metronidazole has been researched along with Cholestasis, Intrahepatic in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Capron, JP | 1 |
| Gineston, JL | 1 |
| Herve, MA | 1 |
| Braillon, A | 1 |
| Kubota, A | 1 |
| Okada, A | 1 |
| Imura, K | 1 |
| Kawahara, H | 1 |
| Nezu, R | 1 |
| Kamata, S | 1 |
| Takagi, Y | 1 |
| Freund, HR | 1 |
| Muggia-Sullam, M | 1 |
| LaFrance, R | 1 |
| Enrione, EB | 1 |
| Popp, MB | 1 |
| Bjornson, HS | 1 |
4 other studies available for metronidazole and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Metronidazole in prevention of cholestasis associated with total parenteral nutrition.
Topics: Acute Disease; Anaerobiosis; Bacteria; Cholestasis, Intrahepatic; Crohn Disease; Female; Humans; Int | 1983 |
Metronidazole, cholestasis, and total parenteral nutrition.
Topics: Adult; Bacteroides fragilis; Cholestasis, Intrahepatic; Humans; Intestinal Fistula; Intestines; Male | 1983 |
The effect of metronidazole on TPN-associated liver dysfunction in neonates.
Topics: Cholestasis, Intrahepatic; Humans; Infant, Newborn; Liver; Metronidazole; Parenteral Nutrition, Tota | 1990 |
A possible beneficial effect of metronidazole in reducing TPN-associated liver function derangements.
Topics: Amino Acids; Animals; Bacteria; Cholestasis, Intrahepatic; Fatty Liver; Injections, Intravenous; Int | 1985 |