metronidazole has been researched along with Digestive System Disorders in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, a correct dosing regimen for the time-dependent molecules (i." | 2.44 | [Pharmacological rationale for choice of antibiotics for intraabdominal infections]. ( Mazzei, T; Novelli, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wacha, H | 1 |
| Warren, B | 1 |
| Bassaris, H | 1 |
| Nikolaidis, P | 1 |
| Mazzei, T | 1 |
| Novelli, A | 1 |
| Colón, AR | 1 |
| Klein, LH | 1 |
| Asorey Carballeira, A | 1 |
| Alguacil Muñoz, A | 1 |
| Guerra Vales, JM | 1 |
| Vilalta Castel, E | 1 |
| Broze, B | 1 |
| De Mees, J | 1 |
| Droissart, R | 1 |
| Nolens, VP | 1 |
| Staudt, JP | 1 |
| Verstraeten, ME | 1 |
| de Lame, PA | 1 |
2 reviews available for metronidazole and Digestive System Disorders
| Article | Year |
|---|---|
[Pharmacological rationale for choice of antibiotics for intraabdominal infections].
Topics: Abdominal Abscess; Acetamides; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; beta-L | 2008 |
[Invasive amebiasis (II): Extra-intestinal forms and complications. Parasitological and serological diagnosis. Treatment].
Topics: Amebiasis; Amebicides; Animals; Anti-Bacterial Agents; Brain Abscess; Digestive System Diseases; Eme | 1985 |
2 trials available for metronidazole and Digestive System Disorders
| Article | Year |
|---|---|
Comparison of sequential intravenous/oral ciprofloxacin plus metronidazole with intravenous ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections.
Topics: Abdomen; Abdominal Abscess; Administration, Oral; Anti-Bacterial Agents; Bacterial Infections; Cipro | 2006 |
Randomized comparison of imipenem/cilastatin and ceftazidime in the empiric therapy of severe abdominal infections. A multicenter study.
Topics: Bacterial Infections; Ceftazidime; Cilastatin; Cyclopropanes; Digestive System Diseases; Dipeptidase | 1987 |
1 other study available for metronidazole and Digestive System Disorders
| Article | Year |
|---|---|
"Universal" Crohn's disease.
Topics: Child; Crohn Disease; Digestive System Diseases; Humans; Male; Metronidazole | 1979 |