Infections, Microspora

Synonym
Microsporidia Infection
Infections, Microspora
Microsporidiosis
Microspora Infections

Excerpt	Reference
"Since microsporidiosis is becoming an important opportunistic infection in AIDS patients, a microsporidiosis model is being developed using SIV/DeltaB670-infected rhesus macaque monkeys (Macaca mulatta)."	( Aldras, AM; Bohm, R; Didier, ES; Didier, PJ; Millichamp, NJ; Murphey-Corb, M; Shadduck, JA; Varner, PW, 1994)
"Microsporidiosis is a common finding in HIV-infected patients who have diarrhoea."	( Diehl, V; Fätkenheuer, G; Franzen, C; Mahrle, G; Müller, A; Salzberger, B; Schrappe, M; Schwenk, A, 1995)
"Microsporidiosis is a common cause of chronic diarrhea in human immunodeficiency virus (HIV)-seropositive individuals and often does not respond to treatment."	( Barrett, M; Ellis, D; Francis, N; Gazzard, B; Rowbottom, A; Sharpstone, D; Tovey, G, 1997)
"Microsporidiosis is recognized as an increasingly important infection, particularly in patients with human immunodeficiency virus (HIV) infection."	( Crowe, SM; Leder, K; Ryan, N; Spelman, D, 1998)
"Intestinal microsporidiosis is most commonly associated with persistent diarrhea in advanced AIDS cases."	( Abraham, Y; Endeshaw, T; Kebede, A; Messele, T; Petros, B; Polderman, AM; Tsige, K; Verweij, JJ; Wolday, D; Woldemichael, T; Zewide, A, 2006)
"Intestinal microsporidiosis is the most common cause of chronic diarrhea in HIV/AIDS infected patients."	( Defera, M; Endeshaw, T; Kebede, A; Mohammed, H, 2009)
"Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency."	( Audemard, A; Carluer, L; Castrale, C; Dargère, S; Hurault de Ligny, B; Le Bellec, ML; Lobbedez, T; Verdon, R, 2012)
"Microsporidiosis is a common disease in animals and humans around the world."	( Cong, W; Lou, ZL; Ma, JG; Yao, QX; Zhang, XX; Zhao, Q; Zheng, WB; Zhu, XQ, 2016)
"Microsporidiosis is a rare, but emerging opportunistic infection in solid organ transplant and stem cell transplant recipients."	( Annigeri, RA; Jacob, SS; Kumar, S; Mahesh, R; Mani, R; Parameswaran, A; Shah, S; Uppuluri, R, 2020)
"Human microsporidiosis is an increasingly recognized multisystem opportunistic infection."	( Bradt, AR; Fullen, DR; Goldsmith, CS; Nadelman, DA; Qvarnstrom, Y; Smith, EH; Wang, F; Zaki, SR, 2020)
"Microsporidiosis is a very rare infection after liver transplantation but can induce severe dehydration and renal failure."	( Abergel, A; Angoulvant, A; Argy, N; Autier, B; Bellanger, AP; Botterel, F; Coilly, A; Conti, F; Dumortier, J; Duvoux, C; Francoz, C; Garrouste, C; Houssel-Debry, P; Iriart, X; Kamar, N; Laverdure, N; Poirier, P; Rabodonirina, M; Radenne, S; Thellier, M; Vanlemmens, C, 2021)
"Stromal microsporidiosis is recalcitrant and very often requires therapeutic keratoplasty for effective eradication."	( Raghavan, A; Raja, DR; Rammohan, R; Venkatapathy, N, 2022)

Excerpt	Reference
"Microsporidiosis has been largely reported in patients with acquired immunodeficiency syndrome, but emerged as a cause of persistent diarrhea in solid organ transplant patients."	( Abergel, A; Angoulvant, A; Argy, N; Autier, B; Bellanger, AP; Botterel, F; Coilly, A; Conti, F; Dumortier, J; Duvoux, C; Francoz, C; Garrouste, C; Houssel-Debry, P; Iriart, X; Kamar, N; Laverdure, N; Poirier, P; Rabodonirina, M; Radenne, S; Thellier, M; Vanlemmens, C, 2021)

Excerpt	Reference
"Intestinal microsporidiosis due to Enterocytozoon bieneusi is a frequent cause of chronic diarrhoea in patients with HIV infection for which there is no available therapy."	( Chastang, C; Cotte, L; Derouin, F; Desportes-Livage, I; Goguel, J; Katlama, C; Leport, C; Maslo, C; Michiels, JF; Modaï, J; Molina, JM; Raffi, F; Sarfati, C, 1997)
"HIV-1 infected patients with chronic microsporidiosis (five), cryptosporidiosis (three), or dual infection (one), were treated with combination therapy that included at least one HIV-1 protease inhibitor."	( Carr, A; Cooper, DA; Field, A; Marriott, D; Vasak, E, 1998)
"Intestinal microsporidiosis caused by Enterocytozoon bieneusi is a cause of chronic diarrhoea in patients with HIV infection for which there is no current therapy."	( Balkan, S; Chastang, C; Cotte, L; Decazes, JM; Derouin, F; Desportes-Livage, I; Goguel, J; Maslo, C; Michiels, JF; Molina, JM; Sarfati, C; Struxiano, A, 2000)
"The most effective drugs for treating microsporidiosis in humans currently include albendazole, which is effective against the Encephalitozoon species but not against Enterocytozoon bieneusi, and fumagillin, which has broader anti-microsporidia activity but is toxic in mammals, suggesting a need to identify better drugs."	( Brindley, PJ; Didier, ES; Didier, PJ; Green, LC; Sestak, K; Stovall, ME, 2004)
"This case of microsporidiosis manifested as mutiple intracranial lesions separated in space and time, and neurological and radiological findings were improved with albendazole administration."	( Kanamori, M; Kumabe, T; Okuyama, H; Tominaga, T; Watanabe, M, 2008)
"We report 10 cases of intestinal microsporidiosis due to Enterocytozoon bieneusi in renal transplant (RT) recipients who were treated with fumagillin."	( Champion, L; Chauvet, C; Delahousse, M; Durrbach, A; Glotz, D; Lang, P; Molina, JM; Sarfati, C, 2010)
"To report a case of stromal microsporidiosis that responded to medical treatment with systemic albendazole and topical chlorhexidine."	( Garg, P; Murthy, SI; Sangit, VA, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	72 (26.57)	12.5806
2000's	91 (33.58)	18.1394
2010's	78 (28.78)	28.8240
2020's	30 (11.07)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
butyric acid	low	1	0
carbamates	low	1	0
formic acid	low	1	0
formaldehyde	low	5	0
glycerol	low	2	0
iodine	low	2	0
nitrites	low	1	0
oxalic acid	low	1	0
thiamine	low	1	0
albendazole	medium	60	3
ciprofloxacin	low	2	0
dimetridazole	low	1	0
fenbendazole	low	3	0
fluconazole	low	1	0
furazolidone	low	3	0
guaifenesin	low	1	0
hydroxychloroquine	low	1	0
2-propanol	low	1	0
lansoprazole	low	1	0
mebendazole	low	2	0
metronidazole	low	5	0
norfloxacin	low	2	0
omeprazole	low	1	0
pentamidine	low	1	0
propidium	low	2	0
pyrimethamine	low	1	0
rabeprazole	low	1	0
sulfadiazine	low	1	0
thalidomide	medium	5	1
tinidazole	low	1	0
trimethoprim	low	1	0
prednisolone	low	1	0
benzimidazole	low	2	0
prednisolone acetate	low	1	0
prednisone	low	1	0
biguanides	medium	4	1
chloramphenicol	low	2	0
methylene blue	low	2	0
arginine	low	1	0
thiophenes	low	1	0
phenyl salicylate	low	1	0
thiazoles	low	2	0
betamethasone	low	1	0
cyproterone acetate	low	1	0
malondialdehyde	low	1	0
eosine yellowish-(ys)	low	8	0
gentian violet	low	2	0
dibrompropamidine	low	1	0
potassium hydroxide	low	1	0
digoxigenin	low	2	0
stavudine	low	1	0
chromotrope 2r	low	1	0
vantocil	medium	4	1
manganese	low	1	0
cadmium	low	1	0
gold	low	3	0
camptothecin	low	1	0
zinc sulfate	low	1	0
potassium dichromate	low	1	0
chlorine	low	1	0
carbendazim	low	1	0
azides	low	1	0
nitazoxanide	low	3	0
fomesafen	low	1	0
itraconazole	low	2	0
topotecan	low	1	0
lamivudine	low	1	0
irinotecan	low	1	0
propamidine	low	1	0
propamidine isethionate	low	1	0
triazoles	low	1	0
dexrazoxane	low	1	0
voriconazole	low	3	0
foxes	low	6	0
thiamethoxam	low	1	0
omega-n-methylarginine	low	1	0
levofloxacin	low	2	0
moxifloxacin	low	3	0
paromomycin	low	1	0
4,4'-bis(2-di(2-hydroxyethyl)amino-4-(3-sulphophenylamino)-1,3,5-triazine-6-ylamino)stilbene-2,2'-disulphonic acid	low	5	0
trimethoprim, sulfamethoxazole drug combination	low	5	0
o-(chloroacetylcarbamoyl)fumagillol	low	2	0
ritonavir	low	1	0
epiglucan	low	2	0
laminaran	low	1	0
saquinavir	low	1	0
tacrolimus	low	2	0
mycophenolic acid	low	2	0
clindamycin	low	1	0
zithromax	low	1	0
enkephalin, leucine	low	1	0
sodium acetate, anhydrous	low	1	0
stilbenes	low	1	0
sesquiterpenes	medium	37	4
terbinafine	medium	1	1
orlistat	low	1	0
quinine	low	1	0
propidium monoazide	low	1	0
phenylephrine hydrochloride	low	2	0
indinavir sulfate	medium	4	1
c.i. fluorescent brightening agent 28	low	7	0
fumagillin	medium	36	4
staurosporine	low	1	0
chlorhexidine	low	3	0
ants	low	10	0
fungiqual	low	1	0
lactoferricin b	low	1	0
phosphatidylcholines	low	1	0
sulbutiamine	low	1	0
aniline blue	low	1	0
oxytetracycline, anhydrous	low	1	0
salicylates	low	1	0
sybr green i	low	1	0
bassianolide	low	4	0
hyaluronoglucosaminidase	low	1	0
cyclosporine	low	2	0
lactoferrin	low	1	0
ovalicin	low	1	0
muramidase	low	2	0
exudates	low	12	0
acyclovir	low	1	0
rifampin	low	1	0
ganciclovir	low	1	0
trypan blue	low	1	0
imidacloprid	low	4	0
eye	low	2	0
concanavalin a	low	1	0

Protein Targets (993)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
RAR-related orphan receptor gamma	27	0	0	27
GLI family zinc finger 3	36	0	0	36
AR protein	43	0	0	43
aldehyde dehydrogenase 1 family, member A1	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
retinoid X nuclear receptor alpha	32	0	0	32
estrogen nuclear receptor alpha	51	0	0	51
peroxisome proliferator-activated receptor delta	19	0	0	19
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	28	0	0	28
activating transcription factor 6	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	20	0	0	20
Histone H2A.x	18	0	0	18
thyroid hormone receptor beta isoform a	16	0	0	16
heat shock protein beta-1	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 1	39	0	0	39
lamin isoform A-delta10	28	0	0	28
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Glutamate receptor 2	19	1	0	20
Free fatty acid receptor 3	0	0	2	2
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Ferritin light chain	8	0	0	8
Thymidine kinase	0	2	0	2
thioredoxin reductase	13	0	0	13
phosphopantetheinyl transferase	11	0	0	11
GLS protein	7	0	0	7
TDP1 protein	44	0	0	44
Smad3	8	0	0	8
thyroid stimulating hormone receptor	15	0	0	15
EWS/FLI fusion protein	26	0	0	26
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	24	0	0	24
Bloom syndrome protein isoform 1	11	0	0	11
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Solute carrier family 22 member 1	0	10	0	14
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	34	0	34
Solute carrier family 22 member 6	0	0	0	2
Bile salt export pump	0	4	0	4
Bile salt export pump	0	40	0	40
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	6
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	13	0	13
Cytochrome P450 2J2	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	33	0	33
Thymidine kinase	0	1	0	1
Chain A, Beta-lactamase	7	0	0	7
Luciferase	19	0	0	19
glp-1 receptor, partial	11	0	0	11
ATAD5 protein, partial	9	0	0	9
Fumarate hydratase	11	0	0	11
caspase 7, apoptosis-related cysteine protease	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
progesterone receptor	28	0	0	28
glucocorticoid receptor [Homo sapiens]	30	0	0	30
estrogen-related nuclear receptor alpha	38	0	0	38
farnesoid X nuclear receptor	23	0	0	23
pregnane X nuclear receptor	34	0	0	34
polyprotein	11	0	0	11
67.9K protein	14	0	0	14
peroxisome proliferator activated receptor gamma	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	22	0	0	22
caspase-3	8	0	0	8
IDH1	12	0	0	12
aryl hydrocarbon receptor	21	0	0	21
nuclear receptor subfamily 1, group I, member 2	13	0	0	13
cellular tumor antigen p53 isoform a	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
chromobox protein homolog 1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
transcriptional regulator ERG isoform 3	6	0	0	6
thyroid hormone receptor beta isoform 2	27	0	0	27
histone deacetylase 9 isoform 3	10	0	0	10
mitogen-activated protein kinase 1	10	0	0	10
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
geminin	35	0	0	35
Vif	0	0	0	1
peripheral myelin protein 22	15	0	0	15
survival motor neuron protein isoform d	11	0	0	11
muscleblind-like protein 1 isoform 1	7	0	0	7
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
Interferon beta	25	0	0	25
Cellular tumor antigen p53	31	0	0	31
Integrin beta-3	5	0	0	5
Integrin alpha-IIb	5	0	0	5
Methionine aminopeptidase	0	5	0	5
Fatty-acid amide hydrolase 1	1	6	0	7
Inositol monophosphatase 1	6	0	0	6
ATPase family AAA domain-containing protein 5	17	0	0	17
Ataxin-2	18	0	0	18
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	5	0	0	5
alpha-galactosidase	4	0	0	4
cytochrome P450 2C19 precursor	8	0	0	8
flap endonuclease 1	7	0	0	7
DNA polymerase iota isoform a (long)	12	0	0	12
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	10	0	0	10
Cytochrome P450 3A4	0	19	0	22
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	2	1	5
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	1	0	2
GTPase KRas	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	4	1	5
Membrane primary amine oxidase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
pregnane X receptor	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	28	0	0	28
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	10	2	18
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	2	2
Chain A, Nitrile Hydratase alpha subunit	0	1	0	1
Chain B, Nitrile Hydratase beta subunit	0	1	0	1
SMAD family member 2	15	0	0	15
SMAD family member 3	15	0	0	15
Lysine-specific demethylase 4E	0	1	0	1
thyroid stimulating hormone receptor	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	19	0	0	19
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	4	0	4
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, Cruzipain	8	0	0	8
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
PPM1D protein	9	0	0	9
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
regulator of G-protein signaling 4	5	0	0	5
glucocerebrosidase	3	0	0	3
putative alpha-glucosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
peripheral myelin protein 22 isoform 1	3	0	0	3
huntingtin isoform 2	8	0	0	8
ras-related protein Rab-9A	4	0	0	4
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	13	0	0	13
cytochrome P450 3A4 isoform 1	15	0	0	15
M-phase phosphoprotein 8	3	0	0	3
histone acetyltransferase KAT2A isoform 1	8	0	0	8
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	15	2	0	17
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	1	0	2
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	2	3	11
DNA topoisomerase 2-alpha	0	4	0	8
Gamma-aminobutyric acid receptor subunit beta-1	15	2	0	17
Gamma-aminobutyric acid receptor subunit delta	15	2	0	17
Gamma-aminobutyric acid receptor subunit gamma-2	15	2	0	17
Gamma-aminobutyric acid receptor subunit alpha-5	15	2	0	17
Gamma-aminobutyric acid receptor subunit alpha-3	15	2	0	17
Gamma-aminobutyric acid receptor subunit gamma-1	15	2	0	17
Gamma-aminobutyric acid receptor subunit alpha-2	15	2	0	17
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	15	2	0	17
Gamma-aminobutyric acid receptor subunit gamma-3	15	2	0	17
Gamma-aminobutyric acid receptor subunit alpha-6	15	2	0	17
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	15	2	0	17
Gamma-aminobutyric acid receptor subunit beta-3	15	2	0	17
Gamma-aminobutyric acid receptor subunit beta-2	15	2	0	17
DNA topoisomerase 2-beta	0	2	0	3
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	15	2	0	17
DNA topoisomerase type IB small subunit	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	15	2	0	17
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
interleukin 8	7	0	0	7
estrogen receptor 2 (ER beta)	18	0	0	18
G	16	0	0	16
cytochrome P450 2D6	16	0	0	16
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Inositol hexakisphosphate kinase 1	16	0	0	16
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	16	0	0	16
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
acid sphingomyelinase	1	0	0	1
acetylcholinesterase	11	0	0	11
PAX8	0	0	0	2
USP1 protein, partial	12	0	0	12
PINK1	1	0	0	1
Parkin	2	0	0	2
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	4	0	0	4
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	5	0	0	5
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
importin subunit beta-1 isoform 1	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	2
snurportin-1	2	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA polymerase kappa isoform 1	8	0	0	8
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	2	2
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	7	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	5	0	5
Glutathione reductase, mitochondrial	0	2	0	4
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	4	1	0	5
Histamine H2 receptor	9	0	0	9
Nuclear receptor ROR-gamma	9	0	0	9
Spike glycoprotein	19	0	1	20
TAR DNA-binding protein 43	9	0	0	9
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	6	0	6
Rap guanine nucleotide exchange factor 4	3	0	0	3
Multidrug and toxin extrusion protein 1	0	8	0	8
Spermine oxidase	0	1	0	1
Cytochrome P450 1A2	0	3	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	3	0	6
DNA gyrase subunit B	0	3	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	3	0	4
Cytochrome P450 2D6	0	9	0	9
DNA gyrase subunit A	0	2	0	3
Cytochrome P450 2C19	0	7	0	8
Multidrug resistance protein MdtK	0	0	2	2
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	4	0	5
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	10	0	12
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
endonuclease IV	4	0	0	4
dopamine D1 receptor	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	11	0	0	11
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Progesterone receptor	0	3	0	4
Androgen receptor	0	4	0	4
Androgen receptor	0	5	0	5
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Mu-type opioid receptor	0	10	1	11
Urokinase-type plasminogen activator	0	2	0	2
Acrosin	0	3	0	3
Suppressor of tumorigenicity 14 protein	0	2	0	2
Albumin	0	0	7	13
Reverse transcriptase/RNaseH	0	4	5	14
Chain A, DigA16	0	0	1	1
Chain A, DigA16	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	7	1	8
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	1	0	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Rap guanine nucleotide exchange factor 3	6	0	0	6
Mitogen-activated protein kinase 14	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
apical membrane antigen 1, AMA1	4	0	0	4
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	8	0	10
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Methionine aminopeptidase 2	0	3	0	3
Methionine aminopeptidase 1	0	1	0	1
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
Microtubule-associated protein tau	12	0	0	13
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	3	0	0	3
luciferase	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Epidermal growth factor receptor	0	1	0	1
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	7	0	7
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	7	0	7
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	4	0	4
60 kDa heat shock protein, mitochondrial	0	3	0	3
Muscarinic acetylcholine receptor M1	0	3	0	3
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	8	0	8
Alpha-2B adrenergic receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	5	0	5
Muscarinic acetylcholine receptor M3	0	3	0	3
Substance-K receptor	0	8	0	8
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	5	0	5
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
Adenosine receptor A2a	0	2	0	2
D(3) dopamine receptor	0	8	0	8
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	8	0	8
10 kDa heat shock protein, mitochondrial	0	3	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	3	0	3
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	3	0	3
Leukotriene B4 receptor 2	1	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	2	1	3
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	3	1	4
Replicase polyprotein 1ab	0	5	1	6
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Gag-Pol polyprotein	0	5	0	5
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	3	0	3
Gag polyprotein	0	2	0	2
Gag-Pol polyprotein	0	3	0	3
Gag-Pol polyprotein	0	5	0	5
Alpha-1D adrenergic receptor	0	4	0	4
Thromboxane-A synthase	0	3	0	3
Gag-Pol polyprotein	0	3	0	3
Thromboxane-A synthase	0	0	0	3
Genome polyprotein	0	2	0	2
Solute carrier family 22 member 1	0	5	0	6
Protease	0	6	4	19
Protease	0	6	3	9
Protease	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	1
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
GALC protein	6	0	0	6
Hsf1 protein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase PLK1	4	0	0	4
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	4	0	5
Amyloid-beta precursor protein	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Microtubule-associated protein tau	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	8	0	8
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	3	0	3
Histone-lysine N-methyltransferase 2A	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	3	0	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	0	8
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA polymerase beta	4	0	0	4
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Tyrosine-protein kinase ABL1	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	3	0	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Calmodulin-domain protein kinase 1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
isocitrate dehydrogenase 1, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	4	0	0	4
caspase-3 isoform a preproprotein	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
Vpr	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	1	5
Cruzipain	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
pyruvate kinase	1	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Neutrophil elastase	0	1	0	1
Proteinase-activated receptor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	2	0	2
Collagenase 3	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Mcl-1	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	2	0	2
Muscarinic acetylcholine receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Phosphatidylserine lipase ABHD16A	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	3
Lipoprotein lipase	0	1	0	1
Hepatic triacylglycerol lipase	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Translocator protein	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Neutral cholesterol ester hydrolase 1	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Diacylglycerol lipase-beta	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Acyl-protein thioesterase 2	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Endothelial lipase	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Protein arginine N-methyltransferase 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Protein tyrosine phosphatase type IVA 3	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Protein S100-B	0	1	1	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Protein S100-B	0	0	1	1
Trypsin-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
Amiloride-sensitive amine oxidase [copper-containing]	0	1	0	1
Diamine acetyltransferase 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Protein tyrosine phosphatase type IVA 2	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Protein tyrosine phosphatase type IVA 1	0	1	0	1
Aurora kinase B	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Caspase-7	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Dihydrofolate reductase	0	4	0	4
Dihydrofolate reductase	0	2	0	2
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Dihydrofolate reductase	0	4	1	6
Bifunctional dihydrofolate reductase-thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	4	0	5
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Trace amine-associated receptor 5	0	0	2	2
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Insulin-degrading enzyme	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Cytochrome P450 3A5	0	2	0	2
Vasopressin V1a receptor	0	4	0	4
Sodium/bile acid cotransporter	0	1	0	1
Plasmepsin V	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Exoribonuclease H	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Thymidine kinase 2	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Aurora kinase A	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
nonstructural protein 1	1	0	0	1
NPYLR7B	0	0	1	1
tyrosine-protein kinase Yes	2	0	0	2
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Deoxycytidine kinase	0	1	0	1
C-X-C chemokine receptor type 4	0	0	1	1
Solute carrier family 22 member 7	0	0	0	2
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (271)

Protein Targets (993)

Infections, Microspora

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (271)

Drugs Studied (141)

Protein Targets (993)