Megacolon, Toxic

An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.

Synonym
Toxic Megacolon
Megacolon, Toxic

Excerpt	Reference
"Toxic megacolon is associated with the appearance of inducible NO synthase in the colonic muscularis propria."	( Casellas, F; Guarner, F; Malagelada, JR; Moncada, S; Mourelle, M; Riveros-Moreno, V; Salas, A, 1995)
"Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity."	( Dignass, AU; Müller, AR; Pascu, M; Wiedenmann, B, 2003)
"Toxic megacolon is a well known complication in inflammatory bowel disease such as ulcerative colitis or Crohn's disease."	( Koerner, RJ; McElroy, J; Nayar, DM; Pai, P; Vetrivel, S, 2006)
"Toxic megacolon is a life-threatening complication of ulcerative colitis (UC) characterized by systemic toxicity, loss of blood per rectum and severe pain."	( Lindley, K; Lloyd-Thomas, A; Shah, N; Thomas, M; White, M, 2006)
"Toxic megacolon is an infrequent but life-threatening complication that occurs most commonly in patients with severe ulcerative colitis."	( Abe, Y; Fujiwara, K; Fukunishi, S; Higuchi, K; Iguchi, M; Inoue, T; Ishida, K; Kakimoto, K; Masuda, D; Narabayashi, K; Nouda, S; Okada, T; Sakanaka, T; Takeuchi, T; Umegaki, E; Yorifuji, N, 2014)

Excerpt	Reference
"A review of 29 patients with toxic megacolon complicating ulcerative colitis was undertaken to (1) compare the results of medical and surgical treatment; (2) determine the optimal timing for surgical intervention, and (3) identify possible precipitating factors."	( Arvanitakis, C; Hartong, WA; Klotz, AP; Skibba, RM, 1977)
"This first described case of toxic megacolon following leukaemia treatment is compared with three previously described cases following cytotoxic chemotherapy for other conditions."	( Reilly, JT; Snowden, JA; Wodziński, MA, 1994)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	31 (33.70)	23.3326
1990's	23 (25.00)	12.5806
2000's	18 (19.57)	18.1394
2010's	18 (19.57)	28.8240
2020's	2 (2.17)	9.53

Drug	Relationship Strength	Studies
acetic acid	low	1
hydrogen carbonate	low	1
phenytoin	low	1
oxyquinoline	low	1
amsacrine	low	1
azathioprine	low	1
cefuroxime	low	1
ciprofloxacin	low	2
pentetic acid	low	1
fluorouracil	low	1
gentamicin	low	1
imipramine	low	1
ketamine	low	1
loperamide	low	7
meperidine	low	1
mesalamine	low	2
metronidazole	low	8
omeprazole	low	1
procaine	low	1
sulfasalazine	low	5
prednisolone	low	4
prednisone	low	1
penicillin g	low	1
cloxacillin	low	1
ampicillin	low	1
cytarabine	low	1
arginine	low	1
methylprednisolone	low	2
cyclohexanol	low	1
thiazoles	low	1
citrulline	low	1
diphenoxylate	low	1
vancomycin	low	11
streptomycin	low	1
technetium	low	1
phosphoric acid, trisodium salt	low	1
barium sulfate	low	4
trolamine salicylate	low	2
cephalexin	low	1
daunorubicin	low	1
amoxicillin	low	2
etoposide	low	1
nitazoxanide	low	1
pefloxacin	low	1
venlafaxine hydrochloride	low	1
cephalosporin c	low	1
triazoles	low	1
voriconazole	low	1
methotrexate	low	1
carbapenems	low	1
atropine	low	2
cortisone	low	1
tacrolimus	low	2
clindamycin	low	8
posaconazole	low	1
mercaptopurine	low	1
lincomycin	low	1
indium oxine	low	1
codeine	low	2
morphine	low	1
s 1743	low	2
fidaxomicin	low	1
technetium tc 99m exametazime	low	2
clove	low	1
piperidines	low	1
colistin	low	1
cyclosporine	low	4
acyclovir	low	1
clozapine	low	2
ganciclovir	low	2
pralidoxime	low	1

Protein Targets (801)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	26	0	0	26
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	2	0	2
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	11	0	0	11
GLS protein	10	0	0	10
TDP1 protein	25	0	0	25
Smad3	2	0	0	2
thyroid stimulating hormone receptor	12	0	0	12
EWS/FLI fusion protein	14	0	0	14
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
activating transcription factor 6	8	0	0	8
Histone H2A.x	14	0	0	14
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	16	0	0	16
Solute carrier family 22 member 1	0	7	0	9
ATP-binding cassette sub-family C member 3	0	24	0	24
Multidrug resistance-associated protein 4	0	24	0	25
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	7	0	7
Bile salt export pump	0	34	0	34
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	13	0	14
Cytochrome P450 2J2	0	7	0	8
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	3	3
Solute carrier family 22 member 6	0	0	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	25	0	26
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, Beta-lactamase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
AR protein	25	0	0	25
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
DNA polymerase kappa isoform 1	7	0	0	7
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	2	0	4
Solute carrier family 15 member 1	0	7	0	7
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	5	0	6
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
GLI family zinc finger 3	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
farnesoid X nuclear receptor	12	0	0	12
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	12	0	0	12
thyroid hormone receptor beta isoform 2	16	0	0	16
DNA polymerase beta	4	0	0	4
geminin	21	0	0	21
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	1	6
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	2
Spike glycoprotein	14	0	1	15
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	1	0	3
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	9	0	0	9
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	7	0	0	7
USP1 protein, partial	11	0	0	11
PPM1D protein	5	0	0	5
Thrombopoietin	3	0	0	3
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
regulator of G-protein signaling 4	5	0	0	5
polyprotein	7	0	0	7
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cellular tumor antigen p53 isoform a	7	0	0	7
cytochrome P450 2C9 precursor	6	0	0	6
D(1A) dopamine receptor	3	0	0	3
flap endonuclease 1	7	0	0	7
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
cytochrome P450 3A4 isoform 1	10	0	0	10
caspase-1 isoform alpha precursor	3	0	0	3
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	10	3	0	13
Interferon beta	16	0	0	16
Integrin beta-3	4	0	0	4
Integrin alpha-IIb	4	0	0	4
Cytochrome P450 2D6	0	6	0	7
DNA topoisomerase 2-alpha	0	3	2	17
Gamma-aminobutyric acid receptor subunit beta-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit delta	10	3	0	13
Gamma-aminobutyric acid receptor subunit gamma-2	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-3	10	3	0	13
Gamma-aminobutyric acid receptor subunit gamma-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-2	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-4	10	3	0	13
Gamma-aminobutyric acid receptor subunit gamma-3	10	3	0	13
Gamma-aminobutyric acid receptor subunit alpha-6	10	3	0	13
Histamine H2 receptor	11	1	0	14
D(1A) dopamine receptor	4	0	0	4
5-hydroxytryptamine receptor 7	0	5	0	5
Caspase-7	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit beta-3	10	3	0	13
Gamma-aminobutyric acid receptor subunit beta-2	10	3	0	13
Aldehyde oxidase 1	0	1	0	1
DNA topoisomerase 2-beta	0	2	2	11
Aldehyde oxidase	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	12	0	13
GABA theta subunit	10	3	0	13
Ataxin-2	18	0	0	18
Gamma-aminobutyric acid receptor subunit epsilon	10	3	0	13
Aldehyde oxidase 1	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
Cytochrome P450 3A4	0	9	1	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
glucocorticoid receptor [Homo sapiens]	19	0	0	19
retinoid X nuclear receptor alpha	19	0	0	19
pregnane X nuclear receptor	20	0	0	20
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	2	2
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	2	9
Muscarinic acetylcholine receptor M4	0	4	2	8
Muscarinic acetylcholine receptor M1	0	5	1	8
Muscarinic acetylcholine receptor M3	0	5	1	8
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M5	0	6	1	9
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	5	1	9
Muscarinic acetylcholine receptor M1	0	4	2	9
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	2	8
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	5	1	6
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	2	1	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
interleukin 8	3	0	0	3
acetylcholinesterase	9	0	0	9
RAR-related orphan receptor gamma	18	0	0	18
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
Microtubule-associated protein tau	11	0	0	11
thioredoxin glutathione reductase	3	0	0	3
estrogen-related nuclear receptor alpha	17	0	0	17
G	12	0	0	12
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	13	0	0	13
peroxisome proliferator activated receptor gamma	14	0	0	14
IDH1	6	0	0	6
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
thyroid stimulating hormone receptor	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
peripheral myelin protein 22 isoform 1	6	0	0	6
heat shock protein beta-1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
peripheral myelin protein 22	12	0	0	12
survival motor neuron protein isoform d	10	0	0	10
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Cellular tumor antigen p53	17	0	0	17
Glutamate receptor 2	14	0	0	14
Nuclear receptor ROR-gamma	4	0	0	4
Inositol hexakisphosphate kinase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	15	0	0	15
Protein-arginine deiminase type-4	0	6	0	6
cytochrome P450 2C9, partial	12	0	0	12
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
vitamin D3 receptor isoform VDRA	9	0	0	9
mitogen-activated protein kinase 1	6	0	0	6
Solute carrier family 22 member 8	0	2	0	3
Cytochrome P450 1A2	0	1	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	3	0	6
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 8	0	2	0	5
Beta-lactamase TEM	0	2	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
5-hydroxytryptamine receptor 3E	0	1	0	1
Luciferase	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
caspase 7, apoptosis-related cysteine protease	6	0	0	6
estrogen receptor 2 (ER beta)	10	0	0	10
progesterone receptor	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
cytochrome P450 2D6	6	0	0	6
Beta-1 adrenergic receptor	0	1	0	1
glucocerebrosidase	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
caspase-3	6	0	0	6
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2D6 isoform 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	9	0	0	9
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Albumin	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	6	1	11
5-hydroxytryptamine receptor 1A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	5	0	6
Alpha-2A adrenergic receptor	0	3	1	4
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	5	0	8
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-1B adrenergic receptor	0	5	1	6
Alpha-2B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	5	1	6
D(2) dopamine receptor	0	2	0	2
Endothelin receptor type B	1	1	0	2
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	3	0	5
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	5	1	6
UDP-glucuronosyltransferase 1A4	0	1	0	4
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	5	0	5
Sodium-dependent dopamine transporter	0	4	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	4	0	4
Adenosine receptor A1	0	1	0	1
D(1B) dopamine receptor	0	3	0	3
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	6
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	3	0	3
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	1	5
Histamine H1 receptor	0	1	1	2
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	7	0	7
Sodium-dependent serotonin transporter	0	6	0	6
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	4	2	8
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	4	0	6
5-hydroxytryptamine receptor 3A	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	1	5
Alpha-1A adrenergic receptor	0	5	1	6
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	3	0	4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Calmodulin	0	1	2	3
Inositol monophosphatase 1	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
5-hydroxytryptamine receptor 3D	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
D	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Histamine H4 receptor	0	1	1	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transporter	0	4	0	4
Histamine H3 receptor	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Delta-type opioid receptor	0	3	0	4
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	8	3	12
Delta-type opioid receptor	0	7	2	10
Kappa-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	4	1	7
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
endonuclease IV	6	0	0	6
dopamine D1 receptor	2	0	0	2
pregnane X receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
Multidrug and toxin extrusion protein 1	0	2	0	2
glp-1 receptor, partial	3	0	0	3
67.9K protein	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	3
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Caspase-7	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	2	0	0	2
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Platelet-activating factor receptor	2	0	0	2
Multidrug resistance-associated protein 1	0	2	0	4
Histone deacetylase 1	0	1	0	1
Histone deacetylase 8	0	1	1	2
Histone deacetylase 6	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	6
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	4
Glutamate receptor ionotropic, NMDA 2B	0	3	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	4
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	4
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	4
Solute carrier organic anion transporter family member 1B3	0	4	0	6
Glutamate receptor ionotropic, NMDA 3A	0	3	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	4	0	0	4
Vpr	1	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	0	0	1
Aromatase	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ClpP	3	0	0	3
Transitional endoplasmic reticulum ATPase	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Snq2p	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Major prion protein	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Sphingomyelin phosphodiesterase	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Albumin	0	0	2	2
15-lipoxygenase, partial	4	0	0	4
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	2	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Menin	0	1	0	1
Cocaine esterase	0	2	0	2
Transmembrane protease serine 2	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	4	1	8
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Angiotensin-converting enzyme 2	0	0	1	1
Liver carboxylesterase 1	0	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	4
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	5	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
hypothetical protein, conserved	1	0	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Endothelin-1 receptor	1	0	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
Mcl-1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Chain A, Bacterial leucyl aminopeptidase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
GALC protein	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Thermolysin	0	2	0	3
Cholinesterase	0	2	0	2
Botulinum neurotoxin type A	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
Alpha-synuclein	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Gamma-aminobutyric acid	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	2	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cytochrome P450 2B6	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (92)

Protein Targets (801)

Megacolon, Toxic

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (92)

Drugs Studied (80)

Protein Targets (801)