metronidazole has been researched along with Acute Membranous Gingivitis in 44 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " With only partial compliance to local debridement, chlorhexidine oral rinses, and systemic metronidazole therapy, alveolar bone loss resulted in tooth mobility necessitating extraction of 2 involved teeth." | 3.70 | Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis. ( McKaig, R; Patton, LL, 1998) |
| " Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice." | 3.70 | A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000) |
| "Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD)." | 2.44 | Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. ( Feller, L; Lemmer, J, 2008) |
| "Periodontal diseases are common oral diseases that afflict all humans to some degree." | 2.37 | Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985) |
| "Necrotizing stomatitis is more commonly encountered in malnourished children in developing countries, and may subsequently result in devastating facial defects and death." | 1.33 | Necrotizing stomatitis in the developed world. ( Buchanan, JA; Cedro, M; Hodgson, TA; Joseph, T; Mirdin, A; Porter, SR, 2006) |
| " It is also used in high dosage in the chemoprophylaxis and treatment of many strictly anaerobic infections." | 1.26 | Rational use of metronidazole. ( Altman, EG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (79.55) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 5 (11.36) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sangani, I | 1 |
| Watt, E | 1 |
| Cross, D | 1 |
| Gillam, DG | 1 |
| Turner, W | 1 |
| Phiri, R | 1 |
| Feller, L | 3 |
| Blignaut, E | 2 |
| DAVIES, AH | 1 |
| MCFADZEAN, JA | 2 |
| SQUIRES, S | 2 |
| SHINN, DL | 1 |
| Shangase, L | 1 |
| Buchanan, JA | 1 |
| Cedro, M | 1 |
| Mirdin, A | 1 |
| Joseph, T | 1 |
| Porter, SR | 1 |
| Hodgson, TA | 1 |
| Lemmer, J | 1 |
| Loesche, WJ | 1 |
| Syed, SA | 1 |
| Laughon, BE | 1 |
| Stoll, J | 1 |
| Altman, EG | 1 |
| Patton, LL | 1 |
| McKaig, R | 1 |
| Palmer, NA | 1 |
| Pealing, R | 1 |
| Ireland, RS | 1 |
| Martin, MV | 1 |
| Ghayoumi, N | 1 |
| Webb, CH | 1 |
| Jones, JH | 1 |
| Miglani, DC | 2 |
| Subramanian, S | 2 |
| Paramasivan, CN | 2 |
| Jayanthi, S | 2 |
| Chiranjeevi, K | 1 |
| Rajasekher, A | 1 |
| Winkler, JR | 1 |
| Murray, PA | 1 |
| Grassi, M | 1 |
| Hammerle, C | 1 |
| Higgins, TJ | 1 |
| Hunter, N | 1 |
| Knox, KW | 1 |
| Davies, RM | 1 |
| Stirland, RM | 1 |
| Stephens, AP | 1 |
| Onan, U | 1 |
| Olsen, I | 1 |
| Lindner, RR | 1 |
| Adeniyi-Jones, C | 1 |
| Glenwright, HD | 1 |
| Sidaway, DA | 1 |
| Lozdan, J | 1 |
| Sheiham, A | 2 |
| Pearlman, BA | 1 |
| Keiser, B | 1 |
| Rachanis, CC | 1 |
| Meyer, R | 1 |
| Duckworth, R | 1 |
| Waterhouse, JP | 1 |
| Britton, DE | 1 |
| Nuki, K | 1 |
| Winter, R | 1 |
| Blake, GC | 2 |
| Stephen, KW | 1 |
| McLatchie, MF | 1 |
| Mason, DK | 1 |
| Noble, HW | 1 |
| Stevenson, DM | 1 |
| Wade, AB | 1 |
| Mirza, KB | 1 |
| Fletcher, JP | 1 |
| Plant, CG | 1 |
| Stawiński, K | 1 |
| Magas, A | 1 |
| Wierzbicka, M | 1 |
| Reynolds, C | 1 |
| Gyenes, V | 1 |
| Miczbán, I | 1 |
| Benes, G | 1 |
| Chawla, TN | 1 |
| Mathur, RM | 1 |
| Ahlin, JH | 1 |
| Chawla, YC | 1 |
| Emslie, RD | 2 |
| Ashley, FP | 1 |
| Proctor, DB | 1 |
| Baker, CG | 1 |
| Takada, I | 1 |
| Yamane, T | 1 |
| Kawai, M | 1 |
| Omori, H | 1 |
| Devanath, KR | 1 |
| Prabhu, T | 1 |
| Ramachandra, S | 1 |
| Venkatraman, BK | 1 |
| Weinmann, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for metronidazole and Acute Membranous Gingivitis
| Article | Year |
|---|---|
Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
Topics: Anti-Infective Agents; Candida albicans; Chlorhexidine; Cytokines; Dental Scaling; Gingivitis, Necro | 2008 |
The use of metronidazole in the treatment of periodontal diseases.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Gingivitis, Necrotizing Ulcerative; HIV Infections; Huma | 2001 |
Diagnosis and management of HIV-associated periodontal lesions.
Topics: Chlorhexidine; Dental Care for Disabled; Dental Scaling; Gingivitis; Gingivitis, Necrotizing Ulcerat | 1989 |
Current concepts in periodontal diseases.
Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc | 1985 |
[Metronidazole. Efficacy in certain infections of the oral mucosa and the urogenital tract].
Topics: Female; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Penicillins; Pregnancy | 1973 |
8 trials available for metronidazole and Acute Membranous Gingivitis
| Article | Year |
|---|---|
Comparative study of the effectiveness of metronidazole, and spiramycin on the bacterial isolates in cases of ANUG and mixed oral infection.
Topics: Bacteria; Clinical Trials as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Leucomycins; Metroni | 1975 |
The comparative assessment of the use of metronidazole, penicillin & combination of both in acute ulcerative gingivitis (Vincent's disease).
Topics: Clinical Trials as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Penicillins | 1975 |
Effect of metronidazole and spiramycin in cases of ANUG and mixed oral infection--a double blind clinical trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Gingivitis, Necrotizing Ulcerative; Humans; Leucomyci | 1975 |
The effect of metronidazole on tropical ulcers.
Topics: Clinical Trials as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Placebos | 1968 |
The use of metronidazole in the treatment of acute ulcerative gingivitis.
Topics: Adolescent; Adult; Clinical Trials as Topic; Female; Gingivitis, Necrotizing Ulcerative; Humans; Mal | 1966 |
The use of nitrimidazine in the treatment of acute ulcerative gingivitis. A double-blind controlled trial.
Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Female; Gingivitis; Gingivitis, Necrotiz | 1971 |
Acute ulcerative gingivitis. A double-blind controlled clinical trial of metronidazole.
Topics: Adolescent; Adult; Clinical Trials as Topic; Female; Gingivitis, Necrotizing Ulcerative; Humans; Mal | 1966 |
Treatment of acute ulcerative gingivitis. A clinical trial using chewing gums containing metronidazole or penicillin.
Topics: Chewing Gum; Clinical Trials as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Pe | 1967 |
31 other studies available for metronidazole and Acute Membranous Gingivitis
| Article | Year |
|---|---|
Necrotizing ulcerative gingivitis and the orthodontic patient: a case series.
Topics: Adolescent; Anti-Infective Agents; Chlorhexidine; Female; Gingivitis, Necrotizing Ulcerative; Humans | 2013 |
Antibiotics in the treatment of periodontal disease: a guide for the general dental practitioner.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Biofilms; Chronic Periodontitis | 2014 |
The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count.
Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; CD4 Lymphocyte Count; Child; | 2010 |
TREATMENT OF VINCENT'S STOMATITIS WITH METRONIDAZOLE.
Topics: Drug Resistance; Drug Resistance, Microbial; Gingivitis, Necrotizing Ulcerative; Humans; Imidazoles; | 1964 |
THE TREATMENT OF VINCENT'S DISEASE WITH METRONIDAZOLE.
Topics: Drug Therapy; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole | 1965 |
Necrotising ulcerative gingivitis/periodontitis as indicators of HIV-infection.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Anti-Infective Ag | 2004 |
Necrotizing stomatitis in the developed world.
Topics: Aged; Analgesics; Debridement; Deglutition Disorders; Developed Countries; Dietary Supplements; Ging | 2006 |
The bacteriology of acute necrotizing ulcerative gingivitis.
Topics: Bacteria; Bacteriological Techniques; Dental Plaque; Fusobacterium; Gingivitis, Necrotizing Ulcerati | 1982 |
Rational use of metronidazole.
Topics: Bacteria; Drug Interactions; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole | 1980 |
Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Alveolar Bone Loss; Anti-Infective Agents; Anti-Infect | 1998 |
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England.
Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti | 2000 |
Mismanaged facial infection.
Topics: Anti-Bacterial Agents; Bacteroides Infections; Child; Diagnostic Errors; Gingivitis, Necrotizing Ulc | 1977 |
Healthy and diseased gingiva.
Topics: Adult; Child; Chronic Disease; Dental Plaque; Diabetes Complications; Gingiva; Gingival Diseases; Gi | 1975 |
The in-vitro sensitivity of oral spirochaetes to metronidazole.
Topics: Gingivitis, Necrotizing Ulcerative; In Vitro Techniques; Metronidazole; Microbial Sensitivity Tests; | 1970 |
Acute fusospirochaetal stomatitis associated with a partial upper denture.
Topics: Adult; Denture, Partial, Removable; Gingivitis, Necrotizing Ulcerative; Humans; Male; Metronidazole; | 1972 |
[The treatment of acute necrotizing ulcerative gingivitis].
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole | 1972 |
Treatment of acute ulcerative gingivitis (Vincent's type).
Topics: Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Penicillin V | 1966 |
Effectiveness of metronidazole in treating the acute phase of ulcerative gingivitis.
Topics: Adult; Borates; Female; Gingivitis, Necrotizing Ulcerative; Humans; Male; Metronidazole | 1966 |
An assessment of metronidazole in the treatment of acute ulcerative pseudomembranous gingivitis (Vincent's disease).
Topics: Adolescent; Adult; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole | 1966 |
[Clinical and bacteriologic evaluation of metronidazole in the treatment of ulcerative gingivitis and stoniatitis].
Topics: Bacteria; Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole | 1968 |
Metronidazole.
Topics: Dentistry; Gingivitis, Necrotizing Ulcerative; Metronidazole | 1968 |
[Treatment of stomatitis ulcerosa with metronidazole].
Topics: Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole | 1968 |
An evaluation of metronidazole in cases of acute necrotizing ulceromembranous gingivitis (Vincent's Disease).
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole | 1969 |
Vincent's angina as a postextraction complication: review of current treatment and report of a case.
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole; Penicillins; Tooth Extraction | 1969 |
Effects of metronidazole in ulcerative gingivitis.
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole | 1969 |
Topical treatment of acute ulcerative gingivitis: a comparison of vancomycin with penicillin and metronidazole.
Topics: Adolescent; Adult; Evaluation Studies as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Metronid | 1971 |
Treatment of acute necrotizing ulcerative gingivitis with metronidazole.
Topics: Adolescent; Adult; Dental Prophylaxis; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Pe | 1971 |
[Effect of metronidazole (Flagyl) in the treatment of acute necrotizing ulcerative gingivitis].
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole | 1971 |
Effectiveness of metronidazole (Flagyl) in the treatment of acute ulcerative necrotising gingivitis.
Topics: Gingivitis, Necrotizing Ulcerative; Metronidazole | 1971 |
Acute necrotizing ulcerative gingivitis (ANUG: diagnosis and therapy).
Topics: Dentistry; Gingivitis, Necrotizing Ulcerative; Metronidazole; Penicillins | 1968 |
Treatment of acute ulcerative (Vincent's) gingivitis.
Topics: Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Hydrogen Peroxide; Metronidazole; Penicillin | 1966 |