metronidazole has been researched along with Dental Leakage in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dental Leakage: The seepage of fluids, debris, and micro-organisms between the walls of a prepared dental cavity and the restoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No bacteria were recovered from carious lesions in vitro (six samples) or in vivo (four samples) after the lesions were covered by the antibacterial temporary cement." | 1.30 | Bactericidal eradication from carious lesions of prepared abutments by an antibacterial temporary cement. ( Hori, R; Hoshino, E; Kohno, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hori, R | 1 |
| Kohno, S | 1 |
| Hoshino, E | 1 |
1 other study available for metronidazole and Dental Leakage
| Article | Year |
|---|---|
Bactericidal eradication from carious lesions of prepared abutments by an antibacterial temporary cement.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Cefaclor; Cephalosporins; Ciprofloxacin; Colony Count, Micro | 1997 |