metronidazole has been researched along with Inguinal Hernia in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a district rural hospital in Uganda, 850 surgical patients were evaluated prospectively over a 3-year period to compare the clinical efficacy of conventional postoperative penicillin therapy with single-dose ampicillin prophylaxis for hernia repair and ectopic pregnancy, and with single-dose ampicillin-metronidazole prophylaxis for hysterectomy and caesarean section." | 5.08 | Randomized study of antibiotic prophylaxis for general and gynaecological surgery from a single centre in rural Africa. ( Andreata, M; Cocozza, E; Mukasa, F; Ravera, M; Reggiori, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reggiori, A | 1 |
| Ravera, M | 1 |
| Cocozza, E | 1 |
| Andreata, M | 1 |
| Mukasa, F | 1 |
| Luger, A | 1 |
1 trial available for metronidazole and Inguinal Hernia
| Article | Year |
|---|---|
Randomized study of antibiotic prophylaxis for general and gynaecological surgery from a single centre in rural Africa.
Topics: Adolescent; Adult; Aged; Ampicillin; Antibiotic Prophylaxis; Cesarean Section; Drug Therapy, Combina | 1996 |
1 other study available for metronidazole and Inguinal Hernia
| Article | Year |
|---|---|
[Syphilis diagnosis in the age of antibiotics].
Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphe | 1971 |