metronidazole has been researched along with Heart Failure in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although metronidazole is not recommended to treat Clostridioides difficile infection (CDI) in Western countries, it was still to be recommended for the treatment of non-severe CDI among Taiwanese adults in 2020." | 8.12 | Reappraisal of the clinical role of metronidazole therapy for Clostridioides difficile infection in Taiwan: A multicenter prospective study. ( Chiu, CW; Hsueh, PR; Hung, YP; Ko, WC; Lee, CC; Lee, JC; Lee, YT; Tsai, PJ, 2022) |
| "Although metronidazole is not recommended to treat Clostridioides difficile infection (CDI) in Western countries, it was still to be recommended for the treatment of non-severe CDI among Taiwanese adults in 2020." | 4.12 | Reappraisal of the clinical role of metronidazole therapy for Clostridioides difficile infection in Taiwan: A multicenter prospective study. ( Chiu, CW; Hsueh, PR; Hung, YP; Ko, WC; Lee, CC; Lee, JC; Lee, YT; Tsai, PJ, 2022) |
| "The authors report a case of massive Trichuris trichiura infection, resulting in severe anaemia and congestive cardiac failure in a 9-year-old Iban boy, who was resistant to the usual oral anthelmintic treatment, but promptly responded to mebendazole retention enema." | 3.67 | Mebendazole retention enema for severe Trichuris trichiura (whipworm) infection: a case report. ( Bhattacharya, S; Ray, S; Sebastian, VJ, 1989) |
| "Leukocytosis is a sign of severe CDI and is predictive for a complicated course." | 1.39 | [Case report. Leukocytosis in the course of Clostridium difficile infection]. ( Defosse, JM; Sakka, SG; Wappler, F; Weber, KS, 2013) |
| "Colonoscopy revealed a picture of pseudomembranous colitis, and Clostridium difficile toxin was positive." | 1.31 | Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction. ( Pauly, MP; Sheikh, RA; Trudeau, WL; Yasmeen, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JC | 1 |
| Lee, CC | 1 |
| Chiu, CW | 1 |
| Tsai, PJ | 1 |
| Hsueh, PR | 1 |
| Lee, YT | 1 |
| Hung, YP | 1 |
| Ko, WC | 1 |
| Weber, KS | 1 |
| Defosse, JM | 1 |
| Wappler, F | 1 |
| Sakka, SG | 1 |
| Eshar, D | 1 |
| Peddle, GD | 1 |
| Briscoe, JA | 1 |
| Jensen, SL | 1 |
| Amato, JE | 1 |
| Hartstein, ME | 1 |
| Breer, WA | 1 |
| Sheikh, RA | 1 |
| Yasmeen, S | 1 |
| Pauly, MP | 1 |
| Trudeau, WL | 1 |
| Sebastian, VJ | 1 |
| Bhattacharya, S | 1 |
| Ray, S | 1 |
6 other studies available for metronidazole and Heart Failure
| Article | Year |
|---|---|
Reappraisal of the clinical role of metronidazole therapy for Clostridioides difficile infection in Taiwan: A multicenter prospective study.
Topics: Adult; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Heart Failure; Human | 2022 |
[Case report. Leukocytosis in the course of Clostridium difficile infection].
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Colonoscopy; Diabetes Mellitus, Type 2 | 2013 |
Diagnosis and treatment of congestive heart failure secondary to hypertrophic cardiomyopathy in a kinkajou (Potos flavus).
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Infective Agents; Cardiomyopathy, Hypertroph | 2010 |
Bilateral periorbital necrotizing fasciitis.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debri | 2004 |
Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction.
Topics: Aged; Anti-Infective Agents; Biopsy; Colonic Pseudo-Obstruction; Colonoscopy; Contrast Media; Diabet | 2001 |
Mebendazole retention enema for severe Trichuris trichiura (whipworm) infection: a case report.
Topics: Anemia; Brunei; Child; Enema; Entamoebiasis; Heart Failure; Humans; Male; Mebendazole; Metronidazole | 1989 |