metronidazole has been researched along with Granulomas in 25 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with clarithromycin, metronidazole and pantoprazole eradicated H." | 5.31 | Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole. ( Kaddu, S; Kränke, B; Mayr-Kanhäuser, S; Müllegger, RR, 2001) |
| "Metronidazole administered orally in doses of 20 and 200 mg/kg daily suppressed granuloma formation around Schistosoma mansoni eggs which were injected intravenously and lodged in the pulmonary microvasculature of mice." | 3.65 | Suppression of cell-mediated immunity by metronidazole. ( Grove, DI; Mahmound, AA; Warren, KS, 1977) |
| "Although infrequent, metastatic Crohn's disease should be suspected in cases of recalcitrant ulcerative conditions, even in the absence of intestinal disease." | 1.33 | Metastatic Crohn's disease mimicking genital pyoderma gangrenosum in an HIV patient. ( Avilés-Izquierdo, JA; Lázaro-Ochaita, P; Longo-Imedio, I; Suárez-Fernández, R, 2005) |
| "Treatment with clarithromycin, metronidazole and pantoprazole eradicated H." | 1.31 | Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole. ( Kaddu, S; Kränke, B; Mayr-Kanhäuser, S; Müllegger, RR, 2001) |
| "A 55-yr-old man with ileocolic Crohn's disease developed granulomatous dermatitis in the malar region." | 1.27 | Cutaneous metastatic Crohn's disease: treatment with metronidazole. ( Bai, JC; Boerr, LA; Kowalczuk, A; Moran, CE; Olivares, L, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fakih, A | 1 |
| Makhoul, R | 1 |
| Grozdev, I | 1 |
| Aparicio, DV | 1 |
| Bejarano, JIC | 1 |
| de Los Santos, AM | 1 |
| Ramírez-Cortinas, S | 1 |
| de la O Cavazos, M | 1 |
| El Nokrashy, A | 1 |
| Abou Samra, W | 1 |
| Sobeih, D | 1 |
| Lamin, A | 1 |
| Hashish, A | 1 |
| Tarshouby, S | 1 |
| Lightman, S | 1 |
| Sewelam, A | 1 |
| Vricella, GJ | 1 |
| Coplen, DE | 1 |
| Austin, PF | 1 |
| White, FV | 1 |
| Villegas-Betanzo, P | 1 |
| Martínez-Jiménez, MA | 1 |
| Guevara-Torres, L | 1 |
| Quintero-Meza, K | 1 |
| Sánchez-Aguilar, M | 1 |
| Arriaga-Caballero, JE | 1 |
| Mayor-Ibarguren, A | 1 |
| Maseda-Pedrero, R | 1 |
| Feito-Rodríguez, M | 1 |
| Park, HC | 1 |
| Kim, HW | 1 |
| Park, CG | 1 |
| Ko, JY | 1 |
| Palomo, A | 1 |
| Cervigón, I | 1 |
| Torres-Iglesias, LM | 1 |
| Driver, ER | 1 |
| Ryan, GJ | 1 |
| Hoff, DR | 1 |
| Irwin, SM | 1 |
| Basaraba, RJ | 1 |
| Kramnik, I | 1 |
| Lenaerts, AJ | 1 |
| Ozturk, Y | 1 |
| Buyukgebiz, B | 1 |
| Ozer, E | 1 |
| Arslan, N | 1 |
| Bekem, O | 1 |
| Hizli, S | 1 |
| Avilés-Izquierdo, JA | 1 |
| Suárez-Fernández, R | 1 |
| Lázaro-Ochaita, P | 1 |
| Longo-Imedio, I | 1 |
| Cox, ES | 1 |
| Shannon, AB | 1 |
| Sbano, P | 1 |
| Rubegni, P | 1 |
| Risulo, M | 1 |
| De Nisi, MC | 1 |
| Fimiani, M | 1 |
| Via, LE | 1 |
| Lin, PL | 1 |
| Ray, SM | 1 |
| Carrillo, J | 1 |
| Allen, SS | 1 |
| Eum, SY | 1 |
| Taylor, K | 1 |
| Klein, E | 1 |
| Manjunatha, U | 1 |
| Gonzales, J | 1 |
| Lee, EG | 1 |
| Park, SK | 1 |
| Raleigh, JA | 1 |
| Cho, SN | 1 |
| McMurray, DN | 1 |
| Flynn, JL | 1 |
| Barry, CE | 1 |
| Klinkenberg, LG | 1 |
| Sutherland, LA | 1 |
| Bishai, WR | 1 |
| Karakousis, PC | 1 |
| Roberts-Thomson, IC | 1 |
| Anders, RF | 1 |
| Bhathal, PS | 1 |
| Miralles, J | 1 |
| Barnadas, MA | 1 |
| de Moragas, JM | 1 |
| Bourrat, E | 1 |
| Faure, C | 1 |
| Vignon-Pennamen, MD | 1 |
| Rybojad, M | 1 |
| Morel, P | 1 |
| Navarro, J | 1 |
| Mayr-Kanhäuser, S | 1 |
| Kränke, B | 1 |
| Kaddu, S | 1 |
| Müllegger, RR | 1 |
| Adams, EB | 1 |
| MacLeod, IN | 1 |
| Grove, DI | 1 |
| Mahmound, AA | 1 |
| Warren, KS | 1 |
| Martínez-Gigena, MP | 1 |
| Shibayama-Salas, M | 1 |
| Tsutsumi, V | 1 |
| Martínez-Palomo, A | 1 |
| Boerr, LA | 1 |
| Bai, JC | 1 |
| Olivares, L | 1 |
| Moran, CE | 1 |
| Kowalczuk, A | 1 |
| Archampong, EQ | 1 |
| Clark, CG | 1 |
| Pain, AK | 1 |
3 reviews available for metronidazole and Granulomas
| Article | Year |
|---|---|
Childhood granulomatous periorificial dermatitis: case report and review of the literature.
Topics: Administration, Topical; Anti-Infective Agents; Biopsy; Child; Dermatitis, Perioral; Drug Therapy, C | 2020 |
Granulomatous lymphangitis.
Topics: Biopsy, Needle; Child; Crohn Disease; Follow-Up Studies; Granuloma; Humans; Immunohistochemistry; Ly | 2013 |
Surgical problems in amoebiasis.
Topics: Abscess; Amebiasis; Amebicides; Anti-Bacterial Agents; Appendicitis; Colonic Diseases; Dysentery, Am | 1973 |
22 other studies available for metronidazole and Granulomas
| Article | Year |
|---|---|
Case Report: Granulomatous Amebic Encephalitis due to Acanthamoeba spp. in an Immunocompetent Pediatric Patient.
Topics: Acanthamoeba; Adolescent; Amebiasis; Anti-Infective Agents; Brain Abscess; Encephalitis; Fatal Outco | 2021 |
Treatment of presumed trematode-induced granulomatous anterior uveitis among children in rural areas of Egypt.
Topics: Adolescent; Animals; Antiprotozoal Agents; Child; Child, Preschool; Combined Modality Therapy; Corne | 2019 |
[Ameboma: possible therapeutic decisions in an amebiasis-endemic region].
Topics: Abdomen, Acute; Adult; Aged; Appendectomy; Cecal Neoplasms; Colectomy; Combined Modality Therapy; Di | 2015 |
Periorificial Lesions in a Young Girl.
Topics: Adrenal Cortex Hormones; Age of Onset; Child; Contraindications; Dermatitis, Perioral; Drug Substitu | 2016 |
Metastatic Crohn disease clinically reminiscent of erythema nodosum on the right leg.
Topics: Adult; Anti-Inflammatory Agents; Colonoscopy; Crohn Disease; Erythema Nodosum; Female; Glucocorticoi | 2016 |
[Symptomatic perioral, perinasal, and periocular papules].
Topics: Child; Dermatitis, Perioral; Diagnosis, Differential; Facial Dermatoses; Female; Granuloma; Humans; | 2009 |
Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Metronidazole; Mice; Mice, Inbred | 2012 |
Resolution of Helicobacter pylori associated granulomatous gastritis in a child after eradication therapy.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Breath Tests; Drug Therapy, Combi | 2004 |
Metastatic Crohn's disease mimicking genital pyoderma gangrenosum in an HIV patient.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Crohn Disease; Diagnosis, Differential; Gran | 2005 |
Papular facial eruption in an African American adolescent.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Anti-Bacterial Agents; Diagnosis, Diffe | 2006 |
A case of idiopathic granulomatous cheilitis and vulvitis.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Female; Granuloma; Humans; Lip; Melkersson-Rosenthal | 2007 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Imm | 2008 |
Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency.
Topics: Aerosols; Animals; Anti-Infective Agents; Cell Hypoxia; Disease Models, Animal; DNA Transposable Ele | 2008 |
Granulomatous hepatitis and cholangitis associated with giardiasis.
Topics: Antibodies; Female; Giardiasis; Granuloma; Hepatitis; HLA Antigens; Humans; Immunoglobulin A; Liver; | 1982 |
Cheilitis granulomatosa treated with metronidazole.
Topics: Adult; Anti-Inflammatory Agents; Connective Tissue; Female; Granuloma; Humans; Lip; Melkersson-Rosen | 1995 |
[Anitis, vulvar edema and macrocheilitis disclosing Crohn disease in a child: value of metronidazole].
Topics: Cheilitis; Child; Crohn Disease; Edema; Female; Granuloma; Humans; Metronidazole; Proctitis; Treatme | 1997 |
Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Benzimidaz | 2001 |
Invasive amebiasis. I. Amebic dysentery and its complications.
Topics: Adult; Amebiasis; Amebicides; Child, Preschool; Colonic Diseases; Entamoeba histolytica; Granuloma; | 1977 |
Suppression of cell-mediated immunity by metronidazole.
Topics: Animals; Female; Graft Survival; Granuloma; Hypersensitivity, Delayed; Immunity, Cellular; Metronida | 1977 |
Histological changes during healing of experimental amebic liver abscess treated with metronidazole.
Topics: Animals; Cricetinae; Entamoeba histolytica; Granuloma; Liver; Liver Abscess, Amebic; Male; Mesocrice | 1992 |
Cutaneous metastatic Crohn's disease: treatment with metronidazole.
Topics: Crohn Disease; Facial Dermatoses; Granuloma; Humans; Male; Metronidazole; Middle Aged | 1987 |
Amoebic granuloma of the large bowel.
Topics: Adult; Amebiasis; Barium; Biopsy; Colonic Diseases; Diagnosis, Differential; Enema; Granuloma; Human | 1971 |