Page last updated: 2024-10-31

metronidazole and Bilateral Headache

metronidazole has been researched along with Bilateral Headache in 10 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
" We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion."7.76Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era. ( Bollu, PC; Kumar, G; Litofsky, NS; Sahota, P; Soni, CR, 2010)
" We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion."3.76Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era. ( Bollu, PC; Kumar, G; Litofsky, NS; Sahota, P; Soni, CR, 2010)
" Adverse events considered by the investigator to be related to study drug occurred in only 20."2.84A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. ( Koltun, W; Morgan, FG; Nyirjesy, P; Schwebke, JR, 2017)
"Metronidazole is an antimicrobial, antiprotozoal agent that has been widely used in the treatment of a variety of infections."2.69Evaluation of metronidazole toxicity: a prospective study. ( Chandra, M; Gupta, RC; Kapoor, K; Nag, D; Paliwal, JK; Saxena, RC, 1999)
" Mostly, metronidazole is a tolerable drug but rarely presents serious adverse effects on the nervous system."2.49A rare adverse effect of metronidazole: nervous system symptoms. ( Kafadar, I; Klç, BA; Moustafa, F; Yalçın, K, 2013)
"Tetanus is a life-threatening infectious neurological condition that has become uncommon due to large-scale immunization campaigns."1.91Case Report: A Challenging Case of Tetanus Presenting with Headache. ( Azlan, EAM; Ismail, M; Pathi, NM; Rahim, AIA; Rahman, MR; Sulaiman, WAW, 2023)
"Metronidazole is a commonly used antimicrobial worldwide."1.48Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy. ( AlDhaleei, W; AlMarzooqi, A; Gaber, N, 2018)
"Isolated sphenoid sinusitis in childhood is a rare clinical entity which is often very difficult to diagnose, hence, it can easily be misdiagnosed."1.33Sphenoid sinusitis disguised by precocious puberty. ( Kadioglu, HH; Malcok, UA; Sengul, G, 2005)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's3 (30.00)29.6817
2010's5 (50.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Rahim, AIA1
Azlan, EAM1
Rahman, MR1
Pathi, NM1
Ismail, M1
Sulaiman, WAW1
Schwebke, JR1
Morgan, FG1
Koltun, W1
Nyirjesy, P1
AlDhaleei, W1
AlMarzooqi, A1
Gaber, N1
Kafadar, I1
Moustafa, F1
Yalçın, K1
Klç, BA1
Çekin, AH1
Şahintürk, Y1
Akbay Harmandar, F1
Uyar, S1
Yolcular, BO1
Çekin, Y1
Soni, CR1
Kumar, G1
Bollu, PC1
Sahota, P1
Litofsky, NS1
Tan, NC1
Tan, DY1
Tan, LC1
Kadioglu, HH1
Sengul, G1
Malcok, UA1
Kalaycý, M1
Cadavi, F1
Altunkaya, H1
Gül, S1
Ackgöz, B1
Kapoor, K1
Chandra, M1
Nag, D1
Paliwal, JK1
Gupta, RC1
Saxena, RC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)[NCT02201186]Phase 210 participants (Actual)Interventional2014-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metronidazole and Bilateral Headache

ArticleYear
A rare adverse effect of metronidazole: nervous system symptoms.
    Pediatric emergency care, 2013, Volume: 29, Issue:6

    Topics: Anti-Infective Agents; Ataxia; Child, Preschool; Convalescence; Dizziness; Dysentery, Amebic; Headac

2013

Trials

3 trials available for metronidazole and Bilateral Headache

ArticleYear
A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis.
    American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Diarrhea;

2017
Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2017, Volume: 28, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Amoxicillin; Anorexia; Anti-Bacteria

2017
Evaluation of metronidazole toxicity: a prospective study.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:3

    Topics: Adult; Anti-Infective Agents; Female; Headache; Humans; Male; Metronidazole; Middle Aged; Nausea; Pr

1999

Other Studies

6 other studies available for metronidazole and Bilateral Headache

ArticleYear
Case Report: A Challenging Case of Tetanus Presenting with Headache.
    The American journal of tropical medicine and hygiene, 2023, Dec-06, Volume: 109, Issue:6

    Topics: Adult; Female; Headache; Humans; Metronidazole; Tetanus; Tetanus Toxoid; Trismus

2023
Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy.
    BMJ case reports, 2018, Apr-20, Volume: 2018

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibito

2018
Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era.
    Journal of neurovirology, 2010, Volume: 16, Issue:1

    Topics: Abscess; Anti-Infective Agents; Azathioprine; Brain; Ciprofloxacin; Drug Administration Schedule; Fe

2010
An Unusual Headache: Lemierre's Syndrome.
    Journal of neurology, 2003, Volume: 250, Issue:2

    Topics: Aged; Female; Fusobacterium Infections; Headache; Humans; Metronidazole; Neck; Penicillins; Syndrome

2003
Sphenoid sinusitis disguised by precocious puberty.
    International journal of pediatric otorhinolaryngology, 2005, Volume: 69, Issue:2

    Topics: Anti-Infective Agents; Child; Drainage; Female; Headache; Humans; Metronidazole; Penicillins; Pubert

2005
Subdural empyema due to spinal anesthesia.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:3

    Topics: Adult; Anesthesia, Spinal; Anti-Bacterial Agents; Anti-Infective Agents; Brain; Ceftriaxone; Cesarea

2005