metronidazole has been researched along with Cholecystoduodenal Fistula in 17 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many patients with Crohn's disease present with the complications of infection." | 2.65 | Infection and the use of antibiotics in Crohn's disease. ( Keighley, MR, 1984) |
| "Genital fistulas are a significant problem in female Crohn's disease patients." | 1.38 | Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy. ( Bermejo, F; de la Poza, G; Gisbert, JP; López-Sanroman, A; Marín-Jimenez, I; Muriel, A; Opio, V; Taxonera, C, 2012) |
| "Perianal fistulizing Crohn's disease (PFCD) treatment is based on fistula drainage, antibiotics, immunosuppressant (IS) drugs, and infliximab." | 1.35 | Predicting factors of fistula healing and clinical remission after infliximab-based combined therapy for perianal fistulizing Crohn's disease. ( Koning, E; Lerebours, E; Michot, F; Savoye, G; Savoye-Collet, C; Tougeron, D, 2009) |
| "Outcome data such as recurrence and intractability, and clinical features were retrospectively analysed." | 1.33 | Nonsurgical treatment of abdominal or pelvic abscess in consecutive patients with Crohn's disease. ( Chang, DK; Kim, JH; Kim, JJ; Kim, YH; Lee, H; Paik, SW; Rhee, JC; Rhee, PL; Son, HJ, 2006) |
| "A patient had Crohn's disease in relapse with multiple small bowel fistulae and mesenteric abscesses." | 1.30 | Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids. ( Broekelschen, P; Challa, S; Lyons, KP; Milne, N, 1997) |
| "The postoperative complications were suppuration of the wall (n = 4), intestinal fistula (n = 3), evisceration, and residual abscess." | 1.29 | [Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases]. ( Ibile, A; Malonga, E; Masso-Misse, P; Yao, JG, 1994) |
| "All patients had ileocolitis or pancolitis." | 1.27 | Metronidazole therapy for Crohn's disease and associated fistulae. ( Jakobovits, J; Schuster, MM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tougeron, D | 1 |
| Savoye, G | 1 |
| Savoye-Collet, C | 1 |
| Koning, E | 1 |
| Michot, F | 1 |
| Lerebours, E | 1 |
| de la Poza, G | 1 |
| López-Sanroman, A | 1 |
| Taxonera, C | 1 |
| Marín-Jimenez, I | 1 |
| Gisbert, JP | 1 |
| Bermejo, F | 1 |
| Opio, V | 1 |
| Muriel, A | 1 |
| Lee, H | 1 |
| Kim, YH | 1 |
| Kim, JH | 1 |
| Chang, DK | 1 |
| Son, HJ | 1 |
| Rhee, PL | 1 |
| Kim, JJ | 1 |
| Paik, SW | 1 |
| Rhee, JC | 1 |
| Bressler, B | 1 |
| Sands, BE | 1 |
| Schneider, MU | 2 |
| Strobel, S | 1 |
| Riemann, JF | 2 |
| Demling, L | 1 |
| Loprinzi, C | 1 |
| Heaton, JW | 1 |
| Kelly, PC | 1 |
| Keighley, MR | 1 |
| Jakobovits, J | 1 |
| Schuster, MM | 1 |
| Yao, JG | 1 |
| Masso-Misse, P | 1 |
| Ibile, A | 1 |
| Malonga, E | 1 |
| Lyons, KP | 2 |
| Challa, S | 2 |
| Broekelschen, P | 2 |
| Milne, N | 2 |
| Nielsen, R | 1 |
| Bülow, S | 1 |
| Moesgaard, F | 1 |
| Malchow, H | 1 |
| Laudage, G | 1 |
| Guggenmoos-Holzmann, I | 1 |
| Balikian, JP | 1 |
| Uthman, SM | 1 |
| Khouri, NF | 1 |
| Archampong, EQ | 1 |
| Clark, CG | 1 |
2 reviews available for metronidazole and Cholecystoduodenal Fistula
| Article | Year |
|---|---|
Review article: Medical therapy for fistulizing Crohn's disease.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Ciprofloxacin; Crohn Diseas | 2006 |
Surgical problems in amoebiasis.
Topics: Abscess; Amebiasis; Amebicides; Anti-Bacterial Agents; Appendicitis; Colonic Diseases; Dysentery, Am | 1973 |
2 trials available for metronidazole and Cholecystoduodenal Fistula
| Article | Year |
|---|---|
Infection and the use of antibiotics in Crohn's disease.
Topics: Abscess; Anus Diseases; Bacterial Infections; Clinical Trials as Topic; Crohn Disease; Drug Combinat | 1984 |
[Metronidazole in the treatment of Crohn disease. Results of a controlled randomized prospective study].
Topics: Clinical Trials as Topic; Crohn Disease; Follow-Up Studies; Humans; Intestinal Fistula; Metronidazol | 1985 |
13 other studies available for metronidazole and Cholecystoduodenal Fistula
| Article | Year |
|---|---|
Predicting factors of fistula healing and clinical remission after infliximab-based combined therapy for perianal fistulizing Crohn's disease.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Ciprof | 2009 |
Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibod | 2012 |
Nonsurgical treatment of abdominal or pelvic abscess in consecutive patients with Crohn's disease.
Topics: Abdominal Abscess; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Bacterial Agents; Cephalos | 2006 |
[Treatment of Crohn's disease with metronidazole (author's transl)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Crohn Disease; Drug Therapy, Combination; Female; | 1981 |
Metronidazole, cholestasis, and total parenteral nutrition.
Topics: Adult; Bacteroides fragilis; Cholestasis, Intrahepatic; Humans; Intestinal Fistula; Intestines; Male | 1983 |
Enterohepatic fistula associated with amebic liver abscess.
Topics: Adult; Aged; Biopsy, Needle; Entamoeba histolytica; Entamoebiasis; Female; Fistula; Humans; Intestin | 1983 |
Metronidazole therapy for Crohn's disease and associated fistulae.
Topics: Adult; Crohn Disease; Female; Follow-Up Studies; Humans; Intestinal Fistula; Male; Metronidazole; Mi | 1984 |
[Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases].
Topics: Adult; Aged; Ampicillin; Anastomosis, Surgical; Cameroon; Chloramphenicol; Colon; Combined Modality | 1994 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn disease and steroid use.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Contaminated fistula following J-pouch ileoanal reservoir. Treatment with a collagen sponge containing gentamicin and metronidazole. Case report.
Topics: Anal Canal; Anastomosis, Surgical; Bacterial Infections; Bone Diseases; Collagen; Female; Gentamicin | 1991 |
[Fistulas in Crohn disease--conservative versus operative treatment. The internist viewpoint].
Topics: Adolescent; Adult; Child; Combined Modality Therapy; Crohn Disease; Female; Humans; Intestinal Fistu | 1985 |
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis, | 1974 |