metronidazole has been researched along with Bilateral Headache in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion." | 7.76 | Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era. ( Bollu, PC; Kumar, G; Litofsky, NS; Sahota, P; Soni, CR, 2010) |
| " We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion." | 3.76 | Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era. ( Bollu, PC; Kumar, G; Litofsky, NS; Sahota, P; Soni, CR, 2010) |
| " Adverse events considered by the investigator to be related to study drug occurred in only 20." | 2.84 | A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. ( Koltun, W; Morgan, FG; Nyirjesy, P; Schwebke, JR, 2017) |
| "Metronidazole is an antimicrobial, antiprotozoal agent that has been widely used in the treatment of a variety of infections." | 2.69 | Evaluation of metronidazole toxicity: a prospective study. ( Chandra, M; Gupta, RC; Kapoor, K; Nag, D; Paliwal, JK; Saxena, RC, 1999) |
| " Mostly, metronidazole is a tolerable drug but rarely presents serious adverse effects on the nervous system." | 2.49 | A rare adverse effect of metronidazole: nervous system symptoms. ( Kafadar, I; Klç, BA; Moustafa, F; Yalçın, K, 2013) |
| "Tetanus is a life-threatening infectious neurological condition that has become uncommon due to large-scale immunization campaigns." | 1.91 | Case Report: A Challenging Case of Tetanus Presenting with Headache. ( Azlan, EAM; Ismail, M; Pathi, NM; Rahim, AIA; Rahman, MR; Sulaiman, WAW, 2023) |
| "Metronidazole is a commonly used antimicrobial worldwide." | 1.48 | Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy. ( AlDhaleei, W; AlMarzooqi, A; Gaber, N, 2018) |
| "Isolated sphenoid sinusitis in childhood is a rare clinical entity which is often very difficult to diagnose, hence, it can easily be misdiagnosed." | 1.33 | Sphenoid sinusitis disguised by precocious puberty. ( Kadioglu, HH; Malcok, UA; Sengul, G, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahim, AIA | 1 |
| Azlan, EAM | 1 |
| Rahman, MR | 1 |
| Pathi, NM | 1 |
| Ismail, M | 1 |
| Sulaiman, WAW | 1 |
| Schwebke, JR | 1 |
| Morgan, FG | 1 |
| Koltun, W | 1 |
| Nyirjesy, P | 1 |
| AlDhaleei, W | 1 |
| AlMarzooqi, A | 1 |
| Gaber, N | 1 |
| Kafadar, I | 1 |
| Moustafa, F | 1 |
| Yalçın, K | 1 |
| Klç, BA | 1 |
| Çekin, AH | 1 |
| Şahintürk, Y | 1 |
| Akbay Harmandar, F | 1 |
| Uyar, S | 1 |
| Yolcular, BO | 1 |
| Çekin, Y | 1 |
| Soni, CR | 1 |
| Kumar, G | 1 |
| Bollu, PC | 1 |
| Sahota, P | 1 |
| Litofsky, NS | 1 |
| Tan, NC | 1 |
| Tan, DY | 1 |
| Tan, LC | 1 |
| Kadioglu, HH | 1 |
| Sengul, G | 1 |
| Malcok, UA | 1 |
| Kalaycý, M | 1 |
| Cadavi, F | 1 |
| Altunkaya, H | 1 |
| Gül, S | 1 |
| Ackgöz, B | 1 |
| Kapoor, K | 1 |
| Chandra, M | 1 |
| Nag, D | 1 |
| Paliwal, JK | 1 |
| Gupta, RC | 1 |
| Saxena, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)[NCT02201186] | Phase 2 | 10 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Bilateral Headache
| Article | Year |
|---|---|
A rare adverse effect of metronidazole: nervous system symptoms.
Topics: Anti-Infective Agents; Ataxia; Child, Preschool; Convalescence; Dizziness; Dysentery, Amebic; Headac | 2013 |
3 trials available for metronidazole and Bilateral Headache
| Article | Year |
|---|---|
A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Diarrhea; | 2017 |
Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Amoxicillin; Anorexia; Anti-Bacteria | 2017 |
Evaluation of metronidazole toxicity: a prospective study.
Topics: Adult; Anti-Infective Agents; Female; Headache; Humans; Male; Metronidazole; Middle Aged; Nausea; Pr | 1999 |
6 other studies available for metronidazole and Bilateral Headache
| Article | Year |
|---|---|
Case Report: A Challenging Case of Tetanus Presenting with Headache.
Topics: Adult; Female; Headache; Humans; Metronidazole; Tetanus; Tetanus Toxoid; Trismus | 2023 |
Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibito | 2018 |
Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era.
Topics: Abscess; Anti-Infective Agents; Azathioprine; Brain; Ciprofloxacin; Drug Administration Schedule; Fe | 2010 |
An Unusual Headache: Lemierre's Syndrome.
Topics: Aged; Female; Fusobacterium Infections; Headache; Humans; Metronidazole; Neck; Penicillins; Syndrome | 2003 |
Sphenoid sinusitis disguised by precocious puberty.
Topics: Anti-Infective Agents; Child; Drainage; Female; Headache; Humans; Metronidazole; Penicillins; Pubert | 2005 |
Subdural empyema due to spinal anesthesia.
Topics: Adult; Anesthesia, Spinal; Anti-Bacterial Agents; Anti-Infective Agents; Brain; Ceftriaxone; Cesarea | 2005 |