Page last updated: 2024-09-27

Rocky Mountain Spotted Fever

An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.

Synonyms(1)

Synonym
Rocky Mountain Spotted Fever

Research Excerpts

Overview

ExcerptReference
"Rocky Mountain spotted fever is caused by the tick-borne bacterium Rickettsia rickettsii."( Buckingham, SC; Minniear, TD, 2009)

Context

ExcerptReference
"Additionally, Rocky Mountain spotted fever has not been associated with IgA vasculitis despite being described in cutaneous and systemic vasculitis cases."( Abdelrahman Alkhidir, AG; Alchalabi, M; Gerais, Y; Laskova, A; Lodhi, O; Mohammed, BT; Sun, C, 2023)

Treatment

ExcerptReference
"Prophylactic treatment of Rocky Mountain spotted fever with a single dose of oxytetracycline was investigated in guinea pigs."( Kenyon, RH; Oster, CN; Pedersen, CE; Williams, RG, 1978)

Research

Studies (191)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990135 (70.68)23.3326
1990's25 (13.09)12.5806
2000's15 (7.85)18.1394
2010's11 (5.76)28.8240
2020's5 (2.62)9.53
DrugIndicatedRelationship StrengthStudiesTrials
benzoic acid0low10
formaldehyde0low20
glycine0low10
kynurenine0medium21
thioctic acid0low10
4-aminobenzoic acid0low180
acetaminophen0low10
amantadine0low10
aspirin0low10
bis(5-amidino-2-benzimidazolyl)methane0low10
deferoxamine0low10
ddt0low10
fluconazole0low10
glutaral0low10
lidocaine0low10
kynurenic acid0medium21
metronidazole0low10
deet0low20
apnea0low10
quinone0low10
phentermine0low10
procaine0low10
sotalol0low10
prednisolone0low10
prednisone0low10
idoxuridine0low10
chloramphenicol0medium531
carbostyril0low10
tyrosine0low10
leucine0low10
methionine0low10
phenylalanine0low10
cycloheximide0low30
ampicillin0low10
cytarabine0low10
tryptophan0medium31
ethyl chloride0low10
methylprednisolone0low20
diphenyl0low10
diatrizoate meglumine0low10
chloroprocaine0low10
thiocyanate0low20
hydantoins0low10
erythromycin0low30
chlorine0low10
trolamine salicylate0low10
amoxicillin0low20
permethrin0low10
decamethrin0low10
trovafloxacin0low10
fluazuron0low10
enrofloxacin0low10
fibrinogen0low80
foxes0low10
prolinedithiocarbamate0low10
5-amidinoindole0low10
proline0low10
cortisone0low30
trimethoprim, sulfamethoxazole drug combination0low10
fibrin0low30
glucosamine0low10
tosylphenylalanyl chloromethyl ketone0low10
digitoxin0low10
indican0low10
zithromax0low10
digoxin0low10
bilirubin0low20
dinoprostone0low20
vitamin k semiquinone radical0low10
6-ketoprostaglandin f1 alpha0low20
amphotericin b0low10
thromboxane b20low10
phosphorus0low20
staurosporine0low10
rivaroxaban0low10
pituitrin0low20
clove0low10
ants0low10
fibrinopeptide a0low10
interleukin-80low10
tetracycline0low460
chlortetracycline0low110
oxytetracycline, anhydrous0low30
minocycline0low10
pyrethrins0low10
digitonin0low10
thromboplastin0low60
muramidase0low10
exudates0low10
acyclovir0low10
folic acid0low10
rifampin0low10
eye0low20

Protein Targets (839)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE160016
Genome polyprotein 0011
USP1 protein, partial110011
AR protein280028
thyroid stimulating hormone receptor160016
glucocorticoid receptor [Homo sapiens]210021
retinoic acid nuclear receptor alpha variant 1220022
estrogen nuclear receptor alpha340034
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
Histone H2A.x8008
chromobox protein homolog 1180018
transcriptional regulator ERG isoform 34004
geminin320032
Polyphenol oxidase 20203
Cellular tumor antigen p53210021
Thiopurine S-methyltransferase0101
Succinate-semialdehyde dehydrogenase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
Cytochrome P450 1B10202
Dihydropteroate synthase 0011
Prothrombin 0202
Plasminogen0303
Urokinase-type plasminogen activator0202
Cationic trypsin0202
Serine protease hepsin0101
Solute carrier organic anion transporter family member 2A10003
RAR-related orphan receptor gamma170017
ATAD5 protein, partial6006
GLS protein120012
Microtubule-associated protein tau120012
Smad36006
aldehyde dehydrogenase 1 family, member A1190019
nuclear receptor subfamily 1, group I, member 3140014
progesterone receptor120012
EWS/FLI fusion protein120012
retinoid X nuclear receptor alpha170017
estrogen-related nuclear receptor alpha240024
peroxisome proliferator activated receptor gamma140014
aryl hydrocarbon receptor9009
thyroid hormone receptor beta isoform 2180018
peripheral myelin protein 229009
cytochrome P450 3A4 isoform 17007
Gamma-aminobutyric acid receptor subunit pi7108
ATP-binding cassette sub-family C member 3018018
Multidrug resistance-associated protein 4018020
Solute carrier family 22 member 60203
Carbonic anhydrase 120205
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0505
Voltage-dependent calcium channel gamma-2 subunit7007
Bile salt export pump027027
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 107010
Carbonic anhydrase 207010
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20203
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30205
Cytochrome P450 3A40819
Cytochrome P450 2D60202
Cytochrome P450 2C9 0909
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-17108
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta7108
Gamma-aminobutyric acid receptor subunit gamma-27108
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 291011
Gamma-aminobutyric acid receptor subunit alpha-57108
Gamma-aminobutyric acid receptor subunit alpha-37108
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40407
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60205
Gamma-aminobutyric acid receptor subunit gamma-17108
Gamma-aminobutyric acid receptor subunit alpha-27108
Gamma-aminobutyric acid receptor subunit alpha-47108
Gamma-aminobutyric acid receptor subunit gamma-37108
Gamma-aminobutyric acid receptor subunit alpha-67108
Carbonic anhydrase 5A, mitochondrial0205
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70205
Nuclear receptor ROR-gamma111113
Cytochrome P450 2J20606
Gamma-aminobutyric acid receptor subunit alpha-17209
Gamma-aminobutyric acid receptor subunit beta-37108
Gamma-aminobutyric acid receptor subunit beta-27108
Carbonic anhydrase 90205
GABA theta subunit7108
Canalicular multispecific organic anion transporter 1017017
Carbonic anhydrase 150306
Carbonic anhydrase 130103
Gamma-aminobutyric acid receptor subunit epsilon7108
Carbonic anhydrase 140205
Carbonic anhydrase 5B, mitochondrial0205
toxin B0001
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein110011
Chain B, HADH2 protein110011
Chain A, ATP-DEPENDENT DNA HELICASE Q16006
Chain A, Ferritin light chain4004
Thymidine kinase 0202
thioredoxin reductase150015
phosphopantetheinyl transferase7007
TDP1 protein240024
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2230023
activating transcription factor 6110011
Bloom syndrome protein isoform 18008
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor4004
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
lamin isoform A-delta10210021
Solute carrier family 22 member 1 0003
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0203
POU domain, class 2, transcription factor 20001
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80003
Thymidine kinase0202
acetylcholinesterase6006
NFKB1 protein, partial2002
GLI family zinc finger 3210021
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 48008
putative alpha-glucosidase1001
heat shock protein beta-16006
histone acetyltransferase KAT2A isoform 15005
Solute carrier family 22 member 20103
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 06111
Spike glycoprotein2013
Glutamate receptor ionotropic, NMDA 2A 0419
Glutamate receptor ionotropic, NMDA 2B0419
Glutamate receptor ionotropic, NMDA 2C0419
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0419
Solute carrier family 22 member 10101
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0419
Multidrug and toxin extrusion protein 10404
Solute carrier family 22 member 20101
Glutamate receptor ionotropic, NMDA 3A0419
ATP-dependent phosphofructokinase100010
Chain A, Beta-lactamase9009
Chain A, 2-oxoglutarate Oxygenase100010
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
apical membrane antigen 1, AMA17007
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)140014
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
DNA polymerase kappa isoform 18008
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10202
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20202
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20202
Beta-lactamase 0001
Beta-lactamase 0001
Chain A, Cruzipain9009
interleukin 8100010
farnesoid X nuclear receptor110011
peroxisome proliferator-activated receptor delta110011
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
tumor necrosis factor2002
vitamin D3 receptor isoform VDRA8008
nuclear factor erythroid 2-related factor 2 isoform 1210021
Cytochrome P450 2C190101
Potassium voltage-gated channel subfamily H member 20505
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Chain A, Mutant Al2 6e7p9g0011
Beta-lactamase 0001
acid sphingomyelinase3003
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1100010
DNA polymerase beta6006
60 kDa heat shock protein, mitochondrial0303
Beta-lactamase OXA-70001
10 kDa heat shock protein, mitochondrial0303
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Thiosulfate sulfurtransferase0303
Metallo-beta-lactamase VIM-130001
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0001
60 kDa chaperonin 0303
Metallo-beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0113
10 kDa chaperonin 0303
Metallo-b-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase VIM-1 0001
D(1A) dopamine receptor2002
neuropeptide S receptor isoform A2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE100010
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 49009
cytochrome P450 2D67007
glucocerebrosidase2002
Rac1 protein0011
IDH1110011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)9009
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0202
Integrin beta-32103
Myeloperoxidase0202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10103
Adenosine receptor A2a0103
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10112
Sigma non-opioid intracellular receptor 10011
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase0101
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase0101
Luciferase3003
estrogen receptor 2 (ER beta)7007
D-amino-acid oxidase0011
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
Tyrosinase0101
D-amino-acid oxidase0213
Metabotropic glutamate receptor 50011
Alpha-glucosidase MAL120101
Monocarboxylate transporter 10001
D-aspartate oxidase0101
Serine racemase0202
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 13003
Solute carrier organic anion transporter family member 1B30507
Solute carrier organic anion transporter family member 1B10507
Chain A, TRYPSIN0101
Chain H, ALPHA THROMBIN0101
Chain H, Thrombin heavy chain0101
Chain A, TRYPSIN0101
Prothrombin0303
Coagulation factor X0404
Tissue-type plasminogen activator0101
Glandular kallikrein0101
Trypsin-10202
Trypsin-20202
Tryptase beta-20101
Chymase0202
Trypsin-30202
Tryptase alpha/beta-10202
Chymotrypsin-C0101
Chain A, serum paraoxonase0101
nuclear receptor ROR-gamma isoform 1100010
Neutrophil cytosol factor 10101
Carbonic anhydrase 130102
Poly [ADP-ribose] polymerase tankyrase-20101
pregnane X nuclear receptor160016
G8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
streptokinase A precursor0044
Dihydroxyacetone phosphate acyltransferase0002
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 8008
30S ribosomal protein S60415
30S ribosomal protein S70415
50S ribosomal protein L150415
50S ribosomal protein L100415
50S ribosomal protein L110415
50S ribosomal protein L7/L120415
50S ribosomal protein L190415
50S ribosomal protein L10415
50S ribosomal protein L200415
50S ribosomal protein L270415
50S ribosomal protein L280415
50S ribosomal protein L290415
50S ribosomal protein L310415
50S ribosomal protein L31 type B0415
50S ribosomal protein L320415
50S ribosomal protein L330415
50S ribosomal protein L340415
50S ribosomal protein L350415
50S ribosomal protein L360415
30S ribosomal protein S100415
30S ribosomal protein S110415
30S ribosomal protein S120415
30S ribosomal protein S130415
30S ribosomal protein S160415
30S ribosomal protein S180415
30S ribosomal protein S190415
30S ribosomal protein S200415
30S ribosomal protein S20415
30S ribosomal protein S30415
30S ribosomal protein S40415
30S ribosomal protein S50415
30S ribosomal protein S80415
30S ribosomal protein S90415
50S ribosomal protein L130415
50S ribosomal protein L140415
50S ribosomal protein L160415
50S ribosomal protein L230415
30S ribosomal protein S150415
50S ribosomal protein L170415
50S ribosomal protein L210415
50S ribosomal protein L300415
50S ribosomal protein L60415
30S ribosomal protein S140415
30S ribosomal protein S170415
30S ribosomal protein S10415
50S ribosomal protein L180415
50S ribosomal protein L20415
50S ribosomal protein L30415
50S ribosomal protein L240415
50S ribosomal protein L40415
50S ribosomal protein L220415
50S ribosomal protein L50415
30S ribosomal protein S210415
50S ribosomal protein L250415
50S ribosomal protein L36 20415
Inositol hexakisphosphate kinase 18008
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial8008
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120202
Protein-arginine deiminase type-40606
endonuclease IV4004
dopamine D1 receptor1001
pregnane X receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)120012
peripheral myelin protein 22 isoform 14004
flap endonuclease 17007
survival motor neuron protein isoform d4004
M-phase phosphoprotein 83003
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 43100010
glp-1 receptor, partial4004
Fumarate hydratase2002
PPM1D protein5005
polyprotein2002
67.9K protein7007
P531001
RPL19A0011
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor3003
cellular tumor antigen p53 isoform a4004
thyroid hormone receptor beta isoform a130013
nuclear factor erythroid 2-related factor 2 isoform 2110011
nuclear factor NF-kappa-B p105 subunit isoform 13003
ras-related protein Rab-9A4004
heat shock protein HSP 90-alpha isoform 20103
transactivating tegument protein VP16 [Human herpesvirus 1]0202
COUP transcription factor 2 isoform a0101
Transmembrane protease serine 20011
Glucose transporter0101
Hexose transporter 1 0101
Procathepsin L0011
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0314
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-synuclein3205
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0112
ATPase family AAA domain-containing protein 57007
Ataxin-29009
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0011
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0002
LMP1 [Human herpesvirus 4]0002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Thymidine kinase0101
Thymidylate synthase0102
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor2002
E3 ubiquitin-protein ligase Mdm20202
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Deoxynucleoside kinase0101
hypoxia-inducible factor 1 alpha subunit6006
SMAD family member 26006
SMAD family member 36006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
thyroid stimulating hormone receptor9009
Caspase-71001
potassium voltage-gated channel subfamily H member 2 isoform d7007
caspase-31001
mitogen-activated protein kinase 17007
Androgen receptor0404
Chain A, Odorant binding protein0011
Chain B, Odorant binding protein0011
Lysine-specific demethylase 4A0101
Guanine nucleotide-binding protein G2002
Methylcytosine dioxygenase TET20101
Deoxyhypusine hydroxylase0101
Hsf1 protein0011
STAT3, partial0202
nuclear receptor subfamily 1, group I, member 25005
signal transducer and activator of transcription 1-alpha/beta isoform alpha0202
Sodium/potassium-transporting ATPase subunit alpha-1 0303
Sodium/potassium-transporting ATPase subunit beta-10303
Sodium/potassium-transporting ATPase subunit alpha-30202
Sodium/potassium-transporting ATPase subunit beta-20202
Sodium/potassium-transporting ATPase subunit alpha-20303
Sodium/potassium-transporting ATPase subunit alpha-10202
Sodium/potassium-transporting ATPase subunit beta-30202
Sodium/potassium-transporting ATPase subunit gamma0202
Sodium/potassium-transporting ATPase subunit alpha-40202
Solute carrier organic anion transporter family member 4C10102
PAX80001
thioredoxin glutathione reductase6006
alpha-galactosidase3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
Solute carrier organic anion transporter family member 1A40203
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10404
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10405
ATP-dependent translocase ABCB10404
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10002
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70002
Transthyretin0001
nonstructural protein 13003
bromodomain adjacent to zinc finger domain 2B7007
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK14004
Motilin receptor0112
Rap guanine nucleotide exchange factor 35005
Albumin0134
60 kDa chaperonin0101
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
Lanosterol 14-alpha demethylase0415
Chain A, BCL-2-RELATED PROTEIN A10011
unnamed protein product0101
bcl-2-like protein 11 isoform 10011
Histone deacetylase 30101
Chymotrypsinogen A0202
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Heme oxygenase 1 0101
Lanosterol 14-alpha demethylase0112
Aromatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
Histone deacetylase 10101
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0011
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
likely tRNA 2'-phosphotransferase0101
Carbonic anhydrase0205
Chain A, Dihydrofolate reductase0011
lysosomal alpha-glucosidase preproprotein3003
Thymidylate synthase0202
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10607
Proton-coupled amino acid transporter 10304
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Protein cereblon0202
importin subunit beta-1 isoform 12002
snurportin-12002
Vpr1001
Thymidine phosphorylase0001
Thymidine kinase0001
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Parkin2002
cytochrome P450 2C19 precursor2002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Mitogen-activated protein kinase 130101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Glutamate receptor 12104
Glutamate receptor 32104
Glutamate receptor 42104
Glutamate receptor ionotropic, kainate 10102
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Aryl hydrocarbon receptor0011
Neuronal acetylcholine receptor subunit alpha-70101
Glutamate receptor ionotropic, kainate 20102
Glutamate receptor ionotropic, kainate 30102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Mitogen-activated protein kinase 120101
Glutamate receptor ionotropic, kainate 40102
Mitogen-activated protein kinase 110101
Gamma-aminobutyric acid receptor subunit alpha-60202
Mitogen-activated protein kinase 140101
G protein-coupled receptor GPR350011
Glutamate receptor ionotropic, kainate 50102
Vesicular glutamate transporter 30101
G-protein coupled receptor 350213
Histamine H3 receptor0011
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0303
Intestinal-type alkaline phosphatase0303
Phospholipase A-2-activating protein0303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0203
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0303
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
muscleblind-like protein 1 isoform 13003
Nuclear receptor subfamily 1 group I member 20022
Nuclear receptor subfamily 1 group I member 20011
Thioredoxin reductase 0101
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Stromelysin-10303
Matrilysin0101
Multidrug transporter MdfA0202
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
WRN2002
Valosin-containing protein0101
microphthalmia-associated transcription factor isoform 90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40202
eukaryotic translation initiation factor 4E isoform 10202
DNA dC->dU-editing enzyme APOBEC-3G isoform 12204
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
serine-protein kinase ATM isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Trace amine-associated receptor 10011
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Plasma kallikrein0003
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Carbonic anhydrase0003
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0003
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0003
Carbonic anhydrase0003
Carbonic anhydrase0003
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 0003
Monocarboxylate transporter 100003
Gamma-aminobutyric acid 0101
cytochrome P450 2C9 precursor2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-20101
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histamine H2 receptor3003
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
cytochrome P450 2D6 isoform 11001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
pyruvate kinase1001
Dihydroorotate dehydrogenase 0101
Cocaine esterase0101
Thymidylate synthase0001
Coagulation factor XII0202
Cholinesterase0202
Liver carboxylesterase 10101
Carbon monoxide dehydrogenase small chain0011
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0202
Liver carboxylesterase 10101
Amine oxidase [flavin-containing] B0101
Dual specificity protein phosphatase 10101
Caspase-10202
M-phase inducer phosphatase 20101
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Dual specificity protein phosphatase 60101
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0101
DNA-directed RNA polymerase subunit beta0101
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Beta-3 adrenergic receptor0112
POU domain, class 2, transcription factor 10001
Beta-2 adrenergic receptor0101
Beta-2 adrenergic receptor 0011
Chain A, Ribosomal protein S6 kinase alpha-10101
Chain X, Tyrosine-protein kinase Lyn0101
Chain A, Dual specificity protein kinase TTK0011
Chain A, Dual specificity protein kinase TTK0011
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Integrase 0101
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
hexokinase0101
SUMO-conjugating enzyme UBC90101
Vif0101
Tat0101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Chain A, PAPAIN1001
Thrombopoietin1001
TPA: protein transporter TIM100101
TPA: protein transporter TIM230101
perilipin-50101
perilipin-10101
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
protein-arginine deiminase type-40101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
replicative DNA helicase0001
recombinase A0011
chaperonin GroEL1001
Trypsin0101
Amyloid-beta precursor protein1001
Cathepsin G0101
Chymotrypsin-like elastase family member 2A0101
Nuclear factor NF-kappa-B p105 subunit0101
Cyclin-dependent kinase 80101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
Thromboxane-A synthase 0101
Sodium-dependent dopamine transporter 0202
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
twin arginine protein translocation system - TatA protein0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]