metronidazole has been researched along with Rectal Neoplasms in 36 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rectal Neoplasms: Tumors or cancer of the RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole 10 g/m(2) was administered per rectum on days 8 and 15." | 2.78 | Phase II study of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer. ( Barsukov, YA; Fedyanin, MY; Gordeyev, SS; Perevoshikov, AG; Tkachev, SI, 2013) |
| "Patients with colorectal cancer treated from May 6, 2004, to April 25, 2005." | 2.73 | Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. ( Fujita, S; Ikeda, E; Kondo, K; Moriya, Y; Ohue, M; Saito, N; Takii, Y; Yamada, T, 2007) |
| "The rate of postoperative wound infections was not significantly different in the groups (p = 0,09)." | 2.66 | [Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention]. ( Athanasiadis, S; Hahnel, E; Kuhlgatz, C, 1985) |
| "Treatment with metronidazole successfully eliminated the protozoa and cured the pyothorax." | 1.30 | Trichomonas tenax empyema in an immunocompromised patient with advanced cancer. ( Arizono, N; Morimoto, T; Nakao, K; Shimatsu, A; Shiota, T, 1998) |
| " While the in vitro studies failed to reveal any synergism between 5-FU and MND, pharmacokinetic evaluation revealed that 5-FU clearance was significantly reduced (26." | 1.27 | 5-Fluorouracil-metronidazole combination therapy in metastatic colorectal cancer. Clinical, pharmacokinetic and in vitro cytotoxicity studies. ( Ayoub, J; Bardakji, Z; Besner, JG; Jolivet, J; Langelier, Y, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (75.00) | 18.7374 |
| 1990's | 4 (11.11) | 18.2507 |
| 2000's | 1 (2.78) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Ulukan, C | 1 |
| Ekizoglu, E | 1 |
| Yesilot, N | 1 |
| Coban, O | 1 |
| Vo, E | 1 |
| Massarweh, NN | 1 |
| Chai, CY | 1 |
| Tran Cao, HS | 1 |
| Zamani, N | 1 |
| Abraham, S | 1 |
| Adigun, K | 1 |
| Awad, SS | 1 |
| Barsukov, YA | 1 |
| Gordeyev, SS | 1 |
| Tkachev, SI | 2 |
| Fedyanin, MY | 1 |
| Perevoshikov, AG | 1 |
| Barsukov, IuA | 1 |
| Tsariuk, VF | 1 |
| Gordeev, SS | 1 |
| Perevoshchikov, AG | 1 |
| Malikhov, AG | 1 |
| Oltarzhevskaia, ND | 1 |
| Aliev, VA | 1 |
| Kuz'michev, DV | 1 |
| Glebovskaia, VV | 1 |
| Osombaev, MSh | 1 |
| Fujita, S | 1 |
| Saito, N | 1 |
| Yamada, T | 1 |
| Takii, Y | 1 |
| Kondo, K | 1 |
| Ohue, M | 1 |
| Ikeda, E | 1 |
| Moriya, Y | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Wacha, H | 1 |
| Probst, M | 1 |
| Kiseleva, ES | 1 |
| Dar'ialova, SL | 1 |
| Baran, LA | 1 |
| el-Musa, A | 1 |
| Ishchenko, VE | 1 |
| Rainey, JB | 3 |
| Maeda, M | 2 |
| Williams, C | 1 |
| Williamson, RC | 2 |
| Aeberhard, P | 1 |
| Flückiger, M | 1 |
| Berger, J | 1 |
| Novak, A | 1 |
| Kronberger, L | 1 |
| Kraft-Kinz, J | 1 |
| Sarkisian, IuKh | 1 |
| Antonova, AM | 1 |
| Voronina, SS | 1 |
| Syromiatnikova, EN | 1 |
| Kallistova, LP | 1 |
| Laitinen, S | 1 |
| Huttunen, R | 1 |
| Ståhlberg, M | 1 |
| Mokka, R | 1 |
| Kairaluoma, M | 1 |
| Larmi, TK | 1 |
| Wang, FA | 1 |
| Liao, HY | 1 |
| Yan, QH | 1 |
| Baur, H | 1 |
| Frimberger, M | 1 |
| Altwein, JE | 1 |
| Shiota, T | 1 |
| Arizono, N | 1 |
| Morimoto, T | 1 |
| Shimatsu, A | 1 |
| Nakao, K | 1 |
| Feathers, RS | 1 |
| Sagor, GR | 1 |
| Lewis, AA | 1 |
| Amirak, ID | 1 |
| Noone, P | 1 |
| Keighley, MR | 1 |
| Arabi, Y | 1 |
| Alexander-Williams, J | 1 |
| Youngs, D | 1 |
| Burdon, DW | 1 |
| Frytak, S | 1 |
| Moertel, CG | 1 |
| Childs, DS | 1 |
| Schutt, AJ | 1 |
| Albers, JW | 1 |
| Munzenrider, JE | 1 |
| Windle, R | 1 |
| Macpherson, S | 1 |
| Bell, PR | 1 |
| Adekunle, OO | 1 |
| Abioye, A | 1 |
| Cai, CJ | 1 |
| Hüskes, KP | 1 |
| Hardt, KU | 1 |
| Kling, PA | 1 |
| Dahlgren, S | 1 |
| Bittner, R | 1 |
| Butters, M | 1 |
| Rampf, W | 1 |
| Kapfer, X | 1 |
| Kingston, RD | 1 |
| Duthie, J | 1 |
| Lau, WY | 1 |
| Chu, KW | 1 |
| Poon, GP | 1 |
| Ho, KK | 1 |
| Mendel, V | 1 |
| Jung, D | 1 |
| Heymann, H | 1 |
| Bardakji, Z | 1 |
| Jolivet, J | 1 |
| Langelier, Y | 1 |
| Besner, JG | 1 |
| Ayoub, J | 1 |
| Athanasiadis, S | 1 |
| Kuhlgatz, C | 1 |
| Hahnel, E | 1 |
| Hildebrandt, J | 1 |
| Diettrich, H | 1 |
| Roland, M | 1 |
| Bergan, T | 1 |
| Bjerkeset, T | 1 |
| Erichsen, H | 1 |
| Hoel, R | 1 |
| Johansen, S | 1 |
| Liavåg, I | 1 |
| Reinertsen, S | 1 |
| Rosseland, A | 1 |
| Teigan, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin[NCT00292708] | Phase 3 | 500 participants | Interventional | 2004-05-31 | Completed | ||
| ERAS Lazio Network Clinical Registry[NCT03353311] | 1,000 participants (Actual) | Observational [Patient Registry] | 2014-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Rectal Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
19 trials available for metronidazole and Rectal Neoplasms
| Article | Year |
|---|---|
Phase II study of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradi | 2013 |
[Effectiveness of neoadjuvant chemoradiotherapy of locally advanced rectal cancer in conjunction with local hyperthermia and metronidazole].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; D | 2011 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Healing of the sacral wound cavity after abdomino-perineal extirpation of the rectum. A prospective randomized study using metronidazole].
Topics: Abdomen; Clinical Trials as Topic; Humans; Metronidazole; Perineum; Postoperative Complications; Pro | 1984 |
[Parenteral antibiotic prophylaxis or oral antimicrobial bowel preparation for colorectal surgery (author's transl)].
Topics: Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Colonic Neoplasms; D | 1981 |
[Prevention of septic complications in colorectal surgery (author's transl)].
Topics: Anti-Bacterial Agents; Colonic Neoplasms; Drug Therapy, Combination; Humans; Metronidazole; Preopera | 1981 |
[Scanning electron microscopy of intestinal mucosa after enteric preparation in patients with carcinoma of large bowel].
Topics: Colon, Sigmoid; Humans; Intestinal Mucosa; Metronidazole; Microscopy, Electron, Scanning; Premedicat | 1994 |
Prophylactic systemic antibiotics in colorectal surgery.
Topics: Abscess; Adult; Aged; Bacteroides fragilis; Clinical Trials as Topic; Colitis; Colon; Colonic Neopla | 1977 |
Comparison between systemic and oral antimicrobial prophylaxis in colorectal surgery.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Colon; Colonic Neoplasms; Drug Evaluati | 1979 |
Phase II study of metronidazole therapy for advanced colorectal carcinoma.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Male; Met | 1978 |
[Clinical study of prophylactic use of gentamicin and metronidazole in the surgery of colorectal carcinoma].
Topics: Colonic Neoplasms; Female; Gentamicins; Humans; Male; Metronidazole; Middle Aged; Premedication; Pro | 1992 |
Oral prophylaxis with neomycin and erythromycin in colorectal surgery. More proof for efficacy than failure.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ceftriaxone; Clinical Trials as Topic; Colonic | 1989 |
[Duration of the preventive use of antibiotics in colorectal surgery--single administration versus short-term prevention].
Topics: Aged; Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ma | 1989 |
Serious postoperative bleeding associated with a single intravenous dose of cefuroxime and metronidazole.
Topics: Aged; Cefuroxime; Cephalosporins; Colonic Neoplasms; Drug Combinations; Female; Gastrointestinal Hem | 1986 |
Prophylactic antibiotics in elective colorectal surgery.
Topics: Administration, Oral; Anti-Bacterial Agents; Colon; Colonic Neoplasms; Erythromycin; Female; Gentami | 1988 |
Single-shot antibiotic prophylaxis in colon surgery.
Topics: Bacteria; Ceftizoxime; Clinical Trials as Topic; Colonic Neoplasms; Diverticulitis; Humans; Metronid | 1987 |
[Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention].
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Diseases; Colonic Neoplasms; Dose-Response Relationsh | 1985 |
Prophylactic regimens in colorectal surgery: comparisons between metronidazole used alone or with ampicillin for one or three days.
Topics: Adult; Aged; Ampicillin; Colonic Neoplasms; Drug Therapy, Combination; Female; Humans; Male; Metroni | 1985 |
15 other studies available for metronidazole and Rectal Neoplasms
| Article | Year |
|---|---|
Metronidazole-induced cytotoxic edema of corpus callosum: a case report.
Topics: Adenocarcinoma; Anti-Infective Agents; Brain Edema; Corpus Callosum; Diarrhea; Digestive System Surg | 2020 |
Association of the Addition of Oral Antibiotics to Mechanical Bowel Preparation for Left Colon and Rectal Cancer Resections With Reduction of Surgical Site Infections.
Topics: Administration, Oral; Aged; Anastomotic Leak; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cathart | 2018 |
[Combined and radiation therapy of rectal cancer using metronidazole].
Topics: Combined Modality Therapy; Humans; Metronidazole; Radiation-Sensitizing Agents; Rectal Neoplasms | 1984 |
The cocarcinogenic effect of intrarectal deoxycholate in rats is reduced by oral metronidazole.
Topics: Animals; Azoxymethane; Cocarcinogenesis; Colonic Neoplasms; Deoxycholic Acid; Intestines; Male; Metr | 1984 |
[Experience in using trichopol in the combined radiation therapy of rectal cancer].
Topics: Adenocarcinoma; Aged; Cobalt Radioisotopes; Drug Evaluation; Female; Humans; Male; Metronidazole; Mi | 1981 |
Experiences with the EEA stapling instrument for colorectal anastomosis.
Topics: Adult; Aged; Clindamycin; Colectomy; Colon; Colonic Neoplasms; Disposable Equipment; Female; Gentami | 1980 |
Simultaneous radical prostatectomy and partial rectum resection without colostomy.
Topics: Anastomosis, Surgical; Antitrichomonal Agents; Cefotaxime; Cephalosporins; Humans; Male; Metronidazo | 1997 |
Trichomonas tenax empyema in an immunocompromised patient with advanced cancer.
Topics: Acromegaly; Adenocarcinoma; Animals; Antitrichomonal Agents; Bone Marrow Neoplasms; Brain Neoplasms; | 1998 |
Neutropenia associated with metronidazole.
Topics: Agranulocytosis; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Metronidazole; | 1979 |
Synchronous leiomyosarcoma and ameboma of the rectum: report of a case.
Topics: Aged; Dysentery, Amebic; Female; Humans; Leiomyosarcoma; Metronidazole; Rectal Diseases; Rectal Neop | 1978 |
[Primary wound healing of the sacral cavity following rectum amputation, also a comment on the discussion contribution by G. Jatzko and D. Schlapper, Chirurg (1988) 59: 855].
Topics: Aged; Aged, 80 and over; Carcinoma; Cephalosporins; Colectomy; Crohn Disease; Enema; Female; Follow- | 1989 |
Bile acids in experimental colorectal cancer.
Topics: Animals; Colonic Neoplasms; Deoxycholic Acid; Feces; Male; Metronidazole; Rats; Rats, Inbred Strains | 1986 |
The tropic effect of intrarectal deoxycholate on rat colorectum is unaffected by oral metronidazole.
Topics: Administration, Rectal; Animals; Cell Division; Colonic Neoplasms; Deoxycholic Acid; Male; Metronida | 1986 |
5-Fluorouracil-metronidazole combination therapy in metastatic colorectal cancer. Clinical, pharmacokinetic and in vitro cytotoxicity studies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colonic Neoplasms; Femal | 1986 |
[Modern mechanical antibiotic preparation in colorectal operations. Results of a prospective study].
Topics: Anti-Bacterial Agents; Chloramphenicol; Colonic Neoplasms; Drug Administration Schedule; Drug Therap | 1985 |