Page last updated: 2024-12-06
benzofuroxan
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
ID Source | ID |
---|---|
PubMed CID | 68075 |
CHEMBL ID | 2413971 |
SCHEMBL ID | 8492 |
MeSH ID | M0062834 |
Synonyms (40)
Synonym |
---|
AC-18336 |
1-oxido-[2,1,3]benzoxadiazol-1-ium |
nsc-19930 |
480-96-6 |
nsc19930 |
benzofurazan n-oxide |
benzofuroxane |
benzofurazan oxide |
benzofurazan, 1-oxide |
benzofurazan 1-oxide |
benzofuroxan |
inchi=1/c6h4n2o2/c9-8-6-4-2-1-3-5(6)7-10-8/h1-4 |
2,1,3-benzoxadiazole, 1-oxide |
2,1,3-benzoxadiazole 1-oxide |
STK383927 |
B1316 , |
AKOS000271068 |
3-oxido-2,1,3-benzoxadiazol-3-ium |
1-benzo-2-oxa-1,3-diazole oxide |
34ffo6y520 , |
benzo[c][1,2,5]oxadiazole 1-oxide |
CHEMBL2413971 |
A827467 |
3-oxido-2,1,3-benzoxadiazol-3-ium;benzofuroxane |
FT-0622700 |
S10207 |
AM1026 |
SCHEMBL8492 |
OKEAMBAZBICIFP-UHFFFAOYSA-N |
benzofurazan-1-oxide |
2,1,3-benzoxadiazol-1-ium-1-olate |
Q-200690 |
F8889-9375 |
mfcd00005807 |
SY020196 |
kih 403 |
AS-17336 |
Q63398345 |
EN300-213956 |
CS-0159321 |
Research Excerpts
Overview
Benzofuroxan is an interesting ring system, which has shown a wide spectrum of biological responses against tumor cell lines.
Excerpt | Reference | Relevance |
---|---|---|
"Benzofuroxan is an interesting ring system, which has shown a wide spectrum of biological responses against tumor cell lines. " | ( BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity. Azevedo, RA; Barbuto, JA; de Sá Junior, PL; Farias, CF; Ferreira, AC; Ferreira, AK; Figueiredo, CR; Jorge, SD; Kruyt, FA; Palace-Berl, F; Pasqualoto, KF; Rodrigues, CP; Salomón, MA; Tavares, LC; Turra, KM, 2016) | 1.88 |
Effects
Excerpt | Reference | Relevance |
---|---|---|
"Benzofuroxan derivatives have been shown to inhibit the growth of Trypanosoma cruzi, the etiological agent of Chagas' disease. " | ( New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: quantitative structure-activity relationship studies. Aguirre, G; Barreiro, EJ; Boiani, L; Boiani, M; Castellano, EE; Cerecetto, H; Denicola, A; Di Maio, R; González, M; Piro, OE; Porcal, W; Sant'Anna, CM, 2005) | 2.07 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" Dose-response studies were done on the more representative compounds (12, 20, and 26)." | ( Synthesis and herbicidal activity of N-oxide derivatives. Cerecetto, H; Di Maio, R; Dias, E; Fernández, G; González, M; Lema, M; Mombrú, A; Pacce, S; Saenz, P; Seoane, G; Suescun, L; Villalba, J, 2000) | 0.31 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1100948 | Pre-emergence herbicidal activity against Triticum aestivum (wheat) assessed as germination seeds level at 50 mol/ha relative to untreated control | 2000 | Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7 | Synthesis and herbicidal activity of N-oxide derivatives. |
AID1100949 | Pre-emergence herbicidal activity against Triticum aestivum (wheat) assessed as reduction in radicular weight at 50 mol/ha relative to untreated control | 2000 | Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7 | Synthesis and herbicidal activity of N-oxide derivatives. |
AID1100951 | Pre-emergence herbicidal activity against Triticum aestivum (wheat) assessed as reduction in length of the first leaf at 50 mol/ha relative to untreated control | 2000 | Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7 | Synthesis and herbicidal activity of N-oxide derivatives. |
AID1100950 | Pre-emergence herbicidal activity against Triticum aestivum (wheat) assessed as reduction in aerial weight at 50 mol/ha relative to untreated control | 2000 | Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7 | Synthesis and herbicidal activity of N-oxide derivatives. |
AID1100944 | Post-emergence herbicidal activity against Triticum aestivum (wheat) at 50 mol/ha measured 10 days post compound application | 2000 | Journal of agricultural and food chemistry, Jul, Volume: 48, Issue:7 | Synthesis and herbicidal activity of N-oxide derivatives. |
AID763547 | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs by microdilution method | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15 | Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (48)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 6 (12.50) | 18.7374 |
1990's | 2 (4.17) | 18.2507 |
2000's | 11 (22.92) | 29.6817 |
2010's | 21 (43.75) | 24.3611 |
2020's | 8 (16.67) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 24.49
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.49) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 4 (8.33%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 44 (91.67%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |