metronidazole has been researched along with Periapical Diseases in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Periapical Diseases: Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amoxicillin still treats these infections effectively." | 1.40 | Microbiological examination and antibiotic sensitivity of infections in the head and neck. Has anything changed? ( Ameerally, PJ; Farmahan, S; Kotecha, R; Sisodia, B; Tuopar, D, 2014) |
| "Bacteria taken from carious dentine (25 cases) and infected pulps (12 cases) were also sensitive to the drug combination." | 1.29 | In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. ( Hoshino, E; Iwaku, M; Kota, K; Kurihara-Ando, N; Sato, I; Sato, M; Uematsu, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kahler, B | 1 |
| Mistry, S | 1 |
| Moule, A | 1 |
| Ringsmuth, AK | 1 |
| Case, P | 1 |
| Thomson, A | 1 |
| Holcombe, T | 1 |
| Farmahan, S | 1 |
| Tuopar, D | 1 |
| Ameerally, PJ | 1 |
| Kotecha, R | 1 |
| Sisodia, B | 1 |
| Aminabadi, NA | 1 |
| Huang, B | 1 |
| Samiei, M | 1 |
| Agheli, S | 1 |
| Jamali, Z | 1 |
| Shirazi, S | 1 |
| Kusgoz, A | 1 |
| Yildirim, T | 1 |
| Er, K | 1 |
| Arslan, I | 1 |
| Taneja, S | 1 |
| Kumari, M | 1 |
| Barrett, AP | 1 |
| Schifter, M | 1 |
| Hoshino, E | 1 |
| Kurihara-Ando, N | 1 |
| Sato, I | 1 |
| Uematsu, H | 1 |
| Sato, M | 1 |
| Kota, K | 1 |
| Iwaku, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparative Clinical and Radiographic Study of 3Mixstatin vs Tri-Antibiotic Mix and Simvastatin in the Treatment of Primary Molars With Inflammatory Root Resorption A Randomized Clinical Trial[NCT03585751] | 45 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | |||
| A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945] | 24 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Periapical Diseases
| Article | Year |
|---|---|
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
6 other studies available for metronidazole and Periapical Diseases
| Article | Year |
|---|---|
Revascularization outcomes: a prospective analysis of 16 consecutive cases.
Topics: Amoxicillin; Anti-Bacterial Agents; Apexification; Bicuspid; Blood Coagulation; Child; Ciprofloxacin | 2014 |
Microbiological examination and antibiotic sensitivity of infections in the head and neck. Has anything changed?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Bacteria; Bacteria, Anaerobic; Child; Child | 2014 |
Retreatment of a resected tooth associated with a large periradicular lesion by using a triple antibiotic paste and mineral trioxide aggregate: a case report with a thirty-month follow-up.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Apicoectomy; Calcium Compounds; Child; Ciprofloxacin; Cus | 2009 |
Use of triple antibiotic paste in the treatment of large periradicular lesions.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Combinations; Humans; Japan; Male; Metronidazole; Minocyc | 2012 |
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot | 1994 |
In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria, Anaerobic; Cip | 1996 |