metronidazole has been researched along with Substance-Related Disorders in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang'ondu, RW | 1 |
| Murray, TS | 1 |
| Martínez, JG | 1 |
| Saus, C | 1 |
| Morey, A | 1 |
| Alarcón, A | 1 |
| Giannini, AJ | 1 |
| DeFrance, DT | 1 |
| Siegel, JA | 1 |
| Weisz, S | 1 |
| Uhl, MD | 1 |
| Riely, CA | 1 |
| Kolander, SA | 1 |
| Cosgrove, EM | 1 |
| Molavi, A | 1 |
| O'Neil, JT | 1 |
| Pogge, RC | 1 |
1 review available for metronidazole and Substance-Related Disorders
| Article | Year |
|---|---|
Clostridial endocarditis. Report of a case caused by Clostridium bifermentans and review of the literature.
Topics: Adult; Clostridium Infections; Cocaine; Endocarditis, Bacterial; Humans; Male; Metronidazole; Substa | 1989 |
7 other studies available for metronidazole and Substance-Related Disorders
| Article | Year |
|---|---|
Relapse of polymicrobial endocarditis in an intravenous drug user.
Topics: Adult; Ceftriaxone; Coinfection; Eikenella corrodens; Endocarditis, Bacterial; Gram-Negative Bacteri | 2011 |
[Crohn's disease and renal amyloidosis. Acute renal failure].
Topics: Acetaminophen; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Amyloidosis; Analgesics, Non-Nar | 2002 |
Metronidazole and alcohol--potential for combinative abuse.
Topics: Adolescent; Adult; Drug Interactions; Educational Status; Ethanol; Female; Humans; Metronidazole; Su | 1983 |
The analysis of metronidazole in human serum: an unusual overdose case.
Topics: Adult; Chromatography, High Pressure Liquid; Ethanol; Female; Humans; Metronidazole; Substance-Relat | 1984 |
Drug watch providing essential information.
Topics: Buspirone; Humans; Lactation; Metronidazole; Neoplasms; Nicotine; Paclitaxel; Substance-Related Diso | 1994 |
Metronidazole in treating portosystemic encephalopathy.
Topics: Aged; Female; Hepatic Encephalopathy; Humans; Metronidazole; Substance-Related Disorders | 1996 |
Relative safety of self inflicted overdose with relatively newer medications.
Topics: Adult; Depression; Diazepam; Female; Humans; Lethal Dose 50; Metronidazole; Penicillin V; Substance- | 1973 |