metronidazole has been researched along with Laryngeal Neoplasms in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation." | 9.15 | Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 5.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation." | 5.15 | Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011) |
| "Indices of platelet function, plasmic coagulation and fibrinolysis were studied during gamma-beam therapy in patients with laryngeal, gastric and cervical tumors (potentially at risk for thrombosis) against a background of metronidazole administration." | 3.67 | [Hemostasis in cancer patients during radiation therapy using metronidazole]. ( Andreev, VG; Berdov, BA; Chekalina, SI; Pavlov, VV, 1989) |
| "Patients with locoregional advanced laryngeal cancer (stage T3-4,N0-3,M0) were included: group 1(control, n=30)were not administered of sodium glycididazole; group 2 (test, n=30) received sodium glycididazole at a dose of 700 mg/m(2) intravenous infusion 30 minutes before radiotherapy three times a week." | 2.75 | Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report. ( Chen, W; Chen, XD; Chi, F; Dong, XQ; Fan, GL; Hao, SH; Jia, MX; Jin, XY; Li, X; Li, Y; Wang, EY; Wang, SL; Wang, YM; Wu, LN; Wu, R; Xia, HH; Xiao, FD; Xu, ZG; Zeng, YC; Zhang, HB; Zhang, LB; Zhang, XY; Zhang, ZY; Zheng, W, 2010) |
| "In the cultures from the scar the frequency of isolation of enterococci and Streptococcus viridans was found to be decreased while the frequency of staphylococci and Streptococcus haemolyticys isolation was increased." | 1.29 | [Use of ciprofloxacin and metronidazole in prophylaxis of surgical wound infection in surgical treatment of laryngeal cancer]. ( Chylak, J; Michalska, W, 1994) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 1.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "In combined treatment of the laryngeal cancer patients after a summary focal dose of 32 Gy and 1." | 1.27 | [The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer]. ( Andreev, VG; Mardynskiĭ, IuS, 1985) |
| "The authors described clinicomorphological correlations in the evaluation of the efficacy of preoperative radiotherapy combined with metronidazole (MZ) in laryngeal cancer patients." | 1.27 | [Morphology of laryngeal cancer in radiotherapy combined with the use of metronidazole]. ( Andreev, VG; Lushnikov, EF; Solov'eva, LP, 1985) |
| "The results of combined treatment of 98 laryngeal cancer patients followed up for 1." | 1.27 | [Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole]. ( Andreev, VG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (68.18) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, YC | 1 |
| Wu, R | 1 |
| Xu, ZG | 1 |
| Zhang, XY | 1 |
| Fan, GL | 1 |
| Wu, LN | 1 |
| Wang, YM | 1 |
| Hao, SH | 1 |
| Zheng, W | 1 |
| Chen, XD | 1 |
| Chi, F | 1 |
| Zhang, ZY | 1 |
| Li, X | 1 |
| Jin, XY | 1 |
| Chen, W | 1 |
| Wang, SL | 1 |
| Xiao, FD | 1 |
| Wang, EY | 1 |
| Dong, XQ | 1 |
| Zhang, LB | 1 |
| Jia, MX | 1 |
| Xia, HH | 1 |
| Zhang, HB | 1 |
| Li, Y | 1 |
| Stathas, T | 1 |
| Mallis, A | 1 |
| Mastronikolis, NS | 1 |
| Naxakis, SS | 1 |
| Dimaka, K | 1 |
| Panogeorgou, T | 1 |
| Stavrou, S | 1 |
| Margaritis, V | 1 |
| Kourousis, C | 1 |
| Papadas, TA | 1 |
| Scotton, W | 1 |
| Cobb, R | 1 |
| Pang, L | 1 |
| Nixon, I | 1 |
| Joshi, A | 1 |
| Jeannon, JP | 1 |
| Oakley, R | 1 |
| French, G | 1 |
| Hemsley, C | 1 |
| Simo, R | 1 |
| Tsyb, AF | 1 |
| Konopliannikov, AG | 1 |
| Kudriavtseva, GT | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| D'iakova, AM | 2 |
| Stefani, NV | 2 |
| Andreev, VG | 7 |
| Pavlov, VV | 4 |
| Senokosov, NI | 1 |
| Khait, SE | 1 |
| Kurilets, ES | 1 |
| Innes, AJ | 1 |
| Windle-Taylor, PC | 1 |
| Harrison, DF | 1 |
| Michalska, W | 2 |
| Chylak, J | 2 |
| Szmeja, Z | 1 |
| Szyfter, W | 1 |
| Manasterski, J | 1 |
| Whitmore, GF | 1 |
| Cekalina, SI | 1 |
| Berdov, BA | 2 |
| Guseva, LI | 1 |
| Chekalina, SI | 1 |
| Johansen, LV | 1 |
| Overgaard, J | 1 |
| Elbrønd, O | 1 |
| Geyer, G | 1 |
| Borneff, M | 1 |
| Hartmetz, G | 1 |
| Brusis, T | 1 |
| Luckhaupt, H | 1 |
| Sal'nikov, LV | 1 |
| Mezentsev, AI | 1 |
| Bedrin, LM | 1 |
| Chernova, AS | 1 |
| Mardynskiĭ, IuS | 1 |
| Lushnikov, EF | 1 |
| Solov'eva, LP | 1 |
2 reviews available for metronidazole and Laryngeal Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
The potential for radiation sensitizers and possible strategy for use.
Topics: Animals; Female; Humans; Hypoxia; Laryngeal Neoplasms; Metronidazole; Nitro Compounds; Ovarian Neopl | 1975 |
4 trials available for metronidazole and Laryngeal Neoplasms
| Article | Year |
|---|---|
Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report.
Topics: Carcinoma, Squamous Cell; Female; Humans; Laryngeal Neoplasms; Male; Metronidazole; Middle Aged; Nau | 2010 |
Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help?
Topics: Aged; Anti-Infective Agents; Combined Modality Therapy; Cutaneous Fistula; Female; Humans; Incidence | 2011 |
[Use of electron acceptor compounds in radiotherapy].
Topics: Clinical Trials as Topic; Esophageal Neoplasms; Female; Humans; Laryngeal Neoplasms; Metronidazole; | 1983 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
17 other studies available for metronidazole and Laryngeal Neoplasms
| Article | Year |
|---|---|
Post-operative wound infection in salvage laryngectomy: does antibiotic prophylaxis have an impact?
Topics: Administration, Intravenous; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefuroxime; Cohort Studi | 2012 |
[Kidney function during radiosensitization with metronidazole].
Topics: Blood Urea Nitrogen; Creatinine; Dose-Response Relationship, Radiation; Humans; Kidney; Kidney Funct | 1984 |
[State of the liver after radiotherapy of cancer of the stomach and larynx with metronidazole radiosensitization].
Topics: Humans; Laryngeal Neoplasms; Liver; Liver Function Tests; Metronidazole; Radiation Tolerance; Stomac | 1984 |
[Medullary hematopoiesis in laryngeal cancer during radiotherapy using metronidazole].
Topics: Adult; Aged; Combined Modality Therapy; Hematopoiesis; Humans; Laryngeal Neoplasms; Male; Metronidaz | 1984 |
The role of metronidazole in the prevention of fistulae following total laryngectomy.
Topics: Bacterial Infections; Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal | 1980 |
[Use of ciprofloxacin and metronidazole in prophylaxis of surgical wound infection in surgical treatment of laryngeal cancer].
Topics: Cicatrix; Ciprofloxacin; Humans; Laryngeal Neoplasms; Metronidazole; Surgical Wound Infection | 1994 |
[Unasyn in perioperative prophylaxis in patients with laryngeal cancer].
Topics: Ampicillin; Anti-Bacterial Agents; Body Temperature; Escherichia coli; Gentamicins; Humans; Laryngea | 1994 |
[Bacterial flora in laryngeal carcinoma and in postoperative scars of patients treated prophylactically by ciprofloxacin].
Topics: Cicatrix; Ciprofloxacin; Drug Resistance, Microbial; Humans; Laryngeal Neoplasms; Metronidazole; Sur | 1993 |
[The hemostatic homeostasis of patients with malignant neoplasms of the larynx, stomach and uterine cervix during radiotherapy and radiosensitization with metronidazole].
Topics: Combined Modality Therapy; Female; Hemostasis; Humans; Laryngeal Neoplasms; Metronidazole; Middle Ag | 1990 |
[Hemostasis in cancer patients during radiation therapy using metronidazole].
Topics: Combined Modality Therapy; Female; Hemostasis; Humans; Laryngeal Neoplasms; Metronidazole; Preoperat | 1989 |
Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
Topics: Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal Diseases; Radiation In | 1988 |
[Perioperative prophylaxis with cefmenoxime and metronidazole in patients with head and neck tumors].
Topics: Cefmenoxime; Cefotaxime; Drug Therapy, Combination; Female; Glossectomy; Humans; Laryngeal Neoplasms | 1987 |
[Anaerobic infections in ulcerating tumors of the head and neck. A contribution to the problem of odors].
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Clindamycin; Head and Neck Neopla | 1986 |
[Direct and immediate results of the radiation and combined treatment of laryngeal cancer with local use of metronidazole].
Topics: Adult; Aged; Biopsy; Combined Modality Therapy; Dimethyl Sulfoxide; Humans; Laryngeal Neoplasms; Lym | 1986 |
[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer].
Topics: Adult; Combined Modality Therapy; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Metr | 1985 |
[Morphology of laryngeal cancer in radiotherapy combined with the use of metronidazole].
Topics: Adult; Aged; Humans; Laryngeal Neoplasms; Metronidazole; Middle Aged; Necrosis; Radiation Tolerance; | 1985 |
[Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole].
Topics: Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Humans; Laryngeal Neoplasms; Laryn | 1985 |