidase	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
POU domain, class 2, transcription factor 1	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	4
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase iota isoform a (long)	15	0	0	15
DNA polymerase kappa isoform 1	7	0	0	7
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase SHV-1	0	3	0	5
Beta-lactamase	0	2	0	4
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
Beta-lactamase	0	2	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	3
DNA polymerase beta	3	0	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	9	1	4	14
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	4
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	2	0	3
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	4
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	3	0	5
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	4
Beta-lactamase VIM-1	0	0	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	10	0	0	10
hypothetical protein, conserved	1	0	0	1
peroxisome proliferator-activated receptor delta	17	0	0	17
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
muscarinic acetylcholine receptor M1	10	0	0	10
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	1	0	1
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	1	2	3
acetylcholinesterase	12	0	0	12
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
thioredoxin glutathione reductase	5	0	0	5
G	15	0	0	15
P53	1	0	0	1
thyroid stimulating hormone receptor	13	0	0	13
peripheral myelin protein 22 isoform 1	6	0	0	6
M-phase phosphoprotein 8	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	15	0	0	15
Inositol hexakisphosphate kinase 1	15	0	0	15
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	15	0	0	15
NFKB1 protein, partial	2	0	0	2
regulator of G-protein signaling 4	8	0	0	8
D(1A) dopamine receptor	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
5-hydroxytryptamine receptor 2B	0	7	1	8
Histamine H3 receptor	0	1	0	1
Liver carboxylesterase 1	0	1	0	3
Vpr	3	0	0	3
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	5
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
endonuclease IV	7	0	0	7
huntingtin isoform 2	4	0	0	4
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Glutathione reductase, mitochondrial	0	1	0	1
Alpha-synuclein	1	3	0	4
Glutathione reductase	0	1	0	1
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	3
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	2	0	3
Albumin	0	0	7	7
Beta-lactamase	0	0	0	1
Beta-lactamase	0	2	0	3
Metallo-beta-lactamase VIM-2	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
pregnane X receptor	10	0	0	10
PPM1D protein	7	0	0	7
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	3	0	0	3
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
caspase-3	3	0	0	3
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	5	0	5
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Procathepsin L	0	2	4	6
Aldo-keto reductase family 1 member B1	0	5	0	5
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	6	0	6
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 1A	0	6	1	7
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	10	2	12
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	10	2	12
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Histone deacetylase 4	0	5	0	5
Sodium-dependent dopamine transporter	0	6	2	8
Prostaglandin G/H synthase 2	0	1	0	1
Histone deacetylase 1	0	5	0	5
Mitogen-activated protein kinase 14	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	2	0	2
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	5	0	5
Histone deacetylase 11	0	5	0	5
Histone deacetylase 8	0	5	0	5
P2Y purinoceptor 12	0	1	0	1
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	5	0	5
Histone deacetylase 5	0	5	0	5
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	4	5
Replicase polyprotein 1ab	0	1	4	5
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	4	5
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	1	3	0	4
Histidine-rich protein PFHRP-II	0	2	0	3
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	6	0	6
Replicase polyprotein 1a	0	1	4	5
Replicase polyprotein 1ab	0	1	4	5
Replicase polyprotein 1ab	0	3	4	7
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	4	4	8
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	4	5
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cytochrome P450 2C9 precursor	5	0	0	5
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	3	0	6
DNA gyrase subunit B	0	3	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	11
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	7	0	0	7
DNA gyrase subunit B	0	4	0	5
DNA gyrase subunit A	0	4	0	5
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	3	0	3
Beta-lactamase	0	2	0	2
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	2	0	2
Beta-lactamase TEM	0	4	0	5
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
nonstructural protein 1	6	0	0	6
P2Y purinoceptor 12	0	1	0	1
PAX8	0	0	0	1
Thrombopoietin	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	9	1	21
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
dopamine D1 receptor	2	0	0	2
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Multidrug and toxin extrusion protein 1	0	3	0	3
Solute carrier family 22 member 2	0	2	0	3
Prothrombin	0	2	0	3
Coagulation factor X	0	3	0	3
Plasminogen	0	1	0	1
Coagulation factor XII	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Trypsin-3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
RAD51	0	1	0	1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	2	0	2
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	1	2
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Sodium-dependent dopamine transporter	0	0	2	2
Amine oxidase [flavin-containing] B	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 6	0	0	1	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	6
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(2) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	2	4
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	4	1	6
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	2	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 5	0	1	0	1
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Estrogen receptor 1	0	1	0	1
Parkin	2	0	0	2
fMet-Leu-Phe receptor	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
UDP-glucuronosyltransferase 1A8	0	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Solute carrier family 22 member 1	0	3	0	4
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
NS5	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A1	0	3	1	6
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Cocaine esterase	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Chloroquine resistance transporter	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(16)

Research Excerpts

Overview

Treatment

Research

Studies (188)

Protein Targets (1,107)

6th Nerve Palsy

Synonyms(16)

Research Excerpts

Overview

Treatment

Research

Studies (188)

Drugs Studied (120)

Protein Targets (1,107)