metronidazole has been researched along with Day Blindness in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Mostly, metronidazole is a tolerable drug but rarely presents serious adverse effects on the nervous system." | 2.49 | A rare adverse effect of metronidazole: nervous system symptoms. ( Kafadar, I; Klç, BA; Moustafa, F; Yalçın, K, 2013) |
| "To report the onset of neuro-ophthalmological adverse effects in two children treated with metronidazole for amoebic dysentery." | 1.43 | [Neuro-ophthalmic adverse effects of metronidazole treatment in children: Two case studies]. ( Bouladi, M; Bouraoui, R; El Matri, L; Limaiem, R; Mghaieth, F, 2016) |
| "Metronidazole is a little known cause of drug-induced optic neuropathy." | 1.34 | Reversible optic neuropathy due to metronidazole. ( Kent-Smith, B; McGrath, NM; Sharp, DM, 2007) |
| "Whipple's disease can affect the periorbital tissues and the optic nerve, causing massive exophthalmos and serious transient visual loss." | 1.34 | Orbital manifestation of whipple's disease: an atypical case. ( Arnold, M; Clemetson, IA; Iizuka, T; Lieger, O; Otto, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kafadar, I | 1 |
| Moustafa, F | 1 |
| Yalçın, K | 1 |
| Klç, BA | 1 |
| Agrawal, R | 1 |
| De Salvo, G | 1 |
| Pavlidou, E | 1 |
| Smith, R | 1 |
| Pavesio, C | 1 |
| Cunningham, ET | 1 |
| Shields, CL | 1 |
| Pollett, S | 1 |
| McMullan, B | 1 |
| Lam, VW | 1 |
| Qureshi, C | 1 |
| Kok, J | 1 |
| Bouraoui, R | 1 |
| Limaiem, R | 1 |
| Bouladi, M | 1 |
| Mghaieth, F | 1 |
| El Matri, L | 1 |
| Choi, RY | 1 |
| Engbretson, GA | 1 |
| Solessio, EC | 1 |
| Jones, GA | 1 |
| Coughlin, A | 1 |
| Aleksic, I | 1 |
| Zuber, ME | 1 |
| Parvizi, N | 1 |
| Choudhury, N | 1 |
| Singh, A | 1 |
| Etxeberria, A | 1 |
| Lonneville, S | 1 |
| Rutgers, MP | 1 |
| Gille, M | 1 |
| De Bleecker, JL | 1 |
| Leroy, BP | 1 |
| Meire, VI | 1 |
| McGrath, NM | 1 |
| Kent-Smith, B | 1 |
| Sharp, DM | 1 |
| Lieger, O | 1 |
| Otto, S | 1 |
| Clemetson, IA | 1 |
| Arnold, M | 1 |
| Iizuka, T | 1 |
| Dralands, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)[NCT02201186] | Phase 2 | 10 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Day Blindness
| Article | Year |
|---|---|
A rare adverse effect of metronidazole: nervous system symptoms.
Topics: Anti-Infective Agents; Ataxia; Child, Preschool; Convalescence; Dizziness; Dysentery, Amebic; Headac | 2013 |
10 other studies available for metronidazole and Day Blindness
| Article | Year |
|---|---|
Diagnostic and therapeutic challenges.
Topics: Adult; Antiprotozoal Agents; Eye Diseases; Female; Fluorescein Angiography; Giardia; Giardiasis; Hum | 2015 |
A 68-year-old type 2 diabetic man of Korean ethnicity with fever, abdominal pain, and right eye visual disturbance.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bacteremia; Diabetes Mellitus, Type 2; Endophthalmitis; | 2015 |
[Neuro-ophthalmic adverse effects of metronidazole treatment in children: Two case studies].
Topics: Antiprotozoal Agents; Child; Diplopia; Female; Humans; Male; Metronidazole; Vision Disorders | 2016 |
Cone degeneration following rod ablation in a reversible model of retinal degeneration.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Calbindins; Cell Count; Disease Models, Animal; E | 2011 |
Complicated periorbital cellulitis: case report and literature review.
Topics: Abscess; Adolescent; Anti-Infective Agents; Cefuroxime; Contrast Media; Decompression, Surgical; Dra | 2012 |
Metronidazole-cerebellopathy associated with peripheral neuropathy, downbeat nystagmus, and bilateral ocular abduction deficit.
Topics: Abducens Nerve Diseases; Accommodation, Ocular; Aged, 80 and over; Anti-Infective Agents; Cerebellar | 2012 |
Reversible visual deficit and Corpus callosum lesions due to metronidazole toxicity.
Topics: Adult; Anti-Infective Agents; Colitis, Ulcerative; Corpus Callosum; Diagnosis, Differential; Evoked | 2005 |
Reversible optic neuropathy due to metronidazole.
Topics: Aged; Anti-Infective Agents; Electrophysiology; Female; Humans; Metronidazole; Optic Nerve Diseases; | 2007 |
Orbital manifestation of whipple's disease: an atypical case.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Decompression, Surgical; Exophthalmos; Hu | 2007 |
[Harmful effects of common drugs on the visual apparatus. Anti-infective drugs. D. Antiprotozoal agents].
Topics: Amidines; Antiprotozoal Agents; Blindness; Eye Diseases; Humans; Metronidazole; Papilledema; Photose | 1972 |