metronidazole has been researched along with Uveitis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this work was to assess the effect of broadspectrum antibiotics - combination of metronidazole and ciprofloxacin or metronidazole alone - on the intensity of intraocular inflammation in experimental autoimmune uveitis (EAU)." | 7.91 | Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis. ( Dusek, O; Heissigerova, J; Klimova, A; Kucera, T; Seidler Stangova, P; Svozilkova, P, 2019) |
| " The aim of this work was to assess the effect of broadspectrum antibiotics - combination of metronidazole and ciprofloxacin or metronidazole alone - on the intensity of intraocular inflammation in experimental autoimmune uveitis (EAU)." | 3.91 | Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis. ( Dusek, O; Heissigerova, J; Klimova, A; Kucera, T; Seidler Stangova, P; Svozilkova, P, 2019) |
| "Twelve patients with extremely severe uveitis and two patients with necrotizing (chorio-)retinitis were treated with a combination of antibiotics consisting of penicillin G, gentamicin and metronidazole." | 3.66 | [High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis]. ( Dietze, U; Fricke, HJ; Heydenreich, A; Illéssy, A; Schröder, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seidler Stangova, P | 1 |
| Dusek, O | 1 |
| Klimova, A | 1 |
| Heissigerova, J | 1 |
| Kucera, T | 1 |
| Svozilkova, P | 1 |
| Gelfer, S | 1 |
| Scharf, J | 1 |
| Zonis, S | 1 |
| Mertzbach, D | 1 |
| Fricke, HJ | 1 |
| Heydenreich, A | 1 |
| Dietze, U | 1 |
| Illéssy, A | 1 |
| Schröder, D | 1 |
3 other studies available for metronidazole and Uveitis
| Article | Year |
|---|---|
Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis.
Topics: Animals; Ciprofloxacin; Female; Inflammation; Metronidazole; Mice, Inbred C57BL; Severity of Illness | 2019 |
[Acute uveitis associated with Giardia lamblia infection].
Topics: Acute Disease; Adult; Giardiasis; Humans; Male; Metronidazole; Uveitis | 1984 |
[High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Chorioretinitis; Drug Therapy, Combination; Female; Gentam | 1983 |