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metronidazole and AIDS-Related Complex

metronidazole has been researched along with AIDS-Related Complex in 1 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

AIDS-Related Complex: A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.

Research Excerpts

ExcerptRelevanceReference
"Treatment with metronidazole in most cases improved symptoms."1.28[Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes]. ( Arasteh, K; Gelderblom, HR; Grosse, G; Heise, W; Käsbohrer, A; Koch, MA; L'age, M; Pauli, G; Schönberg, A, 1990)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Käsbohrer, A1
Gelderblom, HR1
Arasteh, K1
Heise, W1
Grosse, G1
L'age, M1
Schönberg, A1
Koch, MA1
Pauli, G1

Other Studies

1 other study available for metronidazole and AIDS-Related Complex

ArticleYear
[Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes].
    Deutsche medizinische Wochenschrift (1946), 1990, Oct-05, Volume: 115, Issue:40

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Complex; Endoscopy; Homosexuality; Hum

1990