metronidazole has been researched along with Necrotizing Enterocolitis in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No antimicrobial regimen has been shown to be superior to ampicillin and gentamicin in decreasing mortality and preventing clinical deterioration in NEC." | 5.41 | Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review. ( Aluvaala, J; Barbieri, E; Bonadies, L; Donà, D; English, M; Gastaldi, A, 2023) |
| "Data were collected prospectively from 32 preterm neonates who received intravenous metronidazole for the treatment of or prophylaxis against necrotizing enterocolitis." | 3.77 | Metronidazole population pharmacokinetics in preterm neonates using dried blood-spot sampling. ( Collier, PS; Halliday, HL; Iheagwaram, G; McElnay, JC; Millar, M; Millership, JS; Suyagh, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donà, D | 1 |
| Gastaldi, A | 1 |
| Barbieri, E | 1 |
| Bonadies, L | 1 |
| Aluvaala, J | 1 |
| English, M | 1 |
| Murphy, C | 1 |
| Nair, J | 1 |
| Wrotniak, B | 1 |
| Polischuk, E | 1 |
| Islam, S | 1 |
| Jensen, ML | 1 |
| Thymann, T | 2 |
| Cilieborg, MS | 2 |
| Lykke, M | 1 |
| Mølbak, L | 1 |
| Jensen, BB | 1 |
| Schmidt, M | 1 |
| Kelly, D | 1 |
| Mulder, I | 1 |
| Burrin, DG | 1 |
| Sangild, PT | 2 |
| Sampson, MR | 1 |
| Bloom, BT | 1 |
| Arrieta, A | 1 |
| Capparelli, E | 1 |
| Benjamin, DK | 1 |
| Smith, PB | 1 |
| Kearns, GL | 1 |
| van den Anker, J | 1 |
| Cohen-Wolkowiez, M | 1 |
| Luo, LJ | 1 |
| Li, X | 1 |
| Yang, KD | 1 |
| Lu, JY | 1 |
| Li, LQ | 1 |
| Birck, MM | 1 |
| Nguyen, DN | 1 |
| Kamal, SS | 1 |
| Nielsen, DS | 1 |
| Damborg, P | 1 |
| Olsen, JE | 1 |
| Lauridsen, C | 1 |
| Grünewald, T | 1 |
| Kist, M | 1 |
| Mutters, R | 1 |
| Ruf, BR | 1 |
| Kern, WV | 1 |
| Suyagh, M | 1 |
| Collier, PS | 1 |
| Millership, JS | 1 |
| Iheagwaram, G | 1 |
| Millar, M | 1 |
| Halliday, HL | 1 |
| McElnay, JC | 1 |
2 reviews available for metronidazole and Necrotizing Enterocolitis
| Article | Year |
|---|---|
Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.
Topics: Ampicillin; Anti-Bacterial Agents; Clinical Deterioration; Enterocolitis, Necrotizing; Female; Fetal | 2023 |
[Clostridium difficile infection].
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Clindamycin; Clostridioides difficile; Colectomy; | 2010 |
1 trial available for metronidazole and Necrotizing Enterocolitis
| Article | Year |
|---|---|
Intestinal fatty-acid binding protein and metronidazole response in premature infants.
Topics: Anti-Infective Agents; Biomarkers; Enterocolitis, Necrotizing; Fatty Acid-Binding Proteins; Female; | 2014 |
5 other studies available for metronidazole and Necrotizing Enterocolitis
| Article | Year |
|---|---|
Antibiotic Treatments and Patient Outcomes in Necrotizing Enterocolitis.
Topics: Ampicillin; Anti-Bacterial Agents; Enterocolitis, Necrotizing; Female; Gentamicins; Humans; Infant, | 2020 |
Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets.
Topics: Amino Acids; Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Antibiotic Prophylaxis; D | 2014 |
Broad-spectrum Antibiotic Plus Metronidazole May Not Prevent the Deterioration of Necrotizing Enterocolitis From Stage II to III in Full-term and Near-term Infants: A Propensity Score-matched Cohort Study.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Case-Control Studies; Cohort Studies; Disease Progress | 2015 |
Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs.
Topics: Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Biological Availability; Disease Model | 2016 |
Metronidazole population pharmacokinetics in preterm neonates using dried blood-spot sampling.
Topics: Blood Specimen Collection; Enterocolitis, Necrotizing; Female; Humans; Infant, Newborn; Infant, Prem | 2011 |